{"id":"https://openalex.org/W66877726","doi":null,"title":"Biofilms and chronic rhinosinusitis: systematic review of evidence, current concepts and directions for research.","display_name":"Biofilms and chronic rhinosinusitis: systematic review of evidence, current concepts and directions for research.","publication_year":2007,"publication_date":"2007-03-01","ids":{"openalex":"https://openalex.org/W66877726","mag":"66877726","pmid":"https://pubmed.ncbi.nlm.nih.gov/17432062"},"language":"en","primary_location":{"id":"pmid:17432062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17432062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rhinology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049555902","display_name":"Richard J. Harvey","orcid":"https://orcid.org/0000-0002-6942-8975","observed_orcids":["https://orcid.org/0000-0002-6942-8975","https://orcid.org/0000-0002-9950-9792"]},"institutions":[{"id":"https://openalex.org/I4210135992","display_name":"Royal National Throat Nose and Ear Hospital","ror":"https://ror.org/03pf5zs64","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210135992"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R J Harvey","raw_affiliation_strings":["Rhinology Research Unit, The Royal National Throat, Nose and Ear Hospital, London, United Kingdom. richard@richardharvey.com.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rhinology Research Unit, The Royal National Throat, Nose and Ear Hospital, London, United Kingdom. richard@richardharvey.com.au","institution_ids":["https://openalex.org/I4210135992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033290575","display_name":"Valerie Joan Lund","orcid":"https://orcid.org/0000-0002-2503-2215","observed_orcids":["https://orcid.org/0000-0002-2503-2215"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V J Lund","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.9966,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.98340311,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"45","issue":"1","first_page":"3","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-rhinosinusitis","display_name":"chronic rhinosinusitis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/biofilm","display_name":"biofilm","score":0.9679999947547913},{"id":"https://openalex.org/keywords/staphylococcus-pneumoniae","display_name":"Staphylococcus pneumoniae","score":0.8090000152587891},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":1.0},{"id":"https://openalex.org/keywords/haemophilus-influenzae","display_name":"Haemophilus influenzae","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":1.0},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.6290000081062317},{"id":"https://openalex.org/keywords/frontal-sinusitis","display_name":"frontal sinusitis","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.9588301181793213},{"id":"https://openalex.org/C3019717275","wikidata":"https://www.wikidata.org/wiki/Q183344","display_name":"Chronic rhinosinusitis","level":2,"score":0.8224843740463257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7842172384262085},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5278361439704895},{"id":"https://openalex.org/C2777768476","wikidata":"https://www.wikidata.org/wiki/Q183344","display_name":"Sinusitis","level":2,"score":0.4305483102798462},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.41568320989608765},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.34314054250717163},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.23948204517364502},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22264650464057922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12818092107772827},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:17432062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17432062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rhinology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:933748","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/933748/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rhinology , 45 (1) pp. 3-13. (2007)","raw_type":"Article"},{"id":"mag:66877726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17432062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W24844467","https://openalex.org/W64390194","https://openalex.org/W75636495","https://openalex.org/W112131515","https://openalex.org/W159157973","https://openalex.org/W185168155","https://openalex.org/W658723397","https://openalex.org/W1480290341","https://openalex.org/W1572968422","https://openalex.org/W1579175606","https://openalex.org/W1820891978","https://openalex.org/W1876214410","https://openalex.org/W1877416461","https://openalex.org/W1930055114","https://openalex.org/W1933698511","https://openalex.org/W1968338138","https://openalex.org/W1975947879","https://openalex.org/W1980855939","https://openalex.org/W1981586910","https://openalex.org/W1981838802","https://openalex.org/W1985346406","https://openalex.org/W1987922328","https://openalex.org/W1990986432","https://openalex.org/W1991593566","https://openalex.org/W1994462493","https://openalex.org/W1995769287","https://openalex.org/W1995978242","https://openalex.org/W1996254542","https://openalex.org/W2007028941","https://openalex.org/W2008349272","https://openalex.org/W2008486583","https://openalex.org/W2012032571","https://openalex.org/W2016158447","https://openalex.org/W2021613721","https://openalex.org/W2030404620","https://openalex.org/W2031043669","https://openalex.org/W2031124217","https://openalex.org/W2034595187","https://openalex.org/W2035820635","https://openalex.org/W2036380708","https://openalex.org/W2037475501","https://openalex.org/W2038625884","https://openalex.org/W2048939836","https://openalex.org/W2050379675","https://openalex.org/W2062128984","https://openalex.org/W2062323906","https://openalex.org/W2065125298","https://openalex.org/W2066484939","https://openalex.org/W2066839192","https://openalex.org/W2070949591","https://openalex.org/W2074994852","https://openalex.org/W2078351117","https://openalex.org/W2079121915","https://openalex.org/W2079698171","https://openalex.org/W2087013744","https://openalex.org/W2089116229","https://openalex.org/W2096210343","https://openalex.org/W2096684565","https://openalex.org/W2104436632","https://openalex.org/W2105173502","https://openalex.org/W2105668748","https://openalex.org/W2105742456","https://openalex.org/W2111049647","https://openalex.org/W2113186567","https://openalex.org/W2114298708","https://openalex.org/W2115574740","https://openalex.org/W2116156866","https://openalex.org/W2118801485","https://openalex.org/W2119608865","https://openalex.org/W2122115838","https://openalex.org/W2122608498","https://openalex.org/W2122721391","https://openalex.org/W2122836009","https://openalex.org/W2126579640","https://openalex.org/W2130168291","https://openalex.org/W2131090972","https://openalex.org/W2131727615","https://openalex.org/W2133059828","https://openalex.org/W2134515577","https://openalex.org/W2135162586","https://openalex.org/W2136734720","https://openalex.org/W2138143534","https://openalex.org/W2138371382","https://openalex.org/W2142027037","https://openalex.org/W2142231730","https://openalex.org/W2142232626","https://openalex.org/W2143034026","https://openalex.org/W2143259318","https://openalex.org/W2144440398","https://openalex.org/W2150389007","https://openalex.org/W2150823065","https://openalex.org/W2152982816","https://openalex.org/W2155327463","https://openalex.org/W2156382695","https://openalex.org/W2158458733","https://openalex.org/W2162335168","https://openalex.org/W2163182389","https://openalex.org/W2164749696","https://openalex.org/W2167324010","https://openalex.org/W2170113031","https://openalex.org/W2171050239","https://openalex.org/W2171527366","https://openalex.org/W2320818646","https://openalex.org/W2993259418"],"related_works":["https://openalex.org/W2104260552","https://openalex.org/W2065319150","https://openalex.org/W4416266292","https://openalex.org/W2804964790","https://openalex.org/W1991563198","https://openalex.org/W7015085947","https://openalex.org/W2013489712","https://openalex.org/W2409134857","https://openalex.org/W2101363729","https://openalex.org/W4382344534"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Chronic":[1],"rhinosinusitis":[2,61],"(CRS)":[3],"possesses":[4],"the":[5,18,24,27,51,194,211],"hallmarks":[6],"of":[7,17,26,50,80,85,115,147],"biofilm":[8,34,95,128,144,171],"mediated":[9],"disease.":[10],"This":[11],"paper":[12],"represents":[13],"a":[14,159,207],"systematic":[15,48],"review":[16,49],"published":[19,52],"evidence":[20,108],"for":[21,42,54,109,201],"biofilms":[22,55,86,110],"as":[23],"mediator":[25],"inflammation":[28],"in":[29,59,87,97,111,123,130,154,165,173,193,210],"CRS.":[30,88,116],"Current":[31],"concepts":[32],"on":[33],"formation":[35,129],"and":[36,40,56,67,139],"properties,":[37],"treatment":[38],"strategies":[39],"directions":[41],"research":[43,84,186],"are":[44,180],"discussed.":[45],"METHODS:":[46],"A":[47],"literature":[53],"their":[57,191],"role":[58,192],"chronic":[60],"was":[62,152,162],"undertaken.":[63],"Both":[64],"Medline":[65],"(1966-2006)":[66],"Embase":[68],"(1988-2006)":[69],"were":[70,91,121],"searched":[71],"until":[72],"November":[73],"2006":[74],"which":[75,81],"yielded":[76],"652":[77],"articles,":[78],"13":[79],"provided":[82],"original":[83],"RESULTS:":[89],"There":[90,197],"7":[92],"studies":[93],"demonstrating":[94],"morphology":[96],"mucosal":[98],"samples":[99],"from":[100],"human":[101],"CRS":[102],"patients.":[103],"One":[104,168],"study":[105,125,169],"showed":[106],"similar":[107],"an":[112],"animal":[113],"model":[114],"FISH":[117],"techniques":[118],"with":[119,158,182],"CLSM":[120],"employed":[122],"one":[124],"to":[126,189],"demonstrate":[127],"situ":[131],"by":[132],"S.":[133,135],"pneumoniae,":[134],"aureus,":[136],"H.":[137],"influenza":[138],"P.":[140],"aeruginosa.":[141],"In":[142],"vitro":[143],"forming":[145],"capacity":[146],"microbiological":[148],"samples,":[149],"after":[150],"culture,":[151],"assessed":[153],"two":[155],"studies.":[156],"Correlation":[157],"clinical":[160],"outcome":[161],"also":[163],"made":[164],"these":[166],"papers.":[167],"demonstrated":[170],"growth":[172],"removed":[174],"frontal":[175],"sinus":[176],"stents.":[177],"CONCLUSIONS:":[178],"Biofilms":[179,204],"associated":[181],"CRS,":[183],"however,":[184],"little":[185],"is":[187,198],"available":[188],"define":[190],"pathogenic":[195],"process.":[196,213],"tremendous":[199],"potential":[200],"future":[202],"research.":[203],"may":[205],"be":[206],"significant":[208],"factor":[209],"inflammatory":[212]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
