{"id":"https://openalex.org/W6860514","doi":null,"title":"Soluble amyloid-\u03b2 aggregates in Alzheimer\u2019s disease","display_name":"Soluble amyloid-\u03b2 aggregates in Alzheimer\u2019s disease","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W6860514","mag":"6860514"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-98512","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98512","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98512","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038514040","display_name":"Hillevi Englund","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hillevi Englund","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038514040"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta-oligomers","display_name":"amyloid-beta oligomers","score":0.7879999876022339},{"id":"https://openalex.org/keywords/amyloid-beta-protofibrils","display_name":"amyloid-beta protofibrils","score":0.8799999952316284},{"id":"https://openalex.org/keywords/alzheimer-s-disease-pathogenesis","display_name":"Alzheimer's disease pathogenesis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.847000002861023},{"id":"https://openalex.org/keywords/epitope-masking","display_name":"epitope masking","score":0.8209999799728394},{"id":"https://openalex.org/keywords/sandwich-elisa","display_name":"sandwich ELISA","score":0.6970000267028809},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.8960000276565552},{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.8460000157356262},{"id":"https://openalex.org/keywords/amyloid-beta-detection","display_name":"amyloid-beta detection","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5769372582435608},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.521669864654541},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4550209939479828},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.423789381980896},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37020403146743774},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33020833134651184},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32080990076065063},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2142086625099182},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18226554989814758},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1729356050491333}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-98512","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98512","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:6860514","doi":null,"is_oa":false,"landing_page_url":"http://uu.diva-portal.org/smash/get/diva2:174745/FULLTEXT01","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-98512","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98512","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2403690402","https://openalex.org/W2410260158","https://openalex.org/W2417143865"],"related_works":["https://openalex.org/W1979688792","https://openalex.org/W1979452762","https://openalex.org/W2774913139","https://openalex.org/W2089810731","https://openalex.org/W2068052697","https://openalex.org/W2152948641","https://openalex.org/W1996403761","https://openalex.org/W7055749641","https://openalex.org/W2741255489","https://openalex.org/W2113372794"],"abstract_inverted_index":{"Soluble":[0],"oligomeric":[1,51,243],"aggregates":[2,29,53,105,187],"of":[3,25,102,122,184,310],"the":[4,57,67,114,130],"amyloid-\u03b2":[5],"(A\u03b2)":[6],"peptide":[7],"are":[8,83,284],"suggested":[9],"to":[10,16,33,69,112,149,179,182,189,217,232,242,321],"initiate":[11],"Alzheimer's":[12],"disease":[13,34,45,323],"(AD),":[14],"leading":[15,188],"impaired":[17,190],"synapse":[18],"signalling,":[19],"widespread":[20],"neuronal":[21],"death":[22],"and":[23,36,56,71,90,126,212,256,264,296],"loss":[24],"cognitive":[26],"functions.":[27],"These":[28,259],"seem":[30],"tightly":[31],"linked":[32],"progression,":[35],"have":[37,63,218,225],"therefore":[38],"gained":[39],"much":[40],"attention":[41],"as":[42,91,318],"potential":[43],"novel":[44],"markers.":[46],"In":[47],"this":[48,238],"thesis":[49],"soluble":[50,103,185],"A\u03b2":[52,58,104,186,220,244,282],"in":[54,61,75,87,144,147,160,166,229,247,274,286],"general,":[55],"protofibril":[59,203,221],"species":[60,245],"particular,":[62],"been":[64],"investigated":[65],"with":[66],"aim":[68],"quantify":[70],"determine":[72],"their":[73],"role":[74],"AD":[76,88,131,223,248,275,294,311],"pathogenesis.":[77,290],"Sandwich-ELISAs":[78],"specifically":[79],"measuring":[80],"A\u03b242":[81,140,266,303],"peptides":[82],"widely":[84],"used":[85,317],"both":[86,254],"research":[89],"complements":[92],"for":[93],"clinical":[94],"diagnosis.":[95],"Here":[96],"it":[97,110],"was":[98,118,164,177,198,240],"demonstrated":[99,216],"that":[100,281,302],"presence":[101,183],"disturbs":[106],"such":[107],"analyses,":[108],"making":[109],"difficult":[111],"interpret":[113],"results.":[115],"This":[116,197],"discovery":[117],"made":[119],"through":[120],"analyses":[121,163],"samples":[123,168,208],"from":[124,169,209,293],"cell-":[125,211],"mouse":[127,213],"models":[128,214],"carrying":[129],"causing":[132],"'Arctic'":[133],"APP":[134],"mutation.":[135],"When":[136],"analyzed":[137,252],"by":[138,152,194,200,206],"ELISA,":[139,205],"levels":[141,150],"were":[142,215,251,262,272],"reduced":[143,226],"Arctic":[145,210],"samples,":[146],"contrast":[148],"measured":[151],"denaturing":[153,255],"SDS-PAGE":[154],"Western":[155],"blot.":[156],"The":[157,173,291],"same":[158],"divergence":[159],"A\u03b242-levels":[161,228,250],"between":[162,175],"observed":[165],"CSF":[167,230,287],"Down":[170,298],"syndrome":[171,299],"infants.":[172],"discrepancy":[174],"methods":[176],"hypothesized":[178],"be":[180,316],"due":[181,241],"ELISA":[191],"detection":[192],"caused":[193],"epitope":[195],"masking.":[196],"confirmed":[199],"developing":[201],"a":[202,319],"specific":[204],"which":[207,313],"enhanced":[219],"levels.":[222],"patients":[224,276,295],"ELISA-measured":[227],"compared":[231],"healthy":[233,278],"controls.":[234],"To":[235],"test":[236],"if":[237],"reduction":[239],"present":[246,285],"CSF,":[249],"under":[253],"non-denaturing":[257],"conditions.":[258],"two":[260],"measures":[261],"combined":[263],"an":[265,307],"oligomer":[267,304],"ratio":[268],"established.":[269],"Higher":[270],"ratios":[271],"found":[273],"than":[277],"controls,":[279],"implying":[280],"oligomers":[283],"during":[288],"Alzheimer":[289],"observations":[292],"young":[297],"individuals":[300],"suggest":[301],"formation":[305],"is":[306],"early":[308],"mechanism":[309],"pathogenesis,":[312],"potentially":[314],"could":[315],"biomarker":[320],"monitor":[322],"development.":[324]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
