{"id":"https://openalex.org/W67452136","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.946.3","title":"Fibroblast Growth Factor 10 induces goblet cell hyperplasia independently from Notch signaling","display_name":"Fibroblast Growth Factor 10 induces goblet cell hyperplasia independently from Notch signaling","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W67452136","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.946.3","mag":"67452136"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.27.1_supplement.946.3","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.946.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.946.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024226423","display_name":"Denise Al Alam","orcid":"https://orcid.org/0000-0003-3148-7352","observed_orcids":["https://orcid.org/0000-0003-3148-7352"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital of Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"funder","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise Al Alam","raw_affiliation_strings":["Surgery Children's Hospital Los Angeles Los Angeles CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery Children's Hospital Los Angeles Los Angeles CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Frederic G Sala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital of Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"funder","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederic G Sala","raw_affiliation_strings":["Surgery Childrens Hospital Los Angeles Los Angeles CA","SurgeryChildrens hospital los angelesLos AngelesCA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery Childrens Hospital Los Angeles Los Angeles CA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"SurgeryChildrens hospital los angelesLos AngelesCA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088480379","display_name":"Soula Danopoulos","orcid":"https://orcid.org/0000-0002-2495-4445","observed_orcids":["https://orcid.org/0000-0002-2495-4445"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital of Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"funder","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soula Danopoulos","raw_affiliation_strings":["Childrens Hospital Los Angeles Los Angeles CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Childrens Hospital Los Angeles Los Angeles CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065194210","display_name":"Mark R. Frey","orcid":"https://orcid.org/0000-0002-2561-5402","observed_orcids":["https://orcid.org/0000-0002-2561-5402"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital of Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"funder","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R Frey","raw_affiliation_strings":["Childrens hospital Los Angeles Los Angeles CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Childrens hospital Los Angeles Los Angeles CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000847126","display_name":"Tracy Cannon Grikscheit","orcid":"https://orcid.org/0000-0003-0842-4820","observed_orcids":["https://orcid.org/0000-0003-0842-4820"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital of Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"funder","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy Grikscheit","raw_affiliation_strings":["Surgery Childrens hospital los angeles Los Angeles CA","SurgeryChildrens hospital los angelesLos AngelesCA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery Childrens hospital los angeles Los Angeles CA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"SurgeryChildrens hospital los angelesLos AngelesCA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062554273","display_name":"Sav\u00e9rio Bellusci","orcid":"https://orcid.org/0000-0001-5987-4579","observed_orcids":["https://orcid.org/0000-0001-5987-4579","https://orcid.org/0000-0002-9699-5262","https://orcid.org/0000-0002-1164-3795"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital of Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"funder","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saverio Bellusci","raw_affiliation_strings":["Childrens hospital Los Angeles Los Angeles CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Childrens hospital Los Angeles Los Angeles CA","institution_ids":["https://openalex.org/I1336910626"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1336910626"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00372281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.23649999499320984,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf10","display_name":"FGF10","score":0.9739999771118164},{"id":"https://openalex.org/keywords/goblet-cell-hyperplasia","display_name":"goblet cell hyperplasia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.875},{"id":"https://openalex.org/keywords/small-intestine","display_name":"small intestine","score":0.5809999704360962},{"id":"https://openalex.org/keywords/ileal-epithelium","display_name":"ileal epithelium","score":0.7839999794960022},{"id":"https://openalex.org/keywords/paneth-cells","display_name":"Paneth cells","score":0.8429999947547913},{"id":"https://openalex.org/keywords/intestinal-cell-proliferation","display_name":"intestinal cell proliferation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/villus-height","display_name":"villus height","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dll1","display_name":"DLL1","score":0.7770000100135803},{"id":"https://openalex.org/keywords/delta-like-ligand-4","display_name":"DLL4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intestinal-adaptation","display_name":"intestinal adaptation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/small-bowel-resection","display_name":"small bowel resection","score":0.8040000200271606},{"id":"https://openalex.org/keywords/intestinal-homeostasis","display_name":"intestinal homeostasis","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C146759223","wikidata":"https://www.wikidata.org/wiki/Q17927902","display_name":"FGF10","level":4,"score":0.9459851980209351},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.6830626130104065},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6331119537353516},{"id":"https://openalex.org/C2775941134","wikidata":"https://www.wikidata.org/wiki/Q813622","display_name":"Goblet cell","level":3,"score":0.6217907667160034},{"id":"https://openalex.org/C2776145723","wikidata":"https://www.wikidata.org/wiki/Q2004084","display_name":"Paneth cell","level":3,"score":0.6212943196296692},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5898829102516174},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.5242024660110474},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5012843608856201},{"id":"https://openalex.org/C2780283210","wikidata":"https://www.wikidata.org/wiki/Q18027301","display_name":"HES1","level":4,"score":0.49211424589157104},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.34551599621772766},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28775960206985474},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2483486533164978},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17374199628829956},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.17029792070388794},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08631753921508789}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.27.1_supplement.946.3","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.946.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.946.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5600000023841858,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2007898372","https://openalex.org/W2073929498","https://openalex.org/W2237293534","https://openalex.org/W2072966096","https://openalex.org/W1983527388","https://openalex.org/W1989415637","https://openalex.org/W2158918896","https://openalex.org/W2025187874","https://openalex.org/W2332160328","https://openalex.org/W2766565931"],"abstract_inverted_index":{"During":[0],"gut":[1],"adaptation,":[2],"fibroblast":[3],"growth":[4,39,58,155],"factor":[5,59],"10":[6,78],"(Fgf10)":[7],"is":[8,42],"highly":[9],"expressed":[10],"in":[11,60,107,119,127,150],"the":[12,25,54,61,108,143,146],"ileal":[13],"epithelium,":[14],"where":[15],"its":[16],"levels":[17,132],"are":[18],"normally":[19],"very":[20],"low":[21],"during":[22],"homeostasis.":[23],"In":[24],"colon,":[26],"FGF10":[27,96],"stimulates":[28],"cell":[29,101,140,148,165],"proliferation":[30,102],"and":[31,40,70,85,93,103,130],"survival.":[32],"However,":[33],"whether":[34],"it":[35],"regulates":[36],"small":[37,62,176],"intestinal":[38,164],"homeostasis":[41],"unknown.":[43],"Using":[44],"a":[45,151],"mouse":[46],"model":[47],"of":[48,56,145],"inducible":[49],"Fgf10":[50,134,137],"expression,":[51],"we":[52],"tested":[53],"role":[55],"this":[57],"intestine.":[63],"METHODS":[64],"3\u2010week":[65],"old":[66],"R26rtTA;":[67],"tet(O)Fgf10":[68],"mice":[69],"littermate":[71],"controls":[72],"were":[73,89],"given":[74],"doxycycline":[75],"food":[76],"for":[77],"days.":[79],"Cell":[80],"proliferation,":[81],"epithelial":[82],"lineage":[83],"markers,":[84],"Notch":[86],"ligand":[87],"expression":[88],"quantified":[90],"by":[91],"immunofluorescence":[92],"qPCR.":[94],"RESULTS":[95],"induction":[97],"led":[98],"to":[99,172],"increased":[100],"greater":[104],"villus":[105],"height":[106],"ileum.":[109],"We":[110],"observed":[111],"more":[112],"goblet":[113,139],"cells,":[114,118],"but":[115],"fewer":[116],"Paneth":[117,147],"induced":[120],"mutants.":[121],"Interestingly,":[122],"there":[123],"was":[124],"no":[125],"change":[126],"Dll1,":[128],"Dll4":[129],"Hes1":[131],"with":[133],"induction.":[135],"CONCLUSIONS":[136],"induces":[138],"hyperplasia,":[141],"at":[142],"expense":[144],"lineage,":[149],"Notch\u2010independent":[152],"manner.":[153],"Fibroblast":[154],"factors":[156],"may":[157],"have":[158],"selective":[159],"trophic":[160],"effects":[161],"on":[162],"individual":[163],"types,":[166],"which":[167],"could":[168],"be":[169],"exploited":[170],"therapeutically":[171],"improve":[173],"adaptation":[174],"after":[175],"bowel":[177],"resection.":[178]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}