{"id":"https://openalex.org/W67536932","doi":null,"title":"Effects of oral isotretinoin on lipids and liver enzymes in acne patients.","display_name":"Effects of oral isotretinoin on lipids and liver enzymes in acne patients.","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W67536932","mag":"67536932","pmid":"https://pubmed.ncbi.nlm.nih.gov/25474452"},"language":"en","primary_location":{"id":"pmid:25474452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25474452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cutis","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033340560","display_name":"Okan K\u0131z\u0131lyel","orcid":"https://orcid.org/0000-0002-1319-9405","observed_orcids":["https://orcid.org/0000-0002-1319-9405"]},"institutions":[{"id":"https://openalex.org/I64134780","display_name":"Atat\u00fcrk University","ror":"https://ror.org/03je5c526","country_code":"TR","type":"education","lineage":["https://openalex.org/I64134780"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Okan K\u0131z\u0131lyel","raw_affiliation_strings":["Department of Dermatology, Faculty of Medicine, Atat\u00fcrk University, 25000 Erzurum, Turkey. erester.34@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Faculty of Medicine, Atat\u00fcrk University, 25000 Erzurum, Turkey. erester.34@hotmail.com","institution_ids":["https://openalex.org/I64134780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030160860","display_name":"Mahmut Sami Metin","orcid":"https://orcid.org/0000-0002-5099-8521","observed_orcids":["https://orcid.org/0000-0002-5099-8521"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahmut S Metin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023672542","display_name":"\u00d6mer Faruk Elmas","orcid":"https://orcid.org/0000-0002-5474-6508","observed_orcids":["https://orcid.org/0000-0002-5474-6508"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u00d6mer F Elmas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054313720","display_name":"Yasemin \u00c7ay\u0131r","orcid":"https://orcid.org/0000-0001-5825-3033","observed_orcids":["https://orcid.org/0000-0001-5825-3033"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasemin \u00c7ay\u0131r","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078813097","display_name":"Ak\u0131n Akta\u015f","orcid":"https://orcid.org/0000-0002-4972-6713","observed_orcids":["https://orcid.org/0000-0002-4972-6713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ak\u0131n Akta\u015f","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.083,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.85100067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"94","issue":"5","first_page":"234","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isotretinoin","display_name":"isotretinoin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.8650000095367432},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.6259999871253967},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8709999918937683},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":1.0},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6230000257492065},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2776285725","wikidata":"https://www.wikidata.org/wiki/Q287029","display_name":"Isotretinoin","level":3,"score":0.9664521217346191},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9115787744522095},{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.8062702417373657},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.6562070250511169},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.605613648891449},{"id":"https://openalex.org/C2992872382","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine aminotransferase","level":2,"score":0.5089931488037109},{"id":"https://openalex.org/C2780541478","wikidata":"https://www.wikidata.org/wiki/Q410020","display_name":"High-density lipoprotein","level":3,"score":0.49901747703552246},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.47891080379486084},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.43606802821159363},{"id":"https://openalex.org/C3020359197","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver enzyme","level":2,"score":0.4294321835041046},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.4184764325618744},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4107782244682312},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40461036562919617},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3619294762611389},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.2453773319721222},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13602563738822937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.062302231788635254}],"mesh":[{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003879","descriptor_name":"Dermatologic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003879","descriptor_name":"Dermatologic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014421","descriptor_name":"Turkey","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015474","descriptor_name":"Isotretinoin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015474","descriptor_name":"Isotretinoin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015474","descriptor_name":"Isotretinoin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:25474452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25474452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cutis","raw_type":"Journal Article"},{"id":"mag:67536932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25474452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393410186","https://openalex.org/W2032672195","https://openalex.org/W3112520858","https://openalex.org/W3016062492","https://openalex.org/W2972472466","https://openalex.org/W2347273108","https://openalex.org/W2335335165","https://openalex.org/W4390412098","https://openalex.org/W3194602175","https://openalex.org/W1982881182"],"abstract_inverted_index":{"Isotretinoin":[0],"has":[1],"been":[2,46],"used":[3],"to":[4,12,64,84,121,148],"treat":[5],"severe":[6],"inflammatory":[7],"acne":[8,42],"that":[9],"is":[10,170],"resistant":[11],"antibiotics":[13],"or":[14],"topical":[15],"agents;":[16],"however,":[17],"it":[18],"also":[19,127,139],"may":[20],"cause":[21],"alterations":[22],"in":[23,35,40,103,136],"lipids":[24,36,154],"and":[25,37,78,89,105],"liver":[26,38,156],"enzymes.":[27,157],"In":[28,143],"this":[29],"retrospective":[30],"study,":[31,145],"we":[32],"evaluated":[33,63],"changes":[34,130],"enzymes":[39],"322":[41],"patients":[43],"who":[44],"had":[45],"treated":[47],"with":[48,96,112],"oral":[49,97],"isotretinoin":[50,113,146,162],"at":[51,87],"our":[52,144],"institution":[53],"over":[54],"a":[55,150],"3-year":[56],"period.":[57],"Each":[58],"patient's":[59],"medical":[60],"records":[61],"were":[62,108,119,131,140],"determine":[65],"baseline":[66],"triglyceride":[67],"(TG),":[68],"low-density":[69],"lipoprotein":[70,73],"(LDL),":[71],"high-density":[72],"(HDL),":[74],"aspartate":[75],"aminotransferase":[76,80],"(AST),":[77],"alanine":[79],"(ALT)":[81],"levels":[82,85,107,118,126,138],"compared":[83],"recorded":[86],"3":[88],"6":[90],"months":[91],"following":[92,110],"initiation":[93],"of":[94],"treatment":[95,111],"isotretinoin.":[98],"Overall,":[99],"statistically":[100,133],"significant":[101,134],"increases":[102,135],"TG":[104],"LDL":[106],"noted":[109,141],"(P<.001,":[114],"respectively),":[115],"while":[116],"HDL":[117],"shown":[120],"decrease":[122],"(P=.016).":[123],"Although":[124],"ALT":[125],"increased,":[128],"the":[129],"not":[132,160],"AST":[137],"(P=.72).":[142],"appeared":[147],"have":[149],"greater":[151],"effect":[152],"on":[153],"than":[155],"Dermatologists":[158],"should":[159],"avoid":[161],"use":[163],"for":[164],"appropriate":[165],"indications,":[166],"but":[167],"close":[168],"follow-up":[169],"important.":[171]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
