{"id":"https://openalex.org/W66625871","doi":"https://doi.org/10.1016/b978-012373961-2.00094-1","title":"GLIA/ASTROCYTES | Glial-Mediated Mechanisms of Epileptogenesis in Tuberous Sclerosis","display_name":"GLIA/ASTROCYTES | Glial-Mediated Mechanisms of Epileptogenesis in Tuberous Sclerosis","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W66625871","doi":"https://doi.org/10.1016/b978-012373961-2.00094-1","mag":"66625871"},"language":"en","primary_location":{"id":"doi:10.1016/b978-012373961-2.00094-1","doi":"https://doi.org/10.1016/b978-012373961-2.00094-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-012373961-2.00094-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Basic Epilepsy Research","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4206435554","display_name":"Encyclopedia of Basic Epilepsy Research"},"type":"reference-entry","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"L.H. Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.H. Zeng","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO, USA","Washington University, School of Medicine, St. Louis, MO, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University, School of Medicine, St. Louis, MO, USA;","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065106421","display_name":"David H. Gutmann","orcid":"https://orcid.org/0000-0002-3127-5045","observed_orcids":["https://orcid.org/0000-0002-3127-5045"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210164563","display_name":"Neurology, Inc","ror":"https://ror.org/05ne0gd95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210164563"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.H. Gutmann","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO, USA","Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Neurology","institution_ids":["https://openalex.org/I4210164563"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058587345","display_name":"Michael L. Wong","orcid":"https://orcid.org/0000-0002-3796-743X","observed_orcids":["https://orcid.org/0000-0002-3796-743X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Wong","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, MO, USA","Washington University, School of Medicine, St. Louis, MO, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University, School of Medicine, St. Louis, MO, USA;","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"391","last_page":"397"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.0706000030040741,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberous-sclerosis-complex","display_name":"tuberous sclerosis complex","score":0.9959999918937683},{"id":"https://openalex.org/keywords/epileptogenesis","display_name":"epileptogenesis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/glia","display_name":"glia","score":0.8169999718666077},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tsc1","display_name":"TSC1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/astrocyte-proliferation","display_name":"astrocyte proliferation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/glutamate-uptake","display_name":"glutamate uptake","score":0.9779999852180481},{"id":"https://openalex.org/keywords/potassium-homeostasis","display_name":"potassium homeostasis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.6909999847412109},{"id":"https://openalex.org/keywords/spontaneous-seizures","display_name":"spontaneous seizures","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C57236427","wikidata":"https://www.wikidata.org/wiki/Q5382987","display_name":"Epileptogenesis","level":3,"score":0.983567476272583},{"id":"https://openalex.org/C2778980267","wikidata":"https://www.wikidata.org/wiki/Q1362721","display_name":"Tuberous sclerosis","level":2,"score":0.8408718109130859},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7703062295913696},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.7574344873428345},{"id":"https://openalex.org/C2776773979","wikidata":"https://www.wikidata.org/wiki/Q898669","display_name":"TSC1","level":4,"score":0.7246037125587463},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6831664443016052},{"id":"https://openalex.org/C2777594495","wikidata":"https://www.wikidata.org/wiki/Q5569540","display_name":"Glial scar","level":4,"score":0.5116215348243713},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.4846208989620209},{"id":"https://openalex.org/C2780884517","wikidata":"https://www.wikidata.org/wiki/Q177105","display_name":"Neuroglia","level":3,"score":0.42489033937454224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38700753450393677},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2828066647052765},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25307998061180115},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.24413380026817322},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2427786886692047},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.23653241991996765},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17685160040855408},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11315903067588806},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06289336085319519}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-012373961-2.00094-1","doi":"https://doi.org/10.1016/b978-012373961-2.00094-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-012373961-2.00094-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Basic Epilepsy Research","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.75,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1867691379","https://openalex.org/W1952006903","https://openalex.org/W1995814484","https://openalex.org/W1997557640","https://openalex.org/W2014298077","https://openalex.org/W2059246723","https://openalex.org/W2061066931","https://openalex.org/W2069499439","https://openalex.org/W2074077310","https://openalex.org/W2092491756","https://openalex.org/W2102561151","https://openalex.org/W2105709022","https://openalex.org/W2112374487","https://openalex.org/W2140657162","https://openalex.org/W2383259826"],"related_works":["https://openalex.org/W3032641101","https://openalex.org/W1931685279","https://openalex.org/W2070399526","https://openalex.org/W94148435","https://openalex.org/W2509245279","https://openalex.org/W3202266851","https://openalex.org/W2278057409","https://openalex.org/W2417624839","https://openalex.org/W2176581559","https://openalex.org/W2222141033"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2025-10-10T00:00:00"}