{"id":"https://openalex.org/W6767451","doi":"https://doi.org/10.1177/135965350701200407","title":"Some HIV Antiretrovirals Increase Oxidative Stress and Alter Chemokine, Cytokine or Adiponectin Production in Human Adipocytes and Macrophages","display_name":"Some HIV Antiretrovirals Increase Oxidative Stress and Alter Chemokine, Cytokine or Adiponectin Production in Human Adipocytes and Macrophages","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W6767451","doi":"https://doi.org/10.1177/135965350701200407","mag":"6767451","pmid":"https://pubmed.ncbi.nlm.nih.gov/17668557"},"language":"en","primary_location":{"id":"doi:10.1177/135965350701200407","doi":"https://doi.org/10.1177/135965350701200407","is_oa":false,"landing_page_url":"https://doi.org/10.1177/135965350701200407","pdf_url":null,"source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073665889","display_name":"Claire Lagathu","orcid":"https://orcid.org/0000-0003-0700-8286","observed_orcids":["https://orcid.org/0000-0003-0700-8286"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claire Lagathu","raw_affiliation_strings":["Inserm, U680, Paris, France","Universit\u00e9 Pierre et Marie Curie Paris6, UMR S680, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, U680, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie Paris6, UMR S680, Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068119691","display_name":"Brenda K. Eustace","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenda Eustace","raw_affiliation_strings":["Vertex Pharmaceuticals Inc., Biology Sector, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals Inc., Biology Sector, Cambridge, MA, USA","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088376136","display_name":"Matthieu Prot","orcid":"https://orcid.org/0000-0003-2337-2491","observed_orcids":["https://orcid.org/0000-0003-2337-2491"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Matthieu Prot","raw_affiliation_strings":["Inserm, U680, Paris, France","Universit\u00e9 Pierre et Marie Curie Paris6, UMR S680, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, U680, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie Paris6, UMR S680, Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048543305","display_name":"Dan Frantz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Frantz","raw_affiliation_strings":["Vertex Pharmaceuticals Inc., Biology Sector, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals Inc., Biology Sector, Cambridge, MA, USA","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113160125","display_name":"Yong Gu","orcid":"https://orcid.org/0000-0002-0482-1610","observed_orcids":["https://orcid.org/0000-0002-0482-1610"]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Gu","raw_affiliation_strings":["Vertex Pharmaceuticals Inc., Biology Sector, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals Inc., Biology Sector, Cambridge, MA, USA","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110009205","display_name":"Jean\u2010Philippe Bastard","orcid":"https://orcid.org/0000-0001-9787-7535","observed_orcids":["https://orcid.org/0000-0001-9787-7535"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210166768","display_name":"H\u00f4pital Tenon","ror":"https://ror.org/05h5v3c50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210166768"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Philippe Bastard","raw_affiliation_strings":["AP-HP, H\u00f4pital Tenon, Service de Biochimie et Hormonologie, Paris, France","Inserm, U680, Paris, France","Universit\u00e9 Pierre et Marie Curie Paris6, UMR S680, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AP-HP, H\u00f4pital Tenon, Service de Biochimie et Hormonologie, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210166768"]},{"raw_affiliation_string":"Inserm, U680, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie Paris6, UMR S680, Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041042200","display_name":"Mustapha Maachi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210166768","display_name":"H\u00f4pital Tenon","ror":"https://ror.org/05h5v3c50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210166768"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mustapha Maachi","raw_affiliation_strings":["AP-HP, H\u00f4pital Tenon, Service de Biochimie et Hormonologie, Paris, France","Inserm, U680, Paris, France","Universit\u00e9 Pierre et Marie Curie Paris6, UMR S680, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AP-HP, H\u00f4pital Tenon, Service de Biochimie et Hormonologie, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210166768"]},{"raw_affiliation_string":"Inserm, U680, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie Paris6, UMR S680, Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090269367","display_name":"St\u00e9phane Azoulay","orcid":"https://orcid.org/0000-0002-1125-9291","observed_orcids":["https://orcid.org/0000-0002-1125-9291"]},"institutions":[{"id":"https://openalex.org/I4210086528","display_name":"Institut de Chimie de Nice","ror":"https://ror.org/000pvc513","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210086528","https://openalex.org/I4210128300"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Stephane Azoulay","raw_affiliation_strings":["Laboratoire de Chimie des Mol\u00e9cules Bioactives et Aromatiques, UMR 6001, Universit\u00e9 Nice-Sophia Antipolis, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie des Mol\u00e9cules Bioactives et Aromatiques, UMR 6001, Universit\u00e9 Nice-Sophia Antipolis, Nice, France","institution_ids":["https://openalex.org/I4210086528","https://openalex.org/I4387154757"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Briggs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Briggs","raw_affiliation_strings":["Vertex Pharmaceuticals Inc., Biology Sector, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals Inc., Biology Sector, Cambridge, MA, USA","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111756743","display_name":"Martine Caron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Martine Caron","raw_affiliation_strings":["Inserm, U680, Paris, France","Universit\u00e9 Pierre et Marie Curie Paris6, UMR S680, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, U680, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie Paris6, UMR S680, Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035291390","display_name":"Jacqueline Capeau","orcid":"https://orcid.org/0000-0002-1710-4186","observed_orcids":["https://orcid.org/0000-0002-1710-4186"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210166768","display_name":"H\u00f4pital Tenon","ror":"https://ror.org/05h5v3c50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210166768"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jacqueline Capeau","raw_affiliation_strings":["AP-HP, H\u00f4pital Tenon, Service de Biochimie et Hormonologie, Paris, France","Inserm, U680, Paris, France","Universit\u00e9 Pierre et Marie Curie Paris6, UMR S680, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AP-HP, H\u00f4pital Tenon, Service de Biochimie et Hormonologie, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210166768"]},{"raw_affiliation_string":"Inserm, U680, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie Paris6, UMR S680, Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5035291390"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210097159","https://openalex.org/I4210166768","https://openalex.org/I4405264447"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":11.4064,"has_fulltext":false,"cited_by_count":190,"citation_normalized_percentile":{"value":0.98951915,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"12","issue":"4","first_page":"489","last_page":"500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.8740000128746033},{"id":"https://openalex.org/keywords/nucleoside-reverse-transcriptase-inhibitors","display_name":"nucleoside reverse transcriptase inhibitors","score":0.9929999709129333},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9399999976158142},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9959999918937683},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.6909999847412109},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9599999785423279},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.9369999766349792},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9300000071525574},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.7490000128746033},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7239999771118164},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6449999809265137},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8619999885559082},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.6790000200271606},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.722000002861023},{"id":"https://openalex.org/keywords/lipoatrophy","display_name":"lipoatrophy","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5286351442337036},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.4965551495552063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49621087312698364},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.45877915620803833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4169021248817444},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4155963361263275},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.352106511592865},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.35204625129699707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31306421756744385},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3111841678619385},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.19756975769996643},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19323793053627014},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.10923793911933899}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D039682","descriptor_name":"HIV-Associated Lipodystrophy Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/135965350701200407","doi":"https://doi.org/10.1177/135965350701200407","is_oa":false,"landing_page_url":"https://doi.org/10.1177/135965350701200407","pdf_url":null,"source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},{"id":"pmid:17668557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17668557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W79601317","https://openalex.org/W179857658","https://openalex.org/W319470940","https://openalex.org/W1524321743","https://openalex.org/W1913740938","https://openalex.org/W1967632729","https://openalex.org/W1967964480","https://openalex.org/W1969118157","https://openalex.org/W1974599416","https://openalex.org/W1979927283","https://openalex.org/W1991079474","https://openalex.org/W2010819899","https://openalex.org/W2013824819","https://openalex.org/W2019113684","https://openalex.org/W2019762373","https://openalex.org/W2028614513","https://openalex.org/W2028657303","https://openalex.org/W2036884568","https://openalex.org/W2037561994","https://openalex.org/W2043155515","https://openalex.org/W2051243229","https://openalex.org/W2053701857","https://openalex.org/W2057576473","https://openalex.org/W2061431235","https://openalex.org/W2061613314","https://openalex.org/W2062286166","https://openalex.org/W2067416157","https://openalex.org/W2068078604","https://openalex.org/W2092084431","https://openalex.org/W2096876054","https://openalex.org/W2097992625","https://openalex.org/W2109391648","https://openalex.org/W2111966641","https://openalex.org/W2117022390","https://openalex.org/W2117312836","https://openalex.org/W2124821727","https://openalex.org/W2147574216","https://openalex.org/W2151101396","https://openalex.org/W2153335144","https://openalex.org/W2159229970","https://openalex.org/W2161935034","https://openalex.org/W2164676747","https://openalex.org/W2317583984","https://openalex.org/W2342149286","https://openalex.org/W2404282988","https://openalex.org/W2413877209","https://openalex.org/W2414039742","https://openalex.org/W2473495692","https://openalex.org/W4238221516","https://openalex.org/W4320578154"],"related_works":["https://openalex.org/W4320578154","https://openalex.org/W319470940","https://openalex.org/W2028614513","https://openalex.org/W2012023821","https://openalex.org/W2169332278","https://openalex.org/W7100934592","https://openalex.org/W2055172234","https://openalex.org/W1967632729","https://openalex.org/W2090809939","https://openalex.org/W2077947040"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Adipose":[1],"tissue":[2],"from":[3],"patients":[4],"with":[5,71,97],"HIV-related":[6],"lipodystrophy":[7],"presents":[8],"a":[9],"state":[10],"of":[11,16,60,103,171,175,182,211],"chronic":[12],"inflammation.":[13],"Altered":[14],"expression":[15],"cytokines/adipokines":[17],"and":[18,28,41,47,66,80,90,115,125,140,145,151,154,160,165,197,203,209,214,224,257,265,269],"macrophage":[19,193,263],"infiltration":[20],"could":[21,259],"be":[22,260],"involved":[23,261],"in":[24,156,230,262,267],"patients'":[25],"insulin":[26,270],"resistance":[27],"lipoatrophy.":[29],"We":[30],"tested":[31],"whether":[32,49],"antiretrovirals":[33],"affected":[34],"adipokine":[35,222,243],"release":[36,127,153,210],"by":[37,44,110,118,130,179,248,255],"human":[38,45,64,137,231],"subcutaneous":[39,232],"adipocytes":[40,65,256],"cytokine/chemokine":[42],"production":[43,117,159,208,229,250,254],"macrophages":[46,68,258],"examined":[48],"reactive":[50],"oxygen":[51],"species":[52],"(ROS)":[53],"hyperproduction":[54],"was":[55,108,128,245],"related":[56],"to":[57],"the":[58,180],"effect":[59,241],"antiretrovirals.":[61],"METHODS:":[62],"Differentiated":[63],"PMA-THP-1":[67,185],"were":[69,177],"treated":[70],"protease":[72],"inhibitors":[73,86],"(PIs:":[74],"indinavir,":[75],"nelfinavir,":[76,201],"amprenavir,":[77,143],"lopinavir,":[78],"ritonavir":[79],"atazanavir)":[81],"or":[82,96,132],"nucleoside":[83],"reverse":[84],"transcriptase":[85],"(NRTIs:":[87],"stavudine,":[88],"zidovudine":[89,202],"abacavir)":[91,146],"for":[92],"24-48":[93],"h":[94],"without":[95],"diphenylene":[98],"iodonium":[99],"(DPI),":[100],"an":[101],"inhibitor":[102],"oxidative":[104],"stress.":[105],"Lipid":[106],"content":[107,226],"assessed":[109],"Oil":[111],"Red":[112],"O":[113],"staining":[114],"ROS":[116,158,207,228,249],"nitroblue":[119],"tetrazolium":[120],"(NBT)":[121],"reduction.":[122],"Cytokine/chemokines,":[123],"adiponectin":[124,150],"leptin":[126,152],"evaluated":[129],"ELISA":[131],"multiplex":[133],"assays.":[134],"RESULTS:":[135],"In":[136,184],"adipocytes,":[138],"PIs":[139,220],"NRTIs":[141],"(except":[142],"atazanavir":[144],"reduced":[147],"lipid":[148,225],"content,":[149],"increased":[155,192,206],"parallel":[157],"monocyte":[161],"chemoattractant":[162],"protein":[163],"(MCP)-1":[164],"interleukin":[166],"(IL)-6":[167],"release.":[168,199],"The":[169],"effects":[170],"PIs,":[172,188],"but":[173,189,239],"not":[174,246],"NRTIs,":[176],"prevented":[178],"addition":[181],"DPI.":[183],"macrophages,":[186],"all":[187],"no":[190],"NRTI,":[191],"inflammatory":[194],"protein-1":[195],"alpha":[196],"MCP-1":[198],"Lopinavir,":[200],"stavudine":[204],"markedly":[205],"IL-1":[212],"beta":[213],"tumour":[215],"necrosis":[216],"factor-alpha.":[217],"CONCLUSIONS:":[218],"Some":[219],"altered":[221,236],"secretion":[223,244],"through":[227],"adipocytes.":[233],"Thymidine":[234],"analogues":[235],"adipocyte":[237],"functions":[238],"their":[240],"on":[242],"reverted":[247],"inhibition.":[251],"Increased":[252],"chemokine/cytokine":[253],"recruitment":[264],"participate":[266],"lipoatrophy":[268],"resistance.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
