{"id":"https://openalex.org/W67974252","doi":null,"title":"Involvement of NAD biosynthesis in the development of stress-induced mutation in Mesorhizobium loti strain R7A","display_name":"Involvement of NAD biosynthesis in the development of stress-induced mutation in Mesorhizobium loti strain R7A","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W67974252","mag":"67974252"},"language":"en","primary_location":{"id":"pmh:oai:alma.64OTAGO_INST:11396774750001891","doi":null,"is_oa":true,"landing_page_url":"https://ourarchive.otago.ac.nz/esploro/outputs/graduate/Involvement-of-NAD-biosynthesis-in-the/9926479603001891","pdf_url":"https://ourarchive.otago.ac.nz/view/delivery/64OTAGO_INST/12396774740001891/13397201040001891","source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Masters Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ourarchive.otago.ac.nz/view/delivery/64OTAGO_INST/12396774740001891/13397201040001891","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003323447","display_name":"William James Ashbrook","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"William James Ashbrook","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003323447"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11470","display_name":"Legume Nitrogen Fixing Symbiosis","score":0.037300001829862595,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesorhizobium-loti","display_name":"Mesorhizobium loti","score":0.9039999842643738},{"id":"https://openalex.org/keywords/nad-biosynthesis","display_name":"NAD biosynthesis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/niacin","display_name":"nicotinic acid","score":0.7360000014305115},{"id":"https://openalex.org/keywords/mutator-phenotype","display_name":"mutator phenotype","score":0.7910000085830688},{"id":"https://openalex.org/keywords/succinate-utilization","display_name":"succinate utilization","score":0.8479999899864197},{"id":"https://openalex.org/keywords/integrative-and-conjugative-elements","display_name":"integrative and conjugative elements","score":0.746999979019165},{"id":"https://openalex.org/keywords/reca","display_name":"RecA","score":0.5669999718666077},{"id":"https://openalex.org/keywords/mfd","display_name":"Mfd","score":0.9900000095367432},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8180000185966492},{"id":"https://openalex.org/keywords/transcription-coupled-repair","display_name":"transcription-coupled repair","score":0.984000027179718},{"id":"https://openalex.org/keywords/nudix-hydrolase","display_name":"Nudix hydrolase","score":0.6230000257492065},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.6018922328948975},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.5659313797950745},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49898648262023926},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4770338237285614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38863229751586914},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17559951543807983},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13815173506736755},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.12022793292999268},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:alma.64OTAGO_INST:11396774750001891","doi":null,"is_oa":true,"landing_page_url":"https://ourarchive.otago.ac.nz/esploro/outputs/graduate/Involvement-of-NAD-biosynthesis-in-the/9926479603001891","pdf_url":"https://ourarchive.otago.ac.nz/view/delivery/64OTAGO_INST/12396774740001891/13397201040001891","source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Masters Thesis"},{"id":"pmh:oai:ourarchive.otago.ac.nz:10523/2208","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10523/2208","pdf_url":"http://hdl.handle.net/10523/2208","source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},{"id":"mag:67974252","doi":null,"is_oa":false,"landing_page_url":"https://ourarchive.otago.ac.nz/bitstream/10523/2208/3/AshbrookWilliamJ2012MSc.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:alma.64OTAGO_INST:11396774750001891","doi":null,"is_oa":true,"landing_page_url":"https://ourarchive.otago.ac.nz/esploro/outputs/graduate/Involvement-of-NAD-biosynthesis-in-the/9926479603001891","pdf_url":"https://ourarchive.otago.ac.nz/view/delivery/64OTAGO_INST/12396774740001891/13397201040001891","source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Masters Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W67974252.pdf","grobid_xml":"https://content.openalex.org/works/W67974252.grobid-xml"},"referenced_works_count":112,"referenced_works":["https://openalex.org/W43736083","https://openalex.org/W1528151765","https://openalex.org/W1542116187","https://openalex.org/W1546783991","https://openalex.org/W1563605265","https://openalex.org/W1566245339","https://openalex.org/W1729125278","https://openalex.org/W1787690277","https://openalex.org/W1828771602","https://openalex.org/W1832974928","https://openalex.org/W1865873333","https://openalex.org/W1964113321","https://openalex.org/W1967178850","https://openalex.org/W1968445954","https://openalex.org/W1976103636","https://openalex.org/W1976530609","https://openalex.org/W1976992773","https://openalex.org/W1977852064","https://openalex.org/W1979333735","https://openalex.org/W1982750748","https://openalex.org/W1985074609","https://openalex.org/W1993234114","https://openalex.org/W1995133494","https://openalex.org/W2000989085","https://openalex.org/W2006365527","https://openalex.org/W2008561095","https://openalex.org/W2013524551","https://openalex.org/W2017056267","https://openalex.org/W2017831962","https://openalex.org/W2019121099","https://openalex.org/W2021274612","https://openalex.org/W2022648619","https://openalex.org/W2023099428","https://openalex.org/W2024356736","https://openalex.org/W2025155914","https://openalex.org/W2026626251","https://openalex.org/W2031121902","https://openalex.org/W2034009934","https://openalex.org/W2038202952","https://openalex.org/W2038779898","https://openalex.org/W2043668597","https://openalex.org/W2043748488","https://openalex.org/W2048351057","https://openalex.org/W2050499271","https://openalex.org/W2051520886","https://openalex.org/W2051695178","https://openalex.org/W2052657449","https://openalex.org/W2054312396","https://openalex.org/W2055192452","https://openalex.org/W2059521104","https://openalex.org/W2059754005","https://openalex.org/W2062763504","https://openalex.org/W2063221309","https://openalex.org/W2063455781","https://openalex.org/W2064825195","https://openalex.org/W2064830028","https://openalex.org/W2064956451","https://openalex.org/W2069780164","https://openalex.org/W2070524329","https://openalex.org/W2075970797","https://openalex.org/W2079891940","https://openalex.org/W2080355037","https://openalex.org/W2082618820","https://openalex.org/W2085602133","https://openalex.org/W2085773333","https://openalex.org/W2091960966","https://openalex.org/W2094103217","https://openalex.org/W2098217300","https://openalex.org/W2101418148","https://openalex.org/W2101486288","https://openalex.org/W2102156421","https://openalex.org/W2104777136","https://openalex.org/W2105303007","https://openalex.org/W2107365500","https://openalex.org/W2108528950","https://openalex.org/W2113443189","https://openalex.org/W2116406836","https://openalex.org/W2116514865","https://openalex.org/W2119192147","https://openalex.org/W2123026180","https://openalex.org/W2124765964","https://openalex.org/W2125821524","https://openalex.org/W2129009120","https://openalex.org/W2129432952","https://openalex.org/W2133989673","https://openalex.org/W2135721494","https://openalex.org/W2136541185","https://openalex.org/W2138952930","https://openalex.org/W2139070005","https://openalex.org/W2140916038","https://openalex.org/W2141427966","https://openalex.org/W2141796595","https://openalex.org/W2142105131","https://openalex.org/W2143887409","https://openalex.org/W2144386534","https://openalex.org/W2144950848","https://openalex.org/W2145401678","https://openalex.org/W2146449823","https://openalex.org/W2146455872","https://openalex.org/W2147101023","https://openalex.org/W2150012832","https://openalex.org/W2152065014","https://openalex.org/W2152585463","https://openalex.org/W2153629311","https://openalex.org/W2156492707","https://openalex.org/W2158937196","https://openalex.org/W2159774536","https://openalex.org/W2161319547","https://openalex.org/W2161565432","https://openalex.org/W2162152219","https://openalex.org/W2162984257","https://openalex.org/W2170343590"],"related_works":["https://openalex.org/W7096681939","https://openalex.org/W2164421452","https://openalex.org/W1494553899","https://openalex.org/W1988276266","https://openalex.org/W2134136313","https://openalex.org/W4412572269","https://openalex.org/W1804011389","https://openalex.org/W199838857","https://openalex.org/W1524570212","https://openalex.org/W1838858312"],"abstract_inverted_index":{"One":[0],"contentious":[1],"method":[2],"by":[3],"which":[4,74,95,158,442,459],"bacteria":[5],"deal":[6],"with":[7,416],"a":[8,43,69,82,122,183,207,213,313,365,390,419,427],"maladapted":[9],"situation":[10],"is":[11,439],"what":[12],"has":[13],"been":[14],"coined":[15],"\u2018adaptive\u2019,":[16],"\u2018directed\u2019":[17],"or":[18,343,396,407],"\u2018stress":[19],"induced-mutation\u2019.":[20],"This":[21,399],"involves":[22],"mutants":[23,108],"that":[24,138,238,276,317],"compensate":[25],"for":[26,164,272,382],"some":[27],"form":[28,133,261],"of":[29,46,68,124,127,160,169,190,201,204,232,244,267,301,306,341,346,351,378,393,409,421,448,455],"sub-lethal":[30],"stress":[31],"appearing":[32],"in":[33,55,236,246,312,321,338,370,386,429,433,441,445,460],"large":[34],"numbers":[35],"from":[36],"an":[37,178],"apparently":[38],"non-dividing":[39],"cell":[40],"population":[41],"after":[42],"protracted":[44],"period":[45],"time.":[47],"In":[48,87,146,374],"Mesorhizobium":[49],"loti":[50],"this":[51,147,191,273],"was":[52,102,119,142,152,380],"first":[53,166],"observed":[54],"the":[56,66,88,91,139,149,155,165,170,194,219,233,240,247,335,339,357,383,443,446,453,463],"non-symbiotic":[57],"strains":[58,77,237],"CJ1":[59],"and":[60,98,177,250,258,323,330],"N18.":[61],"The":[62,349],"stress-induced":[63],"mutation":[64,464],"involved":[65],"activation":[67],"cryptic":[70],"chromosomal":[71],"dctABD":[72],"locus":[73,116,141,151,192,274],"allowed":[75],"these":[76],"to":[78,105,209,229,260,291,297,327,364,426,452,467],"utilize":[79],"succinate":[80],"as":[81,154,418],"sole":[83],"carbon":[84],"source":[85],"(Dct+).":[86],"current":[89],"study":[90],"symbiotic":[92],"strain":[93],"R7A,":[94],"containsan":[96],"integrative":[97],"conjugative":[99],"element":[100],"ICEMlSymR7A,":[101],"also":[103,217],"shown":[104],"produce":[106],"Dct+":[107,262,371],"when":[109,112,289],"under":[110],"stress,":[111],"its":[113],"active":[114],"dct":[115],"on":[117,144,197,222],"ICEMlSymR7A":[118,128],"deleted.":[120],"However":[121],"derivative":[123],"R7A":[125,245],"cured":[126],"(strain":[129],"R7ANS),":[130],"did":[131,354,362],"not":[132,355],"mutant":[134],"colonies":[135,263],"strongly":[136],"suggesting":[137],"causative":[140,150],"located":[143],"ICEMlSymR7A.":[145],"work,":[148],"identified":[153],"nadQABC":[156,241,342],"locus,":[157],"consists":[159],"genes":[161,252,281,311,325],"encoding":[162,182],"enzymes":[163],"three":[167,278,308],"steps":[168],"NAD":[171,210,379,410,434],"de":[172,279,309,404,422],"novo":[173,280,310,405,423],"biosynthetic":[174],"pathway":[175],"(nadABC)":[176],"upstream":[179],"hypothetical":[180],"ORF":[181],"putative":[184],"nudix":[185],"hydrolase-like":[186],"repressor":[187],"(nadQ).":[188],"Addition":[189,300],"conferred":[193,218],"mutator":[195,220,234,336,358,384,430],"phenotype":[196,221,235,337,385,431],"R7ANS.":[198],"Furthermore,":[199],"addition":[200,350],"increased":[202,225,376],"concentrations":[203,266],"nicotinic":[205,226,255,268,302,347,413],"acid,":[206],"precursor":[208],"biosynthesis":[211],"via":[212],"separate":[214],"salvage":[215,408],"pathway,":[216],"R7ANS,":[223],"whereas":[224],"acid":[227,256,303,414],"led":[228],"partial":[230],"repression":[231],"contained":[239],"locus.":[242],"Mutants":[243,320],"nadA,":[248],"nadB":[249],"nadC":[251],"were":[253],"both":[254],"auxotrophs":[257],"unable":[259],"without":[264],"high":[265,344],"acid.":[269,348],"Expression":[270],"data":[271],"showed":[275],"all":[277,307],"had":[282],"significantly":[283],"higher":[284],"expression":[285,305],"during":[286],"prolonged":[287],"incubation":[288],"compared":[290],"exponential":[292],"growth,":[293],"while":[294],"nadQ":[295],"appeared":[296],"be":[298],"constitutive.":[299],"repressed":[304],"concentration-dependent":[314],"manner":[315],"provided":[316],"nadQwas":[318],"intact.":[319],"recA":[322],"mfd,":[324],"essential":[326],"double-strand-break":[328,395],"repair":[329,332],"transcription-coupled":[331,397],"respectively,":[333],"exhibited":[334],"presence":[340],"levels":[345],"exogenous":[352],"catalase":[353],"prevent":[356],"phenotype,":[359],"though":[360,412],"it":[361],"lead":[363],"small":[366],"but":[367],"consistent":[368],"decrease":[369,428],"colony":[372],"formation.":[373],"conclusion,":[375],"production":[377],"responsible":[381],"M.":[387],"loti,":[388],"through":[389,402],"mechanism":[391],"independent":[392],"either":[394,403],"repair.":[398],"can":[400],"occur":[401],"synthesis":[406],"precursors,":[411],"acted":[415],"NadQ":[417],"co-repressor":[420],"synthesis,":[424],"leading":[425],"function":[432],"prototrophic":[435],"strains.":[436],"A":[437],"model":[438],"proposed":[440],"increase":[444],"concentration":[447],"pro-oxidant":[449],"NAD(H)":[450],"leads":[451],"formation":[454],"reactive":[456],"oxygen":[457],"species":[458],"turn":[461],"elevate":[462],"rate":[465],"due":[466],"genotoxic":[468],"stress.":[469]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-08-29T07:29:34.045763","created_date":"2016-06-24T00:00:00"}