{"id":"https://openalex.org/W68026618","doi":null,"title":"Screening for primary aldosteronism--normal ranges for aldosterone and renin in three South African population groups.","display_name":"Screening for primary aldosteronism--normal ranges for aldosterone and renin in three South African population groups.","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W68026618","mag":"68026618","pmid":"https://pubmed.ncbi.nlm.nih.gov/11544978"},"language":"en","primary_location":{"id":"pmid:11544978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11544978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009408665","display_name":"Brian Lindsay Rayner","orcid":"https://orcid.org/0000-0002-0167-9591","observed_orcids":["https://orcid.org/0000-0002-0167-9591"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I2802258008","display_name":"Groote Schuur Hospital","ror":"https://ror.org/00c879s84","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I1307091933","https://openalex.org/I2802258008"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"B L Rayner","raw_affiliation_strings":["Hypertension Clinic, Groote Schuur Hospital and University of Cape Town"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension Clinic, Groote Schuur Hospital and University of Cape Town","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I2802258008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109808396","display_name":"Jonny E. Myers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J E Myers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109944534","display_name":"Lionel Henry Opie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L H Opie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027510192","display_name":"Yvonne A. Trinder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y A Trinder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110005506","display_name":"Jack Davidson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J S Davidson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6725,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.83559587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"91","issue":"7","first_page":"594","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12876","display_name":"Potassium and Related Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-aldosteronism","display_name":"primary aldosteronism","score":0.9950000047683716},{"id":"https://openalex.org/keywords/plasma-aldosterone-concentration","display_name":"plasma aldosterone","score":0.7820000052452087},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.9779999852180481},{"id":"https://openalex.org/keywords/aldosterone-to-renin-ratio","display_name":"aldosterone-renin ratio","score":0.9869999885559082},{"id":"https://openalex.org/keywords/reference-values","display_name":"reference values","score":0.6039999723434448},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.5529999732971191},{"id":"https://openalex.org/keywords/normotensive-population","display_name":"normotensive population","score":0.6129999756813049},{"id":"https://openalex.org/keywords/ethnic-differences","display_name":"ethnic differences","score":0.6650000214576721},{"id":"https://openalex.org/keywords/salt-retention","display_name":"salt retention","score":0.7210000157356262},{"id":"https://openalex.org/keywords/screening","display_name":"screening","score":0.5049999952316284},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.734000027179718},{"id":"https://openalex.org/keywords/south-africa","display_name":"South Africa","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.8978250622749329},{"id":"https://openalex.org/C2780233176","wikidata":"https://www.wikidata.org/wiki/Q1939330","display_name":"Primary aldosteronism","level":3,"score":0.8670313358306885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8206066489219666},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.8085976243019104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7274854779243469},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7126284241676331},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.6686708927154541},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5915393829345703},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5040816068649292},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4974103271961212},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.4267529249191284},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.38355767726898193},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005006","descriptor_name":"Ethnicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D013019","descriptor_name":"South Africa","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11544978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11544978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde","raw_type":"Journal Article"},{"id":"mag:68026618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11544978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1988655575","https://openalex.org/W2283838150","https://openalex.org/W2073568974","https://openalex.org/W2156180097","https://openalex.org/W3006553718","https://openalex.org/W2095045206","https://openalex.org/W2129950671","https://openalex.org/W2957988097","https://openalex.org/W2975615252","https://openalex.org/W7096616107"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"establish":[2],"normal":[3],"ranges":[4],"for":[5,71,221,223,254,279],"plasma":[6,61,65,83,123,258],"aldosterone,":[7,64],"renin":[8,66,84,164,235,259],"and":[9,21,41,45,48,68,112,146,236,260],"aldosterone/renin":[10],"(A/R)":[11],"ratio":[12,197],"in":[13,32,86,103,125,137,163,185,246,263],"South":[14],"African":[15],"normotensives":[16,127,193],"under":[17],"typical":[18],"outpatient":[19],"conditions,":[20],"to":[22],"estimate":[23],"the":[24,169,186,192,255,277],"prevalence":[25],"of":[26,58,178,191,210,229,257,271,281],"primary":[27,33,53,267],"aldosteronism":[28],"(PA)":[29],"among":[30],"hypertensives":[31,50,211,272],"care":[34,54,268],"settings.":[35],"DESIGN":[36],"AND":[37],"METHODS:":[38],"One":[39],"hundred":[40],"thirty-six":[42],"normotensive":[43,88,231],"subjects":[44,89,232],"154":[46],"sex-":[47],"age-matched":[49],"at":[51],"three":[52,170,187],"clinics":[55],"had":[56,194,233,273],"measurements":[57],"blood":[59],"pressure,":[60],"creatinine,":[62],"K+,":[63],"activity,":[67],"spot":[69],"urine":[70],"urinary":[72],"Na+/creatinine":[73,174],"ratio.":[74],"Medication":[75],"was":[76,99,132],"not":[77,182],"withdrawn":[78],"before":[79],"testing.":[80],"RESULTS:":[81],"Mean":[82,122],"activity":[85],"black":[87,126,230,247],"(0.95":[90],"+/-":[91,95,106,115,129,140,149],"1.25":[92],"ng/ml/h,":[93,117],"mean":[94],"standard":[96],"deviation":[97],"(SD))":[98],"significantly":[100,134,183],"lower":[101,135],"than":[102,136],"white":[104,138],"(2.09":[105],"1.12":[107],"ng/ml/h;":[108],"P":[109,118,143,152],"<":[110],"0.0001)":[111],"coloured":[113,147],"(1.81":[114],"1.86":[116],"=":[119,144,153,200,206],"0.013)":[120],"normotensives.":[121,155],"aldosterone":[124,166,203,237,261],"(306":[128],"147":[130],"pmol/l)":[131],"also":[133],"(506":[139],"324":[141],"pmol/l,":[142,151],"0.0002)":[145],"(418":[148],"304":[150],"0.0148)":[154],"In":[156,266],"hypertensives,":[157],"there":[158],"were":[159,181],"no":[160],"significant":[161],"differences":[162],"or":[165,199,205],"levels":[167,238,262],"between":[168],"population":[171,188],"groups.":[172,189],"Urinary":[173],"ratios,":[175],"an":[176,195],"index":[177],"Na+":[179],"intake,":[180],"different":[184],"None":[190],"A/R":[196],">":[198,204],"1,000":[201],"plus":[202],"750,":[207],"while":[208],"7.1%":[209,270],"exceeded":[212],"these":[213],"levels,":[214],"suggesting":[215,242],"that":[216],"they":[217],"are":[218],"appropriate":[219],"criteria":[220],"screening":[222],"PA.":[224,282],"CONCLUSIONS:":[225],"A":[226],"large":[227],"fraction":[228],"low":[234],"compared":[239],"with":[240],"whites,":[241],"a":[243],"salt-retaining":[244],"tendency":[245],"subjects.":[248],"These":[249],"results":[250,275],"have":[251],"important":[252],"implications":[253],"interpretation":[256],"hypertensive":[264],"patients.":[265],"settings,":[269],"biochemical":[274],"indicating":[276],"need":[278],"investigation":[280]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}