{"id":"https://openalex.org/W68017725","doi":null,"title":"Use of antioxidants in the prevention and treatment of disease.","display_name":"Use of antioxidants in the prevention and treatment of disease.","publication_year":1998,"publication_date":"1998-03-01","ids":{"openalex":"https://openalex.org/W68017725","mag":"68017725","pmid":"https://pubmed.ncbi.nlm.nih.gov/10181011"},"language":"en","primary_location":{"id":"pmid:10181011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10181011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International Federation of Clinical Chemistry","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014676435","display_name":"Frank J. Kelly","orcid":"https://orcid.org/0000-0003-2558-8392","observed_orcids":["https://orcid.org/0000-0003-2558-8392"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"F J Kelly","raw_affiliation_strings":["International Antioxidant Research Centre, United Medical School, Guys Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Antioxidant Research Centre, United Medical School, Guys Hospital, London, UK","institution_ids":["https://openalex.org/I1298207432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014676435"],"corresponding_institution_ids":["https://openalex.org/I1298207432"],"apc_list":null,"apc_paid":null,"fwci":0.9406,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.69904306,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"21","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.9950000047683716},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9940000176429749},{"id":"https://openalex.org/keywords/antioxidant-deficiency","display_name":"antioxidant deficiency","score":0.6800000071525574},{"id":"https://openalex.org/keywords/vitamins-c-and-e","display_name":"vitamins C and E","score":0.796999990940094},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/micronutrients","display_name":"micronutrients","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7979999780654907},{"id":"https://openalex.org/keywords/coronary-heart-disease-risk","display_name":"coronary heart disease risk","score":0.9039999842643738},{"id":"https://openalex.org/keywords/fruit-and-vegetable-intake","display_name":"fruit and vegetable intake","score":0.8029999732971191},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9760000109672546},{"id":"https://openalex.org/keywords/microvascular-complications","display_name":"microvascular complications","score":0.7919999957084656},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9319999814033508},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8395482897758484},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.8390092849731445},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5921429395675659},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5450385808944702},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4666115641593933},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.44551539421081543},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.43650802969932556},{"id":"https://openalex.org/C14522933","wikidata":"https://www.wikidata.org/wiki/Q531507","display_name":"Micronutrient","level":2,"score":0.4156213402748108},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3171951174736023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3131212592124939},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31258249282836914},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25229284167289734},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1505613923072815}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019207","descriptor_name":"beta Carotene","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:10181011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10181011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International Federation of Clinical Chemistry","raw_type":"Journal Article"},{"id":"mag:2616892114","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/the-use-of-antioxidants-in-the-prevention-and-treatment-of-disease(ddded727-9874-41d2-b91a-86eee2e12f3c)/export.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306508991","display_name":"EJIFCC","issn_l":"1051-2292","issn":["1051-2292","1650-3414"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of the International Federation of Clinical Chemistry","raw_type":null},{"id":"mag:68017725","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10181011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2060510133","https://openalex.org/W2355462469","https://openalex.org/W147286967","https://openalex.org/W6997317762","https://openalex.org/W2105813588","https://openalex.org/W2475926221","https://openalex.org/W128398796","https://openalex.org/W2989482190","https://openalex.org/W7135324544","https://openalex.org/W7096231863"],"abstract_inverted_index":{"Considerable":[0],"interest":[1],"has":[2],"risen":[3],"in":[4,12,76,140,227],"the":[5,13,24,101,105,147,228],"idea":[6],"that":[7,158,221],"oxidative":[8,96,167,189,198],"stress":[9,20,168],"is":[10,123,133,155,216],"instrumental":[11],"etiology":[14],"of":[15,27,34,37,47,58,108,113,121,135,146,188,207],"numerous":[16],"human":[17],"diseases.":[18],"Oxidative":[19],"can":[21,42],"arise":[22],"through":[23],"increased":[25,68],"production":[26],"reactive":[28],"oxygen":[29,195],"species":[30],"(ROS)":[31],"and/or":[32],"because":[33],"a":[35,45,126,136,205],"deficiency":[36],"antioxidant":[38,49,69,72,148,172],"defenses.":[39],"Antioxidant":[40],"deficiencies":[41],"develop":[43,178],"as":[44,52,61,85],"result":[46,206],"decreased":[48,81],"intake":[50],"(such":[51,60,84],"vitamins":[53,150],"C":[54,151],"and":[55,64,89,115,152,160,169,197],"E),":[56],"synthesis":[57,74],"enzymes":[59],"superoxide":[62],"dismutase":[63],"glutathione":[65],"peroxidase)":[66],"or":[67],"utilization.":[70],"Insufficient":[71],"enzyme":[73],"may":[75],"turn":[77],"be":[78],"due":[79],"to":[80,219],"micronutrient":[82],"availability":[83],"selenium,":[86],"magnese,":[87],"copper":[88],"zinc).":[90],"Of":[91],"those":[92],"diseases":[93],"linked":[94],"with":[95,125,142,164],"stress,":[97],"cardiovascular":[98],"disease":[99],"provides":[100],"strongest":[102],"evidence":[103,134,187,215],"for":[104,193],"protective":[106],"role":[107],"antioxidants.":[109],"A":[110],"high":[111,143],"consumption":[112],"fruit":[114],"vegetables,":[116],"which":[117],"are":[118,223],"good":[119],"sources":[120],"antioxidants,":[122],"associated":[124,163],"lower":[127],"coronary":[128,138],"risk.":[129],"More":[130],"specifically,":[131],"there":[132],"reduced":[137],"risk":[139],"populations":[141],"blood":[144],"levels":[145],"nutrients,":[149],"E.":[153],"Evidence":[154],"also":[156,184],"accumulating":[157],"diabetes,":[159,165],"microvascular":[161],"complications":[162],"involve":[166],"have":[170],"compromised":[171],"status.":[173],"In":[174],"addition,":[175],"patients":[176],"who":[177],"acute":[179],"respiratory":[180],"distress":[181],"syndrome":[182],"(ARDS)":[183],"exhibit":[185],"clear":[186],"stress.":[190],"Definitive":[191],"proof":[192],"active":[194],"formation":[196],"cell":[199],"damage":[200],"being":[201],"causative":[202],"rather":[203],"than":[204],"other":[208],"underlying":[209],"these":[210],"pathologies":[211],"remains":[212],"elusive;":[213],"however,":[214],"sufficiently":[217],"compelling":[218],"suggest":[220],"antioxidants":[222],"potential":[224],"therapeutic":[225],"agents":[226],"above":[229],"conditions.":[230]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}