{"id":"https://openalex.org/W67357550","doi":null,"title":"Blood flow and vascular endothelial cell function.","display_name":"Blood flow and vascular endothelial cell function.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W67357550","mag":"67357550","pmid":"https://pubmed.ncbi.nlm.nih.gov/8136312"},"language":"en","primary_location":{"id":"pmid:8136312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8136312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J Ando","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J Ando","raw_affiliation_strings":["Department of Cardiovascular Biomechanics, Faculty of Medicine, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Biomechanics, Faculty of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002557561","display_name":"Aayush Kamiya","orcid":"https://orcid.org/0000-0002-7975-7991","observed_orcids":["https://orcid.org/0000-0002-7975-7991"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Kamiya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8147,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.66741422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"5","issue":"4","first_page":"245","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.7562999725341797,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.7562999725341797,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.1559000015258789,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.7329999804496765},{"id":"https://openalex.org/keywords/blood-flow","display_name":"blood flow","score":0.9449999928474426},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.656000018119812},{"id":"https://openalex.org/keywords/atherogenesis","display_name":"atherogenesis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/vascular-tone","display_name":"vascular tone","score":0.49900001287460327},{"id":"https://openalex.org/keywords/endothelium-derived-relaxing-factor","display_name":"endothelium-derived relaxing factor","score":0.8999999761581421},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/endothelin","display_name":"endothelin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.8149999976158142},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.9129999876022339},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.925000011920929},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.871999979019165},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.5609999895095825},{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.64969801902771},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5381174683570862},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.48253652453422546},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.4514632523059845},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4492616653442383},{"id":"https://openalex.org/C21141959","wikidata":"https://www.wikidata.org/wiki/Q657936","display_name":"Shear stress","level":2,"score":0.4467867612838745},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4419613480567932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4114200472831726},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.41022273898124695},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3348230719566345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2722427248954773},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2613176703453064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22173061966896057},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.103709876537323},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09670001268386841},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08537676930427551},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001698","descriptor_name":"Biomedical Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8136312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8136312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","raw_type":"Journal Article"},{"id":"mag:67357550","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8136312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2260591256","https://openalex.org/W2161452814","https://openalex.org/W1982028040","https://openalex.org/W2120556384","https://openalex.org/W1834747511","https://openalex.org/W2009842133","https://openalex.org/W2003535165","https://openalex.org/W2080798849","https://openalex.org/W2021078657","https://openalex.org/W2809239061"],"abstract_inverted_index":{"Vascular":[0],"endothelial":[1,69],"cells":[2,46,52],"(ECs)":[3],"are":[4,62,179],"not":[5,233],"merely":[6],"a":[7,30,73,85,107],"selective":[8],"permeability":[9,137],"barrier":[10],"between":[11],"blood":[12,82,90,174,236],"and":[13,36,42,53,102,104,132,134,138,184,201,240],"underlying":[14],"tissue":[15,158],"but":[16,242],"actively":[17],"play":[18],"an":[19,149],"important":[20],"role":[21],"in":[22,111,173,208],"maintaining":[23],"homeostasis":[24],"of":[25,32,80,114,122,154,213,216,235],"circulation.":[26],"ECs":[27,166],"that":[28,59,145,165,198],"have":[29,143],"variety":[31],"synthetic,":[33],"metabolic,":[34],"secretory":[35],"self-adaptive":[37],"capabilities":[38],"regulate":[39],"vascular":[40,49],"tonus":[41],"interact":[43],"with":[44],"other":[45],"such":[47,88,125,156],"as":[48,89,126,157,168],"smooth":[50],"muscle":[51],"white":[54],"cells.":[55],"Recent":[56],"evidence":[57],"suggests":[58],"these":[60],"functions":[61],"affected":[63],"by":[64,170,181],"shear":[65,95,146,177,210,224],"stress":[66,96,117,147,178],"on":[67,151],"the":[68,77,81,112,120,152,182,185,202,209,220,231],"wall,":[70],"which":[71,171],"is":[72,187],"rheological":[74],"force":[75],"shearing":[76],"luminal":[78],"surface":[79],"vessel":[83,100,238],"when":[84],"viscous":[86],"fluid":[87],"flows":[91],"over":[92],"it.":[93],"Wall":[94],"reportedly":[97],"regulates":[98,135],"adaptive":[99],"growth":[101,239],"angiogenesis,":[103],"might":[105,205],"be":[106,206],"local":[108],"risk":[109],"factor":[110],"pathogenesis":[113],"atherosclerosis.":[115],"Shear":[116],"also":[118,243],"modulates":[119],"production":[121],"vasoactive":[123],"substances":[124],"endothelium-derived":[127],"relaxing":[128],"factor,":[129],"prostacyclin,":[130],"histamine":[131],"endothelin,":[133],"macromolecule":[136],"endocytosis.":[139],"More":[140],"recent":[141],"studies":[142],"shown":[144],"exerts":[148],"influence":[150],"expression":[153],"mRNA":[155],"plasminogen":[159],"activator":[160],"mRNA.":[161],"These":[162],"facts":[163],"suggest":[164],"serve":[167],"mechanoreceptors":[169],"changes":[172],"flow":[175],"or":[176],"recognized":[180],"EC":[183,217,221],"signal":[186],"transmitted":[188],"to":[189,223,229],"intracellular":[190,199],"organelles.":[191],"It":[192],"has":[193],"been":[194],"indicated":[195],"so":[196],"far":[197],"Ca2+":[200],"membrane":[203],"potential":[204],"involved":[207],"stress-sensing":[211],"mechanism":[212,232],"ECs.":[214],"Knowledge":[215],"biomechanics,":[218],"i.e.":[219],"response":[222],"stress,":[225],"will":[226],"help":[227],"us":[228],"understand":[230],"only":[234],"flow-dependent":[237],"remodeling":[241],"atherogenesis.":[244]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}