{"id":"https://openalex.org/W68591885","doi":"https://doi.org/10.1002/j.1460-2075.1994.tb06948.x","title":"Regulated degradation of the transcription factor Gcn4.","display_name":"Regulated degradation of the transcription factor Gcn4.","publication_year":1994,"publication_date":"1994-12-01","ids":{"openalex":"https://openalex.org/W68591885","doi":"https://doi.org/10.1002/j.1460-2075.1994.tb06948.x","mag":"68591885","pmid":"https://pubmed.ncbi.nlm.nih.gov/7813440","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/395579"},"language":"en","primary_location":{"id":"doi:10.1002/j.1460-2075.1994.tb06948.x","doi":"https://doi.org/10.1002/j.1460-2075.1994.tb06948.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1460-2075.1994.tb06948.x","pdf_url":"https://link.springer.com/content/pdf/10.1002/j.1460-2075.1994.tb06948.x.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1002/j.1460-2075.1994.tb06948.x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029947273","display_name":"Daniel Kornitzer","orcid":"https://orcid.org/0000-0002-5062-2735","observed_orcids":["https://orcid.org/0000-0002-5062-2735"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Kornitzer","raw_affiliation_strings":["Whitehead Institute, Nine Cambridge Center, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute, Nine Cambridge Center, MA 02142","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055866311","display_name":"Bilha Raboy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Raboy","raw_affiliation_strings":["Whitehead Institute, Nine Cambridge Center, MA, 02142, USA","Whitehead Institute, Nine Cambridge Center, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute, Nine Cambridge Center, MA, 02142, USA","institution_ids":["https://openalex.org/I4210157710"]},{"raw_affiliation_string":"Whitehead Institute, Nine Cambridge Center, MA 02142","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026510570","display_name":"Richard G. Kulka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.G. Kulka","raw_affiliation_strings":["Whitehead Institute, Nine Cambridge Center, MA, 02142, USA","Whitehead Institute, Nine Cambridge Center, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute, Nine Cambridge Center, MA, 02142, USA","institution_ids":["https://openalex.org/I4210157710"]},{"raw_affiliation_string":"Whitehead Institute, Nine Cambridge Center, MA 02142","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103084852","display_name":"Gerald R. Fink","orcid":"https://orcid.org/0000-0003-3704-2899","observed_orcids":["https://orcid.org/0000-0003-3704-2899"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.R. Fink","raw_affiliation_strings":["Whitehead Institute, Nine Cambridge Center, MA, 02142, USA","Whitehead Institute, Nine Cambridge Center, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute, Nine Cambridge Center, MA, 02142, USA","institution_ids":["https://openalex.org/I4210157710"]},{"raw_affiliation_string":"Whitehead Institute, Nine Cambridge Center, MA 02142","institution_ids":["https://openalex.org/I4210157710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210157710"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":6.9005,"has_fulltext":true,"cited_by_count":266,"citation_normalized_percentile":{"value":0.98045283,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"24","first_page":"6021","last_page":"6030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gcn4","display_name":"GCN4","score":0.996999979019165},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.8519999980926514},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cdc34","display_name":"Cdc34","score":0.9309999942779541},{"id":"https://openalex.org/keywords/rad6","display_name":"Rad6","score":0.972000002861023},{"id":"https://openalex.org/keywords/ubiquitin-conjugating-enzyme","display_name":"E2 ubiquitin-conjugating enzyme","score":0.7900000214576721},{"id":"https://openalex.org/keywords/amino-acid-starvation","display_name":"amino acid starvation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/bzip-transcription-factors","display_name":"bZIP transcription factors","score":0.859000027179718},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8769999742507935},{"id":"https://openalex.org/keywords/amino-acid-biosynthesis","display_name":"amino acid biosynthesis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/purine-biosynthesis","display_name":"purine biosynthesis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/transcriptional-activator","display_name":"transcriptional activator","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2779463800","wikidata":"https://www.wikidata.org/wiki/Q5062222","display_name":"Center (category theory)","level":2,"score":0.5523767471313477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5218895077705383},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.3949119746685028},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11976733803749084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.08621779084205627},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.0637345016002655}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008025","descriptor_name":"Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043743","descriptor_name":"Ubiquitin-Protein Ligase Complexes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044763","descriptor_name":"Ubiquitin-Conjugating Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064173","descriptor_name":"Anaphase-Promoting Complex-Cyclosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/j.1460-2075.1994.tb06948.x","doi":"https://doi.org/10.1002/j.1460-2075.1994.tb06948.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1460-2075.1994.tb06948.x","pdf_url":"https://link.springer.com/content/pdf/10.1002/j.1460-2075.1994.tb06948.x.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:221374","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC395579","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:395579","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/395579","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"},{"id":"pmid:7813440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7813440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"},{"id":"mag:2322730813","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Daniel_Kornitzer2/publication/15386648_Regulated_degradation_of_the_transcription_factor_Gcn4/links/0fcfd5108af74dbb1a000000.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1002/j.1460-2075.1994.tb06948.x","doi":"https://doi.org/10.1002/j.1460-2075.1994.tb06948.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1460-2075.1994.tb06948.x","pdf_url":"https://link.springer.com/content/pdf/10.1002/j.1460-2075.1994.tb06948.x.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320947","display_name":"German-Israeli Foundation for Scientific Research and Development","ror":"https://ror.org/00tntzp09"},{"id":"https://openalex.org/F4320320950","display_name":"United States-Israel Binational Science Foundation","ror":"https://ror.org/00j8z2m73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W68591885.pdf","grobid_xml":"https://content.openalex.org/works/W68591885.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W5959882","https://openalex.org/W142046229","https://openalex.org/W252949253","https://openalex.org/W263799869","https://openalex.org/W1483766000","https://openalex.org/W1496897161","https://openalex.org/W1526043578","https://openalex.org/W1559325314","https://openalex.org/W1571547690","https://openalex.org/W1585503692","https://openalex.org/W1606065549","https://openalex.org/W1653065940","https://openalex.org/W1817433838","https://openalex.org/W1837558751","https://openalex.org/W1838616807","https://openalex.org/W1869200816","https://openalex.org/W1872090290","https://openalex.org/W1897176773","https://openalex.org/W1964931840","https://openalex.org/W1966263533","https://openalex.org/W1970921900","https://openalex.org/W1978186903","https://openalex.org/W1978611748","https://openalex.org/W1979067014","https://openalex.org/W1991101546","https://openalex.org/W2001553480","https://openalex.org/W2001597380","https://openalex.org/W2010601153","https://openalex.org/W2011882215","https://openalex.org/W2013007761","https://openalex.org/W2015598117","https://openalex.org/W2030154932","https://openalex.org/W2030712030","https://openalex.org/W2041770258","https://openalex.org/W2046404781","https://openalex.org/W2050060181","https://openalex.org/W2061050157","https://openalex.org/W2061688076","https://openalex.org/W2067397983","https://openalex.org/W2071056869","https://openalex.org/W2071660645","https://openalex.org/W2081062649","https://openalex.org/W2081744774","https://openalex.org/W2091160336","https://openalex.org/W2107915635","https://openalex.org/W2128462886","https://openalex.org/W2132024812","https://openalex.org/W2160870861","https://openalex.org/W2164941141","https://openalex.org/W2169333620","https://openalex.org/W2170939558","https://openalex.org/W2175093343","https://openalex.org/W2214383802","https://openalex.org/W2555397528"],"related_works":["https://openalex.org/W2033456186","https://openalex.org/W4394844133","https://openalex.org/W2799703465","https://openalex.org/W2056554448","https://openalex.org/W2401194883","https://openalex.org/W2409495396","https://openalex.org/W2189783757","https://openalex.org/W72640425","https://openalex.org/W147792619","https://openalex.org/W2471025053"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}