{"id":"https://openalex.org/W67517625","doi":null,"title":"Inhibition of lymphocyte activation by catecholamines: evidence for a non-classical mechanism of catecholamine action.","display_name":"Inhibition of lymphocyte activation by catecholamines: evidence for a non-classical mechanism of catecholamine action.","publication_year":1995,"publication_date":"1995-08-01","ids":{"openalex":"https://openalex.org/W67517625","mag":"67517625","pmid":"https://pubmed.ncbi.nlm.nih.gov/7558147","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1383781"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1383781","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1383781","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1383781","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054547696","display_name":"Joan M. Cook\u2010Mills","orcid":"https://orcid.org/0000-0003-1564-5218","observed_orcids":["https://orcid.org/0000-0003-1564-5218"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J M Cook-Mills","raw_affiliation_strings":["Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109254566","display_name":"Rhonna L. Cohen","orcid":"https://orcid.org/0009-0004-6669-9907","observed_orcids":["https://orcid.org/0009-0004-6669-9907"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R L Cohen","raw_affiliation_strings":["University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053382593","display_name":"Robert L. Perlman","orcid":"https://orcid.org/0000-0003-2150-4753","observed_orcids":["https://orcid.org/0000-0003-2150-4753"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R L Perlman","raw_affiliation_strings":["University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103426375","display_name":"Donald A. Chambers","orcid":"https://orcid.org/0009-0008-3176-9716","observed_orcids":["https://orcid.org/0009-0008-3176-9716"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D A Chambers","raw_affiliation_strings":["University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":null,"apc_paid":null,"fwci":0.3112,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.45470808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"85","issue":"4","first_page":"544","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.10360000282526016,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.04430000111460686,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.9729999899864197},{"id":"https://openalex.org/keywords/lymphocyte-activation","display_name":"lymphocyte activation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9879999756813049},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9369999766349792},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.9879999756813049},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.996999979019165},{"id":"https://openalex.org/keywords/adrenergic-receptors","display_name":"adrenergic receptors","score":0.7269999980926514},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.8529999852180481},{"id":"https://openalex.org/keywords/alpha-adrenergic-receptors","display_name":"alpha-adrenergic receptors","score":0.9300000071525574},{"id":"https://openalex.org/keywords/dopamine-receptors","display_name":"dopamine receptors","score":0.9290000200271606},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.8140000104904175},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.9010000228881836},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.968999981880188},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.6470000147819519},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.7639999985694885},{"id":"https://openalex.org/keywords/phentolamine","display_name":"phentolamine","score":0.8360000252723694},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.9580000042915344},{"id":"https://openalex.org/keywords/adrenergic-antagonists","display_name":"adrenergic antagonists","score":0.7450000047683716},{"id":"https://openalex.org/keywords/dna-synthesis-inhibition","display_name":"DNA synthesis inhibition","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6743651032447815},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6557811498641968},{"id":"https://openalex.org/C2780253649","wikidata":"https://www.wikidata.org/wiki/Q420360","display_name":"Phentolamine","level":3,"score":0.5321357250213623},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.5232152938842773},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.521070122718811},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5100832581520081},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48557087779045105},{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.4813897907733917},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47994759678840637},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.4412466883659363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36154991388320923},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1363847851753235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12591403722763062},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09321063756942749}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003208","descriptor_name":"Concanavalin A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017981","descriptor_name":"Receptors, Neurotransmitter","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D018674","descriptor_name":"Adrenergic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1383781","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1383781","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:7558147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7558147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:67517625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7558147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1383781","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1383781","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W341404584","https://openalex.org/W1602924353","https://openalex.org/W1643307304","https://openalex.org/W2002896923","https://openalex.org/W2004388116","https://openalex.org/W2013943307","https://openalex.org/W2020403707","https://openalex.org/W2025409639","https://openalex.org/W2029878362","https://openalex.org/W2047629904","https://openalex.org/W2056188558","https://openalex.org/W2071616809","https://openalex.org/W2075507370","https://openalex.org/W2076354776","https://openalex.org/W2096557101","https://openalex.org/W2128635872","https://openalex.org/W2145394737","https://openalex.org/W2147529531","https://openalex.org/W2155502587","https://openalex.org/W2169503005","https://openalex.org/W2461485684"],"related_works":["https://openalex.org/W7097471545","https://openalex.org/W2016853043","https://openalex.org/W2032920165","https://openalex.org/W2055001653","https://openalex.org/W2188020337","https://openalex.org/W1970448065","https://openalex.org/W309342444","https://openalex.org/W27280687","https://openalex.org/W2343207233","https://openalex.org/W2462692069"],"abstract_inverted_index":{"The":[0,70,104,116],"effects":[1,105],"of":[2,33,46,61,78,106,118,164,192],"noradrenaline":[3],"and":[4,14,24,40,48,58,93,156],"other":[5,195],"adrenergic":[6,107,197],"agonists":[7,83],"on":[8,110],"lymphocyte":[9,25,89,111,119,165,184],"activation":[10,26,45,60,120,185],"were":[11,20,73,113],"studied.":[12,115],"Spleen":[13],"thymus":[15,49],"cells":[16,50,63],"from":[17],"BALB/c":[18],"mice":[19],"stimulated":[21],"by":[22,29,51,64,121,127,186],"mitogens":[23],"was":[27],"monitored":[28],"measuring":[30],"the":[31,44,59,152,161],"incorporation":[32],"[methyl-3H]thymidine":[34],"into":[35],"DNA.":[36],"Noradrenaline,":[37,91],"adrenaline,":[38],"isoproterenol":[39,94],"dopamine":[41],"all":[42],"inhibited":[43,96],"spleen":[47,62],"concanavalin":[52],"A,":[53],"a":[54,66,187],"T-cell":[55],"specific":[56],"mitogen,":[57],"lipopolysaccharide,":[65],"T-independent":[67],"B-cell":[68],"mitogen.":[69],"various":[71],"catecholamines":[72,122,179],"approximately":[74,79],"equipotent,":[75],"having":[76],"IC50":[77],"10":[80],"microM.":[81],"alpha-adrenergic":[82,133],"(phenylephrine,":[84],"clonidine)":[85],"did":[86,158],"not":[87,124,159],"inhibit":[88,182],"activation.":[90,166],"adrenaline":[92],"also":[95,114],"DNA":[97],"synthesis":[98],"in":[99],"S49":[100],"T":[101],"lymphoma":[102],"cells.":[103],"receptor":[108],"antagonists":[109,128,154],"function":[112],"inhibition":[117,163],"could":[123],"be":[125],"reversed":[126],"to":[129,175,181],"beta-adrenergic":[130,153,170],"receptors":[131,134,138,171],"(propranolol),":[132],"(phentolamine),":[135],"or":[136,194],"dopaminergic":[137],"(haloperidol).":[139],"Experiments":[140],"with":[141,149],"human":[142],"peripheral":[143],"blood":[144],"leucocytes":[145],"revealed":[146],"that,":[147],"as":[148],"murine":[150,183],"cells,":[151],"propranolol":[155],"nadalol":[157],"affect":[160],"catecholamine-mediated":[162],"Although":[167],"lymphocytes":[168],"contain":[169],"that":[172,189],"are":[173],"coupled":[174],"adenylyl":[176],"cyclase":[177],"activity,":[178],"appear":[180],"mechanism":[188],"is":[190],"independent":[191],"these":[193],"classical":[196],"receptors.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
