{"id":"https://openalex.org/W67465871","doi":null,"title":"Chemo- and radio-protective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs.","display_name":"Chemo- and radio-protective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs.","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W67465871","mag":"67465871","pmid":"https://pubmed.ncbi.nlm.nih.gov/11749812"},"language":"en","primary_location":{"id":"pmid:11749812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11749812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073675081","display_name":"H Q Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H Q Zhang","raw_affiliation_strings":["The Medical and Pharmaceutical Academe of Yangzhou University, Yangzhou 225001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Medical and Pharmaceutical Academe of Yangzhou University, Yangzhou 225001, China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111379736","display_name":"Aixing Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A P Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032886888","display_name":"Yan Sun","orcid":"https://orcid.org/0000-0001-7021-7799","observed_orcids":["https://orcid.org/0000-0001-7021-7799"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Y M Deng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y M Deng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.266,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.5726281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"12","first_page":"1121","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.7544000148773193,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.7544000148773193,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.07739999890327454,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.07289999723434448,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arthrospira-platensis","display_name":"Spirulina platensis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/polysaccharides","display_name":"polysaccharides","score":0.9440000057220459},{"id":"https://openalex.org/keywords/chemoprotection","display_name":"chemoprotection","score":0.7710000276565552},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hematopoietic-system","display_name":"hematopoietic system","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cobalt-60-gamma-irradiation","display_name":"cobalt-60 gamma irradiation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/bone-marrow-injury","display_name":"bone marrow damage","score":0.9869999885559082},{"id":"https://openalex.org/keywords/leukocytes","display_name":"leukocytes","score":0.6330000162124634},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.7419999837875366},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.9290000200271606},{"id":"https://openalex.org/keywords/berberine-hydrochloride","display_name":"berberine hydrochloride","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.8514559864997864},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7860437631607056},{"id":"https://openalex.org/C2779784034","wikidata":"https://www.wikidata.org/wiki/Q285335","display_name":"Spirulina (dietary supplement)","level":3,"score":0.7021957039833069},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4869748055934906},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.48216432332992554},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4588842988014221},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.4270312786102295},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42433488368988037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3575752079486847},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3459049463272095},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3447221517562866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2591131925582886},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.252258837223053},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.24707940220832825},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2086123526096344},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18010935187339783},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.11002600193023682},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0751480758190155},{"id":"https://openalex.org/C206139338","wikidata":"https://www.wikidata.org/wiki/Q192355","display_name":"Raw material","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003037","descriptor_name":"Cobalt Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006397","descriptor_name":"Hematinics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006413","descriptor_name":"Hematopoietic System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053545","descriptor_name":"Spirulina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11749812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11749812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},{"id":"mag:67465871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11749812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2962526075","https://openalex.org/W2364722302","https://openalex.org/W2384576826","https://openalex.org/W2383599532","https://openalex.org/W3143770440","https://openalex.org/W2381147317","https://openalex.org/W2350186234","https://openalex.org/W2382229532","https://openalex.org/W4409692080","https://openalex.org/W2349067621"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"observe":[2],"polysaccharide":[3],"of":[4,12,21,49,101,132,155,163],"Spirulina":[5],"platensis":[6],"(PSp)":[7],"on":[8,121],"the":[9,41,58,71,99,102,130,153],"hematopoietic":[10],"system":[11,87],"mouse":[13],"and":[14,24,29,40,55,62,70,82,91,107,110,124,137,141,152,172,175],"dogs":[15,148],"which":[16],"were":[17,33,44,68,76,159],"damaged":[18],"by":[19,78],"injection":[20],"cyclophosphamide":[22],"(CTX)":[23],"60Co-gamma":[25,83],"irradiation.":[26],"METHODS:":[27],"CTX":[28,81],"60Co":[30],"gamma":[31],"ray":[32],"used":[34],"to":[35,181],"induce":[36],"bone":[37,66,74,113,145],"marrow":[38,67,75,114,146],"damage,":[39],"experimental":[42],"animals":[43],"ig":[45],"with":[46],"different":[47],"dose":[48],"PSp":[50,94,126,156,169],"in":[51,65,73,89,105,112,115,139,144,147],"vivo,":[52],"after":[53],"12-d":[54],"21-d":[56],"administration,":[57],"whole":[59],"blood":[60,106,140],"cells":[61,64,104,109,123,143],"nucleated":[63,108,142],"measured,":[69],"DNA":[72,111],"inspected":[77],"UV-spectrophotometer.":[79],"RESULTS:":[80],"irradiation":[84],"induced":[85],"hemopoietic":[86],"damage":[88],"mice":[90,116],"dogs,":[92],"respectively.":[93],"30,":[95],"60":[96,157,166],"mg/kg":[97,128,158],"increased":[98,129],"level":[100,131],"white":[103,135],"but":[117],"had":[118],"no":[119],"effects":[120,154],"red":[122,133],"hemoglobins.":[125],"12":[127],"cells,":[134,136],"hemoglobins":[138],"(P":[149],"<":[150],"0.01),":[151],"better":[160],"than":[161],"that":[162],"berbamine":[164],"hydrochloride":[165],"mg/kg.":[167],"CONCLUSION:":[168],"has":[170],"chemo-protective":[171],"radio-protective":[173],"capability,":[174],"may":[176],"be":[177],"a":[178],"potential":[179],"adjunct":[180],"cancer":[182],"therapy.":[183]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}