{"id":"https://openalex.org/W67430820","doi":null,"title":"Mast cell involvement in rheumatoid arthritis.","display_name":"Mast cell involvement in rheumatoid arthritis.","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W67430820","mag":"67430820","pmid":"https://pubmed.ncbi.nlm.nih.gov/24152834"},"language":"en","primary_location":{"id":"pmid:24152834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24152834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Editorial"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010719890","display_name":"Spyridon K. Kritas","orcid":"https://orcid.org/0000-0002-3540-9928","observed_orcids":["https://orcid.org/0000-0002-3540-9928"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"S K Kritas","raw_affiliation_strings":["Department of Microbiology and Infectious Diseases, School of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Infectious Diseases, School of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051567934","display_name":"Andrea Saggini","orcid":"https://orcid.org/0000-0001-8814-441X","observed_orcids":["https://orcid.org/0000-0001-8814-441X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Saggini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080902126","display_name":"Giuseppe Varvara","orcid":"https://orcid.org/0000-0002-7501-0794","observed_orcids":["https://orcid.org/0000-0002-7501-0794"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Varvara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009678026","display_name":"Giovanna Murmura","orcid":"https://orcid.org/0000-0003-3054-0203","observed_orcids":["https://orcid.org/0000-0003-3054-0203","https://orcid.org/0009-0005-6252-8913"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Murmura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085861175","display_name":"A. Caraffa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Caraffa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063376067","display_name":"Pierluigi Antinolfi","orcid":"https://orcid.org/0000-0002-9049-3683","observed_orcids":["https://orcid.org/0000-0002-9049-3683"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Antinolfi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068152459","display_name":"Elena Toniato","orcid":"https://orcid.org/0000-0002-2389-5375","observed_orcids":["https://orcid.org/0000-0002-2389-5375"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Toniato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074670642","display_name":"Andrea Pantalone","orcid":"https://orcid.org/0000-0003-2356-811X","observed_orcids":["https://orcid.org/0000-0003-2356-811X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Pantalone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084120005","display_name":"Giampiero Neri","orcid":"https://orcid.org/0000-0002-4078-3973","observed_orcids":["https://orcid.org/0000-0002-4078-3973"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Neri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084999451","display_name":"Stavros Frydas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Frydas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Rosati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Rosati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065655146","display_name":"Matteo Maria Tei","orcid":"https://orcid.org/0000-0002-3254-2205","observed_orcids":["https://orcid.org/0000-0002-3254-2205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085191929","display_name":"Andrea Speziali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Speziali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059987642","display_name":"Raoul Saggini","orcid":"https://orcid.org/0000-0002-6379-4472","observed_orcids":["https://orcid.org/0000-0002-6379-4472","https://orcid.org/0000-0002-2729-0461"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Saggini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106571602","display_name":"Franco Pandolfi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Pandolfi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085356549","display_name":"Theoharis Constantin Theoharides","orcid":"https://orcid.org/0000-0002-1598-460X","observed_orcids":["https://orcid.org/0000-0002-1598-460X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T C Theoharides","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054106836","display_name":"Pio Conti","orcid":"https://orcid.org/0000-0002-9475-4924","observed_orcids":["https://orcid.org/0000-0002-9475-4924"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Conti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"3","first_page":"655","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.19339999556541443,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.8190000057220459},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.996999979019165},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.8679999709129333},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.875},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7350000143051147},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7480000257492065},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.8679999709129333},{"id":"https://openalex.org/keywords/il-33","display_name":"IL-33","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cartilage-destruction","display_name":"cartilage destruction","score":0.8479999899864197},{"id":"https://openalex.org/keywords/tnf-antagonists","display_name":"TNF antagonists","score":0.6690000295639038},{"id":"https://openalex.org/keywords/mast-cell-activation","display_name":"mast cell activation","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7730520963668823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7425861954689026},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7050176858901978},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6570262908935547},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.6236110329627991},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.5825279355049133},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.562862753868103},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5236822366714478},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5173436999320984},{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.4751201272010803},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.47190433740615845},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19469612836837769},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.15774396061897278},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053802","descriptor_name":"Tryptases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24152834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24152834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Editorial"},{"id":"mag:67430820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24152834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2011786990","https://openalex.org/W1866450000","https://openalex.org/W2004077642","https://openalex.org/W2080731522","https://openalex.org/W2110578003","https://openalex.org/W2999681827","https://openalex.org/W2044140684","https://openalex.org/W2606654314","https://openalex.org/W6983338350","https://openalex.org/W2555651881"],"abstract_inverted_index":{"Autoimmunity":[0],"is":[1,15,70],"a":[2,92],"failure":[3],"of":[4,19,24,32,83],"self-tolerance":[5],"resulting":[6],"in":[7,40,57,61,63,95],"immune":[8],"reactions":[9],"against":[10,86],"autologous":[11],"antigen.":[12],"Rheumatoid":[13],"arthritis":[14,59,105],"characterized":[16],"by":[17],"inflammation":[18,35],"synovium":[20],"associated":[21],"with":[22],"destruction":[23,82],"the":[25,64,87,101],"join":[26],"cartilage":[27],"and":[28,36,51,60,106],"bone.":[29],"A":[30],"role":[31],"mast":[33,107],"cell-mediated":[34],"antibodies":[37],"are":[38],"involved":[39],"this":[41,96],"disease.":[42,97],"Numerous":[43],"cytokines":[44],"such":[45],"as":[46],"IL-1,":[47],"TNF,":[48],"IL-8,":[49],"IL-33":[50],"IFN":[52],"gamma":[53],"have":[54,91],"been":[55],"implicated":[56],"rheumatoid":[58,104],"particular":[62],"synovial":[65,75],"joint":[66],"fluid.":[67],"Since":[68],"TNF":[69,90],"believed":[71],"to":[72,77],"activates":[73],"resident":[74],"cells":[76],"produce":[78],"collagenase":[79],"that":[80],"mediate":[81],"cartilage,":[84],"antagonists":[85],"inflammatory":[88],"cytokine":[89],"beneficial":[93],"effects":[94],"Here":[98],"we":[99],"review":[100],"interrelationship":[102],"between":[103],"cell":[108],"activation.":[109]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
