{"id":"https://openalex.org/W67747596","doi":null,"title":"Severe isolated aortic stenosis with normal left ventricular systolic function and low transvalvular gradients: pathophysiologic and prognostic insights.","display_name":"Severe isolated aortic stenosis with normal left ventricular systolic function and low transvalvular gradients: pathophysiologic and prognostic insights.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W67747596","mag":"67747596","pmid":"https://pubmed.ncbi.nlm.nih.gov/18365573"},"language":"en","primary_location":{"id":"pmid:18365573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18365573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart valve disease","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025735731","display_name":"Eddy Barasch","orcid":"https://orcid.org/0000-0003-0585-2424","observed_orcids":["https://orcid.org/0000-0003-0585-2424"]},"institutions":[{"id":"https://openalex.org/I4210094963","display_name":"St. Francis Hospital","ror":"https://ror.org/00mj4n083","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210094963"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eddy Barasch","raw_affiliation_strings":["Department of Research and Education, St. Francis Hospital, Roslyn, NY, SUNY at Stony Brook 11576, USA. eddy.barasch@chsli.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research and Education, St. Francis Hospital, Roslyn, NY, SUNY at Stony Brook 11576, USA. eddy.barasch@chsli.org","institution_ids":["https://openalex.org/I4210094963","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100953200","display_name":"Dali Fan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dali Fan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112911803","display_name":"Ebere O. Chukwu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ebere O Chukwu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060201311","display_name":"Jing Han","orcid":"https://orcid.org/0000-0001-9872-9817","observed_orcids":["https://orcid.org/0000-0001-9872-9817"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Han","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006786346","display_name":"Michael Passick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Passick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019571248","display_name":"Florentina Petillo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Florentina Petillo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030700157","display_name":"Aracely Norales","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aracely Norales","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003217797","display_name":"Nathaniel Reichek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nathaniel Reichek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.888,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.96411103,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"17","issue":"1","first_page":"81","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aortic-stenosis","display_name":"aortic stenosis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/preserved-left-ventricular-systolic-function","display_name":"preserved left ventricular systolic function","score":0.8560000061988831},{"id":"https://openalex.org/keywords/aortic-valve-area","display_name":"aortic valve area","score":0.6370000243186951},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.7910000085830688},{"id":"https://openalex.org/keywords/left-ventricular-end-diastolic-volume","display_name":"left ventricular end-diastolic volume","score":0.847000002861023},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.49799999594688416},{"id":"https://openalex.org/keywords/aortic-valve-replacement","display_name":"aortic valve replacement","score":0.8059999942779541},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6700000166893005},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7210000157356262},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.6859999895095825},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.4699999988079071},{"id":"https://openalex.org/keywords/aortic-valve-replacement-timing","display_name":"aortic valve replacement timing","score":0.5},{"id":"https://openalex.org/keywords/transcatheter-aortic-valve-replacement","display_name":"transcatheter aortic valve implantation","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9452688694000244},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.8551226258277893},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8206577301025391},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.6376973390579224},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.6026872396469116},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.5142940878868103},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.5125257968902588},{"id":"https://openalex.org/C2776570981","wikidata":"https://www.wikidata.org/wiki/Q4413093","display_name":"Aortic valve replacement","level":3,"score":0.49304696917533875},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.48118215799331665},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4674331545829773},{"id":"https://openalex.org/C2781414266","wikidata":"https://www.wikidata.org/wiki/Q531019","display_name":"Aortic valve stenosis","level":3,"score":0.46145614981651306},{"id":"https://openalex.org/C2775914520","wikidata":"https://www.wikidata.org/wiki/Q12335414","display_name":"Sinus rhythm","level":3,"score":0.42716872692108154},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2822014093399048},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2786747217178345},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.10142600536346436}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006328","descriptor_name":"Cardiac Catheterization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009518","descriptor_name":"New York","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013599","descriptor_name":"Systole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015150","descriptor_name":"Echocardiography, Doppler","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017548","descriptor_name":"Echocardiography, Transesophageal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18365573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18365573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart valve disease","raw_type":"Comparative Study"},{"id":"mag:67747596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18365573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W199420291","https://openalex.org/W615161412","https://openalex.org/W1507413178","https://openalex.org/W1921637439","https://openalex.org/W2003379318","https://openalex.org/W2006425997","https://openalex.org/W2042293234","https://openalex.org/W2054436867","https://openalex.org/W2079007437","https://openalex.org/W2080037774","https://openalex.org/W2100139301","https://openalex.org/W2111247251","https://openalex.org/W2115309842","https://openalex.org/W2121513563","https://openalex.org/W2137038354","https://openalex.org/W2152282974","https://openalex.org/W2160337198","https://openalex.org/W2397115535"],"related_works":["https://openalex.org/W2104707238","https://openalex.org/W2044446390","https://openalex.org/W143415454","https://openalex.org/W2039721282","https://openalex.org/W1997085036","https://openalex.org/W2764054135","https://openalex.org/W2803321944","https://openalex.org/W2163547708","https://openalex.org/W2618549703","https://openalex.org/W2076697185"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIM":[2],"OF":[3],"THE":[4],"STUDY:":[5],"A":[6],"significant":[7],"proportion":[8],"of":[9,38,44,57,148,183,229,294],"patients":[10,39,49,118,316],"with":[11,40,261,279],"severe":[12,277],"valvular":[13],"aortic":[14,78,108],"stenosis":[15,184],"(AS)":[16],"and":[17,36,89,103,128,199,223,247,268,304,323],"preserved":[18],"left":[19],"ventricular":[20],"(LV)":[21],"systolic":[22],"function":[23],"have":[24],"low":[25],"transvalvular":[26,121],"gradients.":[27],"The":[28,94,215],"study":[29],"aim":[30],"was":[31,98,259],"to":[32,139,266,290,311,321],"determine":[33],"the":[34,55,60,104,141,312],"mechanisms":[35],"outcome":[37],"this":[41],"hemodynamic":[42],"profile":[43],"AS.":[45],"METHODS:":[46],"Among":[47],"1,679":[48],"who":[50],"underwent":[51],"transthoracic":[52],"echocardiography":[53],"for":[54],"evaluation":[56],"AS":[58,76,278],"at":[59],"authors'":[61],"institution,":[62],"215":[63],"(105":[64],"females,":[65],"110":[66],"males;":[67],"mean":[68,95,122],"age:":[69],"77":[70],"+/-":[71,83,100,156,160,171,175,190,194,206,210],"10":[72],"years)":[73],"had":[74,119,130,144,324],"isolated":[75],"(mean":[77],"valve":[79,109,186],"area":[80,187],"index":[81,154,169,188,226],"0.39":[82],"0.1":[84],"cm2/m2),":[85],"normal":[86,90,281],"sinus":[87],"rhythm":[88],"LV":[91,151,166,216,282,298],"ejection":[92,283],"fraction.":[93],"follow":[96],"up":[97],"23":[99],"12":[101,161,172],"months,":[102],"end-points":[105],"were":[106,227,317],"mortality,":[107],"replacement":[110],"(AVR),":[111],"or":[112,114,133],"mortality":[113],"AVR.":[115],"RESULTS:":[116],"Forty-seven":[117],"a":[120,145,180,200,269,280,291,296,300,305,325],"gradient":[123],"(MG)":[124],"<30":[125,231,256,286],"mmHg":[126,136,232,257,287],"(MG(low))":[127],"168":[129],"MG":[131,230,255,285],">":[132],"=":[134,234,241,249],"30":[135],"(MG(high)).":[137],"Compared":[138,310],"MG(high),":[140],"MG(low)":[142],"group":[143],"higher":[146,201,306,326],"prevalence":[147],"hypertension,":[149],"lower":[150,165,264,301],"end-diastolic":[152,217],"volume":[153,218],"(47":[155],"9":[157],"versus":[158,173,192,208],"56":[159],"ml/m2,":[162],"p":[163,178,197],"<0.0001),":[164],"stroke":[167],"vol-ume":[168],"(37":[170],"41":[174],"11":[176],"ml/beat,":[177],"<0.0002),":[179],"lesser":[181,292],"severity":[182,293],"(aortic":[185],"0.37":[189],"0.09":[191,195],"0.46":[193],"cm2/m2,":[196],"<0.0001)":[198],"systemic":[202,220,307],"vascular":[203,221,308],"resistance":[204,222],"(2163":[205],"754":[207],"1879":[209],"528":[211],"dyne":[212],"cm":[213],"s(-5).":[214],"index,":[219],"energy":[224],"loss":[225],"predictors":[228],"(OR":[233],"0.30,":[235],"95%":[236,243,251],"CI,":[237,244,252],"0.12,":[238],"0.62;":[239],"OR":[240,248],"3.05,":[242],"1.71,":[245],"6.26;":[246],"6.76,":[250],"3.44,15.38,":[253],"respectively).":[254],"(MGhigh)":[258],"associated":[260],"almost":[262],"50%":[263],"referral":[265],"surgery":[267,322],"two-fold":[270],"increase":[271],"in":[272],"preoperative":[273],"mortality.":[274,327],"CONCLUSION:":[275],"In":[276],"fraction,":[284],"is":[288],"related":[289],"stenosis,":[295],"smaller":[297],"volume,":[299],"flow":[302],"rate":[303],"resistance.":[309],"MG(high)":[313],"group,":[314],"these":[315],"less":[318],"frequently":[319],"referred":[320]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
