{"id":"https://openalex.org/W6737952","doi":null,"title":"Genetic and hypoxic effects on germline tumor development in caenorhabditis elegans","display_name":"Genetic and hypoxic effects on germline tumor development in caenorhabditis elegans","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W6737952","mag":"6737952"},"language":"en","primary_location":{"id":"pmh:oai:TheScholarship.intra.ecu.edu:10342/4327","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10342/4327","pdf_url":null,"source":{"id":"https://openalex.org/S4306402312","display_name":"The Scholarship East Carolina University's Institutional Repository (East Carolina University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186335123","host_organization_name":"East Carolina University","host_organization_lineage":["https://openalex.org/I186335123"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master's Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027983647","display_name":"Udaya Sree Datla","orcid":"https://orcid.org/0000-0001-7224-0714","observed_orcids":["https://orcid.org/0000-0001-7224-0714"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Udaya Sree Datla","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7224-0714","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5027983647"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.05689999833703041,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8619999885559082},{"id":"https://openalex.org/keywords/dedifferentiation","display_name":"dedifferentiation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1","display_name":"HIF-1","score":0.9079999923706055},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cobalt-chloride","display_name":"cobalt chloride","score":0.9480000138282776},{"id":"https://openalex.org/keywords/germline-stem-cells","display_name":"germline stem cells","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.761168360710144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7013598084449768},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.603225588798523},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.6022338271141052},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5794938206672668},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5531246066093445},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5092123746871948},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.4964979290962219},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4906262457370758},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4606940448284149},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.346943736076355},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25566476583480835},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.16706788539886475},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10691046714782715}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:TheScholarship.intra.ecu.edu:10342/4327","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10342/4327","pdf_url":null,"source":{"id":"https://openalex.org/S4306402312","display_name":"The Scholarship East Carolina University's Institutional Repository (East Carolina University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186335123","host_organization_name":"East Carolina University","host_organization_lineage":["https://openalex.org/I186335123"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master's Thesis"},{"id":"mag:6737952","doi":null,"is_oa":false,"landing_page_url":"https://thescholarship.ecu.edu/bitstream/10342/4327/1/Datla_ecu_0600M_11056.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1542686183","https://openalex.org/W1593405557","https://openalex.org/W1647075334","https://openalex.org/W1756647715","https://openalex.org/W1944127002","https://openalex.org/W1961228933","https://openalex.org/W1966288564","https://openalex.org/W1967552166","https://openalex.org/W1972745320","https://openalex.org/W1973092951","https://openalex.org/W1973288412","https://openalex.org/W1975350101","https://openalex.org/W1975984062","https://openalex.org/W1976944452","https://openalex.org/W1981487137","https://openalex.org/W1986429916","https://openalex.org/W1988321698","https://openalex.org/W1991840668","https://openalex.org/W2004916479","https://openalex.org/W2005868568","https://openalex.org/W2008841186","https://openalex.org/W2011076742","https://openalex.org/W2012698328","https://openalex.org/W2014290242","https://openalex.org/W2024206845","https://openalex.org/W2029886559","https://openalex.org/W2030543103","https://openalex.org/W2040031153","https://openalex.org/W2046440184","https://openalex.org/W2049402769","https://openalex.org/W2050433648","https://openalex.org/W2052028890","https://openalex.org/W2058334613","https://openalex.org/W2064193818","https://openalex.org/W2066113694","https://openalex.org/W2066484804","https://openalex.org/W2072839085","https://openalex.org/W2075269611","https://openalex.org/W2078133688","https://openalex.org/W2084896326","https://openalex.org/W2084915577","https://openalex.org/W2085562680","https://openalex.org/W2085609942","https://openalex.org/W2089692551","https://openalex.org/W2091068407","https://openalex.org/W2097976367","https://openalex.org/W2098085839","https://openalex.org/W2098179765","https://openalex.org/W2102526923","https://openalex.org/W2109821031","https://openalex.org/W2119107921","https://openalex.org/W2125029761","https://openalex.org/W2125691342","https://openalex.org/W2127491141","https://openalex.org/W2127562514","https://openalex.org/W2139956822","https://openalex.org/W2144625075","https://openalex.org/W2145643221","https://openalex.org/W2146472503","https://openalex.org/W2152002370","https://openalex.org/W2154142775","https://openalex.org/W2154465060","https://openalex.org/W2167761137","https://openalex.org/W2169300762","https://openalex.org/W2169441235","https://openalex.org/W2172174823","https://openalex.org/W2188759087","https://openalex.org/W7099369812"],"related_works":["https://openalex.org/W4298295594","https://openalex.org/W3179413281","https://openalex.org/W4318482144","https://openalex.org/W3093465205","https://openalex.org/W2946252488","https://openalex.org/W429832495","https://openalex.org/W4281763032","https://openalex.org/W3196639564","https://openalex.org/W1973849851","https://openalex.org/W2466877915"],"abstract_inverted_index":{"The":[0],"process":[1,19,54,305],"of":[2,4,20,23,47,51,94,108,128,154,168,193,231,235,255,265,293,306,316,342],"differentiation":[3],"stem":[5,38,66,295],"cells":[6,26,67,296],"to":[7,28,135,158,225,276],"committed,":[8],"progenitor":[9],"specific":[10],"cell":[11,39],"types":[12],"is":[13],"well":[14],"studied":[15,45,198,262],"but":[16],"the":[17,21,29,48,52,64,69,87,91,100,106,126,132,149,172,191,194,216,223,233,253,263,281,290,304,309,314,340],"reverse":[18],"dedifferentiation":[22,53,127],"these":[24],"committed":[25],"back":[27],"undifferentiated":[30],"state":[31,140],"still":[32],"remains":[33],"a":[34,136,151,166,181,228,286,336],"major":[35,49],"challenge":[36],"in":[37,124,184,240,303,344],"biology.":[40],"In":[41,61,90],"my":[42,95,169],"project,":[43,96,170],"we":[44,97,260],"some":[46],"regulators":[50],"taking":[55],"C.":[56,62],"elegans":[57],"germline":[58,65,143,294,349],"model":[59],"system.":[60],"elegans,":[63],"at":[68,131],"distal":[70],"end":[71,134],"that":[72,99,179,210,218,332],"initially":[73],"divide":[74],"mitotically":[75],"then":[76],"enter":[77],"meiosis":[78],"and":[79,115,299,302,347],"differentiate":[80],"into":[81],"gametes":[82],"as":[83],"they":[84],"progress":[85],"towards":[86],"proximal":[88,133,142],"end.":[89],"first":[92],"part":[93],"proposed":[98],"Ras-ERK":[101,247],"MAPK":[102,248],"signaling":[103],"activated":[104],"by":[105,146,318],"removal":[107],"two":[109],"negative":[110],"regulators,":[111],"PUF-8":[112],"RNA-binding":[113],"protein":[114],"LIP-1":[116],"dual":[117],"specificity":[118],"phosphatase,":[119],"plays":[120,180],"an":[121],"important":[122],"role":[123,183],"controlling":[125],"secondary":[129],"spermatocytes":[130],"more":[137],"undifferentiated,":[138],"multipotent":[139],"forming":[141],"tumor.":[144],"Further,":[145],"RNAi":[147],"screening,":[148],"RSKN-1/P90RSK,":[150],"downstream":[152],"effector":[153],"MPK-1/ERK":[155],"was":[156],"identified":[157],"be":[159,335],"critical":[160],"for":[161,190,199],"this":[162,204],"(already":[163],"published).":[164],"As":[165],"continuation":[167],"next,":[171],"HIF-1":[173,236,317,343],"(Hypoxia":[174],"inducible":[175],"factor-1)":[176],"transcription":[177],"factor":[178],"key":[182],"oxygen":[185],"homeostasis":[186],"during":[187],"hypoxic":[188,212],"conditions":[189,213,217],"survival":[192],"organism":[195],"has":[196],"been":[197],"its":[200],"pronounced":[201],"effect":[202,254,264],"on":[203,252,257,267],"dedifferentiation-mediated":[205,238,258,346],"tumorigenesis":[206,239,279],"process.":[207],"We":[208],"found":[209],"under":[211,215],"or":[214,322],"mimic":[219],"hypoxia":[220,256,266],"(by":[221],"exposing":[222],"worms":[224],"cobalt":[226,323],"chloride,":[227],"chemical":[229],"inducer":[230],"hypoxia),":[232],"activation":[234,315],"inhibits":[237],"puf-8;":[241],"lip-1":[242],"mutant":[243,273],"germline,":[244],"probably":[245],"through":[246],"signaling.":[249],"Besides":[250],"focusing":[251],"tumorigenesis,":[259],"also":[261,269,326],"glp-1(ar202),":[268],"called":[270],"glp-1(gf)":[271],"gain-of-function":[272],"-":[274],"used":[275],"study":[277],"GLP-1/Notch-mediated":[278,328,348],"where":[280,289],"tumor":[282,310],"development":[283],"occurs":[284],"via":[285],"different":[287],"pathway":[288],"meiotic":[291],"entry":[292],"are":[297],"inhibited":[298,327],"instead":[300],"self-renews":[301],"self-renewal":[307],"forms":[308],"cell-like":[311],"cells.":[312],"Interestingly,":[313],"either":[319],"genetic":[320],"manipulation":[321],"chloride":[324],"treatment":[325],"tumorigenesis.":[329],"It":[330],"suggests":[331],"there":[333],"might":[334],"common":[337],"mechanism":[338],"underlying":[339],"action":[341],"both":[345],"tumors.":[350]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}