{"id":"https://openalex.org/W67168731","doi":null,"title":"Gene therapy to the kidney using viral vectors.","display_name":"Gene therapy to the kidney using viral vectors.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W67168731","mag":"67168731","pmid":"https://pubmed.ncbi.nlm.nih.gov/20827394","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2935311"},"language":"en","primary_location":{"id":"pmid:20827394","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20827394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paediatriki","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2935311","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081245199","display_name":"Talha Akbulut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Talha Akbulut","raw_affiliation_strings":["Department of Physiology, Medical College of Wisconsin, Milwaukee, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019199691","display_name":"Frank Park","orcid":"https://orcid.org/0000-0003-2324-2937","observed_orcids":["https://orcid.org/0000-0003-2324-2937"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Park","raw_affiliation_strings":["Medical College of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204308271"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00628137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"71","issue":"3","first_page":"177","last_page":"185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.9760000109672546},{"id":"https://openalex.org/keywords/viral-vectors","display_name":"viral vectors","score":0.9049999713897705},{"id":"https://openalex.org/keywords/childhood-diseases","display_name":"childhood diseases","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.8145154714584351},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5705054402351379},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5460517406463623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5451686382293701},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.453622043132782},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.43907430768013},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.419564813375473},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4107874631881714},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3618583679199219},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34776291251182556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3045945167541504},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29758256673812866},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15017151832580566},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10296809673309326},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:20827394","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20827394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paediatriki","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2935311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2935311","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Paidiatrike","raw_type":"Text"},{"id":"mag:67168731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20827394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2935311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2935311","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Paidiatrike","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6044918484","display_name":"Gene transfer to the kidney using lentiviral vectors","funder_award_id":"R21DK062920","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W120480743","https://openalex.org/W1481565655","https://openalex.org/W1599588446","https://openalex.org/W1901002830","https://openalex.org/W1942221917","https://openalex.org/W1964033324","https://openalex.org/W1965218579","https://openalex.org/W1967033604","https://openalex.org/W1971741612","https://openalex.org/W1983411688","https://openalex.org/W1983682307","https://openalex.org/W1985095994","https://openalex.org/W1989997219","https://openalex.org/W1992912012","https://openalex.org/W1994284232","https://openalex.org/W1995700570","https://openalex.org/W1996746326","https://openalex.org/W2007276010","https://openalex.org/W2009761723","https://openalex.org/W2012714016","https://openalex.org/W2020130264","https://openalex.org/W2022383785","https://openalex.org/W2027926820","https://openalex.org/W2028253705","https://openalex.org/W2030699641","https://openalex.org/W2031465191","https://openalex.org/W2032678451","https://openalex.org/W2034036966","https://openalex.org/W2035834158","https://openalex.org/W2035957783","https://openalex.org/W2036546908","https://openalex.org/W2039028985","https://openalex.org/W2040892387","https://openalex.org/W2042712894","https://openalex.org/W2043909205","https://openalex.org/W2044919488","https://openalex.org/W2047608515","https://openalex.org/W2047724621","https://openalex.org/W2048287126","https://openalex.org/W2048570948","https://openalex.org/W2049340874","https://openalex.org/W2050770858","https://openalex.org/W2052148578","https://openalex.org/W2055791890","https://openalex.org/W2057005002","https://openalex.org/W2061448062","https://openalex.org/W2065380345","https://openalex.org/W2068302815","https://openalex.org/W2074127387","https://openalex.org/W2077317257","https://openalex.org/W2080044481","https://openalex.org/W2084879867","https://openalex.org/W2088767843","https://openalex.org/W2090864647","https://openalex.org/W2093424805","https://openalex.org/W2093771899","https://openalex.org/W2096000931","https://openalex.org/W2103060185","https://openalex.org/W2104567143","https://openalex.org/W2105007068","https://openalex.org/W2109751467","https://openalex.org/W2114906984","https://openalex.org/W2116591094","https://openalex.org/W2118944608","https://openalex.org/W2124375652","https://openalex.org/W2125160350","https://openalex.org/W2127008143","https://openalex.org/W2128486910","https://openalex.org/W2136614869","https://openalex.org/W2137440275","https://openalex.org/W2145399106","https://openalex.org/W2146010752","https://openalex.org/W2147529770","https://openalex.org/W2155552993","https://openalex.org/W2157894968","https://openalex.org/W2157978020","https://openalex.org/W2160641725","https://openalex.org/W2168208695","https://openalex.org/W2171427593","https://openalex.org/W2172109879","https://openalex.org/W2172230191","https://openalex.org/W2179122767","https://openalex.org/W2182534497","https://openalex.org/W2188888142","https://openalex.org/W2323613689","https://openalex.org/W2323827309","https://openalex.org/W2397952478","https://openalex.org/W2400688734","https://openalex.org/W2401811518","https://openalex.org/W2412590387","https://openalex.org/W2413236724","https://openalex.org/W2462664107","https://openalex.org/W2605613428"],"related_works":["https://openalex.org/W4392031800","https://openalex.org/W4380202588","https://openalex.org/W2109860489","https://openalex.org/W2968872901","https://openalex.org/W2417282925","https://openalex.org/W1517399658","https://openalex.org/W2409271394","https://openalex.org/W2053785525","https://openalex.org/W2064502691","https://openalex.org/W1965154840"],"abstract_inverted_index":{"Many":[0],"pediatric":[1,102],"diseases":[2],"have":[3,59],"reached":[4],"a":[5,95],"therapeutic":[6,40],"plateau":[7],"using":[8],"currently":[9],"available":[10],"surgical":[11],"and":[12,31,51,71,80,85],"pharmacological":[13],"approaches.":[14],"Gene":[15],"therapy":[16,76,93],"has":[17,37],"emerged":[18],"as":[19,47,94],"an":[20],"exciting":[21],"new":[22],"technology":[23],"to":[24,43,54,77,87],"manipulate":[25],"cells":[26,58],"in":[27,32,98],"the":[28,48,69,78,82,88,99],"mammalian":[29],"system,":[30],"some":[33],"cases,":[34],"this":[35],"method":[36],"achieved":[38],"amazing":[39],"benefits.":[41],"Compared":[42],"other":[44],"organs,":[45],"such":[46],"brain,":[49],"liver":[50],"lung,":[52],"methods":[53],"genetically":[55],"modify":[56],"renal":[57],"received":[60],"relatively":[61],"little":[62],"attention.":[63],"The":[64],"current":[65],"review":[66],"will":[67],"discuss":[68],"challenges":[70],"important":[72],"developments":[73],"regarding":[74],"gene":[75,92],"kidney,":[79],"relate":[81],"recent":[83],"successes":[84],"failures":[86],"future":[89],"potential":[90],"of":[91,101],"treatment":[96],"modality":[97],"context":[100],"disease.":[103]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}