{"id":"https://openalex.org/W68604783","doi":null,"title":"Cell signaling by nitric oxide.","display_name":"Cell signaling by nitric oxide.","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W68604783","mag":"68604783","pmid":"https://pubmed.ncbi.nlm.nih.gov/10226328"},"language":"en","primary_location":{"id":"pmid:10226328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10226328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in nephrology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015888453","display_name":"Paul B. Lane","orcid":"https://orcid.org/0000-0003-1595-3237","observed_orcids":["https://orcid.org/0000-0003-1595-3237"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Lane","raw_affiliation_strings":["Department of Pharmacology, Cornell University Medical College, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Cornell University Medical College, New York, NY 10021, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066232316","display_name":"S S Gross","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S S Gross","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.997,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.97610636,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"19","issue":"3","first_page":"215","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.972000002861023},{"id":"https://openalex.org/keywords/nitric-oxide-signaling","display_name":"nitric oxide signaling","score":0.8730000257492065},{"id":"https://openalex.org/keywords/covalent-modification","display_name":"covalent modification","score":0.6330000162124634},{"id":"https://openalex.org/keywords/s-nitrosylation","display_name":"S-nitrosylation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.6510000228881836},{"id":"https://openalex.org/keywords/protein-modification","display_name":"protein modification","score":0.4650000035762787},{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.8276337385177612},{"id":"https://openalex.org/C171852809","wikidata":"https://www.wikidata.org/wiki/Q731154","display_name":"Chemical biology","level":2,"score":0.5774355530738831},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5602195262908936},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.5597594380378723},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5477015376091003},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5370306968688965},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49857211112976074},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.48065030574798584},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46837693452835083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3829643428325653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35820770263671875},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09043410420417786}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10226328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10226328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in nephrology","raw_type":"Journal Article"},{"id":"mag:68604783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10226328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1122040679","https://openalex.org/W2400067424","https://openalex.org/W105208581","https://openalex.org/W624538913","https://openalex.org/W2131474149","https://openalex.org/W2059407737","https://openalex.org/W2070795117","https://openalex.org/W992309826","https://openalex.org/W1983886923","https://openalex.org/W1980458823"],"abstract_inverted_index":{"Appreciation":[0],"of":[1,4,86,91,98,124,161,205],"the":[2,14,70,84,89,92,106,122,167,176,199],"role":[3],"nitric":[5,30],"oxide":[6,31],"(NO)":[7],"in":[8,46,53,68,153,179,188],"mammalian":[9],"cell":[10],"biology":[11],"has":[12,143],"toppled":[13],"paradigm":[15],"that":[16,36,73,108,128,149],"biological":[17],"signaling":[18,104,206],"is":[19,32,100],"initiated":[20],"exclusively":[21],"by":[22,38,77,105,151,166,207],"noncovalent,":[23],"lock-and-key-type":[24],"interactions":[25],"with":[26,41,66,112,117,171],"receptor":[27],"proteins.":[28],"Remarkably,":[29],"a":[33,50,146],"free":[34],"radical":[35],"signals":[37,150],"chemical":[39],"reaction":[40],"its":[42],"protein":[43,54],"targets,":[44],"resulting":[45],"covalent":[47],"modifications":[48],"and":[49,56,88,133,159,185,203],"stable":[51],"alteration":[52],"structure":[55],"function.":[57],"Although":[58],"most":[59,200],"proteins":[60,72],"may":[61],"be":[62,198],"coerced":[63],"to":[64,121,174,181,197],"react":[65],"NO":[67,78,87,103,113,142,162,189],"vitro,":[69],"specific":[71],"are":[74,131],"functionally":[75],"modified":[76],"within":[79],"cells":[80],"will":[81],"depend":[82],"on":[83],"concentration":[85],"composition":[90],"intracellular":[93],"milieu.":[94],"A":[95],"further":[96],"level":[97],"complexity":[99],"introduced":[101],"into":[102],"fact":[107],"reactions":[109],"can":[110],"occur":[111],"directly,":[114],"or":[115],"secondarily":[116],"NO-derived":[118],"species.":[119],"Much":[120],"surprise":[123],"those":[125],"who":[126],"thought":[127],"reactive":[129],"molecules":[130],"generated":[132],"act":[134],"only":[135],"under":[136],"pathophysiological":[137],"conditions":[138],"(e.g.,":[139],"ischemia-reperfusion":[140],"injury),":[141],"emerged":[144],"as":[145],"prototype":[147],"molecule":[148],"chemistry":[152],"normal":[154],"physiology.":[155],"The":[156],"unique":[157],"attributes":[158],"importance":[160],"were":[163],"recently":[164],"recognized":[165],"Nobel":[168],"Prize":[169,178],"Committee,":[170],"their":[172],"decision":[173],"award":[175],"1998":[177],"Medicine":[180],"Drs":[182],"Furchgott,":[183],"Ignarro,":[184],"Murad,":[186],"pioneers":[187],"biology.":[190],"This":[191],"review":[192],"surveys":[193],"what":[194],"we":[195],"believe":[196],"important":[201],"mechanisms":[202],"targets":[204],"NO.":[208]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
