{"id":"https://openalex.org/W67353522","doi":null,"title":"Dynamique de l'infection grippale : mod\u00e9lisation et applications","display_name":"Dynamique de l'infection grippale : mod\u00e9lisation et applications","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W67353522","mag":"67353522"},"language":"fr","primary_location":{"id":"pmh:oai:HAL:tel-00827770v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00827770","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bio-Informatique, Biologie Syst\u00e9mique [q-bio.QM]. Universit\u00e9 Pierre et Marie Curie - Paris VI, 2012. Fran\u00e7ais. ⟨NNT : 2012PAO66158⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://theses.hal.science/tel-00827770","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010072826","display_name":"La\u00ebtitia Canini","orcid":"https://orcid.org/0000-0001-7643-1219","observed_orcids":["https://orcid.org/0000-0001-7643-1219"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"La\u00ebtitia Canini","raw_affiliation_strings":["Epid\u00e9miologie des maladies infectieuses et mod\u00e9lisation"],"raw_orcid":"https://orcid.org/0000-0001-7643-1219","affiliations":[{"raw_affiliation_string":"Epid\u00e9miologie des maladies infectieuses et mod\u00e9lisation","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010072826"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza","display_name":"influenza","score":0.6629999876022339},{"id":"https://openalex.org/keywords/viral-dynamics","display_name":"viral dynamics","score":0.8560000061988831},{"id":"https://openalex.org/keywords/symptom-dynamics","display_name":"symptom dynamics","score":0.7940000295639038},{"id":"https://openalex.org/keywords/population-based-model","display_name":"population-based model","score":0.5479999780654907},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.8569999933242798},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.7429999709129333},{"id":"https://openalex.org/keywords/parameter-estimation","display_name":"parameter estimation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/neuraminidase-inhibitors","display_name":"neuraminidase inhibitors","score":0.8820000290870667},{"id":"https://openalex.org/keywords/oseltamivir","display_name":"oseltamivir","score":0.9789999723434448},{"id":"https://openalex.org/keywords/drug-resistance-emergence","display_name":"drug resistance emergence","score":0.6610000133514404},{"id":"https://openalex.org/keywords/immunodeficient-patients","display_name":"immunodeficient patients","score":0.7620000243186951},{"id":"https://openalex.org/keywords/treatment-timing","display_name":"treatment timing","score":0.5849999785423279},{"id":"https://openalex.org/keywords/influenza-epidemiology","display_name":"influenza epidemiology","score":0.3230000138282776}],"concepts":[{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.4818100333213806},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.47108376026153564},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34378868341445923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19794818758964539}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:HAL:tel-00827770v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00827770","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bio-Informatique, Biologie Syst\u00e9mique [q-bio.QM]. Universit\u00e9 Pierre et Marie Curie - Paris VI, 2012. Fran\u00e7ais. ⟨NNT : 2012PAO66158⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:67353522","doi":null,"is_oa":false,"landing_page_url":"https://tel.archives-ouvertes.fr/tel-00827770","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:HAL:tel-00827770v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00827770","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bio-Informatique, Biologie Syst\u00e9mique [q-bio.QM]. Universit\u00e9 Pierre et Marie Curie - Paris VI, 2012. Fran\u00e7ais. ⟨NNT : 2012PAO66158⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W99295644","https://openalex.org/W286277626","https://openalex.org/W1548037568","https://openalex.org/W1596437242","https://openalex.org/W1967579117","https://openalex.org/W1974628378","https://openalex.org/W1976160369","https://openalex.org/W1985106130","https://openalex.org/W1988044361","https://openalex.org/W1991592276","https://openalex.org/W1996824979","https://openalex.org/W1999869434","https://openalex.org/W2004554957","https://openalex.org/W2011630381","https://openalex.org/W2020320358","https://openalex.org/W2020410723","https://openalex.org/W2021612332","https://openalex.org/W2022098233","https://openalex.org/W2028461060","https://openalex.org/W2033157825","https://openalex.org/W2036331433","https://openalex.org/W2037438924","https://openalex.org/W2042063390","https://openalex.org/W2042295185","https://openalex.org/W2046094044","https://openalex.org/W2046745698","https://openalex.org/W2048595864","https://openalex.org/W2049633694","https://openalex.org/W2049812311","https://openalex.org/W2054154637","https://openalex.org/W2061268350","https://openalex.org/W2063830806","https://openalex.org/W2072658090","https://openalex.org/W2080927210","https://openalex.org/W2081484203","https://openalex.org/W2097229052","https://openalex.org/W2103963431","https://openalex.org/W2106449126","https://openalex.org/W2109977701","https://openalex.org/W2112093515","https://openalex.org/W2113876228","https://openalex.org/W2114526758","https://openalex.org/W2126615685","https://openalex.org/W2127759858","https://openalex.org/W2128060816","https://openalex.org/W2129728733","https://openalex.org/W2130441728","https://openalex.org/W2144578442","https://openalex.org/W2149943693","https://openalex.org/W2157177671","https://openalex.org/W2161135604","https://openalex.org/W2161872802","https://openalex.org/W2162728487","https://openalex.org/W2169497667","https://openalex.org/W2170097211","https://openalex.org/W2171405797","https://openalex.org/W2171888133","https://openalex.org/W2230049830","https://openalex.org/W2316532936","https://openalex.org/W2334261876","https://openalex.org/W3176003056"],"related_works":["https://openalex.org/W7011165519","https://openalex.org/W58902473","https://openalex.org/W2300937574","https://openalex.org/W7148116056","https://openalex.org/W86633449","https://openalex.org/W2600456904","https://openalex.org/W201607944","https://openalex.org/W7134390913","https://openalex.org/W7143413593","https://openalex.org/W2019548397"],"abstract_inverted_index":{"L'objectif":[0],"principal":[1],"de":[2,6,18,24,31,63,72,94,97,129,148,165,177,184,199,201,217,230,234],"cette":[3],"th\u00e8se":[4,221],"\u00e9tait":[5],"d\u00e9finir":[7],"un":[8,61,127,213],"ensemble":[9,128],"d'outils":[10],"m\u00e9hodologiques":[11],"pour":[12,36,114,141,159,186,196,208],"d\u00e9crire":[13],"et":[14,21,86,96,135,170,195,239],"\u00e9tudier":[15,160],"la":[16,19,32,41,53,82,98,104,144,171,228],"dynamique":[17,54,229],"grippe":[20,33],"les":[22,117,161,206],"param\u00e8tres":[23,93,118],"l'hitsoire":[25],"naturelle.":[26],"La":[27],"cin\u00e9tique":[28,64],"virale":[29],"(VK)":[30],"est":[34,40,50,112],"utilis\u00e9":[35],"repr\u00e9senter":[37],"l'infectiosit\u00e9,":[38],"qui":[39],"capacit\u00e9":[42],"\u00e0":[43,137,143],"transmettre":[44],"l'infection,":[45],"alors":[46],"que":[47,174],"l'histoire":[48],"naturele":[49],"d\u00e9crite":[51],"par":[52],"des":[55,66,77,89,92,163,190,225],"sympt\u00f4mes":[56,67],"(SD).":[57],"Nous":[58,180,203],"avons":[59,125,153,181,204],"d\u00e9velopp\u00e9":[60],"mod\u00e8le":[62,75],"virale/dynamique":[65],"(VKSD)":[68],"bas\u00e9":[69],"sur":[70,167,175,227],"approche":[71],"population.":[73],"Notre":[74],"prolonge":[76],"travaux":[78],"pr\u00e9c\u00e9dents":[79],"en":[80,87,100,102,139,146],"incluant":[81],"r\u00e9ponse":[83],"immunitaire":[84],"inn\u00e9e":[85],"apportant":[88],"estimations":[90],"r\u00e9alistes":[91],"l'infection":[95,168,231],"maladie,":[99],"prenant":[101],"compte":[103],"variabilit\u00e9":[105],"interindividuelle.":[106],"Le":[107],"choix":[108],"d'un":[109],"protocole":[110],"d'\u00e9tude":[111],"crucial":[113],"estimer":[115],"pr\u00e9cisement":[116],"du":[119],"mod\u00e8le.":[120],"Dans":[121],"ce":[122],"but":[123],"nous":[124,152],"optimis\u00e9":[126],"protocoles":[130],"afin":[131,233],"qu'ils":[132],"soient":[133],"\u00e9conomiques":[134],"faciles":[136],"mettre":[138],"place":[140,147],"aider":[142],"mise":[145],"futures":[149],"\u00e9tudes.":[150],"Enfin,":[151],"r\u00e9alis\u00e9":[154],"une":[155],"\u00e9tude":[156],"in":[157],"silico":[158],"effets":[162],"inhibiteurs":[164],"neuraminidases":[166],"grippale":[169,232],"maladie":[172],"ainsi":[173],"l'\u00e9mergence":[176],"virus":[178,218],"r\u00e9sistants.":[179],"explor\u00e9":[182],"l'efficacit\u00e9":[183],"l'oseltamivir":[185],"diff\u00e9rentes":[187,197],"posologies,":[188],"chez":[189],"sujets":[191],"sains":[192],"ou":[193],"immunod\u00e9ficients":[194],"dates":[198],"d\u00e9but":[200],"traitement.":[202],"identifi\u00e9":[205],"situations":[207],"lesquelles":[209],"le":[210],"traitement":[211],"entra\u00eene":[212],"\u00e9quilibre":[214],"efficacit\u00e9/faible":[215],"\u00e9mergence":[216],"r\u00e9sistant.":[219],"Cette":[220],"souligne":[222],"l'importance":[223],"d'acqu\u00e9rir":[224],"connaissance":[226],"faire":[235],"face":[236],"aux":[237],"\u00e9pid\u00e9mies/pand\u00e9mies":[238],"d'en":[240],"att\u00e9nuer":[241],"l'impact":[242]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}