{"id":"https://openalex.org/W67660646","doi":null,"title":"Modulation of Neuroinflammation by Dietary Flavonoids","display_name":"Modulation of Neuroinflammation by Dietary Flavonoids","publication_year":2012,"publication_date":"2012-11-30","ids":{"openalex":"https://openalex.org/W67660646","mag":"67660646"},"language":"en","primary_location":{"id":"pmh:oai:uhra.herts.ac.uk:2299/13285","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2299/13285","pdf_url":null,"source":{"id":"https://openalex.org/S4306400241","display_name":"University of Hertfordshire Research Archive (University of Hertfordshire)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I141584323","host_organization_name":"University of Hertfordshire","host_organization_lineage":["https://openalex.org/I141584323"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045749402","display_name":"David Vauzour","orcid":"https://orcid.org/0000-0001-5952-8756","observed_orcids":["https://orcid.org/0000-0001-5952-8756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Vauzour","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5952-8756","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036026424","display_name":"Alison Spilsbury","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alison Spilsbury","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109908574","display_name":"Katerina Vafeiadou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katerina Vafeiadou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028047049","display_name":"Marcus Rattray","orcid":"https://orcid.org/0000-0002-6620-9830","observed_orcids":["https://orcid.org/0000-0002-6620-9830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcus Rattray","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6620-9830","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111830593","display_name":"Jeremy P. E. Spencer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy P. E. Spencer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00810373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.7416999936103821,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.7416999936103821,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.21719999611377716,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-flavonoids","display_name":"dietary flavonoids","score":0.9139999747276306},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9829999804496765},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9300000071525574},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9800000190734863},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.8240000009536743},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.6899999976158142},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9649999737739563},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9729999899864197},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7039999961853027},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.7940000295639038},{"id":"https://openalex.org/keywords/neuroprotective-mechanisms","display_name":"neuroprotection mechanism","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.9398428797721863},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.9377205967903137},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6706411242485046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4960990846157074},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.4333755373954773},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4226202964782715},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4123690724372864},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.38943976163864136},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.25019147992134094},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2130720615386963},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08903703093528748}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uhra.herts.ac.uk:2299/13285","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2299/13285","pdf_url":null,"source":{"id":"https://openalex.org/S4306400241","display_name":"University of Hertfordshire Research Archive (University of Hertfordshire)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I141584323","host_organization_name":"University of Hertfordshire","host_organization_lineage":["https://openalex.org/I141584323"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:67660646","doi":null,"is_oa":false,"landing_page_url":"https://centaur.reading.ac.uk/25850/","pdf_url":null,"source":{"id":"https://openalex.org/S4306476971","display_name":"Nova eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Nova eBooks","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1977122148","https://openalex.org/W2134439788","https://openalex.org/W2752981360","https://openalex.org/W3081648941","https://openalex.org/W2130409253","https://openalex.org/W4410446741","https://openalex.org/W2090556347","https://openalex.org/W4221119764","https://openalex.org/W2151443649","https://openalex.org/W4205879533"],"abstract_inverted_index":{"There":[0],"is":[1,158],"increasing":[2],"evidence":[3,131,218],"to":[4,9,16,55,68,159,173,210],"suggest":[5,132],"neuroinflammatory":[6],"processes":[7,38],"contribute":[8],"the":[10,17,46,56,69,77,85,96,117,141,144,155,161,177,187,196,205,217,226],"cascade":[11,206],"of":[12,45,58,79,99,143,154,165,170,186,198,207,228,237],"events":[13,208],"that":[14,133,219],"lead":[15],"progressive":[18],"neuronal":[19,74,211],"damage":[20],"observed":[21],"in":[22,84,105,114,168,176,192,204],"neurodegenerative":[23,37],"disorders":[24],"such":[25,36],"as":[26],"Parkinson\u2018s":[27],"disease":[28],"and":[29,42,51,72,82,88,111,147,194,232],"Alzheimer\u2018s":[30],"disease.":[31],"The":[32,152],"molecular":[33],"mechanisms":[34,119,236],"underlying":[35],"are":[39],"rather":[40],"complex":[41],"involve":[43],"modulation":[44,142],"mitogen-activated":[47],"protein":[48],"kinase":[49],"(MAPK)":[50],"NF-\u03baB":[52],"pathways":[53],"leading":[54,209],"generation":[57],"nitric":[59],"oxide":[60],"(NO).":[61],"Such":[62],"a":[63],"small":[64],"molecule":[65],"may":[66,123,135,221],"diffuse":[67],"neighbouring":[70],"neurons":[71],"trigger":[73],"death":[75],"through":[76,140],"inhibition":[78],"mitochondrial":[80],"respiration":[81],"increases":[83],"reactive":[86],"oxygen":[87],"nitrogen":[89],"species.":[90],"Recently,":[91],"attention":[92],"has":[93],"focused":[94],"on":[95],"neuroprotective":[97,126,138,163],"effects":[98,127,139],"flavonoids":[100,122,167,220],"which":[101,121],"have":[102],"been":[103],"effective":[104],"protecting":[106],"against":[107],"both":[108],"age-related":[109],"cognitive":[110],"motor":[112],"decline":[113],"vivo.":[115],"Although,":[116],"precise":[118],"by":[120,202,224],"exert":[124,136],"their":[125,137,171,234],"remain":[128],"unclear,":[129],"accumulating":[130],"they":[134],"MAP":[145],"Kinase":[146,149],"PI3":[148],"signaling":[150],"pathways.":[151],"aim":[153],"present":[156,216],"chapter":[157],"highlight":[160],"potential":[162,235],"role":[164,188],"dietary":[166],"terms":[169],"ability":[172],"modulate":[174,222],"neuroinflammation":[175,193,223],"central":[178],"nervous":[179],"system.":[180],"We":[181,213],"will":[182,214],"provide":[183],"an":[184],"outline":[185],"glial":[189],"cells":[190],"play":[191],"describe":[195],"involvement":[197],"inflammatory":[199,230],"mediators,":[200],"produced":[201],"glia,":[203],"degeneration.":[212],"then":[215],"inhibiting":[225],"production":[227],"these":[229],"agents":[231],"summarise":[233],"action.":[238]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}