{"id":"https://openalex.org/W680847","doi":null,"title":"Mechanisms of Dietary Protein-Induced Changes in Calcium Absorption Efficiency","display_name":"Mechanisms of Dietary Protein-Induced Changes in Calcium Absorption Efficiency","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W680847","mag":"680847"},"language":"en","primary_location":{"id":"pmh:oai:opencommons.uconn.edu:dissertations-6495","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/dissertations/308","pdf_url":"https://opencommons.uconn.edu/dissertations/308","source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://opencommons.uconn.edu/dissertations/308","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056500905","display_name":"Jessica Dauz Bihuniak","orcid":"https://orcid.org/0000-0001-9609-888X","observed_orcids":["https://orcid.org/0000-0001-9609-888X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jessica Bihuniak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5056500905"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.2921999990940094,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.2921999990940094,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.25459998846054077,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.10109999775886536,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-protein","display_name":"dietary protein","score":0.9900000095367432},{"id":"https://openalex.org/keywords/calcium-absorption","display_name":"calcium absorption","score":0.7889999747276306},{"id":"https://openalex.org/keywords/calcium-sensing-receptor","display_name":"calcium-sensing receptor","score":0.7839999794960022},{"id":"https://openalex.org/keywords/dibasic-amino-acids","display_name":"dibasic amino acids","score":0.8709999918937683},{"id":"https://openalex.org/keywords/intestinal-calcium-transport","display_name":"intestinal calcium transport","score":0.8410000205039978},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/low-protein-diet","display_name":"low-protein diet","score":0.8299999833106995},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6552746295928955},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.5405035018920898},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5144481658935547},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.42489245533943176},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.38108304142951965},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3769066333770752},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3273022174835205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22258642315864563},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.13056156039237976},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11410501599311829},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:opencommons.uconn.edu:dissertations-6495","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/dissertations/308","pdf_url":"https://opencommons.uconn.edu/dissertations/308","source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.913.6850","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.913.6850","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://digitalcommons.uconn.edu/cgi/viewcontent.cgi?article%3D6495%26context%3Ddissertations","raw_type":"text"},{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-6495","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/308","pdf_url":null,"source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"mag:680847","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.uconn.edu/dissertations/308/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:opencommons.uconn.edu:dissertations-6495","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/dissertations/308","pdf_url":"https://opencommons.uconn.edu/dissertations/308","source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033},{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.5}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G8052269359","display_name":"Yale University Clinical and Translational Science Award Program","funder_award_id":"UL1RR024139","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W680847.pdf","grobid_xml":"https://content.openalex.org/works/W680847.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W24684502","https://openalex.org/W39424341","https://openalex.org/W67908481","https://openalex.org/W134787914","https://openalex.org/W181395832","https://openalex.org/W1526429385","https://openalex.org/W1550721041","https://openalex.org/W1558138103","https://openalex.org/W1574019439","https://openalex.org/W1783506634","https://openalex.org/W1787081010","https://openalex.org/W1829337084","https://openalex.org/W1832699793","https://openalex.org/W1850146802","https://openalex.org/W1856528466","https://openalex.org/W1872666522","https://openalex.org/W1877998438","https://openalex.org/W1890457554","https://openalex.org/W1897313498","https://openalex.org/W1905500883","https://openalex.org/W1929046653","https://openalex.org/W1951351840","https://openalex.org/W1953200941","https://openalex.org/W1970368696","https://openalex.org/W1973488401","https://openalex.org/W1978325636","https://openalex.org/W1979207410","https://openalex.org/W1982509114","https://openalex.org/W2010802101","https://openalex.org/W2015205186","https://openalex.org/W2022302468","https://openalex.org/W2023865665","https://openalex.org/W2024005495","https://openalex.org/W2027359909","https://openalex.org/W2037124948","https://openalex.org/W2037965200","https://openalex.org/W2041454039","https://openalex.org/W2041581349","https://openalex.org/W2043669519","https://openalex.org/W2050850405","https://openalex.org/W2055583849","https://openalex.org/W2056758672","https://openalex.org/W2057583097","https://openalex.org/W2074124405","https://openalex.org/W2074840086","https://openalex.org/W2079932850","https://openalex.org/W2082445559","https://openalex.org/W2083095583","https://openalex.org/W2086955602","https://openalex.org/W2089854201","https://openalex.org/W2090919168","https://openalex.org/W2093814876","https://openalex.org/W2094943858","https://openalex.org/W2098256087","https://openalex.org/W2098661969","https://openalex.org/W2101317851","https://openalex.org/W2103731258","https://openalex.org/W2103871176","https://openalex.org/W2107031757","https://openalex.org/W2107499542","https://openalex.org/W2111937069","https://openalex.org/W2116469631","https://openalex.org/W2124388416","https://openalex.org/W2125922598","https://openalex.org/W2128616002","https://openalex.org/W2130465780","https://openalex.org/W2132422608","https://openalex.org/W2134345995","https://openalex.org/W2136256418","https://openalex.org/W2139462080","https://openalex.org/W2147582072","https://openalex.org/W2149899704","https://openalex.org/W2154303973","https://openalex.org/W2154694053","https://openalex.org/W2163474855","https://openalex.org/W2164587391","https://openalex.org/W2164634482","https://openalex.org/W2165889237","https://openalex.org/W2165989629","https://openalex.org/W2170080359","https://openalex.org/W2171397205","https://openalex.org/W2182875022","https://openalex.org/W2294322138","https://openalex.org/W2296988628","https://openalex.org/W2308427268","https://openalex.org/W2403455145","https://openalex.org/W2442642739"],"related_works":["https://openalex.org/W2098834383","https://openalex.org/W163197917","https://openalex.org/W2291624910","https://openalex.org/W24416720","https://openalex.org/W1970368696","https://openalex.org/W2863580211","https://openalex.org/W3171825273","https://openalex.org/W2062042571","https://openalex.org/W2047426927","https://openalex.org/W2171854268"],"abstract_inverted_index":{"We":[0],"undertook":[1],"a":[2,16,105,134,191],"randomized,":[3],"double-blind,":[4],"crossover":[5],"study":[6],"in":[7,42,136,167,184,205,220,233,239],"14":[8],"healthy":[9],"women":[10],"who":[11],"were":[12,143],"required":[13],"to":[14,46,145,199,229],"ingest":[15],"6-day":[17],"low":[18],"protein":[19,80,126,194,204],"diet":[20,49],"supplemented":[21],"with":[22,96,113],"CaSR-AAA":[23,97],"(calcium-sensing":[24],"receptor-activating":[25],"amino":[26,30,149,157,230],"acids),":[27],"DAA":[28,114],"(dibasic":[29],"acids)":[31],"or":[32],"methylcellulose":[33],"capsules":[34],"(control).":[35],"All":[36],"subjects":[37,50],"ingested":[38],"all":[39],"three":[40],"diets":[41],"random":[43],"order.":[44],"Prior":[45],"each":[47,65],"experimental":[48],"consumed":[51],"an":[52],"11":[53],"day":[54,62],"adjustment":[55],"diet.":[56],"Calcium":[57],"absorption":[58,87,110],"was":[59,111,196,211,216],"measured":[60],"on":[61,178],"5":[63],"of":[64,84,148,182,227],"dietary":[66,79,125,203],"intervention":[67],"using":[68],"dual-stable":[69],"calcium":[70,86,91],"isotopes.":[71],"The":[72,225],"clinical":[73],"trial":[74],"tested":[75],"the":[76,82,90,121,179],"hypothesis":[77],"that":[78,195],"affects":[81],"efficiency":[83],"intestinal":[85],"by":[88,123,202],"activating":[89],"sensing":[92],"receptor":[93],"(CaSR).":[94],"Supplementation":[95],"did":[98],"not":[99],"significantly":[100,160,212],"increase":[101],"Ca":[102,109,128,164,187,209,234],"absorption.":[103],"However,":[104],"trend":[106],"towards":[107],"improved":[108],"observed":[112],"(25.2\u00b11.4%":[115],"vs.":[116],"22.3\u00b11.4%,":[117],"P=0.094).\\nTo":[118],"further":[119],"elucidate":[120],"mechanisms":[122],"which":[124],"improves":[127],"absorption,":[129],"we":[130],"established":[131],"and":[132,153,176],"validated":[133,173],"45Ca":[135],"vitro":[137,168],"transport":[138,165,174,210,235],"model.":[139],"Differentiated":[140],"Caco-2":[141,221],"cells":[142,222],"exposed":[144],"different":[146],"concentrations":[147],"acids":[150],"for":[151],"6":[152],"72":[154],"hours.":[155],"Prolonged":[156],"acid":[158],"treatment":[159],"enhanced":[161],"total":[162,185],"transepithelial":[163,186,208],"(P=0.0048).\\nSubsequent":[166],"studies":[169],"utilized":[170],"our":[171],"recently":[172],"model":[175],"focused":[177],"functional":[180],"role":[181],"Cldn-2":[183,189,215,228],"transport.":[188],"is":[190],"tight":[192],"junction":[193],"previously":[197],"shown":[198],"be":[200,237],"upregulated":[201],"rats.":[206],"Total":[207],"reduced":[213],"when":[214],"stably":[217],"knocked":[218],"down":[219],"(P<":[223],"0.0001).":[224],"contribution":[226],"acid-induced":[231],"increases":[232],"will":[236],"explored":[238],"future":[240],"studies.":[241]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
