{"id":"https://openalex.org/W67231565","doi":null,"title":"Current management of glaucoma and the need for complete therapy.","display_name":"Current management of glaucoma and the need for complete therapy.","publication_year":2008,"publication_date":"2008-02-01","ids":{"openalex":"https://openalex.org/W67231565","mag":"67231565","pmid":"https://pubmed.ncbi.nlm.nih.gov/18284312"},"language":"en","primary_location":{"id":"pmid:18284312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18284312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of managed care","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108478412","display_name":"Stuart J. McKinnon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart J McKinnon","raw_affiliation_strings":["Departments of Ophthalmology and Neurobiology, Duke University Medical Center, Box 3802, Erwin Rd, Durham, NC 27710, USA. stuart.mckinnon@duke.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Ophthalmology and Neurobiology, Duke University Medical Center, Box 3802, Erwin Rd, Durham, NC 27710, USA. stuart.mckinnon@duke.edu","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071040041","display_name":"Lawrence D Goldberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lawrence D Goldberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071188023","display_name":"Patti Peeples","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patti Peeples","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103579509","display_name":"John G. Walt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John G Walt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079067628","display_name":"Thomas J. Bramley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas J Bramley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.0686,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.9883784,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"14","issue":"1 Suppl","first_page":"S20","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.9279999732971191},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8640000224113464},{"id":"https://openalex.org/keywords/primary-open-angle-glaucoma","display_name":"primary open-angle glaucoma","score":0.8320000171661377},{"id":"https://openalex.org/keywords/intraocular-pressure-reduction","display_name":"intraocular pressure reduction","score":0.9570000171661377},{"id":"https://openalex.org/keywords/prostaglandin-analogs","display_name":"prostaglandin analogues","score":0.9419999718666077},{"id":"https://openalex.org/keywords/beta-adrenergic-receptor-blockers","display_name":"beta-adrenergic receptor blockers","score":0.9850000143051147},{"id":"https://openalex.org/keywords/alpha-adrenergic-agonists","display_name":"alpha-adrenergic agonists","score":0.8410000205039978},{"id":"https://openalex.org/keywords/carbonic-anhydrase-inhibitors","display_name":"carbonic anhydrase inhibitors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cholinergic-agonists","display_name":"cholinergic agonists","score":0.8960000276565552},{"id":"https://openalex.org/keywords/memantine","display_name":"memantine","score":0.796999990940094},{"id":"https://openalex.org/keywords/retinal-ganglion-cell-loss","display_name":"retinal ganglion cell death","score":0.9079999923706055},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.935918927192688},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.6865110397338867},{"id":"https://openalex.org/C2778190193","wikidata":"https://www.wikidata.org/wiki/Q577377","display_name":"Brimonidine","level":3,"score":0.6019752025604248},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.47316914796829224},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.43560469150543213}],"mesh":[{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001766","descriptor_name":"Blindness","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008329","descriptor_name":"Managed Care Programs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008403","descriptor_name":"Mass Screening","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010349","descriptor_name":"Patient Compliance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18284312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18284312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of managed care","raw_type":"Journal Article"},{"id":"mag:67231565","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18284312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000905508","display_name":"Center Core Grant for Vision Research","funder_award_id":"P30EY005722","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W129079388","https://openalex.org/W3044674918","https://openalex.org/W2112605601","https://openalex.org/W2153121930","https://openalex.org/W1996615611","https://openalex.org/W1552609401","https://openalex.org/W1986775417","https://openalex.org/W2170322450","https://openalex.org/W2061766512","https://openalex.org/W2973157250"],"abstract_inverted_index":{"Glaucoma":[0],"is":[1,23,161],"a":[2,35,177,214],"long-term":[3],"ocular":[4],"neuropathy":[5],"defined":[6],"by":[7,55,71,122,203],"optic":[8],"disc":[9],"or":[10,63,73,140],"retinal":[11,125],"nerve":[12],"fiber":[13],"structural":[14],"abnormalities":[15],"and":[16,44,78,82,103,108,130,175,208,218],"visual":[17],"field":[18],"abnormality.":[19],"Primary":[20],"open-angle":[21],"glaucoma":[22,96,173],"the":[24,118,162,167,205],"most":[25],"common":[26],"type":[27],"of":[28,106,124,133,182,186,216],"glaucoma.":[29],"Currently":[30],"available":[31],"treatments,":[32],"initiated":[33],"in":[34,95,141,166,192],"stepwise":[36],"process,":[37],"focus":[38],"on":[39],"intraocular":[40],"pressure":[41],"(IOP)":[42],"reduction,":[43],"initially":[45],"include":[46,91,114],"topical":[47,74,88],"drug":[48],"therapy":[49,145,197],"(single":[50],"then":[51,57],"multidrug":[52],"combinations),":[53],"followed":[54,70],"laser":[56],"surgical":[58],"treatment.":[59],"Topical":[60],"prostaglandin":[61],"analogues":[62],"beta-adrenergic":[64],"receptor":[65,155],"blockers":[66],"are":[67,191],"first":[68],"used,":[69],"alpha-agonists":[72],"carbonic":[75],"anhydrase":[76],"inhibitors,":[77],"infrequently,":[79],"cholinergic":[80],"agonists":[81],"oral":[83],"therapy.":[84],"Limitations":[85],"to":[86],"existing":[87],"IOP-reducing":[89],"medications":[90],"continued":[92],"disease":[93,119,219],"progression":[94],"patients":[97],"with":[98,143],"normal":[99],"IOP,":[100],"treatment":[101,147,174],"failure,":[102],"low":[104],"rates":[105],"compliance":[107],"persistence.":[109],"Therapeutic":[110],"agents":[111],"under":[112],"investigation":[113],"neuroprotectants,":[115],"which":[116],"target":[117],"process":[120,168],"manifested":[121],"death":[123],"ganglion":[126],"cells,":[127],"axonal":[128],"loss,":[129],"irreversible":[131],"loss":[132],"vision.":[134],"Neuroprotectants":[135],"may":[136],"be":[137],"used":[138],"alone":[139],"combination":[142],"IOPreducing":[144],"(a":[146],"strategy":[148],"called":[149],"complete":[150],"therapy).":[151],"Memantine,":[152],"an":[153],"N-methyl-D-aspartate":[154],"blocker":[156],"currently":[157],"approved":[158],"for":[159,172,200],"dementia,":[160],"neuroprotectant":[163],"farthest":[164],"along":[165],"seeking":[169],"regulatory":[170],"approval":[171],"has":[176],"favorable":[178],"safety":[179],"profile":[180],"because":[181],"its":[183],"selective":[184],"mechanism":[185],"action.":[187],"Several":[188],"other":[189],"neuroprotectants":[190],"early":[193],"stage":[194],"investigation.":[195],"Complete":[196],"provides":[198],"hope":[199],"improved":[201],"outcomes":[202],"reducing":[204],"significant":[206],"morbidity":[207],"economic":[209],"consequences":[210],"that":[211],"occur":[212],"as":[213],"result":[215],"neurodegeneration":[217],"progression.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}