{"id":"https://openalex.org/W6773470","doi":null,"title":"Detection of procalcitonin (PCT) in healthy controls and patients with local infection by a sensitive ILMA.","display_name":"Detection of procalcitonin (PCT) in healthy controls and patients with local infection by a sensitive ILMA.","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W6773470","mag":"6773470","pmid":"https://pubmed.ncbi.nlm.nih.gov/12071576"},"language":"en","primary_location":{"id":"pmid:12071576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12071576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical laboratory","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108463967","display_name":"Nils G. Morgenthaler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nils G Morgenthaler","raw_affiliation_strings":["Research Department, B.R.A.H.M.S. AG, Biotechnology Centre Hennigsdorf/Berlin, Germany. n.morgenthaler@brahms.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Department, B.R.A.H.M.S. AG, Biotechnology Centre Hennigsdorf/Berlin, Germany. n.morgenthaler@brahms.de","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015846826","display_name":"Joachim Struck","orcid":"https://orcid.org/0000-0002-9793-7160","observed_orcids":["https://orcid.org/0000-0002-9793-7160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joachim Struck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038158678","display_name":"Christina Fischer-Schulz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christina Fischer-Schulz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004280811","display_name":"Elke Seidel-Mueller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elke Seidel-Mueller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009028786","display_name":"Wilfried Beier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wilfried Beier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036583068","display_name":"Andreas Bergmann","orcid":"https://orcid.org/0000-0002-4466-1682","observed_orcids":["https://orcid.org/0000-0002-4466-1682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Bergmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4034,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.88190351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"48","issue":"5-6","first_page":"263","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/procalcitonin","display_name":"procalcitonin","score":1.0},{"id":"https://openalex.org/keywords/healthy-controls","display_name":"healthy controls","score":0.5989999771118164},{"id":"https://openalex.org/keywords/chemiluminescence-immunoassay","display_name":"chemiluminescence immunoassay","score":0.9070000052452087},{"id":"https://openalex.org/keywords/reference-values","display_name":"reference values","score":0.8889999985694885},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hook-effect","display_name":"hook effect","score":0.6000000238418579},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.621999979019165},{"id":"https://openalex.org/keywords/peritonitis","display_name":"peritonitis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sepsis-biomarkers","display_name":"sepsis biomarkers","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C10936531","wikidata":"https://www.wikidata.org/wiki/Q786600","display_name":"Procalcitonin","level":3,"score":0.9389607906341553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6848231554031372},{"id":"https://openalex.org/C122048520","wikidata":"https://www.wikidata.org/wiki/Q2913954","display_name":"Percentile","level":2,"score":0.6410149335861206},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.6032792329788208},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5948468446731567},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5572701096534729},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.5371874570846558},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5158173441886902},{"id":"https://openalex.org/C145802702","wikidata":"https://www.wikidata.org/wiki/Q2931725","display_name":"Chemiluminescence","level":2,"score":0.431173175573349},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.4306638240814209},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.4158657491207123},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.38396430015563965},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.23613294959068298},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19769877195358276},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001064","descriptor_name":"Appendicitis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001064","descriptor_name":"Appendicitis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002116","descriptor_name":"Calcitonin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005335","descriptor_name":"Fever of Unknown Origin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015740","descriptor_name":"Calcitonin Gene-Related Peptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12071576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12071576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical laboratory","raw_type":"Comparative Study"},{"id":"mag:6773470","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12071576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2211631449","https://openalex.org/W16480759","https://openalex.org/W2472869904","https://openalex.org/W1504668","https://openalex.org/W2234219145","https://openalex.org/W2349969431","https://openalex.org/W2357493541","https://openalex.org/W2390034196","https://openalex.org/W2770460799","https://openalex.org/W52484821"],"abstract_inverted_index":{"BACKGROUND:":[0],"Procalcitonin":[1],"(PCT)":[2],"is":[3,28,266,295],"an":[4,194],"established":[5,273],"marker":[6],"for":[7,213,280],"severe":[8],"systemic":[9],"bacterial":[10,300],"infection":[11,214],"and":[12,57,74,78,182,217,246],"sepsis.":[13],"So":[14],"far":[15],"the":[16,32,44,52,58,124,176,183,197,240,272,281,293],"relevance":[17],"of":[18,34,40,46,54,60,144,155,175,200,215,220],"PCT":[19,50,66,126,166,241,264,284],"in":[20,68,193,239,286],"healthy":[21,80,149,244,287],"individuals":[22,245],"or":[23],"patients":[24,70,247],"with":[25,71,108,210,248],"local":[26,299],"infections":[27,249,301],"unclear":[29],"due":[30],"to":[31,96,123,141,297],"lack":[33],"highly":[35,233],"sensitive":[36,49,270],"assays.":[37],"The":[38,101,147,172,202,262],"aim":[39],"our":[41],"study":[42],"was":[43,105,134,179,186,206,231],"characterization":[45],"a":[47,83,109,142,152,211,218,232],"new":[48,84,263],"assay,":[51,94],"establishment":[53],"reference":[55],"values":[56,67,167],"assessment":[59],"diagnostic":[61],"accuracy.":[62],"METHODS:":[63],"We":[64],"assessed":[65],"522":[69],"different":[72],"infectious":[73,76],"non":[75],"conditions":[77],"410":[79,148],"controls":[81,150,163,256],"by":[82],"coated":[85],"tube":[86],"sandwich":[87],"chemiluminescence":[88],"assay":[89,111,265,275,294],"B.R.A.H.M.S":[90],"ProCa-S":[91],"(2":[92],"step":[93],"time":[95,283],"result":[97],"2.5":[98],"hours).":[99],"RESULTS:":[100],"lower":[102],"detection":[103,285],"limit":[104],"6.0":[106],"ng/L,":[107,209],"functional":[110],"sensitivity":[112,212],"below":[113],"7":[114],"ng/L.":[115,146,188],"Samples":[116],"above":[117],"250":[118],"ng/L":[119,157,181],"gave":[120],"excellent":[121],"correlation":[122],"LUMItest":[125,276],"(r":[127],"=":[128],"0.98,":[129],"p":[130],"<":[131,236],"0.0001).":[132],"There":[133,230],"no":[135],"high":[136],"dose":[137],"hook":[138],"effect":[139],"up":[140],"concentration":[143,154],"21,300":[145],"had":[151,164],"median":[153,242],"12.7":[156],"(95%":[158],"CI:":[159],"12.6-14.7":[160],"ng/L).":[161,171],"65":[162],"non-detectable":[165],"(defined":[168],"as":[169],"5":[170,180],"2.5th":[173],"percentile":[174,185],"normal":[177],"population":[178],"97.5th":[184],"46.7":[187],"ROC":[189],"plot":[190],"analysis":[191],"resulted":[192],"area":[195],"under":[196],"curve":[198],"(AUC)":[199],"0.90.":[201],"optimal":[203],"decision":[204],"threshold":[205],"at":[207],"50":[208],"77.8%":[216],"specificity":[219],"98.5%":[221],"(positive":[222],"predictive":[223,227],"value":[224,228],"97.7%,":[225],"negative":[226],"84.9%).":[229],"significant":[234],"(p":[235],"0.0001)":[237],"difference":[238],"between":[243],"(e.g.":[250,257],"pneumonia,":[251],"peritonitis)":[252],"but":[253],"not":[254],"non-infectious":[255,304],"pregnancy,":[258],"autoimmune":[259],"disease).":[260],"CONCLUSIONS:":[261],"30":[267],"times":[268],"more":[269],"than":[271],"routine":[274],"PCT,":[277],"thus":[278],"allowing":[279],"first":[282],"individuals.":[288],"First":[289],"results":[290],"indicate":[291],"that":[292],"suitable":[296],"differentiate":[298],"from":[302],"other":[303],"diseases.":[305]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
