{"id":"https://openalex.org/W66698535","doi":null,"title":"[Assessment of early immunosuppressive therapy in the prevention of complications of Graves' disease].","display_name":"[Assessment of early immunosuppressive therapy in the prevention of complications of Graves' disease].","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W66698535","mag":"66698535","pmid":"https://pubmed.ncbi.nlm.nih.gov/15789920"},"language":"pl","primary_location":{"id":"pmid:15789920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15789920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Przeglad lekarski","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038062933","display_name":"Bohdan Huszno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Bohdan Huszno","raw_affiliation_strings":["Katedra i Klinika Endokrynologii Collegium Medicum Uniwersytetu Jagiellorskiego w Krakowie. huszno@endo.cm-uj.krakow.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Katedra i Klinika Endokrynologii Collegium Medicum Uniwersytetu Jagiellorskiego w Krakowie. huszno@endo.cm-uj.krakow.pl","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002155077","display_name":"Ma\u0142gorzata Trofimiuk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ma\u0142gorzata Trofimiuk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001493866","display_name":"Filip Go\u0142kowski","orcid":"https://orcid.org/0000-0002-0311-8157","observed_orcids":["https://orcid.org/0000-0002-0311-8157"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Filip Go\u0142kowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052009334","display_name":"Tadeusz Plinta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tadeusz Plinta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5026526102","display_name":"Z Szybi\u0144ski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zbigniew Szybi\u0144ski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.00989623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"61","issue":"8","first_page":"868","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.13539999723434448,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graves-disease","display_name":"Graves' disease","score":1.0},{"id":"https://openalex.org/keywords/azathioprine","display_name":"azathioprine","score":0.8199999928474426},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.9490000009536743},{"id":"https://openalex.org/keywords/antithyroid-drugs","display_name":"antithyroid drugs","score":0.9240000247955322},{"id":"https://openalex.org/keywords/ophthalmopathy","display_name":"ophthalmopathy","score":0.6290000081062317},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.6420000195503235},{"id":"https://openalex.org/keywords/goiter","display_name":"goiter","score":0.7540000081062317},{"id":"https://openalex.org/keywords/leukopenia","display_name":"leukopenia","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2776760755","wikidata":"https://www.wikidata.org/wiki/Q18939","display_name":"Azathioprine","level":3,"score":0.9374797344207764},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9328688383102417},{"id":"https://openalex.org/C2776652619","wikidata":"https://www.wikidata.org/wiki/Q16483","display_name":"Graves' disease","level":3,"score":0.631749153137207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5782544612884521},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.561855137348175},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.561598002910614},{"id":"https://openalex.org/C2778330430","wikidata":"https://www.wikidata.org/wiki/Q249619","display_name":"Immunosuppressive drug","level":3,"score":0.5344074964523315},{"id":"https://openalex.org/C2909564963","wikidata":"https://www.wikidata.org/wiki/Q1365501","display_name":"Antithyroid drugs","level":4,"score":0.5299423933029175},{"id":"https://openalex.org/C2778062832","wikidata":"https://www.wikidata.org/wiki/Q498902","display_name":"Drug withdrawal","level":3,"score":0.4610520899295807},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.45762571692466736},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4412074089050293},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.43184882402420044},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3787420392036438},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.17285239696502686},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.07785394787788391},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001379","descriptor_name":"Azathioprine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008713","descriptor_name":"Methimazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013971","descriptor_name":"Thyrotoxicosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013971","descriptor_name":"Thyrotoxicosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:15789920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15789920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Przeglad lekarski","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2369416542","https://openalex.org/W2338074326","https://openalex.org/W7139288388","https://openalex.org/W2373721693","https://openalex.org/W4402514163","https://openalex.org/W4405655054","https://openalex.org/W2053035828","https://openalex.org/W2043679683","https://openalex.org/W2566519266","https://openalex.org/W1985998616"],"abstract_inverted_index":{"UNLABELLED:":[0],"Regardless":[1],"the":[2,8,28,40,45,57,60,63,82,107,127,143,192,209,261,297],"autoimmune":[3,52],"origin":[4],"of":[5,11,19,30,39,47,51,59,65,99,121,133,199,206,237,278,287,305],"Graves'":[6,87,279,299],"disease,":[7],"preferred":[9],"method":[10],"its":[12,66,306],"treatment":[13,50,128,137,161,247,274,301],"remains":[14],"antithyroid":[15,105,232],"drug":[16,164],"administration.":[17],"Use":[18],"immunosuppressive":[20,49,273],"agents":[21],"(mostly":[22],"steroids)":[23],"is":[24],"still":[25],"limited":[26],"to":[27,43,130,245,249,296],"therapy":[29,147],"disease":[31,61,187,280,300],"complications,":[32],"such":[33],"as":[34],"proliferative":[35],"ophthalmopathy.":[36],"The":[37,68,89,119,136,186,235,285],"aim":[38],"study":[41,69],"was":[42,124,138,149,153,189,211],"assess":[44],"influence":[46],"early":[48,272],"thyrotoxicosis":[53,283],"with":[54,86,104,177,225,231,294],"azathioprine":[55,113,220,288],"on":[56],"course":[58],"and":[62,75,202,256,282,302],"incidence":[64],"complications.":[67,307],"comprised":[70],"64":[71],"patients":[72,101,157,174,198,236,293],"(47":[73],"females":[74],"17":[76],"males":[77],"aged":[78],"20-43":[79],"years)":[80],"for":[81,140],"first":[83],"time":[84],"diagnosed":[85],"disease.":[88],"subjects":[90,110,227],"were":[91,114,167,184,240],"randomised":[92],"into":[93,116],"two":[94],"groups.":[95],"Group":[96],"I":[97,201,239],"consisted":[98],"28":[100],"treated":[102,176,229],"only":[103,230],"drugs,":[106],"remaining":[108],"36":[109],"additionally":[111,175,219],"receiving":[112,218],"included":[115],"group":[117,170,200,207,238],"II.":[118],"dose":[120],"both":[122,264],"drugs":[123,233],"adjusted":[125],"during":[126,191],"according":[129],"metabolic":[131],"status":[132],"each":[134],"patients.":[135],"continued":[139],"8-14":[141],"months,":[142],"follow-up":[144,193],"duration":[145],"after":[146,160],"withdrawal":[148],"5":[150,254],"years.":[151],"Euthyreosis":[152],"achieved":[154],"in":[155,169,195,203,292,303],"all":[156],"2-8":[158],"weeks":[159],"initiation.":[162],"No":[163],"intolerance":[165],"symptoms":[166,223],"observed":[168,190],"I.":[171],"In":[172],"four":[173],"azathioprine,":[178],"gastrointestinal":[179],"side":[180],"effects":[181],"or":[182],"leucopenia":[183],"present.":[185],"relapse":[188],"period":[194],"15":[196],"(53.5%)":[197],"3":[204],"(8.3%)":[205],"II,":[208],"difference":[210,262],"statistically":[212,268],"significant":[213],"(p<0.01).":[214],"Only":[215],"one":[216],"patient":[217],"presented":[221],"ophthalmic":[222],"compared":[224],"seven":[226],"(25%)":[228],"(p<0.001).":[234],"also":[241],"more":[242],"frequently":[243],"referred":[244],"surgical":[246],"due":[248],"rapid":[250],"goitre":[251],"growth":[252],"(accordingly":[253],"(17.8%)":[255],"1":[257],"(2.7%)":[258],"patients,":[259],"p=0.07),":[260],"between":[263],"groups":[265],"not":[266],"being":[267],"significant.":[269],"CONCLUSIONS:":[270],"Additional":[271],"significantly":[275],"decreased":[276],"frequency":[277],"complications":[281],"recurrence.":[284],"use":[286],"may":[289],"be":[290],"advised":[291],"contraindications":[295],"radical":[298],"prophylaxis":[304]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
