{"id":"https://openalex.org/W67915094","doi":"https://doi.org/10.17877/de290r-5603","title":"Sleep loss and the brain vulnerability to neurodegeneration: behavioral, biochemical and neurohistopathological observations in a rat model","display_name":"Sleep loss and the brain vulnerability to neurodegeneration: behavioral, biochemical and neurohistopathological observations in a rat model","publication_year":2013,"publication_date":"2013-08-15","ids":{"openalex":"https://openalex.org/W67915094","doi":"https://doi.org/10.17877/de290r-5603","mag":"67915094","pmid":"https://pubmed.ncbi.nlm.nih.gov/26622210","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4663654"},"language":"en","primary_location":{"id":"pmid:26622210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26622210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EXCLI journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://eldorado.tu-dortmund.de/bitstreams/35fee917-3787-4f75-a43c-631232f8a582/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004772033","display_name":"Mohammad Nasehi","orcid":"https://orcid.org/0000-0002-1981-3592","observed_orcids":["https://orcid.org/0000-0002-1981-3592"]},"institutions":[{"id":"https://openalex.org/I2799586765","display_name":"Iranian Academy of Medical Sciences","ror":"https://ror.org/011jgwj89","country_code":"IR","type":"education","lineage":["https://openalex.org/I2799586765"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Nasehi, Mohammad","raw_affiliation_strings":["Iranian Academy of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iranian Academy of Medical Sciences","institution_ids":["https://openalex.org/I2799586765"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Torabi-Nami, Mohammad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799586765","display_name":"Iranian Academy of Medical Sciences","ror":"https://ror.org/011jgwj89","country_code":"IR","type":"education","lineage":["https://openalex.org/I2799586765"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Torabi-Nami, Mohammad","raw_affiliation_strings":["Iranian Academy of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iranian Academy of Medical Sciences","institution_ids":["https://openalex.org/I2799586765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029936660","display_name":"Mohammad\u2010Reza Zarrindast","orcid":"https://orcid.org/0000-0002-0688-5378","observed_orcids":["https://orcid.org/0000-0002-0688-5378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zarrindast, Mohammad-Reza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1898,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.75032832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"12","issue":null,"first_page":"347","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.05260000005364418,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sleep-deprivation","display_name":"sleep deprivation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8980000019073486},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":0.9179999828338623},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.8799999952316284},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.8600000143051147},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.703000009059906},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hyperphosphorylated-tau","display_name":"hyperphosphorylated tau","score":0.9520000219345093},{"id":"https://openalex.org/keywords/dentate-gyrus","display_name":"dentate gyrus","score":0.9269999861717224},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.7020000219345093},{"id":"https://openalex.org/keywords/shift-work","display_name":"shift work","score":0.8410000205039978},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.6627529859542847},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6595216393470764},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6538747549057007},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6379407644271851},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5370470881462097},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5247064828872681},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5081613063812256},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.451500803232193},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.4513291120529175},{"id":"https://openalex.org/C2780937657","wikidata":"https://www.wikidata.org/wiki/Q5141192","display_name":"Sleep restriction","level":4,"score":0.44473716616630554},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.4393099248409271},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.3891254961490631},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3378605544567108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3133721947669983},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1412745714187622},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.11599999666213989},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmid:26622210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26622210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EXCLI journal","raw_type":"Journal Article"},{"id":"pmh:oai:eldorado.tu-dortmund.de:2003/30491","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2003/30491","pdf_url":"http://eldorado.tu-dortmund.de/bitstreams/35fee917-3787-4f75-a43c-631232f8a582/download","source":{"id":"https://openalex.org/S4306400811","display_name":"Technische Universit\u00e4t Dortmund Eldorado (Technische Universit\u00e4t Dortmund)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210148506","host_organization_name":"Erich-Brost-Institut","host_organization_lineage":["https://openalex.org/I4210148506"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"doi:10.17877/de290r-5603","doi":"https://doi.org/10.17877/de290r-5603","is_oa":true,"landing_page_url":"https://doi.org/10.17877/de290r-5603","pdf_url":null,"source":{"id":"https://openalex.org/S4306400811","display_name":"Technische Universit\u00e4t Dortmund Eldorado (Technische Universit\u00e4t Dortmund)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210148506","host_organization_name":"Erich-Brost-Institut","host_organization_lineage":["https://openalex.org/I4210148506"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:2187603047","doi":null,"is_oa":false,"landing_page_url":"https://www.excli.de/vol12/Zarrindast_30042013_proof.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:67915094","doi":null,"is_oa":false,"landing_page_url":"https://eldorado.tu-dortmund.de/bitstream/2003/30491/1/Zarrindast_30042013_proof.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:eldorado.tu-dortmund.de:2003/30491","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2003/30491","pdf_url":"http://eldorado.tu-dortmund.de/bitstreams/35fee917-3787-4f75-a43c-631232f8a582/download","source":{"id":"https://openalex.org/S4306400811","display_name":"Technische Universit\u00e4t Dortmund Eldorado (Technische Universit\u00e4t Dortmund)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210148506","host_organization_name":"Erich-Brost-Institut","host_organization_lineage":["https://openalex.org/I4210148506"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W67915094.pdf","grobid_xml":"https://content.openalex.org/works/W67915094.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W802254","https://openalex.org/W38308602","https://openalex.org/W84689042","https://openalex.org/W103435851","https://openalex.org/W129279618","https://openalex.org/W162285290","https://openalex.org/W1513950906","https://openalex.org/W1521789748","https://openalex.org/W1561090959","https://openalex.org/W1863554980","https://openalex.org/W1930627666","https://openalex.org/W1935738678","https://openalex.org/W1966265284","https://openalex.org/W1967759036","https://openalex.org/W1968745677","https://openalex.org/W1969640104","https://openalex.org/W1972021466","https://openalex.org/W1973800714","https://openalex.org/W1975666267","https://openalex.org/W1982924671","https://openalex.org/W1983686148","https://openalex.org/W1984325684","https://openalex.org/W1987493933","https://openalex.org/W1989108716","https://openalex.org/W1989837301","https://openalex.org/W1993803902","https://openalex.org/W1994989664","https://openalex.org/W1996568613","https://openalex.org/W1999305636","https://openalex.org/W2001602698","https://openalex.org/W2013184659","https://openalex.org/W2017042715","https://openalex.org/W2020897240","https://openalex.org/W2023517019","https://openalex.org/W2024864130","https://openalex.org/W2025084017","https://openalex.org/W2025375665","https://openalex.org/W2030772288","https://openalex.org/W2032792654","https://openalex.org/W2034932565","https://openalex.org/W2038941569","https://openalex.org/W2040622315","https://openalex.org/W2041639784","https://openalex.org/W2044175751","https://openalex.org/W2044594012","https://openalex.org/W2053590571","https://openalex.org/W2055354711","https://openalex.org/W2056769976","https://openalex.org/W2059109913","https://openalex.org/W2059152238","https://openalex.org/W2068392776","https://openalex.org/W2069633448","https://openalex.org/W2071106629","https://openalex.org/W2071610467","https://openalex.org/W2071933552","https://openalex.org/W2079078833","https://openalex.org/W2079236941","https://openalex.org/W2081194850","https://openalex.org/W2083433650","https://openalex.org/W2084595451","https://openalex.org/W2087409544","https://openalex.org/W2096232633","https://openalex.org/W2101478912","https://openalex.org/W2106386523","https://openalex.org/W2108596837","https://openalex.org/W2109172889","https://openalex.org/W2109919607","https://openalex.org/W2111092359","https://openalex.org/W2114390670","https://openalex.org/W2114400985","https://openalex.org/W2117506912","https://openalex.org/W2123138830","https://openalex.org/W2126033961","https://openalex.org/W2129006928","https://openalex.org/W2131575045","https://openalex.org/W2138654723","https://openalex.org/W2141041835","https://openalex.org/W2141528847","https://openalex.org/W2144186309","https://openalex.org/W2144392441","https://openalex.org/W2145533434","https://openalex.org/W2148012008","https://openalex.org/W2150645528","https://openalex.org/W2158595768","https://openalex.org/W2161755947","https://openalex.org/W2162436161","https://openalex.org/W2162584653","https://openalex.org/W2163815564","https://openalex.org/W2166872504","https://openalex.org/W2167266338","https://openalex.org/W2168564039","https://openalex.org/W2413084970","https://openalex.org/W3179533778","https://openalex.org/W4239735790","https://openalex.org/W7135293462"],"related_works":["https://openalex.org/W2187603047","https://openalex.org/W4292649021","https://openalex.org/W2789316320","https://openalex.org/W4378611367","https://openalex.org/W2079660090","https://openalex.org/W3159273806","https://openalex.org/W3142164572","https://openalex.org/W4376271486","https://openalex.org/W4415897755","https://openalex.org/W2093612001"],"abstract_inverted_index":{"Experimentally-induced":[0],"total":[1],"sleep":[2,8,228],"deprivation":[3],"(TSD)":[4],"and":[5,55,59,68,77,106,123,136,161,178,197,234,258],"chronic":[6],"partial":[7],"restriction":[9],"(CPSR)":[10],"leads":[11],"to":[12,21,44,86,100,159],"the":[13,31,63,87,103,113,118,131,142,151,195,199,204,216,235,238,265,274],"emergence":[14],"of":[15,53,71,117,150,173,194,219,273],"cognitive":[16,230,257],"impairments.":[17],"This":[18,268],"is":[19,269],"hypothesized":[20],"result":[22],"from":[23],"a":[24,169],"consequent":[25],"neuroinflammation":[26],"which":[27,163,184],"may":[28],"also":[29,140,262],"hasten":[30],"neurodegenerative":[32],"processes.":[33],"Neuroinflammatory":[34],"markers":[35],"such":[36],"as":[37],"tumor":[38],"necrosis":[39],"factor-alpha":[40],"(TNF\u03b1)":[41],"are":[42],"thought":[43],"be":[45],"potential":[46],"culprits":[47],"in":[48,81,112,145,203,215,237,264,277],"SD-induced":[49],"neurodegeneration.":[50],"The":[51],"effect":[52],"TSD":[54,160],"CPSR":[56,162,182,247],"on":[57],"memory":[58],"anxiety-related":[60],"behaviors":[61],"(using":[62],"Elevated":[64],"Plus-Maze":[65],"test-retest":[66],"protocol)":[67],"serum":[69,176],"level":[70,133],"brain":[72,187],"derived":[73],"neurotrophic":[74],"factor":[75],"(BDNF)":[76],"corticosterone":[78,177],"were":[79,128],"assessed":[80],"male":[82],"Wistar":[83],"rats":[84,146,183],"subjected":[85,158],"modified":[88],"disk-over-water":[89],"(DOW)":[90],"apparatus.":[91],"In":[92],"addition,":[93],"an":[94],"immunohistochemical":[95],"(IHC)":[96],"study":[97,210],"was":[98],"done":[99,129],"possibly":[101,270],"detect":[102],"amyloid-beta":[104],"(A\u03b2)":[105],"hyper-phosphorylated":[107],"tau":[108],"protein":[109],"(HP\u03c4)":[110],"deposition":[111,193,214],"dentate":[114],"gyrus":[115],"(DG)":[116],"examined":[119,221],"rats'":[120],"hippocampi.":[121],"Histomorphology":[122],"neuronal":[124],"numerical":[125,201],"density":[126,202],"assessments":[127],"at":[130],"same":[132],"across":[134],"control":[135],"experimental":[137],"animals.":[138],"We":[139],"studied":[141],"above":[143],"parameters":[144],"after":[147],"intraperitoneal":[148],"injection":[149],"TNF\u03b1":[152],"neutralizing":[153],"antibody,":[154],"infliximab":[155],"(IFX).":[156],"Rats":[157],"did":[164],"not":[165,255],"receive":[166],"IFX,":[167,226],"showed":[168,192],"more":[170],"pronounced":[171],"impairment":[172],"memory,":[174],"elevated":[175],"decreased":[179],"BDNF":[180],"levels.":[181],"underwent":[185],"delayed":[186],"excision":[188],"following":[189],"behavioral":[190],"testing,":[191],"HP\u03c4":[196],"revealed":[198,211],"least":[200],"hippocampal":[205,217,239,266],"DG":[206,218],"neurons.":[207],"Meanwhile,":[208],"IHC":[209],"no":[212],"A\u03b2":[213],"all":[220],"rats.":[222],"Interestingly,":[223],"treatment":[224],"with":[225],"abrogated":[227],"restriction-induced":[229],"decline,":[231],"biochemical":[232,259],"changes":[233],"immunohistopathology":[236],"DG.":[240,267],"Taken":[241],"together,":[242],"our":[243],"findings":[244],"indicated":[245],"that":[246],"(the":[248],"SD":[249],"model":[250],"mimicking":[251],"shift":[252],"work)":[253],"induces":[254],"only":[256],"changes,":[260],"but":[261],"pathology":[263],"via":[271],"activation":[272],"inflammatory":[275],"mechanisms":[276],"part":[278],"through":[279],"TNF\u03b1-dependent":[280],"pathways.":[281]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}