{"id":"https://openalex.org/W67544045","doi":null,"title":"Angiotensin IV and the Molecular Mechanisms Involved in the Development of Insulin Resistance in 3T3-L1 Adipocytes","display_name":"Angiotensin IV and the Molecular Mechanisms Involved in the Development of Insulin Resistance in 3T3-L1 Adipocytes","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W67544045","mag":"67544045"},"language":"en","primary_location":{"id":"mag:67544045","doi":null,"is_oa":false,"landing_page_url":"https://trace.tennessee.edu/utk_gradthes/986/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030961662","display_name":"Julie Ann Jungwirth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Julie Anne Jungwirth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5030961662"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00799046,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.6288999915122986,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.6288999915122986,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.32589998841285706,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-iv","display_name":"angiotensin IV","score":0.996999979019165},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.906000018119812},{"id":"https://openalex.org/keywords/at4-receptor","display_name":"AT4 receptor","score":0.7940000295639038},{"id":"https://openalex.org/keywords/3t3-l1-adipocytes","display_name":"3T3-L1 adipocytes","score":0.9200000166893005},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8190000057220459},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7770000100135803},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9520000219345093},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9909999966621399},{"id":"https://openalex.org/keywords/irs-1-serine-phosphorylation","display_name":"IRS-1 serine phosphorylation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9049999713897705},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.7789999842643738},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6926795244216919},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6577361822128296},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.6546781063079834},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6480025053024292},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.6075767874717712},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.597320020198822},{"id":"https://openalex.org/C185967709","wikidata":"https://www.wikidata.org/wiki/Q101433828","display_name":"Insulin receptor substrate","level":5,"score":0.5963378548622131},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5555136203765869},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5375001430511475},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5252465605735779},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5029472708702087},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.48364102840423584},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.46936681866645813},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35673069953918457},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.35552117228507996},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.35199403762817383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3170297145843506},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27383148670196533},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0812501311302185}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:67544045","doi":null,"is_oa":false,"landing_page_url":"https://trace.tennessee.edu/utk_gradthes/986/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":162,"referenced_works":["https://openalex.org/W10316846","https://openalex.org/W103429211","https://openalex.org/W109183088","https://openalex.org/W233075823","https://openalex.org/W1524321743","https://openalex.org/W1545777920","https://openalex.org/W1585326224","https://openalex.org/W1589072283","https://openalex.org/W1604542334","https://openalex.org/W1631449371","https://openalex.org/W1859411087","https://openalex.org/W1894627265","https://openalex.org/W1901975522","https://openalex.org/W1965650317","https://openalex.org/W1965776633","https://openalex.org/W1968688682","https://openalex.org/W1969503055","https://openalex.org/W1971362133","https://openalex.org/W1972262775","https://openalex.org/W1972866300","https://openalex.org/W1972990982","https://openalex.org/W1973121348","https://openalex.org/W1975702138","https://openalex.org/W1975830080","https://openalex.org/W1976226569","https://openalex.org/W1978280297","https://openalex.org/W1978375489","https://openalex.org/W1978504634","https://openalex.org/W1980243405","https://openalex.org/W1981261500","https://openalex.org/W1981731922","https://openalex.org/W1983801758","https://openalex.org/W1984633752","https://openalex.org/W1985089331","https://openalex.org/W1986751808","https://openalex.org/W1987105067","https://openalex.org/W1989684302","https://openalex.org/W1989884087","https://openalex.org/W1990950873","https://openalex.org/W1992558654","https://openalex.org/W1994101775","https://openalex.org/W1994422148","https://openalex.org/W1995794153","https://openalex.org/W1995845328","https://openalex.org/W1997503928","https://openalex.org/W1997889683","https://openalex.org/W1998052464","https://openalex.org/W1998138065","https://openalex.org/W2000877933","https://openalex.org/W2002006853","https://openalex.org/W2003670762","https://openalex.org/W2004620930","https://openalex.org/W2005685765","https://openalex.org/W2007308578","https://openalex.org/W2008113818","https://openalex.org/W2009790701","https://openalex.org/W2014575233","https://openalex.org/W2014887370","https://openalex.org/W2014972849","https://openalex.org/W2015820364","https://openalex.org/W2018207510","https://openalex.org/W2019724241","https://openalex.org/W2020554424","https://openalex.org/W2023291377","https://openalex.org/W2026633359","https://openalex.org/W2027494269","https://openalex.org/W2028428524","https://openalex.org/W2030338284","https://openalex.org/W2031408580","https://openalex.org/W2032310176","https://openalex.org/W2033538734","https://openalex.org/W2033996868","https://openalex.org/W2039051836","https://openalex.org/W2039840283","https://openalex.org/W2040054030","https://openalex.org/W2040437316","https://openalex.org/W2041113999","https://openalex.org/W2041880968","https://openalex.org/W2042784501","https://openalex.org/W2043580178","https://openalex.org/W2043772361","https://openalex.org/W2044773944","https://openalex.org/W2048359273","https://openalex.org/W2049113370","https://openalex.org/W2049609626","https://openalex.org/W2049618589","https://openalex.org/W2050588795","https://openalex.org/W2051327815","https://openalex.org/W2053007571","https://openalex.org/W2053778204","https://openalex.org/W2056976690","https://openalex.org/W2057841351","https://openalex.org/W2058880748","https://openalex.org/W2060360369","https://openalex.org/W2060696169","https://openalex.org/W2060853617","https://openalex.org/W2061994091","https://openalex.org/W2064210410","https://openalex.org/W2065277415","https://openalex.org/W2065697164","https://openalex.org/W2067756041","https://openalex.org/W2068953741","https://openalex.org/W2069711524","https://openalex.org/W2069983225","https://openalex.org/W2071626570","https://openalex.org/W2076046030","https://openalex.org/W2076418517","https://openalex.org/W2078172019","https://openalex.org/W2080880612","https://openalex.org/W2080951265","https://openalex.org/W2088531472","https://openalex.org/W2090975112","https://openalex.org/W2092294261","https://openalex.org/W2093917387","https://openalex.org/W2097362788","https://openalex.org/W2100295412","https://openalex.org/W2101611318","https://openalex.org/W2105767196","https://openalex.org/W2106528714","https://openalex.org/W2106607972","https://openalex.org/W2107623102","https://openalex.org/W2108685753","https://openalex.org/W2111344297","https://openalex.org/W2111742578","https://openalex.org/W2113390437","https://openalex.org/W2116041291","https://openalex.org/W2119608885","https://openalex.org/W2127695694","https://openalex.org/W2131927337","https://openalex.org/W2132193621","https://openalex.org/W2132197535","https://openalex.org/W2132358997","https://openalex.org/W2134899427","https://openalex.org/W2135788465","https://openalex.org/W2137172291","https://openalex.org/W2138517496","https://openalex.org/W2138944514","https://openalex.org/W2139608294","https://openalex.org/W2141121966","https://openalex.org/W2142459107","https://openalex.org/W2142710423","https://openalex.org/W2142981166","https://openalex.org/W2144565140","https://openalex.org/W2152253844","https://openalex.org/W2156835140","https://openalex.org/W2160539191","https://openalex.org/W2165139442","https://openalex.org/W2166370133","https://openalex.org/W2167026621","https://openalex.org/W2168664410","https://openalex.org/W2170234814","https://openalex.org/W2186569622","https://openalex.org/W2186874838","https://openalex.org/W2188652813","https://openalex.org/W2243201250","https://openalex.org/W2254157679","https://openalex.org/W2291252724","https://openalex.org/W2320197950","https://openalex.org/W2334337188","https://openalex.org/W2402265350","https://openalex.org/W2410707077","https://openalex.org/W2438523465"],"related_works":["https://openalex.org/W2291403464","https://openalex.org/W4281754532","https://openalex.org/W2116041291","https://openalex.org/W2107569408","https://openalex.org/W158695898","https://openalex.org/W2024214080","https://openalex.org/W2324586504","https://openalex.org/W2021378561","https://openalex.org/W2582611686","https://openalex.org/W1984633752"],"abstract_inverted_index":{"This":[0,198,326],"study":[1,327],"explored":[2],"angiotensin":[3,172],"IV\u2019s":[4,86,154,207,238,243,319],"(Ang":[5],"IV)":[6],"affects":[7],"on":[8,125,180,209,258,290,322],"the":[9,14,27,35,38,117,159,175,190,226,249,269,280,283,336],"signaling":[10,33],"pathways":[11],"involved":[12,278],"in":[13,19,268,279,308,341],"development":[15,270,337],"of":[16,37,73,95,150,161,177,192,216,228,245,251,266,271,282,300,311,338],"insulin":[17,32,65,183,272,323,339],"resistance":[18,340],"3T3-L1":[20],"adipocytes.":[21],"Ang":[23,85,96,114,140,153,187,206,223,237,242,263,275,296,318],"IV,":[24,97],"working":[25],"through":[26,34,44],"AT4":[28,74,98],"receptor,":[29],"interferes":[30],"with":[31,93,139,203,234,306,315],"blockade":[36],"phosphatidylinositol":[39],"3-kinases":[40],"(PI3K)/Akt":[41],"pathway":[42],"and":[43,56,102,111,134,195,230,293,303],"activating":[45,128],"mitogen":[46],"activated":[47],"protein":[48],"kinases":[49],"(MAPK):":[50],"extracellular":[51],"signal":[52,184],"regulated":[53],"kinase":[54,58],"(ERK)":[55],"c-Jun-N-terminal":[57],"(JNK)":[59],"which":[60,260],"are":[61],"known":[62],"to":[63,158,254,335],"impair":[64],"receptor":[66,99],"substrate-1":[67],"(IRS-1)":[68],"signaling.":[69,324],"The":[71],"expression":[72],"receptors":[75],"was":[76,199],"confirmed":[77],"by":[78,90,108,127,171,201,214,219,286],"reverse":[79],"transcription":[80],"polymerase":[81],"chain":[82],"reaction.":[83],"effects":[87,124,208,321],"were":[88,106,212],"found":[89,213],"treating":[91],"adipocytes":[92,126,246],"combinations":[94],"inhibitor":[100],"Norleual,":[101],"insulin.":[103],"Cell":[104],"lysates":[105],"resolved":[107],"SDS-PAGE":[109,220],"electrophoresis":[110],"immunoblotted.":[112],"IV":[115,141,188,224,264,276,297],"down-regulated":[116],"PI3K/Akt":[118],"pathway.":[119],"Insulin":[121],"exerts":[122],"its":[123],"this":[129],"pathway,":[130],"phosphorylating":[131],"Akt":[132,146,162,291],"(S473":[133,292],"T308)":[135],"residues.":[136,163],"Pre-treatment":[138,314],"blocked":[142,152],"insulin\u2019s":[143,288],"effects,":[144],"reversing":[145],"activation.":[147],"Addition":[149],"Norleual":[151,235,316],"inhibitory":[155],"actions,":[156],"leading":[157],"phosphorylation":[160,176,227,250,257,289,299,310],"Studies":[165],"show":[166],"elevated":[167],"MAPK":[168,252,267],"levels":[169],"produced":[170],"peptides":[173],"catalyze":[174],"serine":[178,255,309],"residues":[179,211],"IRS-1,":[181,259],"impairing":[182],"transduction.":[185],"increased":[189,225,298],"activation":[191,265],"ERK":[193,301],"1/2":[194,302],"JNK.":[196],"reversed":[200],"pretreatment":[202],"Norleual.":[204],"IRS-1":[210,217],"immunoprecipitation":[215],"followed":[218],"immunoblotting.":[221],"IRS-1(S307":[229],"S612).":[231],"Pre-incubation":[233],"attenuated":[236],"effects.":[239],"stimulation":[244],"quickly":[247],"caused":[248],"corresponding":[253,305],"residue":[256],"may":[261,333],"implicate":[262],"resistance.":[273],"is":[277],"down-regulation":[281],"insulin-signaling":[284],"cascade":[285],"inhibiting":[287],"T308).":[294],"JNK,":[304],"increases":[307],"IRS-1.":[312],"inhibited":[317],"negative":[320],"elucidates":[328],"a":[329],"new":[330],"mechanism":[331],"that":[332],"lead":[334],"adipose":[342],"tissue.":[343]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}