{"id":"https://openalex.org/W66556493","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1089-a","title":"Abstract 1252: A Multimarker Strategy for Risk Prediction in Heart Failure: Application of Novel Methods in a Community Cohort","display_name":"Abstract 1252: A Multimarker Strategy for Risk Prediction in Heart Failure: Application of Novel Methods in a Community Cohort","publication_year":2008,"publication_date":"2008-10-28","ids":{"openalex":"https://openalex.org/W66556493","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1089-a","mag":"66556493"},"language":"en","primary_location":{"id":"doi:10.1161/circ.118.suppl_18.s_1089-a","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1089-a","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_1089-a","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084957131","display_name":"Shannon M. Dunlay","orcid":"https://orcid.org/0000-0001-5145-7420","observed_orcids":["https://orcid.org/0000-0001-5145-7420"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon M Dunlay","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022688129","display_name":"Yariv Gerber","orcid":"https://orcid.org/0000-0003-4287-8754","observed_orcids":["https://orcid.org/0000-0003-4287-8754"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yariv Gerber","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105422086","display_name":"Susan A. Weston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan A Weston","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025883880","display_name":"Jill M. Killian","orcid":"https://orcid.org/0000-0003-3906-4020","observed_orcids":["https://orcid.org/0000-0003-3906-4020"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill M Killian","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028644714","display_name":"Margaret M. Redfield","orcid":"https://orcid.org/0000-0002-0946-7518","observed_orcids":["https://orcid.org/0000-0002-0946-7518"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret M Redfield","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"suppl_18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.8450000286102295},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9950000047683716},{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/troponin-t","display_name":"troponin T","score":0.9980000257492065},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6100000143051147},{"id":"https://openalex.org/keywords/net-reclassification-improvement","display_name":"net reclassification improvement","score":0.8610000014305115},{"id":"https://openalex.org/keywords/integrated-discrimination-improvement","display_name":"integrated discrimination improvement","score":0.9950000047683716},{"id":"https://openalex.org/keywords/community-based-cohort","display_name":"community-based cohort","score":0.5339999794960022},{"id":"https://openalex.org/keywords/risk-discrimination","display_name":"risk discrimination","score":0.4869999885559082},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7960000038146973},{"id":"https://openalex.org/keywords/olmsted-county-minnesota","display_name":"Olmsted County, Minnesota","score":0.7590000033378601},{"id":"https://openalex.org/keywords/risk-factors-for-heart-failure","display_name":"heart failure risk","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9512666463851929},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7173594832420349},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.584698498249054},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5398523211479187},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5306189060211182},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.5221419930458069},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.49204108119010925},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.48674893379211426},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.47557154297828674},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4646591246128082},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.44727569818496704},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.4170495867729187},{"id":"https://openalex.org/C2777984932","wikidata":"https://www.wikidata.org/wiki/Q7336293","display_name":"Risk of mortality","level":2,"score":0.41208094358444214},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.19634884595870972},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.1423363983631134},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.118.suppl_18.s_1089-a","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1089-a","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_1089-a","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7098355085","https://openalex.org/W2159405064","https://openalex.org/W7219525152","https://openalex.org/W2098833615","https://openalex.org/W2589686046","https://openalex.org/W2111425862","https://openalex.org/W2344537348","https://openalex.org/W2048808386","https://openalex.org/W1988895199","https://openalex.org/W2104174124"],"abstract_inverted_index":{"Introduction:":[0],"Mortality":[1],"among":[2],"patients":[3,135],"with":[4,76,142,160,173,199,202],"heart":[5],"failure":[6],"(HF)":[7],"is":[8],"high.":[9],"Though":[10],"individual":[11],"biomarkers":[12,164,175,235,242],"have":[13],"been":[14],"studied":[15],"to":[16,62,81,87,100,222,253],"determine":[17,48],"their":[18],"value":[19],"in":[20,29,38,244,247,268,292,311],"risk":[21,34,64,69,105,110,227,269,296,309],"prediction,":[22,228],"the":[23,151,155,166,177,223,229,248,287,326],"role":[24],"of":[25,95,208,231,260,280,289,299],"a":[26,39,101,256,264,300],"multimarker":[27,301],"strategy":[28,302],"predicting":[30],"mortality":[31,68,109,157,184,226,291],"above":[32,165,176],"established":[33,63,104,295],"indicators":[35,65,106],"requires":[36],"evaluation":[37],"relevant":[40],"cohort":[41],"using":[42,112],"robust":[43],"analytical":[44],"methods.":[45],"Objective:":[46],"To":[47],"whether":[49,93],"adding":[50,216],"C-reactive":[51],"protein":[52],"(CRP),":[53],"B-type":[54],"natriuretic":[55],"peptide":[56],"(BNP),":[57],"and":[58,98,147,171,194,212,219,263,283,306],"troponin":[59],"T":[60],"(TnT)":[61],"improved":[66,107,225,286],"HF":[67,77,293,312],"prediction.":[70],"Methods:":[71],"Olmsted":[72],"County":[73],"residents":[74],"presenting":[75],"from":[78,251,325],"July":[79],"2004":[80],"September":[82],"2007":[83],"were":[84,196],"prospectively":[85],"recruited":[86],"undergo":[88],"biomarker":[89],"measurement.":[90],"We":[91],"investigated":[92],"addition":[94],"CRP,":[96,192,217,281,304],"BNP,":[97,193,218,282,305],"TnT":[99,148,195,220,284,307],"model":[102,224],"including":[103,303],"6-month":[108,183,290],"prediction":[111,288,310],"multiple":[113],"methods":[114],"(":[115],"c":[116,249],"statistic,":[117],"net":[118,257],"reclassification":[119,258],"index,":[120],"integrated":[121],"discrimination":[122,270,272],"improvement).":[123],"Results:":[124],"Of":[125],"566":[126],"participants":[127],"(mean":[128],"age":[129],"77\u00b113":[130],"years,":[131],"48%":[132],"male),":[133],"87(15%)":[134],"died":[136],"after":[137],"6":[138],"months":[139],"follow-up.":[140],"Patients":[141],"CRP":[143],"(<12.1mg/L),":[144],"BNP":[145],"(<341pg/mL),":[146],"(\u22650.01ng/mL)":[149],"below":[150],"median":[152,167,178],"(n=112)":[153],"had":[154,168,180],"lowest":[156],"(3%),":[158],"those":[159,172],"one":[161],"or":[162,233,321],"two":[163,232],"intermediate":[169],"mortality,":[170,201],"all":[174,241],"(n=105)":[179],"markedly":[181,285],"increased":[182,200],"(33%).":[185],"After":[186],"adjustment":[187],"for":[188,308],"other":[189],"predictors,":[190],"higher":[191],"each":[197],"associated":[198],"odds":[203],"ratios":[204],"(95%":[205],"confidence":[206],"intervals)":[207],"1.66(1.24":[209],"\u20132.24),":[210],"2.06(1.42\u20133.07),":[211],"1.45(1.12\u20131.87),":[213],"respectively.":[214],"While":[215],"individually":[221],"combination":[230],"more":[234],"offered":[236],"greater":[237],"incremental":[238],"benefit.":[239],"Using":[240],"resulted":[243],"an":[245],"increase":[246],"statistic":[250],"0.747":[252],"0.832":[254],"(p<0.001),":[255,262],"index":[259],"0.33":[261],"100%":[265],"relative":[266],"improvement":[267,273],"(integrated":[271],"0.097,":[274],"p<0.001).":[275],"Conclusions:":[276],"The":[277],"combined":[278],"use":[279],"beyond":[294],"indicators.":[297],"Implementation":[298],"should":[313],"be":[314],"considered.":[315],"This":[316],"research":[317],"has":[318],"received":[319],"full":[320],"partial":[322],"funding":[323],"support":[324],"American":[327],"Heart":[328],"Association,":[329],"AHA":[330],"Midwest":[331],"Affiliate":[332],"(Illinois,":[333],"Indiana,":[334],"Iowa,":[335],"Kansas,":[336],"Michigan,":[337],"Minnesota,":[338],"Missouri,":[339],"Nebraska,":[340],"North":[341],"Dakota,":[342],"South":[343],"Dakota":[344],"&":[345],"Wisconsin).":[346]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}