{"id":"https://openalex.org/W67145348","doi":null,"title":"[A case of advanced sigmoid colon cancer with metastases in the liver and the paraaortic lymph nodes successfully treated with 5-FU/l-LV and FOLFOX4 followed by S-1 leading to long-term complete response].","display_name":"[A case of advanced sigmoid colon cancer with metastases in the liver and the paraaortic lymph nodes successfully treated with 5-FU/l-LV and FOLFOX4 followed by S-1 leading to long-term complete response].","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W67145348","mag":"67145348","pmid":"https://pubmed.ncbi.nlm.nih.gov/24423964"},"language":"ja","primary_location":{"id":"pmid:24423964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24423964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"Case Reports"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070904304","display_name":"Ikuo Nagano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255485","display_name":"Hekinan Municipal Hospital","ror":"https://ror.org/032jssp65","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405255485"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikuo Nagano","raw_affiliation_strings":["Dept. of Surgery, Hekinan Municipal Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgery, Hekinan Municipal Hospital","institution_ids":["https://openalex.org/I4405255485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050787550","display_name":"Ikuo Yamada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ikuo Yamada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Masaki Niwa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaki Niwa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054520911","display_name":"\u82f1\u4fca \u91d1\u6fa4","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hidetoshi Kanazawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024479154","display_name":"Taichi Sato","orcid":"https://orcid.org/0000-0002-2158-3730","observed_orcids":["https://orcid.org/0000-0002-2158-3730"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taichi Sato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041823290","display_name":"Naoki Matsumoto","orcid":"https://orcid.org/0000-0002-9982-6130","observed_orcids":["https://orcid.org/0000-0002-9982-6130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoki Matsumoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013908824","display_name":"Hisaaki Yoshinaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisaaki Yoshinaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1607,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54317468,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"41","issue":"1","first_page":"113","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.06129999831318855,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sigmoid-colon-cancer","display_name":"sigmoid colon cancer","score":0.9710000157356262},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.843999981880188},{"id":"https://openalex.org/keywords/para-aortic-lymph-node-metastasis","display_name":"para-aortic lymph node metastasis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/5-fluorouracil-leucovorin","display_name":"5-fluorouracil/leucovorin","score":0.8109999895095825},{"id":"https://openalex.org/keywords/folfox4","display_name":"FOLFOX4","score":0.996999979019165},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.9070000052452087},{"id":"https://openalex.org/keywords/s-1","display_name":"S-1","score":0.7940000295639038},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.9240000247955322},{"id":"https://openalex.org/keywords/sigmoidectomy","display_name":"sigmoidectomy","score":0.5799999833106995},{"id":"https://openalex.org/keywords/lymph-node-dissection","display_name":"lymph node dissection","score":0.7950000166893005},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9135540723800659},{"id":"https://openalex.org/C2781212463","wikidata":"https://www.wikidata.org/wiki/Q7133679","display_name":"Paraaortic lymph nodes","level":4,"score":0.9025038480758667},{"id":"https://openalex.org/C2779804826","wikidata":"https://www.wikidata.org/wiki/Q45435667","display_name":"Folinic acid","level":4,"score":0.7955026626586914},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.6916149258613586},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.5563315153121948},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5135186314582825},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4974248707294464},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4891827404499054},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.4453417658805847},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.42301642894744873},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40918850898742676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33231019973754883},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.33039820194244385},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.310046911239624},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13719400763511658}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010094","descriptor_name":"Oxonic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012811","descriptor_name":"Sigmoid Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012811","descriptor_name":"Sigmoid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012811","descriptor_name":"Sigmoid Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24423964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24423964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"Case Reports"},{"id":"mag:67145348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24423964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3123767957","https://openalex.org/W2266568005","https://openalex.org/W2984834993","https://openalex.org/W2409791331","https://openalex.org/W140513190","https://openalex.org/W142145240","https://openalex.org/W167317102","https://openalex.org/W2414699284","https://openalex.org/W28733295","https://openalex.org/W2416156272"],"abstract_inverted_index":{"The":[0,28,50],"patient":[1],"was":[2,32,39,55,67,76,85,142],"a":[3,98],"70-year-old":[4],"woman":[5],"with":[6,24],"sigmoid":[7],"colon":[8],"cancer":[9],"and":[10,15,61,72,128,136,161],"metastases":[11,43,127],"in":[12,35,44],"the":[13,16,45,121,129,156,172],"liver":[14],"paraaortic":[17,46],"lymph":[18,25,47,125],"nodes.":[19],"We":[20],"performed":[21,41],"sigmoidectomy":[22],"along":[23],"node":[26,126],"dissection.":[27],"solitary":[29],"hepatic":[30,130],"metastasis":[31,131],"3":[33,110,134],"cm":[34],"diameter;":[36],"however,":[37],"hepatectomy":[38],"not":[40],"because":[42],"nodes":[48],"persisted.":[49],"serum":[51,114],"carcino":[52],"embryonic":[53],"antigen(CEA)level":[54],"above":[56],"200":[57],"ng/mL,":[58],"both":[59],"preoperatively":[60],"postoperatively.":[62],"After":[63,109],"surgery,":[64],"chemo-":[65],"therapy":[66,141],"initiated.":[68,108],"Initially,":[69],"weekly":[70],"5-fluorouracil":[71],"l":[73],"/":[74],"-Leucovorin(5-FU/l-LV)therapy":[75],"administered":[77,86],"4":[78],"times.":[79],"Subsequently,":[80],"5-FU/folinic":[81],"acid":[82],"plus":[83],"oxaliplatin(FOLFOX4)therapy":[84],"12":[87],"times":[88],"every":[89],"2":[90],"weeks.":[91],"Thereafter,":[92],"S-1":[93,140,159],"therapy(orally,":[94],"40":[95],"mg":[96],"twice":[97],"day,":[99],"28":[100],"days,":[101],"followed":[102],"by":[103],"14":[104],"days":[105],"of":[106,112,158],"rest)was":[107],"months":[111,135],"chemotherapy,":[113],"CEA":[115],"levels":[116],"decreased":[117],"rapidly":[118],"to":[119],"within":[120],"normal":[122],"limit.":[123],"Paraaortic":[124],"disappeared":[132],"after":[133],"11":[137],"months,":[138],"respectively.":[139],"continued":[143],"for":[144,167],"over":[145,152,168],"7":[146],"years.":[147],"Currently,":[148],"it":[149],"has":[150,164],"been":[151,165],"1":[153],"year":[154],"since":[155,171],"discontinuation":[157],"therapy,":[160],"complete":[162],"response":[163],"maintained":[166],"9":[169],"years":[170],"surgery.":[173]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}