{"id":"https://openalex.org/W68023738","doi":"https://doi.org/10.1007/978-1-60761-543-9_3","title":"Phorbol Esters and Diacylglycerol: The PKC Activators","display_name":"Phorbol Esters and Diacylglycerol: The PKC Activators","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W68023738","doi":"https://doi.org/10.1007/978-1-60761-543-9_3","mag":"68023738"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-60761-543-9_3","doi":"https://doi.org/10.1007/978-1-60761-543-9_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-543-9_3","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Kinase C in Cancer Signaling and Therapy","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2477665982","display_name":"Protein Kinase C in Cancer Signaling and Therapy"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010714518","display_name":"Peter M. Blumberg","orcid":"https://orcid.org/0009-0005-3698-6064","observed_orcids":["https://orcid.org/0009-0005-3698-6064"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter M. Blumberg","raw_affiliation_strings":["Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Room 4048, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Room 4048, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052710405","display_name":"No\u00e9mi Kedei","orcid":"https://orcid.org/0000-0002-6625-6119","observed_orcids":["https://orcid.org/0000-0002-6625-6119"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noemi Kedei","raw_affiliation_strings":["Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Room 4048, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Room 4048, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052511576","display_name":"Nancy E. Lewin","orcid":"https://orcid.org/0000-0001-5364-158X","observed_orcids":["https://orcid.org/0000-0001-5364-158X"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy E. Lewin","raw_affiliation_strings":["Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Room 4048, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Room 4048, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070646510","display_name":"Dazhi Yang","orcid":"https://orcid.org/0000-0003-0316-8346","observed_orcids":["https://orcid.org/0000-0003-0316-8346"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dazhi Yang","raw_affiliation_strings":["Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Room 4048, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Room 4048, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056631481","display_name":"Juan Tao","orcid":"https://orcid.org/0000-0001-6571-6649","observed_orcids":["https://orcid.org/0000-0001-6571-6649"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Tao","raw_affiliation_strings":["Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Room 4048, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Room 4048, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069327244","display_name":"Andrea Telek","orcid":"https://orcid.org/0000-0002-1202-2907","observed_orcids":["https://orcid.org/0000-0002-1202-2907"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Telek","raw_affiliation_strings":["Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Room 4048, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Room 4048, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088544979","display_name":"Tam\u00e1s G\u00e9czy","orcid":"https://orcid.org/0000-0002-8199-8831","observed_orcids":["https://orcid.org/0000-0002-8199-8831"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamas Geczy","raw_affiliation_strings":["Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Room 4048, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Room 4048, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010714518"],"corresponding_institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"],"apc_list":null,"apc_paid":null,"fwci":0.3899,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.61221241,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"25","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9670000076293945},{"id":"https://openalex.org/keywords/phorbol-ester","display_name":"phorbol ester","score":0.9879999756813049},{"id":"https://openalex.org/keywords/diacylglycerol","display_name":"diacylglycerol","score":0.996999979019165},{"id":"https://openalex.org/keywords/c1-domain","display_name":"C1 domain","score":0.8399999737739563},{"id":"https://openalex.org/keywords/zinc-finger","display_name":"zinc finger","score":0.5830000042915344},{"id":"https://openalex.org/keywords/membrane-association","display_name":"membrane association","score":0.6290000081062317},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.7049999833106995},{"id":"https://openalex.org/keywords/tumor-promotion-inhibition","display_name":"tumor promotion inhibition","score":0.6990000009536743},{"id":"https://openalex.org/keywords/membrane-heterogeneity","display_name":"membrane heterogeneity","score":0.753000020980835},{"id":"https://openalex.org/keywords/cancer-therapeutics","display_name":"cancer therapeutics","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C36020004","wikidata":"https://www.wikidata.org/wiki/Q106951674","display_name":"Diacylglycerol kinase","level":4,"score":0.8923486471176147},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.8767525553703308},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.5946317315101624},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5372225046157837},{"id":"https://openalex.org/C2780122803","wikidata":"https://www.wikidata.org/wiki/Q7852681","display_name":"Tumor promotion","level":4,"score":0.5333846211433411},{"id":"https://openalex.org/C143840085","wikidata":"https://www.wikidata.org/wiki/Q5008102","display_name":"C2 domain","level":3,"score":0.49410346150398254},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4815859794616699},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44427186250686646},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4333678185939789},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4134977459907532},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41320866346359253},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3941417634487152},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3607845902442932},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.317587286233902},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.21672704815864563},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18943655490875244},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.07520949840545654}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-60761-543-9_3","doi":"https://doi.org/10.1007/978-1-60761-543-9_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-543-9_3","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Kinase C in Cancer Signaling and Therapy","raw_type":"book-chapter"},{"id":"pmh:oai:ganymedesd.lib.unideb.hu:2437/155271","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2437/155271","pdf_url":null,"source":{"id":"https://openalex.org/S4306402089","display_name":"University of Debrecen Electronic Archive (University of Debrecen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132735039","host_organization_name":"University of Debrecen","host_organization_lineage":["https://openalex.org/I132735039"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"k\u00f6nyvr\u00e9szlet"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5899999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":138,"referenced_works":["https://openalex.org/W142482983","https://openalex.org/W149713574","https://openalex.org/W191178295","https://openalex.org/W198027235","https://openalex.org/W222863809","https://openalex.org/W1122753795","https://openalex.org/W1483045044","https://openalex.org/W1504884484","https://openalex.org/W1517999082","https://openalex.org/W1573258139","https://openalex.org/W1594065354","https://openalex.org/W1594758412","https://openalex.org/W1606913060","https://openalex.org/W1760081200","https://openalex.org/W1911093385","https://openalex.org/W1931324367","https://openalex.org/W1964119626","https://openalex.org/W1964801428","https://openalex.org/W1965084076","https://openalex.org/W1967306562","https://openalex.org/W1970417260","https://openalex.org/W1970857342","https://openalex.org/W1971470826","https://openalex.org/W1971533879","https://openalex.org/W1973432756","https://openalex.org/W1973824969","https://openalex.org/W1973917220","https://openalex.org/W1977239487","https://openalex.org/W1978535713","https://openalex.org/W1980050211","https://openalex.org/W1981090202","https://openalex.org/W1981880855","https://openalex.org/W1982742890","https://openalex.org/W1982858761","https://openalex.org/W1983872250","https://openalex.org/W1984120526","https://openalex.org/W1984812472","https://openalex.org/W1986270436","https://openalex.org/W1987496015","https://openalex.org/W1988941187","https://openalex.org/W1990924304","https://openalex.org/W1995603763","https://openalex.org/W1998349282","https://openalex.org/W2004872546","https://openalex.org/W2006817479","https://openalex.org/W2008873600","https://openalex.org/W2010994547","https://openalex.org/W2011101614","https://openalex.org/W2011301308","https://openalex.org/W2011567844","https://openalex.org/W2012845499","https://openalex.org/W2013763475","https://openalex.org/W2015080165","https://openalex.org/W2015087800","https://openalex.org/W2017641795","https://openalex.org/W2019705381","https://openalex.org/W2020603414","https://openalex.org/W2026912061","https://openalex.org/W2027066498","https://openalex.org/W2027235796","https://openalex.org/W2029753870","https://openalex.org/W2029758610","https://openalex.org/W2030986763","https://openalex.org/W2031432203","https://openalex.org/W2032959153","https://openalex.org/W2033641895","https://openalex.org/W2034699914","https://openalex.org/W2037954317","https://openalex.org/W2038905259","https://openalex.org/W2042791506","https://openalex.org/W2047047872","https://openalex.org/W2050824478","https://openalex.org/W2052302030","https://openalex.org/W2052500285","https://openalex.org/W2053614493","https://openalex.org/W2055833358","https://openalex.org/W2061148925","https://openalex.org/W2062818651","https://openalex.org/W2065582998","https://openalex.org/W2065831427","https://openalex.org/W2066855988","https://openalex.org/W2067206130","https://openalex.org/W2068085280","https://openalex.org/W2069723308","https://openalex.org/W2070660302","https://openalex.org/W2071495883","https://openalex.org/W2075212824","https://openalex.org/W2075889486","https://openalex.org/W2077784789","https://openalex.org/W2079097093","https://openalex.org/W2080203561","https://openalex.org/W2081225664","https://openalex.org/W2086776394","https://openalex.org/W2086873026","https://openalex.org/W2087681965","https://openalex.org/W2089437333","https://openalex.org/W2090475458","https://openalex.org/W2091457112","https://openalex.org/W2095885185","https://openalex.org/W2096131632","https://openalex.org/W2097331211","https://openalex.org/W2101773993","https://openalex.org/W2103900205","https://openalex.org/W2106102693","https://openalex.org/W2111135552","https://openalex.org/W2112309133","https://openalex.org/W2115544008","https://openalex.org/W2118029674","https://openalex.org/W2120891403","https://openalex.org/W2121168610","https://openalex.org/W2122234786","https://openalex.org/W2123659424","https://openalex.org/W2128341352","https://openalex.org/W2137162707","https://openalex.org/W2137435818","https://openalex.org/W2137882621","https://openalex.org/W2138108925","https://openalex.org/W2147453963","https://openalex.org/W2152450220","https://openalex.org/W2154206349","https://openalex.org/W2155795208","https://openalex.org/W2159084718","https://openalex.org/W2162456309","https://openalex.org/W2165001829","https://openalex.org/W2165066714","https://openalex.org/W2165202142","https://openalex.org/W2167137865","https://openalex.org/W2196524012","https://openalex.org/W2404959436","https://openalex.org/W2412456341","https://openalex.org/W2415338656","https://openalex.org/W2418742902","https://openalex.org/W2912579417","https://openalex.org/W2917236252","https://openalex.org/W4233767967","https://openalex.org/W4235230418","https://openalex.org/W4243803451","https://openalex.org/W4254218028"],"related_works":["https://openalex.org/W2410295749","https://openalex.org/W2091930564","https://openalex.org/W2018397114","https://openalex.org/W2423035669","https://openalex.org/W2401833520","https://openalex.org/W2899882983","https://openalex.org/W2418830774","https://openalex.org/W990573401","https://openalex.org/W2417491548","https://openalex.org/W2077166985"],"abstract_inverted_index":{"Protein":[0],"kinase":[1],"C":[2],"(PKC)":[3],"represents":[4],"the":[5,9,17,28,41,60,63,75,86,99,103,126,143],"most":[6],"prominent":[7],"of":[8,11,62,69,102,139,146],"families":[10],"signaling":[12],"proteins":[13],"integrating":[14],"response":[15],"to":[16,24],"ubiquitous":[18],"lipophilic":[19],"second":[20],"messenger":[21],"sn-1,2-diacylglycerol":[22],"and":[23,71],"its":[25],"ultrapotent":[26],"analogs,":[27],"tumor-promoting":[29],"phorbol":[30],"esters.":[31],"Response":[32],"is":[33],"mediated":[34],"through":[35],"twin":[36,104],"conserved":[37],"zinc":[38],"finger":[39],"structures,":[40],"C1":[42,45,64,87,105],"domains.":[43,106],"The":[44],"domains":[46],"function":[47,136],"as":[48,97,137,154],"hydrophobic":[49,57],"switches,":[50],"for":[51,81,95,128,159],"which":[52],"ligand":[53,82],"binding":[54],"completes":[55],"a":[56,155],"surface":[58],"on":[59],"face":[61],"domain,":[65,88],"driving":[66],"membrane":[67,89],"association":[68],"PKC":[70,112,122,132,147,151,163],"enzymatic":[72],"activation.":[73],"Since":[74],"lipid":[76],"bilayer":[77],"provides":[78,91],"critical":[79],"contacts":[80],"binding,":[83],"along":[84],"with":[85,108,161],"heterogeneity":[90],"an":[92],"important":[93],"mechanism":[94],"diversity,":[96,111],"do":[98],"differential":[100],"functions":[101],"Consistent":[107],"such":[109],"mechanistic":[110],"ligands":[113,123,133,164],"can":[114],"differ":[115],"dramatically":[116],"in":[117,134,148,166],"biological":[118],"consequences.":[119],"Thus,":[120],"whereas":[121],"have":[124],"provided":[125],"paradigm":[127],"tumor":[129,140],"promoters,":[130],"some":[131],"fact":[135],"inhibitors":[138],"promotion.":[141],"Reflecting":[142],"central":[144],"role":[145],"cellular":[149],"signaling,":[150],"has":[152],"emerged":[153],"promising":[156],"therapeutic":[157],"target":[158],"cancer":[160],"several":[162],"currently":[165],"clinical":[167],"trials.":[168]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}