{"id":"https://openalex.org/W67038043","doi":"https://doi.org/10.1161/circ.124.suppl_21.a16677","title":"Abstract 16677: Allogeneic Cardiospheres Boost Cardiac Function and Attenuate Adverse Remodeling Without Eliciting Immune Reactions Post-Myocardial Infarction in Immunologically-Mismatched Rat Strains","display_name":"Abstract 16677: Allogeneic Cardiospheres Boost Cardiac Function and Attenuate Adverse Remodeling Without Eliciting Immune Reactions Post-Myocardial Infarction in Immunologically-Mismatched Rat Strains","publication_year":2011,"publication_date":"2011-11-22","ids":{"openalex":"https://openalex.org/W67038043","doi":"https://doi.org/10.1161/circ.124.suppl_21.a16677","mag":"67038043"},"language":"en","primary_location":{"id":"doi:10.1161/circ.124.suppl_21.a16677","doi":"https://doi.org/10.1161/circ.124.suppl_21.a16677","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.124.suppl_21.a16677","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102723192","display_name":"Eleni Tseliou","orcid":"https://orcid.org/0000-0002-9350-2282","observed_orcids":["https://orcid.org/0000-0002-9350-2282"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4210141674","display_name":"Cedars-Sinai Smidt Heart Institute","ror":"https://ror.org/041vn2102","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eleni Tseliou","raw_affiliation_strings":["HEART INSTITUTE, Cedars - Sinai Med Cntr, Los Angeles, CA","Eleni Tseliou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HEART INSTITUTE, Cedars - Sinai Med Cntr, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]},{"raw_affiliation_string":"Eleni Tseliou","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039981589","display_name":"Konstantinos G. Malliaras","orcid":"https://orcid.org/0000-0002-0658-9907","observed_orcids":["https://orcid.org/0000-0002-0658-9907"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4210141674","display_name":"Cedars-Sinai Smidt Heart Institute","ror":"https://ror.org/041vn2102","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Konstantinos Malliaras","raw_affiliation_strings":["HEART INSTITUTE, Cedars - Sinai Med Cntr, Los Angeles, CA","Konstantinos Malliaras"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HEART INSTITUTE, Cedars - Sinai Med Cntr, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]},{"raw_affiliation_string":"Konstantinos Malliaras","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024954879","display_name":"John Terrovitis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"John Terrovitis","raw_affiliation_strings":["3rd CARDIOLOGY DEPARTMENT, Univ of Athens, Athens, Greece","John Terrovitis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3rd CARDIOLOGY DEPARTMENT, Univ of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"John Terrovitis","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091674327","display_name":"Daniel Luthringer","orcid":"https://orcid.org/0000-0001-8189-0540","observed_orcids":["https://orcid.org/0000-0001-8189-0540"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4210141674","display_name":"Cedars-Sinai Smidt Heart Institute","ror":"https://ror.org/041vn2102","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Luthringer","raw_affiliation_strings":["HEART INSTITUTE, Cedars - Sinai Med Cntr, Los Angeles, CA","Daniel Luthringer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HEART INSTITUTE, Cedars - Sinai Med Cntr, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]},{"raw_affiliation_string":"Daniel Luthringer","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069866872","display_name":"Linda Marb\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4210141674","display_name":"Cedars-Sinai Smidt Heart Institute","ror":"https://ror.org/041vn2102","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Marban","raw_affiliation_strings":["HEART INSTITUTE, Cedars - Sinai Med Cntr, Los Angeles, CA","Linda Marban"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HEART INSTITUTE, Cedars - Sinai Med Cntr, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]},{"raw_affiliation_string":"Linda Marban","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046381230","display_name":"Eduardo Marb\u00e1n","orcid":"https://orcid.org/0000-0002-3863-280X","observed_orcids":["https://orcid.org/0000-0002-3863-280X"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4210141674","display_name":"Cedars-Sinai Smidt Heart Institute","ror":"https://ror.org/041vn2102","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo Marban","raw_affiliation_strings":["HEART INSTITUTE, Cedars - Sinai Med Cntr, Los Angeles, CA","Eduardo Marban"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HEART INSTITUTE, Cedars - Sinai Med Cntr, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]},{"raw_affiliation_string":"Eduardo Marban","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":"suppl_21","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.04839999973773956,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.5879999995231628},{"id":"https://openalex.org/keywords/mhc-class-i-expression","display_name":"MHC class I expression","score":0.6340000033378601},{"id":"https://openalex.org/keywords/mhc-class-ii-expression","display_name":"MHC class II expression","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cell-engraftment","display_name":"cell engraftment","score":0.8050000071525574},{"id":"https://openalex.org/keywords/peri-infarct-zone","display_name":"peri-infarct zone","score":0.6819999814033508},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.7419999837875366},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.6309999823570251},{"id":"https://openalex.org/keywords/brown-norway-rats","display_name":"Brown Norway rats","score":0.6439999938011169},{"id":"https://openalex.org/keywords/wistar-kyoto-rats","display_name":"Wistar-Kyoto rats","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.4189999997615814},{"id":"https://openalex.org/keywords/immune-rejection","display_name":"immune rejection","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9653798341751099},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7376691102981567},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.6463939547538757},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6054279804229736},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.5803750157356262},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5518973469734192},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47761625051498413},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25526171922683716},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2424185574054718}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.124.suppl_21.a16677","doi":"https://doi.org/10.1161/circ.124.suppl_21.a16677","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.124.suppl_21.a16677","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.46000000834465027,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2130308734","https://openalex.org/W2033713549","https://openalex.org/W2093273850","https://openalex.org/W2406623489","https://openalex.org/W2011518964","https://openalex.org/W54360213","https://openalex.org/W2051968888","https://openalex.org/W7100258655","https://openalex.org/W2016165259","https://openalex.org/W2623604297"],"abstract_inverted_index":{"BACKGROUND:":[0],"Autologous":[1],"cardiospheres,":[2],"3-dimensional":[3],"heart-derived":[4],"multicellular":[5],"structures":[6],"that":[7],"form":[8],"spontaneously":[9],"in":[10,27,51,71,75,81,101,167,186,201,219,278],"suspension":[11],"culture,":[12],"have":[13],"been":[14,58],"shown":[15],"to":[16,41,289],"ameliorate":[17],"remodeling":[18],"and":[19,43,68,73,180,198,238,259,285],"improve":[20,282],"global":[21],"function":[22,284],"after":[23,78,151,183,311],"intramyocardial":[24],"(IM)":[25],"injection":[26,80,184],"infarcted":[28,280],"pig":[29],"hearts.":[30],"However,":[31],"autologous":[32],"tissue":[33,55],"processing":[34],"is":[35],"fraught":[36],"with":[37,125,153,207],"considerable":[38],"expense,":[39],"delays":[40],"treatment":[42],"potential":[44],"complications.The":[45],"possible":[46],"role":[47],"of":[48,66,85,105,158,241,255,272],"allogeneic":[49,69,177,229,247,265],"cardiospheres":[50,70,134,266,276],"restoring":[52],"ischemic":[53],"heart":[54],"has":[56],"not":[57],"studied.":[59],"OBJECTIVES:":[60],"We":[61],"evaluated":[62],"the":[63,102,168,190,202,208,256,260,264,279,290],"immunologic":[64],"profile":[65],"syngeneic":[67,227,245,294],"vitro":[72],"their":[74,141],"vivo":[76],"efficacy":[77],"IM":[79],"a":[82,156],"rat":[83,97],"model":[84],"acute":[86,312],"myocardial":[87,313],"infarction.":[88,314],"METHODS:":[89],"Cardiospheres":[90,300],"expanded":[91],"from":[92],"male":[93],"Wistar":[94],"Kyoto":[95],"(WKY)":[96],"hearts":[98],"were":[99,147,267],"injected":[100,124],"peri-infarct":[103,261],"zone":[104],"WKY":[106],"female":[107,114,121],"(syngeneic":[108,174],"group,":[109,117],"n=18)":[110],"or":[111],"Brown":[112,119],"Norway":[113,120],"rats":[115,122],"(allogeneic":[116],"n=20).":[118],"(n=12)":[123],"normal":[126],"saline":[127],"served":[128],"as":[129,293,303],"controls.":[130],"RESULTS:":[131],"In":[132,161],"vitro,":[133],"expressed":[135,150],"only":[136,148],"MHC":[137,145],"I":[138],"antigens":[139],"on":[140],"outer":[142],"layer,":[143],"while":[144],"II":[146],"gradually":[149],"stimulation":[152],"\u03b3-interferon":[154],"over":[155],"course":[157],"7":[159],"days.":[160],"vivo,":[162],"cell":[163,307],"engraftment":[164],"was":[165,196],"equivalent":[166],"two":[169,203],"treated":[170],"groups":[171,205,222],"1":[172],"week":[173,225],"4.5%":[175],"vs":[176,233,249],"3%,":[178],"p>0.05)":[179],"3":[181],"weeks":[182,240],"(<0.5%":[185],"both":[187,220],"groups).":[188],"At":[189],"same":[191,291],"time":[192],"points,":[193],"infarct":[194,257,287],"size":[195],"significantly":[197],"equally":[199],"reduced":[200],"cardiosphere-treated":[204,221],"compared":[206],"vehicle-treated":[209],"group":[210],"by":[211],"quantitative":[212],"morphometry.":[213],"Echocardiography":[214],"revealed":[215],"similar":[216],"functional":[217],"improvement":[218],"at":[223],"one":[224],"(EF":[226,244],"45.5\u00b12.9,":[228],"46.4":[230],"\u00b1":[231],"1.7":[232],"control":[234,250],"33.4\u00b11.7,":[235],"p<0.05":[236],")":[237],"three":[239],"follow":[242],"up":[243],"51.5\u00b11.9,":[246],"50.5\u00b12.2":[248],"31.9\u00b10.7,":[251],"p<0.05).":[252],"Histopathologic":[253],"evaluation":[254],"site":[258],"zone,":[262],"where":[263],"injected,":[268],"showed":[269],"no":[270],"signs":[271],"rejection.":[273],"CONCLUSION:":[274],"Allogeneic":[275],"engraft":[277],"heart,":[281],"cardiac":[283],"limit":[286],"size,":[288],"extent":[292],"ones,":[295],"without":[296],"evident":[297],"immune":[298],"reaction.":[299],"may":[301],"serve":[302],"an":[304],"effective":[305],"off-the-shelf":[306],"product":[308],"for":[309],"regeneration":[310]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}