{"id":"https://openalex.org/W68066819","doi":null,"title":"Periodontitis and coronary artery disease: a questioned association between periodontal and vascular plaques.","display_name":"Periodontitis and coronary artery disease: a questioned association between periodontal and vascular plaques.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W68066819","mag":"68066819","pmid":"https://pubmed.ncbi.nlm.nih.gov/22254188","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3253509"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2265013","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3253509","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3253509","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065539150","display_name":"Costas Thomopoulos","orcid":"https://orcid.org/0000-0002-8491-6029","observed_orcids":["https://orcid.org/0000-0002-8491-6029"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Costas Thomopoulos","raw_affiliation_strings":["First Cardiology Clinic, University of Athens, Hippokration Hospital Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Cardiology Clinic, University of Athens, Hippokration Hospital Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107877457","display_name":"Costas P. Tsioufis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Costas Tsioufis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Nikos Soldatos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikos Soldatos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058399015","display_name":"Alexandros Kasiakogias","orcid":"https://orcid.org/0000-0002-1090-4965","observed_orcids":["https://orcid.org/0000-0002-1090-4965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandros Kasiakogias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005228083","display_name":"Christodoulos Stefanadis","orcid":"https://orcid.org/0000-0001-5974-6454","observed_orcids":["https://orcid.org/0000-0001-5974-6454","https://orcid.org/0000-0002-5388-2735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christodoulos Stefanadis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7915,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.87869755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"1","issue":"1","first_page":"76","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12439","display_name":"Dental Research and COVID-19","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":1.0},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":1.0},{"id":"https://openalex.org/keywords/atherosclerotic-plaque","display_name":"atherosclerotic plaque","score":0.7649999856948853},{"id":"https://openalex.org/keywords/bacteremia","display_name":"bacteremia","score":0.8199999928474426},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardiovascular-disease-prevention","display_name":"cardiovascular disease prevention","score":0.6380000114440918},{"id":"https://openalex.org/keywords/oral-hygiene","display_name":"oral hygiene","score":0.8980000019073486},{"id":"https://openalex.org/keywords/periodontal-disease-assessment","display_name":"periodontal disease assessment","score":0.6370000243186951},{"id":"https://openalex.org/keywords/confounding-factors","display_name":"confounding factors","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8919632434844971},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.82062828540802},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.6252464056015015},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.5570606589317322},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5308189392089844},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5009260177612305},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.44351640343666077},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.43579718470573425},{"id":"https://openalex.org/C2780791200","wikidata":"https://www.wikidata.org/wiki/Q673083","display_name":"Gingivitis","level":2,"score":0.41660380363464355},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29900527000427246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28429844975471497},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.24680256843566895},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:2265013","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3253509","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22254188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22254188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cardiovascular disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3253509","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3253509/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cardiovasc Dis","raw_type":"Text"},{"id":"mag:2188549923","doi":null,"is_oa":false,"landing_page_url":"http://www.ajcd.us/files/AJCD1105001.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:68066819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22254188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2265013","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3253509","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1909867565","https://openalex.org/W1965514721","https://openalex.org/W1966562186","https://openalex.org/W1977223297","https://openalex.org/W1985641590","https://openalex.org/W1987934049","https://openalex.org/W2001479866","https://openalex.org/W2007647507","https://openalex.org/W2010184360","https://openalex.org/W2027178964","https://openalex.org/W2032943506","https://openalex.org/W2033431538","https://openalex.org/W2034035669","https://openalex.org/W2048604448","https://openalex.org/W2049138031","https://openalex.org/W2055044297","https://openalex.org/W2058028170","https://openalex.org/W2069245375","https://openalex.org/W2090155923","https://openalex.org/W2091126023","https://openalex.org/W2096683088","https://openalex.org/W2097090404","https://openalex.org/W2104648280","https://openalex.org/W2104838871","https://openalex.org/W2107348072","https://openalex.org/W2118154631","https://openalex.org/W2126628340","https://openalex.org/W2131103140","https://openalex.org/W2134738076","https://openalex.org/W2134868917","https://openalex.org/W2138998943","https://openalex.org/W2145320544","https://openalex.org/W2155259964","https://openalex.org/W2157901583","https://openalex.org/W2165999166","https://openalex.org/W2167671859","https://openalex.org/W2386099697","https://openalex.org/W2399553189","https://openalex.org/W2614805886"],"related_works":["https://openalex.org/W2188549923","https://openalex.org/W7220701820","https://openalex.org/W1986139689","https://openalex.org/W2792526333","https://openalex.org/W2037225897","https://openalex.org/W3128622471","https://openalex.org/W2142463648","https://openalex.org/W33827514","https://openalex.org/W4240809234","https://openalex.org/W6986345777"],"abstract_inverted_index":{"Periodontitis":[0],"is":[1,158],"a":[2,30,76,81],"bacterially-induced,":[3],"localized":[4],"chronic":[5],"inflammatory":[6],"disease":[7,28,47],"destroying":[8],"both":[9,125],"the":[10,14,18,21,27,50,56,108,112,126,134,141,153,170],"connective":[11],"tissue":[12],"and":[13,44,55,72,85,133,173,176],"supporting":[15,80],"bone":[16],"of":[17,26,32,53,62,78,92,115,124,128,137,144,155],"teeth.":[19],"In":[20],"general":[22],"population,":[23],"severe":[24],"forms":[25],"demonstrate":[29],"prevalence":[31],"almost":[33],"5%,":[34],"whereas":[35],"initial":[36,109],"epidemiological":[37,110],"evidence":[38,116],"suggests":[39],"an":[40],"association":[41],"between":[42,83],"periodontitis":[43,54],"coronary":[45],"artery":[46],"(CAD).":[48],"Both":[49],"infectious":[51,60],"nature":[52],"yet":[57],"etiologically":[58],"unconfirmed":[59],"hypothesis":[61],"CAD,":[63],"question":[64],"their":[65],"potential":[66],"association.":[67],"Ephemeral":[68],"bacteremia,":[69],"systemic":[70],"inflammation":[71],"immune-pathological":[73],"reactions":[74],"constitute":[75],"triad":[77],"mechanisms":[79],"cross-talk":[82],"periodontal":[84,138,147,165],"vascular":[86,98],"damage.":[87],"To":[88],"which":[89],"extent":[90],"each":[91],"these":[93],"periodontitis-mediated":[94],"components":[95],"contribute":[96,168,183],"to":[97,169,184],"damage":[99],"still":[100,118],"remains":[101,117],"uncertain.":[102],"More":[103],"than":[104],"twenty":[105],"years":[106],"from":[107],"association,":[111],"positive":[113],"weight":[114],"alive":[119],"but":[120],"rather":[121],"debated,":[122],"because":[123],"presence":[127],"many":[129],"uncontrolled":[130],"confounding":[131],"factors":[132],"different":[135],"assessment":[136],"disease.":[139],"From":[140],"clinical":[142],"point":[143],"view,":[145],"advising":[146],"prevention":[148,154],"or":[149],"treatment":[150],"targeting":[151],"on":[152],"CAD":[156],"it":[157],"unjustified.":[159],"By":[160],"contrast,":[161],"oral":[162],"hygiene":[163],"including":[164],"health":[166],"might":[167,179],"overall":[171],"well-being":[172],"healthy":[174],"lifestyle":[175],"hence":[177],"as":[178],"at":[180],"least":[181],"partially":[182],"cardiovascular":[185],"prevention.":[186]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}