{"id":"https://openalex.org/W66478222","doi":"https://doi.org/10.1023/a:1010931127745","title":"Long-Circulating PEGylated Polycyanoacrylate Nanoparticles as New Drug Carrier for Brain Delivery","display_name":"Long-Circulating PEGylated Polycyanoacrylate Nanoparticles as New Drug Carrier for Brain Delivery","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W66478222","doi":"https://doi.org/10.1023/a:1010931127745","mag":"66478222","pmid":"https://pubmed.ncbi.nlm.nih.gov/11587488"},"language":"en","primary_location":{"id":"doi:10.1023/a:1010931127745","doi":"https://doi.org/10.1023/a:1010931127745","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1010931127745","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049690530","display_name":"Pilar Calvo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210117966","display_name":"Institut Galien Paris-Saclay","ror":"https://ror.org/02mnw9q71","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210117966","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pilar Calvo","raw_affiliation_strings":["Universit\u00e9  Paris-Sud XI, UMR CNRS 8612, Physico-Chimie, Pharmacotechnie, Biopharmacie, Ch\u00e2tenay-Malabry, France","Physico-Chimie, Pharmacotechnie, Biopharmacie, Universit\u00e9 Paris-Sud XI, UMR CNRS 8612, Ch\u00e2tenay-Malabry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9  Paris-Sud XI, UMR CNRS 8612, Physico-Chimie, Pharmacotechnie, Biopharmacie, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Physico-Chimie, Pharmacotechnie, Biopharmacie, Universit\u00e9 Paris-Sud XI, UMR CNRS 8612, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590","https://openalex.org/I4210117966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065994084","display_name":"Bruno Gouritin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Gouritin","raw_affiliation_strings":["Universit\u00e9 Paris-Sud XI, UPRES/EA 2706, 5, rue Jean Baptiste Cl\u00e9ment, 92296, Ch\u00e2tenay-Malabry, France","Universit\u00e9 Paris-Sud XI, UPRES/EA 2706, Ch\u00e2tenay-Malabry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Sud XI, UPRES/EA 2706, 5, rue Jean Baptiste Cl\u00e9ment, 92296, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud XI, UPRES/EA 2706, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029094457","display_name":"H\u00e9l\u00e8ne Chacun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210117966","display_name":"Institut Galien Paris-Saclay","ror":"https://ror.org/02mnw9q71","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210117966","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e8ne Chacun","raw_affiliation_strings":["Physico-Chimie, Pharmacotechnie, Biopharmacie, Universit\u00e9 Paris-Sud XI, UMR CNRS 8612, 5, rue Jean Baptiste Cl\u00e9ment, 92296, Ch\u00e2tenay-Malabry, France","Physico-Chimie, Pharmacotechnie, Biopharmacie, Universit\u00e9 Paris-Sud XI, UMR CNRS 8612, Ch\u00e2tenay-Malabry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physico-Chimie, Pharmacotechnie, Biopharmacie, Universit\u00e9 Paris-Sud XI, UMR CNRS 8612, 5, rue Jean Baptiste Cl\u00e9ment, 92296, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590","https://openalex.org/I4210117966"]},{"raw_affiliation_string":"Physico-Chimie, Pharmacotechnie, Biopharmacie, Universit\u00e9 Paris-Sud XI, UMR CNRS 8612, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590","https://openalex.org/I4210117966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013203026","display_name":"Didier Desma\u00eble","orcid":"https://orcid.org/0000-0003-4013-4655","observed_orcids":["https://orcid.org/0000-0003-4013-4655"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Didier Desma\u00eble","raw_affiliation_strings":["Chimie Organique, Universit\u00e9 Paris-Sud XI, URA CNRS 1843, 5, rue Jean Baptiste Cl\u00e9ment, 92296, Ch\u00e2tenay-Malabry, France","Chimie Organique, Universit\u00e9 Paris-Sud XI, URA CNRS 1843, Ch\u00e2tenay-Malabry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chimie Organique, Universit\u00e9 Paris-Sud XI, URA CNRS 1843, 5, rue Jean Baptiste Cl\u00e9ment, 92296, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Chimie Organique, Universit\u00e9 Paris-Sud XI, URA CNRS 1843, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103509520","display_name":"Jean d\u2019Angelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean D'Angelo","raw_affiliation_strings":["Chimie Organique, Universit\u00e9 Paris-Sud XI, URA CNRS 1843, 5, rue Jean Baptiste Cl\u00e9ment, 92296, Ch\u00e2tenay-Malabry, France","Chimie Organique, Universit\u00e9 Paris-Sud XI, URA CNRS 1843, Ch\u00e2tenay-Malabry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chimie Organique, Universit\u00e9 Paris-Sud XI, URA CNRS 1843, 5, rue Jean Baptiste Cl\u00e9ment, 92296, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Chimie Organique, Universit\u00e9 Paris-Sud XI, URA CNRS 1843, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113563615","display_name":"J. P. No\u00ebl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I2801360556","display_name":"CEA Paris-Saclay - Etablissement de Saclay","ror":"https://ror.org/01fv25t22","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I2801360556","https://openalex.org/I4210128565"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Noel","raw_affiliation_strings":["Service des Molecules Marqu\u00e9es, CEA/Saclay bat, 547, 91191, Gif sur Yvette, France","Service des Molecules Marqu\u00e9es, CEA/Saclay bat, 547, Gif sur Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service des Molecules Marqu\u00e9es, CEA/Saclay bat, 547, 91191, Gif sur Yvette, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I2801360556","https://openalex.org/I4210128565"]},{"raw_affiliation_string":"Service des Molecules Marqu\u00e9es, CEA/Saclay bat, 547, Gif sur Yvette, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I2801360556","https://openalex.org/I4210128565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029157827","display_name":"Dominique Georgin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I2801360556","display_name":"CEA Paris-Saclay - Etablissement de Saclay","ror":"https://ror.org/01fv25t22","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I2801360556","https://openalex.org/I4210128565"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Georgin","raw_affiliation_strings":["Service des Molecules Marqu\u00e9es, CEA/Saclay bat, 547, 91191, Gif sur Yvette, France","Service des Molecules Marqu\u00e9es, CEA/Saclay bat, 547, Gif sur Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service des Molecules Marqu\u00e9es, CEA/Saclay bat, 547, 91191, Gif sur Yvette, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I2801360556","https://openalex.org/I4210128565"]},{"raw_affiliation_string":"Service des Molecules Marqu\u00e9es, CEA/Saclay bat, 547, Gif sur Yvette, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I2801360556","https://openalex.org/I4210128565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073174129","display_name":"Elias Fattal","orcid":"https://orcid.org/0000-0002-3194-961X","observed_orcids":["https://orcid.org/0000-0002-3194-961X"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210117966","display_name":"Institut Galien Paris-Saclay","ror":"https://ror.org/02mnw9q71","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210117966","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elias Fattal","raw_affiliation_strings":["Physico-Chimie, Pharmacotechnie, Biopharmacie, Universit\u00e9 Paris-Sud XI, UMR CNRS 8612, 5, rue Jean Baptiste Cl\u00e9ment, 92296, Ch\u00e2tenay-Malabry, France","Physico-Chimie, Pharmacotechnie, Biopharmacie, Universit\u00e9 Paris-Sud XI, UMR CNRS 8612, Ch\u00e2tenay-Malabry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physico-Chimie, Pharmacotechnie, Biopharmacie, Universit\u00e9 Paris-Sud XI, UMR CNRS 8612, 5, rue Jean Baptiste Cl\u00e9ment, 92296, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590","https://openalex.org/I4210117966"]},{"raw_affiliation_string":"Physico-Chimie, Pharmacotechnie, Biopharmacie, Universit\u00e9 Paris-Sud XI, UMR CNRS 8612, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590","https://openalex.org/I4210117966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001046344","display_name":"J.P. Andreux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean P. Andreux","raw_affiliation_strings":["Universit\u00e9 Paris-Sud XI, UPRES/EA 2706, 5, rue Jean Baptiste Cl\u00e9ment, 92296, Ch\u00e2tenay-Malabry, France","Universit\u00e9 Paris-Sud XI, UPRES/EA 2706, Ch\u00e2tenay-Malabry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Sud XI, UPRES/EA 2706, 5, rue Jean Baptiste Cl\u00e9ment, 92296, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud XI, UPRES/EA 2706, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078174247","display_name":"Patrick Couvreur","orcid":"https://orcid.org/0000-0001-7961-5443","observed_orcids":["https://orcid.org/0000-0001-7961-5443"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210117966","display_name":"Institut Galien Paris-Saclay","ror":"https://ror.org/02mnw9q71","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210117966","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Patrick Couvreur","raw_affiliation_strings":["Physico-Chimie, Pharmacotechnie, Biopharmacie, Universit\u00e9 Paris-Sud XI, UMR CNRS 8612, 5, rue Jean Baptiste Cl\u00e9ment, 92296, Ch\u00e2tenay-Malabry, France","Physico-Chimie, Pharmacotechnie, Biopharmacie, Universit\u00e9 Paris-Sud XI, UMR CNRS 8612, Ch\u00e2tenay-Malabry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physico-Chimie, Pharmacotechnie, Biopharmacie, Universit\u00e9 Paris-Sud XI, UMR CNRS 8612, 5, rue Jean Baptiste Cl\u00e9ment, 92296, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590","https://openalex.org/I4210117966"]},{"raw_affiliation_string":"Physico-Chimie, Pharmacotechnie, Biopharmacie, Universit\u00e9 Paris-Sud XI, UMR CNRS 8612, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590","https://openalex.org/I4210117966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5078174247"],"corresponding_institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590","https://openalex.org/I4210117966"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":5.622,"has_fulltext":false,"cited_by_count":452,"citation_normalized_percentile":{"value":0.96918578,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"18","issue":"8","first_page":"1157","last_page":"1166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.11990000307559967,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pegylated-nanoparticles","display_name":"PEGylated nanoparticles","score":0.8510000109672546},{"id":"https://openalex.org/keywords/drug-delivery-to-the-brain","display_name":"brain drug delivery","score":0.7229999899864197},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.8090000152587891},{"id":"https://openalex.org/keywords/polysorbate-80-coating","display_name":"polysorbate 80 coating","score":0.8999999761581421},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.7269999980926514},{"id":"https://openalex.org/keywords/choroid-plexus","display_name":"choroid plexus","score":0.9300000071525574},{"id":"https://openalex.org/keywords/surface-coating-effects","display_name":"surface coating effects","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.7483546137809753},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.7148094177246094},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5420508980751038},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5386059284210205},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5286595821380615},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5275325775146484},{"id":"https://openalex.org/C2777897440","wikidata":"https://www.wikidata.org/wiki/Q417074","display_name":"Polysorbate","level":3,"score":0.5144631862640381},{"id":"https://openalex.org/C134728086","wikidata":"https://www.wikidata.org/wiki/Q966900","display_name":"Drug delivery to the brain","level":4,"score":0.49327725172042847},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4741900861263275},{"id":"https://openalex.org/C60903277","wikidata":"https://www.wikidata.org/wiki/Q2051926","display_name":"Paracellular transport","level":4,"score":0.4717826545238495},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.467661052942276},{"id":"https://openalex.org/C2778551929","wikidata":"https://www.wikidata.org/wiki/Q146339","display_name":"Polyvinyl alcohol","level":2,"score":0.4514821469783783},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39206427335739136},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.3232259154319763},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.29252147674560547},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2517987787723541},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.24005621671676636},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.23499521613121033},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21604767441749573},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19627785682678223},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1662897765636444},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.11515337228775024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10792389512062073},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000180","descriptor_name":"Acrylic Resins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013501","descriptor_name":"Surface-Active Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013535","descriptor_name":"Suspensions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1010931127745","doi":"https://doi.org/10.1023/a:1010931127745","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1010931127745","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},{"id":"pmid:11587488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11587488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W59300367","https://openalex.org/W291654111","https://openalex.org/W1482904772","https://openalex.org/W1526328115","https://openalex.org/W1528488968","https://openalex.org/W1542924087","https://openalex.org/W1603776666","https://openalex.org/W1614540993","https://openalex.org/W1852301381","https://openalex.org/W1969628438","https://openalex.org/W1986129921","https://openalex.org/W1986144289","https://openalex.org/W1998302888","https://openalex.org/W2002319574","https://openalex.org/W2011857527","https://openalex.org/W2017952116","https://openalex.org/W2020855804","https://openalex.org/W2021246059","https://openalex.org/W2022047142","https://openalex.org/W2029749273","https://openalex.org/W2032381925","https://openalex.org/W2056272101","https://openalex.org/W2076996133","https://openalex.org/W2079078912","https://openalex.org/W2091282668","https://openalex.org/W2134670490","https://openalex.org/W2144907950","https://openalex.org/W2145017051","https://openalex.org/W2146808024","https://openalex.org/W2505104219"],"related_works":["https://openalex.org/W2094952575","https://openalex.org/W2062047270","https://openalex.org/W2048442590","https://openalex.org/W1553061387","https://openalex.org/W2072205289","https://openalex.org/W2068491059","https://openalex.org/W1896390281","https://openalex.org/W2152471217","https://openalex.org/W2150111232","https://openalex.org/W3089065470"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":32},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":32},{"year":2012,"cited_by_count":29}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}