{"id":"https://openalex.org/W6763333","doi":null,"title":"Two types of visual dysfunction in autosomal dominant retinitis pigmentosa.","display_name":"Two types of visual dysfunction in autosomal dominant retinitis pigmentosa.","publication_year":1988,"publication_date":"1988-08-01","ids":{"openalex":"https://openalex.org/W6763333","mag":"6763333","pmid":"https://pubmed.ncbi.nlm.nih.gov/3417410"},"language":"en","primary_location":{"id":"pmid:3417410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3417410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044494487","display_name":"Colin M. Kemp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C M Kemp","raw_affiliation_strings":["Institute of Ophthalmology, University of London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ophthalmology, University of London, United Kingdom","institution_ids":["https://openalex.org/I124357947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075246209","display_name":"Samuel G. Jacobson","orcid":"https://orcid.org/0000-0003-2122-169X","observed_orcids":["https://orcid.org/0000-0003-2122-169X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S G Jacobson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039094695","display_name":"David J. Faulkner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D J Faulkner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.2566,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.95298209,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"29","issue":"8","first_page":"1235","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autosomal-dominant-retinitis-pigmentosa","display_name":"autosomal dominant retinitis pigmentosa","score":0.9980000257492065},{"id":"https://openalex.org/keywords/visual-dysfunction","display_name":"visual dysfunction","score":0.503000020980835},{"id":"https://openalex.org/keywords/rod-photoreceptor-function","display_name":"rod photoreceptor function","score":0.7789999842643738},{"id":"https://openalex.org/keywords/disease-subtypes","display_name":"disease subtypes","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C202033177","wikidata":"https://www.wikidata.org/wiki/Q423107","display_name":"Rhodopsin","level":3,"score":0.9611822366714478},{"id":"https://openalex.org/C2781114197","wikidata":"https://www.wikidata.org/wiki/Q847057","display_name":"Retinitis pigmentosa","level":3,"score":0.9261417388916016},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5535168051719666},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5294413566589355},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.5086377859115601},{"id":"https://openalex.org/C131667965","wikidata":"https://www.wikidata.org/wiki/Q445081","display_name":"Visual phototransduction","level":3,"score":0.4840356707572937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3941039443016052},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3251938223838806},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.19176173210144043}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003623","descriptor_name":"Dark Adaptation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005799","descriptor_name":"Genes, Dominant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012243","descriptor_name":"Rhodopsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012684","descriptor_name":"Sensory Thresholds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014786","descriptor_name":"Vision Disorders","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D014786","descriptor_name":"Vision Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D058609","descriptor_name":"Visual Field Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3417410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3417410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:6763333","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3417410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1968570695","https://openalex.org/W1987060828","https://openalex.org/W1973873138","https://openalex.org/W192528459","https://openalex.org/W2143609676","https://openalex.org/W2059922098","https://openalex.org/W2041337667","https://openalex.org/W160457236","https://openalex.org/W2032445786","https://openalex.org/W2094967199"],"abstract_inverted_index":{"Visual":[0],"thresholds":[1],"and":[2,45],"rhodopsin":[3,80,108],"levels":[4,106],"were":[5,109,116],"determined":[6],"in":[7,52,55,64,146],"nine":[8],"subjects":[9,16],"with":[10,68],"autosomal":[11],"dominant":[12],"retinitis":[13],"pigmentosa.":[14],"The":[15,151],"fell":[17],"into":[18],"two":[19,23,159],"groups,":[20],"corresponding":[21,50],"to":[22,120,142],"subtypes":[24,161],"of":[25,37,78,107,113,130,133,157,162],"the":[26,35,56,73,83,94,105,123,128,136,155,158],"disease":[27,170],"revealed":[28],"by":[29,48,72,135],"two-color,":[30],"dark-adapted":[31],"static":[32],"perimetry.":[33],"In":[34,82],"first":[36],"these":[38],"subtypes,":[39],"rod-mediated":[40],"function":[41,54,87,98],"was":[42,46,88,99],"variably":[43],"reduced":[44,79,90],"accompanied":[47],"a":[49,65,76],"reduction":[51],"cone":[53,97],"same":[57],"retinal":[58],"region.":[59],"Dark-adapted":[60],"threshold":[61,125],"elevations":[62,126],"varied":[63],"way":[66],"consistent":[67],"decreased":[69,131],"quantal":[70],"absorption":[71,134],"rods":[74],"as":[75],"result":[77],"levels.":[81],"second":[84],"subtype,":[85],"rod":[86],"greatly":[89],"or":[91],"absent":[92],"throughout":[93],"retina,":[95],"while":[96],"much":[100,117],"less":[101],"severely":[102],"affected.":[103],"Although":[104],"only":[110],"about":[111],"half":[112],"normal,":[114],"they":[115],"too":[118],"great":[119],"account":[121],"for":[122],"visual":[124,137],"on":[127],"basis":[129],"probabilities":[132],"pigment.":[138],"Rhodopsin":[139],"regeneration":[140],"appeared":[141],"follow":[143],"normal":[144],"kinetics":[145],"patients":[147],"from":[148],"both":[149],"groups.":[150],"results":[152],"indicate":[153],"that":[154],"examples":[156],"psychophysical":[160],"AD":[163],"RP":[164],"investigated":[165],"here":[166],"have":[167],"very":[168],"different":[169],"manifestations.":[171]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}