{"id":"https://openalex.org/W66446572","doi":null,"title":"Crucial role of pancreatic ductal collagenase injection for isolation of pancreatic islets.","display_name":"Crucial role of pancreatic ductal collagenase injection for isolation of pancreatic islets.","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W66446572","mag":"66446572","pmid":"https://pubmed.ncbi.nlm.nih.gov/1965178"},"language":"en","primary_location":{"id":"pmid:1965178","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1965178","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and metabolic research. Supplement series","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064819693","display_name":"Mitsukazu Gotoh","orcid":"https://orcid.org/0000-0001-8839-3192","observed_orcids":["https://orcid.org/0000-0001-8839-3192"]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Gotoh","raw_affiliation_strings":["Second Department of Surgery, Osaka University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Surgery, Osaka University Medical School, Japan","institution_ids":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082516281","display_name":"Hiroki Ohzato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Ohzato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Porter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Porter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047141592","display_name":"Takashi Maki","orcid":"https://orcid.org/0000-0002-2143-3783","observed_orcids":["https://orcid.org/0000-0002-2143-3783"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Maki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038938677","display_name":"Anthony P. Monaco","orcid":"https://orcid.org/0000-0001-7480-3197","observed_orcids":["https://orcid.org/0000-0001-7480-3197"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A P Monaco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.00945957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"25","issue":null,"first_page":"10","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/islet-isolation","display_name":"islet isolation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/collagenase-digestion","display_name":"collagenase digestion","score":0.9070000052452087},{"id":"https://openalex.org/keywords/pancreatic-duct-injection","display_name":"pancreatic duct injection","score":0.8700000047683716},{"id":"https://openalex.org/keywords/portal-vein-injection","display_name":"portal vein injection","score":0.9599999785423279},{"id":"https://openalex.org/keywords/islet-yield","display_name":"islet yield","score":0.6790000200271606},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.925000011920929},{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/normoglycemia","display_name":"normoglycemia","score":0.7739999890327454},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.781000018119812},{"id":"https://openalex.org/keywords/islet-structure","display_name":"islet structure","score":0.4869999885559082},{"id":"https://openalex.org/keywords/islet-purification","display_name":"islet purification","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.8802196979522705},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.8721626996994019},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7120857238769531},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.689694344997406},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.6541386246681213},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.5782732963562012},{"id":"https://openalex.org/C2781357212","wikidata":"https://www.wikidata.org/wiki/Q5275608","display_name":"Digestion (alchemy)","level":2,"score":0.5495197176933289},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4731748402118683},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.45532727241516113},{"id":"https://openalex.org/C103395026","wikidata":"https://www.wikidata.org/wiki/Q5380231","display_name":"Enteroendocrine cell","level":4,"score":0.43414169549942017},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4101703464984894},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.3708987236022949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.348923921585083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3366149067878723},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15289980173110962},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0952443778514862},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.06514438986778259},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003012","descriptor_name":"Microbial Collagenase","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010183","descriptor_name":"Pancreatic Ducts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011169","descriptor_name":"Portal Vein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1965178","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1965178","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and metabolic research. Supplement series","raw_type":"Journal Article"},{"id":"mag:66446572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1965178","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2054777152","https://openalex.org/W2055682770","https://openalex.org/W2748846576","https://openalex.org/W2115582955","https://openalex.org/W2393326866","https://openalex.org/W2027882813","https://openalex.org/W3149854150","https://openalex.org/W2026636727","https://openalex.org/W2370152942","https://openalex.org/W2369524956"],"abstract_inverted_index":{"We":[0,38],"have":[1],"been":[2],"stressing":[3],"the":[4,21,69,118,142,150,197,216,238,256,262],"advantage":[5],"of":[6,10,17,26,71,93,137,170,200,231,241,252],"stationary":[7,27],"digestion":[8,31,72,82,251],"because":[9],"its":[11],"simplicity":[12],"and":[13,34,49,58,80,89,117,153,224,250,258],"reproducible":[14,90],"high":[15,91,162],"yields":[16],"viable":[18],"islets.":[19,176,202],"In":[20],"present":[22],"study":[23],"optimal":[24],"conditions":[25,85],"in":[28,32,63,112,129,141,149,159,182],"vitro":[29],"collagenase":[30,45,75],"mice":[33,133,185],"rats":[35],"were":[36,86],"examined.":[37],"also":[39],"compared":[40,173,195],"two":[41],"possible":[42],"routes":[43],"for":[44],"injection;":[46],"ductal":[47],"(PD)":[48],"portal":[50],"venous":[51],"(PV)":[52],"based":[53],"on":[54],"subsequent":[55],"islet":[56,263],"yield":[57,92,140],"ability":[59,178],"to":[60,161,174,179],"reverse":[61],"diabetes":[62],"rats.":[64],"Three":[65],"parameters":[66],"which":[67],"affect":[68],"quality":[70],"are":[73],"1)":[74],"concentration,":[76],"2)":[77],"incubation":[78],"time":[79],"3)":[81],"temperature.":[83],"Suitable":[84],"easily":[87],"determined":[88],"islets":[94,100,119,158,193,205,218,257],"could":[95,108],"be":[96],"consistently":[97,109],"obtained.":[98],"The":[99,177,203],"from":[101,120,156],"one":[102,113,121],"mouse":[103,116],"pancreas":[104,123],"(approximately":[105],"200":[106],"islets)":[107,125],"restore":[110,127,180],"normoglycemia":[111,128,181],"STZ-induced":[114,131,183],"diabetic":[115,132,184],"rat":[122],"(500-600":[124],"can":[126],"5-6":[130],"within":[134],"a":[135,207,220],"couple":[136],"days.":[138],"Islet":[139],"PD":[143,157,192,204,235],"method":[144],"was":[145,164,186],"greater":[146],"than":[147],"that":[148],"PV":[151,175,201,217],"method,":[152],"insulin":[154],"release":[155],"response":[160],"glucose":[163],"well":[165,187,208,246],"preserved":[166,188,209,265],"after":[167],"24":[168],"hours":[169],"culture":[171],"when":[172,189],"transplanting":[190],"100":[191],"as":[194,245,247],"with":[196,211,261],"same":[198],"number":[199],"revealed":[206],"structure":[210],"healthy":[212],"endocrine":[213,226],"cells,":[214],"while":[215],"showed":[219,237],"dilated":[221],"capillary":[222],"network":[223],"distorted":[225],"cell":[227],"continuity.":[228],"Histological":[229],"examination":[230],"digested":[232],"tissue":[233,254],"following":[234],"injection":[236],"complete":[239],"destruction":[240],"pancreatic":[242],"exocrine":[243,259],"tissue,":[244,260],"mechanical":[248],"separation":[249],"interstitial":[253],"between":[255],"being":[264],"selectively":[266],"intact.(ABSTRACT":[267],"TRUNCATED":[268],"AT":[269],"250":[270],"WORDS)":[271]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
