{"id":"https://openalex.org/W66655774","doi":null,"title":"Effects of zolpidem on the architecture and cyclical structure of sleep in poor sleepers.","display_name":"Effects of zolpidem on the architecture and cyclical structure of sleep in poor sleepers.","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W66655774","mag":"66655774","pmid":"https://pubmed.ncbi.nlm.nih.gov/8529530"},"language":"en","primary_location":{"id":"pmid:8529530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8529530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs under experimental and clinical research","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105774281","display_name":"Alain Besset","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112060","display_name":"H\u00f4pital Gui de Chauliac","ror":"https://ror.org/02w35z347","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210093292","https://openalex.org/I4210112060"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Besset","raw_affiliation_strings":["Sleep and Waking Disorders Unit, Gui de Chauliac Hospital, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep and Waking Disorders Unit, Gui de Chauliac Hospital, Montpellier, France","institution_ids":["https://openalex.org/I4210112060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020640175","display_name":"Mehdi Tafti","orcid":"https://orcid.org/0000-0002-6997-3914","observed_orcids":["https://orcid.org/0000-0002-6997-3914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tafti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065956572","display_name":"Eric Villemin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Villemin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029145346","display_name":"Pascal Borderies","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Borderies","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113658825","display_name":"Michel M. Billiard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Billiard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2768,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.77435002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"21","issue":"4","first_page":"161","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zolpidem","display_name":"zolpidem","score":1.0},{"id":"https://openalex.org/keywords/poor-sleepers","display_name":"poor sleepers","score":0.8289999961853027},{"id":"https://openalex.org/keywords/sleep-architecture","display_name":"sleep architecture","score":0.7319999933242798},{"id":"https://openalex.org/keywords/sleep-onset-latency","display_name":"sleep latency","score":0.574999988079071},{"id":"https://openalex.org/keywords/total-sleep-time","display_name":"total sleep time","score":0.7129999995231628},{"id":"https://openalex.org/keywords/awakening","display_name":"awakening","score":0.7490000128746033},{"id":"https://openalex.org/keywords/rebound-insomnia","display_name":"rebound insomnia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/non-benzodiazepine-hypnotics","display_name":"non-benzodiazepine hypnotics","score":0.9039999842643738},{"id":"https://openalex.org/keywords/sleep-continuity","display_name":"sleep continuity","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C2777123777","wikidata":"https://www.wikidata.org/wiki/Q218842","display_name":"Zolpidem","level":3,"score":0.9729551076889038},{"id":"https://openalex.org/C2780930544","wikidata":"https://www.wikidata.org/wiki/Q62962","display_name":"Hypnotic","level":2,"score":0.8819391131401062},{"id":"https://openalex.org/C2778537899","wikidata":"https://www.wikidata.org/wiki/Q254034","display_name":"Bedtime","level":2,"score":0.7824712991714478},{"id":"https://openalex.org/C20566671","wikidata":"https://www.wikidata.org/wiki/Q1752878","display_name":"Non-rapid eye movement sleep","level":3,"score":0.6567509174346924},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.64149409532547},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.6338809132575989},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5907711386680603},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.5262526869773865},{"id":"https://openalex.org/C2910364982","wikidata":"https://www.wikidata.org/wiki/Q35831","display_name":"Sleep Stages","level":4,"score":0.4843517541885376},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.48298919200897217},{"id":"https://openalex.org/C31094802","wikidata":"https://www.wikidata.org/wiki/Q7539756","display_name":"Sleep induction","level":3,"score":0.46972692012786865},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4629562497138977},{"id":"https://openalex.org/C153050134","wikidata":"https://www.wikidata.org/wiki/Q760256","display_name":"Eye movement","level":2,"score":0.43201541900634766},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.43080294132232666},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.427846759557724},{"id":"https://openalex.org/C63759246","wikidata":"https://www.wikidata.org/wiki/Q7539762","display_name":"Sleep onset","level":3,"score":0.4103473424911499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1909567415714264},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16154533624649048},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.12346890568733215},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077334","descriptor_name":"Zolpidem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012893","descriptor_name":"Sleep Wake Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012894","descriptor_name":"Sleep Stages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012895","descriptor_name":"Sleep, REM","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8529530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8529530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs under experimental and clinical research","raw_type":"Clinical Trial"},{"id":"mag:66655774","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8529530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2050783298","https://openalex.org/W2437233855","https://openalex.org/W2034669842","https://openalex.org/W2150194133","https://openalex.org/W2076247680","https://openalex.org/W2068649357","https://openalex.org/W1762892354","https://openalex.org/W2079503940","https://openalex.org/W70002175","https://openalex.org/W2412682918"],"abstract_inverted_index":{"Effects":[0],"of":[1,71,79,105,135,148,151,167,178],"zolpidem,":[2],"a":[3,33,87,116],"short":[4],"acting":[5],"non":[6],"benzodiazepine":[7],"hypnotic,":[8],"have":[9],"been":[10],"studied":[11],"in":[12,121],"eight":[13],"female":[14],"poor":[15,91],"sleepers,":[16],"aged":[17],"25":[18],"to":[19,32,132],"54":[20],"years,":[21],"documented":[22],"during":[23,107,144,174],"two":[24,122],"consecutive":[25],"adaptation":[26],"nights.":[27,110],"Subjects":[28],"were":[29,62,81],"recorded":[30,109],"according":[31],"22":[34],"day":[35],"single":[36],"blind":[37],"study.":[38],"Placebo":[39],"was":[40,119],"given":[41],"orally":[42],"at":[43],"bedtime":[44],"on":[45,49,55,64,90,186],"nights":[46,50,56,65,147],"2-4,":[47],"zolpidem":[48,182],"5-20":[51],"and":[52,76,101,138,170],"finally":[53],"placebo":[54],"21-22.":[57],"Polygraphic":[58],"recordings":[59],"(conventional":[60],"analysis)":[61],"performed":[63],"1-6;":[66],"12,":[67],"13;":[68],"19-22.":[69],"Parameters":[70],"sleep":[72,74,80,95,99,160,188],"continuity,":[73],"architecture":[75],"cyclical":[77],"structure":[78,162],"studied.":[82],"Zolpidem":[83,125],"10":[84],"mg":[85],"showed":[86,163],"hypnotic":[88],"effect":[89,185],"sleepers.":[92],"It":[93],"reduced":[94],"latency,":[96],"increased":[97],"total":[98],"time":[100],"decreased":[102],"the":[103,112,133,145,152,165,175,179],"number":[104],"awakenings":[106],"all":[108],"During":[111],"first":[113,146,176],"post-drug":[114],"night":[115],"rebound":[117],"insomnia":[118],"observed":[120],"subjects":[123],"only.":[124],"did":[126],"not":[127],"increase":[128,166],"specifically":[129],"stage":[130],"2":[131],"detriment":[134],"stages":[136,168],"3":[137,169],"4":[139,171],"but":[140],"it":[141],"restored":[142],"them":[143],"administration.":[149],"Study":[150],"rapid":[153,156],"eye":[154,157],"movements-non":[155],"movements":[158],"(REM-NREM)":[159],"cycles":[161],"that":[164],"occurred":[172],"only":[173],"part":[177],"night.":[180],"Finally,":[181],"had":[183],"no":[184],"REM":[187],"temporal":[189],"distribution.":[190]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}