{"id":"https://openalex.org/W67444683","doi":null,"title":"Telomere--the twilight to immortality.","display_name":"Telomere--the twilight to immortality.","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W67444683","mag":"67444683","pmid":"https://pubmed.ncbi.nlm.nih.gov/21391375"},"language":"en","primary_location":{"id":"pmid:21391375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21391375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Association of Physicians of India","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056366712","display_name":"Samarth Shukla","orcid":"https://orcid.org/0000-0002-3289-7006","observed_orcids":["https://orcid.org/0000-0002-3289-7006"]},"institutions":[{"id":"https://openalex.org/I4210104297","display_name":"Jawaharlal Nehru Medical College","ror":"https://ror.org/01a4d6k20","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210104297","https://openalex.org/I4210125823"]},{"id":"https://openalex.org/I4210130476","display_name":"Datta Meghe Institute of Higher Education and Research","ror":"https://ror.org/02w7k5y22","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210130476"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Samarth Shukla","raw_affiliation_strings":["Dept. of Pathology, JNMC, DMIMS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pathology, JNMC, DMIMS","institution_ids":["https://openalex.org/I4210104297","https://openalex.org/I4210130476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071533098","display_name":"Sourya Acharya","orcid":"https://orcid.org/0000-0003-1969-0817","observed_orcids":["https://orcid.org/0000-0003-1969-0817"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sourya Acharya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113764843","display_name":"Devendra Rajput","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Devendra Rajput","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086827402","display_name":"Sunita Jayant Vagha","orcid":"https://orcid.org/0000-0002-9763-9921","observed_orcids":["https://orcid.org/0000-0002-9763-9921"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Vagha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Shobha Grover","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shobha Grover","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1867,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.45487036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"58","issue":null,"first_page":"553","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomeres","display_name":"telomeres","score":0.9990000128746033},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.7599999904632568},{"id":"https://openalex.org/keywords/replicative-senescence","display_name":"replicative senescence","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cellular-aging","display_name":"cellular aging","score":0.718999981880188},{"id":"https://openalex.org/keywords/cell-division","display_name":"cell division","score":0.46000000834465027},{"id":"https://openalex.org/keywords/chromosome-integrity","display_name":"chromosome integrity","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cell-lifespan","display_name":"cell lifespan","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.9240286350250244},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.8403314352035522},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.5797886848449707},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.5445655584335327},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5249450206756592},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.5073825716972351},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5073601603507996},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5062745809555054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49192166328430176},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47303125262260437},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3008013367652893},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0777401328086853}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:21391375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21391375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Association of Physicians of India","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1215835221","https://openalex.org/W1497143641","https://openalex.org/W1543500873","https://openalex.org/W1571651130","https://openalex.org/W1574658543","https://openalex.org/W1579661837","https://openalex.org/W1582500812","https://openalex.org/W1829553711","https://openalex.org/W1967017947","https://openalex.org/W1972262563","https://openalex.org/W1983673827","https://openalex.org/W1987965402","https://openalex.org/W1993640192","https://openalex.org/W1999611844","https://openalex.org/W2021489383","https://openalex.org/W2025791374","https://openalex.org/W2026856852","https://openalex.org/W2031792875","https://openalex.org/W2032407757","https://openalex.org/W2072744580","https://openalex.org/W2079378073","https://openalex.org/W2086992094","https://openalex.org/W2088926897","https://openalex.org/W2102839588","https://openalex.org/W2105349209","https://openalex.org/W2108482850","https://openalex.org/W2110286112","https://openalex.org/W2122740168","https://openalex.org/W2123105653","https://openalex.org/W2319007677","https://openalex.org/W2325725181","https://openalex.org/W3187658540"],"related_works":["https://openalex.org/W2025853381","https://openalex.org/W2025372150","https://openalex.org/W2625093020","https://openalex.org/W2144052254","https://openalex.org/W2328103220","https://openalex.org/W2011554679","https://openalex.org/W2089030953","https://openalex.org/W4251824337","https://openalex.org/W7096142964","https://openalex.org/W2400905343"],"abstract_inverted_index":{"Besides":[0],"forming":[1,147],"a":[2,22,31,55,164,172,182,190],"very":[3],"important":[4],"component":[5],"of":[6,15,27,46,51,78,82,93,115,134,171,181],"the":[7,9,28,33,40,47,67,76,79,90,94,106,112,139,159,169,178,185,187,196],"chromosome,":[8],"telomeres":[10,36,157,162],"have":[11],"extremely":[12],"significant":[13],"modes":[14],"action":[16],"and":[17,25,43,96,143,175],"functions,":[18],"right":[19],"from":[20],"maintaining":[21],"basic":[23],"infrastructure":[24],"integrity":[26],"chromosome":[29],"vis":[30,32],"other":[34],"chromosomes,":[35],"are":[37,89,101,151],"responsible":[38],"for":[39],"cell":[41,56,68,95,107,121,135,174],"divisions":[42,53],"replicative":[44,117,141],"senescence":[45],"cell.":[48],"The":[49],"number":[50],"mitotic":[52],"which":[54,149,194],"will":[57],"go":[58],"through":[59,66],"in":[60,146,167],"its":[61],"life":[62,136,179],"span":[63,180],"while":[64],"passing":[65],"cycle":[69],"is":[70,122],"governed":[71],"inturn":[72],"by":[73,192],"these":[74,83],"telomeres,":[75],"crux":[77],"entire":[80],"functioning":[81],"chromosomal":[84],"components":[85],"suggests":[86],"that":[87],"they":[88,98],"ticking":[91],"clocks":[92],"when":[97],"diminish":[99],"or":[100,155],"worn":[102],"out":[103],"so":[104],"does":[105],"reach":[108],"it's":[109,116,125,144],"senility":[110],"at":[111],"fag":[113],"end":[114],"life--resulting":[118],"fate":[119,170],"being--the":[120],"sent":[123],"to":[124,153],"grave":[126],"yard":[127],"(the":[128],"final":[129],"destination).":[130],"Clinical":[131],"implications":[132],"include--regulation":[133],"spans,":[137],"regulating":[138],"cell's":[140],"behavior":[142],"utility":[145],"cells":[148],"usually":[150],"impossible":[152],"divide":[154],"replicate,":[156],"regulate":[158],"cloning":[160],"process,the":[161],"play":[163],"major":[165],"role":[166],"predicting":[168],"neoplastic":[173],"finally":[176],"enhancing":[177],"single":[183],"cell,":[184],"organ,":[186],"body":[188],"as":[189],"whole":[191],"enzymes":[193],"expand":[195],"telomeres--the":[197],"telomerase.":[198]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
