{"id":"https://openalex.org/W68445963","doi":"https://doi.org/10.1096/fasebj.21.6.a1306","title":"Induction of RNA\u2010binding proteins in denervated skeletal muscle","display_name":"Induction of RNA\u2010binding proteins in denervated skeletal muscle","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W68445963","doi":"https://doi.org/10.1096/fasebj.21.6.a1306","mag":"68445963"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.6.a1306","doi":"https://doi.org/10.1096/fasebj.21.6.a1306","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1306","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047449489","display_name":"Ang\u00e8le Chopard","orcid":"https://orcid.org/0000-0001-5241-9899","observed_orcids":["https://orcid.org/0000-0001-5241-9899"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["CA","FR"],"is_corresponding":false,"raw_author_name":"Angele Chopard","raw_affiliation_strings":["Cellular and Molecular Medicine, University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, K1H 8M5 Canada","Universite de Nice-Sophia-Antipolis, 28 avenue de Valrose, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Medicine, University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, K1H 8M5 Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Universite de Nice-Sophia-Antipolis, 28 avenue de Valrose, Nice, France","institution_ids":["https://openalex.org/I4387154757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050664437","display_name":"Anu Heidi Shukla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Anu Heidi Shukla","raw_affiliation_strings":["Cellular and Molecular Medicine, University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, K1H 8M5 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Medicine, University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, K1H 8M5 Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111383653","display_name":"John A. Lunde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John Lunde","raw_affiliation_strings":["Cellular and Molecular Medicine, University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, K1H 8M5 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Medicine, University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, K1H 8M5 Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073725247","display_name":"Bernard Jean Jasmin","orcid":"https://orcid.org/0000-0001-5798-4475","observed_orcids":["https://orcid.org/0000-0001-5798-4475"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bernard Jean Jasmin","raw_affiliation_strings":["Cellular and Molecular Medicine, University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, K1H 8M5 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Medicine, University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, K1H 8M5 Canada","institution_ids":["https://openalex.org/I153718931"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0089311,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.045499999076128006,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.9750000238418579},{"id":"https://openalex.org/keywords/skeletal-muscle-atrophy","display_name":"skeletal muscle atrophy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/denervation","display_name":"denervation","score":0.824999988079071},{"id":"https://openalex.org/keywords/au-rich-elements","display_name":"AU-rich elements","score":0.781000018119812},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.9490000009536743},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.953000009059906},{"id":"https://openalex.org/keywords/ttp","display_name":"TTP","score":0.746999979019165},{"id":"https://openalex.org/keywords/brf1","display_name":"Brf1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hur","display_name":"HuR","score":0.8619999885559082},{"id":"https://openalex.org/keywords/auf1","display_name":"AUF1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ksrp","display_name":"KSRP","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fast-and-slow-muscle-fibers","display_name":"fast and slow muscle fibers","score":0.7710000276565552},{"id":"https://openalex.org/keywords/muscle-disuse","display_name":"muscle disuse","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C2776805190","wikidata":"https://www.wikidata.org/wiki/Q1187030","display_name":"Denervation","level":2,"score":0.8320789337158203},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7174221277236938},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6427969336509705},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.6325191259384155},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.5458739399909973},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5061284899711609},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.5011227130889893},{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.45452845096588135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44473549723625183},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.4412567913532257},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4381333887577057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4235348701477051},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4105677306652069},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36332255601882935},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.350469172000885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22567498683929443},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2028094232082367},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16124668717384338}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.6.a1306","doi":"https://doi.org/10.1096/fasebj.21.6.a1306","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1306","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308162","display_name":"Minnesota Department of Agriculture","ror":"https://ror.org/02rxnmn30"},{"id":"https://openalex.org/F4320309751","display_name":"Association Fran\u00e7aise contre les Myopathies","ror":"https://ror.org/0162y2387"},{"id":"https://openalex.org/F4320321519","display_name":"Centre National d\u2019Etudes Spatiales","ror":"https://ror.org/04h1h0y33"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2945756318","https://openalex.org/W2164533103","https://openalex.org/W4367627513","https://openalex.org/W2089601286","https://openalex.org/W4388940241","https://openalex.org/W3062686304","https://openalex.org/W4411875375","https://openalex.org/W267230923","https://openalex.org/W2012333226","https://openalex.org/W2975243096"],"abstract_inverted_index":{"Several":[0],"transcriptional":[1],"mechanisms":[2,48,190],"are":[3,32],"known":[4,84],"to":[5,20,42,54,85,134,178],"be":[6,210],"involved":[7],"in":[8,49,65,71,101,109,120,155,159,171,181,197],"the":[9,27,44,50,57,66,78,139,162,198],"atrophic":[10,199],"response":[11,51,200],"of":[12,29,40,46,52,60,68,80,94,115,127,148,161,201],"skeletal":[13],"muscle.":[14,202],"However,":[15],"emerging":[16],"data":[17],"lead":[18],"us":[19],"hypothesize":[21],"that":[22,138,191,208],"post\u2010transcriptional":[23,47],"events,":[24],"operating":[25],"at":[26,217],"level":[28],"mRNA":[30,163],"stability,":[31,74],"also":[33],"contributing.":[34],"We":[35],"thus":[36],"initiated":[37],"a":[38,124,156,194],"series":[39],"studies":[41],"determine":[43],"role":[45,59,196],"muscle":[53,219],"disuse.":[55],"Given":[56],"key":[58,195],"AU\u2010rich":[61],"elements":[62],"(ARE)":[63],"located":[64],"3\u2032UTR":[67],"multiple":[69,182],"mRNAs":[70],"controlling":[72],"their":[73],"we":[75,91],"focused":[76],"on":[77],"contribution":[79],"RNA\u2010binding":[81],"proteins":[82],"(RBP)":[83],"interact":[86],"with":[87],"this":[88],"cis\u2010element.":[89],"Specifically,":[90],"examined":[92],"expression":[93,114,160],"HuR,":[95],"AUF1,":[96],"TTP,":[97],"BRF1":[98,170],"and":[99,167,226],"KSRP":[100],"slow":[102,121],"vs":[103],"fast":[104,172],"muscles":[105],"as":[106,108],"well":[107],"denervated":[110],"muscles.":[111,122,173],"In":[112],"general,":[113],"these":[116,175],"RBP":[117],"was":[118],"higher":[119],"Additionally,":[123],"time":[125],"course":[126],"hindlimb":[128],"denervation":[129],"ranging":[130],"from":[131],"12":[132],"hours":[133],"14":[135],"days":[136,147],"revealed":[137],"major":[140],"changes":[141,153],"occurred":[142],"early,":[143],"i.e.":[144],"within":[145],"2":[146],"denervation.":[149],"The":[150],"most":[151],"dramatic":[152],"consisted":[154],"substantial":[157],"increase":[158],"destabilizing":[164],"factors":[165,176],"TTP":[166],"its":[168],"homolog":[169],"Since":[174],"bind":[177],"ARE":[179],"found":[180],"important":[183],"mRNAs,":[184],"our":[185],"results":[186],"identify":[187],"new":[188],"molecular":[189],"likely":[192],"play":[193],"Also,":[203],"they":[204],"provide":[205],"additional":[206],"targets":[207],"may":[209],"useful":[211],"for":[212],"developing":[213],"novel":[214],"therapeutics":[215],"aimed":[216],"countering":[218],"atrophy.":[220],"Funded":[221],"by":[222],"CNES,":[223],"AFM,":[224],"MDA":[225],"CIHR.":[227]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}