{"id":"https://openalex.org/W6745079","doi":null,"title":"Effects of ketamine on the developing central nervous system.","display_name":"Effects of ketamine on the developing central nervous system.","publication_year":2007,"publication_date":"2007-03-30","ids":{"openalex":"https://openalex.org/W6745079","mag":"6745079","pmid":"https://pubmed.ncbi.nlm.nih.gov/17451049"},"language":"en","primary_location":{"id":"pmid:17451049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17451049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ideggyogyaszati szemle","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://archive-ouverte.unige.ch/unige:10146","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062348955","display_name":"L\u00e1szl\u00f3 Vutskits","orcid":"https://orcid.org/0000-0001-8752-9588","observed_orcids":["https://orcid.org/0000-0001-8752-9588"]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"L\u00e1szl\u00f3 Vutskits","raw_affiliation_strings":["Department of Anesthesiology, Pharmacology and Intensive Care, University Hospital of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Pharmacology and Intensive Care, University Hospital of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049765660","display_name":"Eduardo Gascon","orcid":"https://orcid.org/0000-0002-2625-5509","observed_orcids":["https://orcid.org/0000-0002-2625-5509"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Eduardo Gascon","raw_affiliation_strings":["University of Geneva;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Geneva;","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103448906","display_name":"J\u00f3zsef Zolt\u00e1n Kiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"J\u00f3zsef Zolt\u00e1n Kiss","raw_affiliation_strings":["Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0961,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.43806922,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"60","issue":"3-4","first_page":"109","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":1.0},{"id":"https://openalex.org/keywords/developmental-neurotoxicity","display_name":"developmental neurotoxicity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/central-nervous-system-development","display_name":"central nervous system development","score":0.8820000290870667},{"id":"https://openalex.org/keywords/nmda-receptor-blockade","display_name":"NMDA receptor blockade","score":0.8240000009536743},{"id":"https://openalex.org/keywords/glutamate-receptors","display_name":"glutamate receptors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/pediatric-anesthesia","display_name":"pediatric anesthesia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.8649311065673828},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.7426144480705261},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.6731356382369995},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6077483892440796},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5550211668014526},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.5201138257980347},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.4812564551830292},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4802665710449219},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.45064669847488403},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4364153742790222},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.37387919425964355},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3724147081375122},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3285582661628723},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.26093789935112},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1358027458190918},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10983112454414368}],"mesh":[{"descriptor_ui":"D000778","descriptor_name":"Anesthetics, Dissociative","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:17451049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17451049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ideggyogyaszati szemle","raw_type":"Journal Article"},{"id":"pmh:oai:unige.ch:unige:10146","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:10146","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0019-1442","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:6745079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17451049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:unige.ch:unige:10146","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:10146","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0019-1442","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1565010155","https://openalex.org/W1894760805","https://openalex.org/W1965612527","https://openalex.org/W1972214008","https://openalex.org/W1979955365","https://openalex.org/W1981234599","https://openalex.org/W1989074423","https://openalex.org/W1997359806","https://openalex.org/W1997781923","https://openalex.org/W1998748028","https://openalex.org/W2005997117","https://openalex.org/W2008656461","https://openalex.org/W2012971273","https://openalex.org/W2013498560","https://openalex.org/W2020440389","https://openalex.org/W2029060613","https://openalex.org/W2029397645","https://openalex.org/W2034946412","https://openalex.org/W2036650593","https://openalex.org/W2039755216","https://openalex.org/W2042387120","https://openalex.org/W2043158709","https://openalex.org/W2048794781","https://openalex.org/W2051149226","https://openalex.org/W2057409221","https://openalex.org/W2059545303","https://openalex.org/W2062899329","https://openalex.org/W2064355745","https://openalex.org/W2081279850","https://openalex.org/W2091155334","https://openalex.org/W2098219818","https://openalex.org/W2098989477","https://openalex.org/W2105859139","https://openalex.org/W2134031827","https://openalex.org/W2136325018","https://openalex.org/W2137118059","https://openalex.org/W2155471406","https://openalex.org/W2157018930","https://openalex.org/W2170277228","https://openalex.org/W2405235425","https://openalex.org/W2414859212","https://openalex.org/W2444626463","https://openalex.org/W3149541202","https://openalex.org/W4234706236","https://openalex.org/W6720245860"],"related_works":["https://openalex.org/W3153606746","https://openalex.org/W1987497534","https://openalex.org/W2334861214","https://openalex.org/W2745688331","https://openalex.org/W2503278328","https://openalex.org/W7099179705","https://openalex.org/W7101063053","https://openalex.org/W2313409118","https://openalex.org/W2052889675","https://openalex.org/W2012968801"],"abstract_inverted_index":{"Ketamine":[0],"is":[1,56],"a":[2,59],"widely":[3],"used":[4],"drug":[5,38],"in":[6],"pediatric":[7],"anesthesia":[8],"practice,":[9],"acting":[10],"primarily":[11],"through":[12],"the":[13,16,31,45],"blockade":[14],"of":[15,20,26,52,62,78],"N-methyl-D-aspartate":[17],"(NMDA)":[18],"type":[19],"glutamate":[21],"receptors.":[22],"A":[23],"growing":[24],"body":[25],"laboratory":[27],"evidence,":[28],"accumulated":[29],"during":[30],"past":[32],"few":[33],"years,":[34],"suggests":[35],"that":[36],"this":[37,53],"could":[39],"have":[40],"potential":[41,74],"adverse":[42],"effects":[43],"on":[44],"developing":[46],"central":[47],"nervous":[48],"system.":[49],"The":[50],"goal":[51],"short":[54],"review":[55],"to":[57,72,81],"give":[58],"brief":[60],"synopsis":[61],"experimental":[63],"work":[64],"indicating":[65],"ketamine-induced":[66],"developmental":[67],"neurotoxicity":[68],"as":[69,71],"well":[70],"discuss":[73],"limitations":[75],"concerning":[76],"extrapolation":[77],"these":[79],"studies":[80],"clinical":[82],"practice.":[83]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
