{"id":"https://openalex.org/W67246723","doi":"https://doi.org/10.1007/978-1-4615-8149-9_35","title":"The Subunit Specific Effects of Novel Anabaseine-Derived Nicotinic Agents","display_name":"The Subunit Specific Effects of Novel Anabaseine-Derived Nicotinic Agents","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W67246723","doi":"https://doi.org/10.1007/978-1-4615-8149-9_35","mag":"67246723"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4615-8149-9_35","doi":"https://doi.org/10.1007/978-1-4615-8149-9_35","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-8149-9_35","pdf_url":null,"source":{"id":"https://openalex.org/S4306462921","display_name":"Birkh\u00e4user Boston eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer Disease","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4254222470","display_name":"Alzheimer Disease"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077039646","display_name":"Roger L. Papke","orcid":"https://orcid.org/0000-0002-4468-8658","observed_orcids":["https://orcid.org/0000-0002-4468-8658"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger L. Papke","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001238775","display_name":"Christopher M. de Fiebre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. de Fiebre","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023563705","display_name":"William R. Kem","orcid":"https://orcid.org/0000-0001-8492-3969","observed_orcids":["https://orcid.org/0000-0001-8492-3969"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Kem","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103491448","display_name":"Edwin M. Meyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin M. Meyer","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8613,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.90301086,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"206","last_page":"211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.8989999890327454},{"id":"https://openalex.org/keywords/nicotinic-receptor-subtypes","display_name":"nicotinic receptor subtypes","score":0.8429999947547913},{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.6050000190734863},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.7540000081062317},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.871999979019165},{"id":"https://openalex.org/keywords/cognitive-enhancement","display_name":"cognitive enhancement","score":0.4749999940395355},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.722000002861023},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.8530821204185486},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.6682883501052856},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.623257040977478},{"id":"https://openalex.org/C100660578","wikidata":"https://www.wikidata.org/wiki/Q18733","display_name":"Recall","level":2,"score":0.4952806532382965},{"id":"https://openalex.org/C88576662","wikidata":"https://www.wikidata.org/wiki/Q18646","display_name":"Episodic memory","level":3,"score":0.4630354344844818},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.45330461859703064},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4411265254020691},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3336912989616394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30224424600601196},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.19052553176879883},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12456905841827393}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4615-8149-9_35","doi":"https://doi.org/10.1007/978-1-4615-8149-9_35","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-8149-9_35","pdf_url":null,"source":{"id":"https://openalex.org/S4306462921","display_name":"Birkh\u00e4user Boston eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer Disease","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1498196544","https://openalex.org/W1900806927","https://openalex.org/W1986445622","https://openalex.org/W1995971676","https://openalex.org/W2001656611","https://openalex.org/W2007226311","https://openalex.org/W2037877036","https://openalex.org/W2038995429","https://openalex.org/W2050224291","https://openalex.org/W2068987805","https://openalex.org/W2082152717","https://openalex.org/W2092541011","https://openalex.org/W2116249462","https://openalex.org/W4388311259"],"related_works":["https://openalex.org/W2059495695","https://openalex.org/W2025498694","https://openalex.org/W130124518","https://openalex.org/W2087515759","https://openalex.org/W2120349084","https://openalex.org/W1974896225","https://openalex.org/W7099334742","https://openalex.org/W2105233285","https://openalex.org/W2081801828","https://openalex.org/W2045122897"],"abstract_inverted_index":{"Nicotine":[0,41],"readily":[1],"crosses":[2],"the":[3,101,110],"blood-brain":[4],"barrier":[5],"and":[6,12,22,35,45,112,131],"elicits":[7],"a":[8,18,80,105,116],"variety":[9,19,81],"of":[10,20,61,82,104,107],"behavioral":[11],"physiological":[13],"actions.":[14],"Generally,":[15],"nicotine":[16],"improves":[17],"spatial-memory":[21],"avoidance":[23],"tasks":[24],"in":[25,39,56,64,98,109,129,133],"animals,":[26],"while":[27],"enhancing":[28],"delayed":[29],"recall,":[30],"information":[31],"manipulation,":[32],"focused":[33],"attention":[34],"other":[36],"memory-related":[37,57,65],"behaviors":[38,66],"humans.":[40],"also":[42],"alters":[43],"mood":[44],"reaction":[46],"time,":[47],"which":[48,114],"can":[49],"be":[50,96],"difficult":[51],"to":[52,100,122,135],"distinguish":[53],"from":[54],"changes":[55],"behaviors.":[58],"One":[59],"characteristic":[60],"nicotine-induced":[62],"improvements":[63],"is":[67,115],"that":[68,85],"these":[69],"are":[70],"generally":[71],"seen":[72],"over":[73],"narrow":[74,92],"dose-ranges,":[75],"with":[76,87],"higher":[77],"doses":[78],"causing":[79],"side":[83],"effects":[84],"interfere":[86],"performance":[88],"(Warburton,":[89],"1990).":[90],"This":[91],"dose-response":[93],"range":[94],"may":[95],"due":[97],"part":[99],"nicotinic":[102,124],"activation":[103],"multiplicity":[106],"receptors":[108],"brain":[111],"periphery,":[113],"powerful":[117],"impetus":[118],"for":[119],"targeting":[120],"drugs":[121],"those":[123],"receptor":[125],"subtypes":[126],"selectively":[127],"involved":[128],"learning":[130],"memory":[132],"order":[134],"treat":[136],"conditions":[137],"such":[138],"as":[139],"Alzheimer\u2019s":[140],"disease":[141],"(AD).":[142]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}