{"id":"https://openalex.org/W66178905","doi":null,"title":"Rodent models of Autism Spectrum Disorder: strengths and limitations","display_name":"Rodent models of Autism Spectrum Disorder: strengths and limitations","publication_year":2016,"publication_date":"2016-06-07","ids":{"openalex":"https://openalex.org/W66178905","mag":"66178905"},"language":"en","primary_location":{"id":"mag:66178905","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/291825","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"book","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082858948","display_name":"Saskia Kliphuis","orcid":"https://orcid.org/0000-0001-5832-7418","observed_orcids":["https://orcid.org/0000-0001-5832-7418"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Saskia Kliphuis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5832-7418","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5082858948"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1653,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.56902985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9860000014305115},{"id":"https://openalex.org/keywords/rodent-models","display_name":"rodent models","score":0.9750000238418579},{"id":"https://openalex.org/keywords/animal-models-of-autism","display_name":"animal models of autism","score":0.7990000247955322},{"id":"https://openalex.org/keywords/behavioral-phenotyping","display_name":"behavioral phenotyping","score":0.9039999842643738},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.7609999775886536},{"id":"https://openalex.org/keywords/model-validity","display_name":"model validity","score":0.8069999814033508},{"id":"https://openalex.org/keywords/genetic-and-environmental-risk-factors","display_name":"genetic and environmental risk factors","score":0.6779999732971191},{"id":"https://openalex.org/keywords/multi-model-approach","display_name":"multi-model approach","score":0.6660000085830688},{"id":"https://openalex.org/keywords/natural-behavior","display_name":"natural behavior","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.8668708801269531},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.6198740005493164},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.5502856969833374},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.48648732900619507},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.4774540066719055},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.42905133962631226},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3653489947319031},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.25748348236083984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2365654706954956},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2212335467338562},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:66178905","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/291825","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W349823034","https://openalex.org/W593727103","https://openalex.org/W628847457","https://openalex.org/W1496028880","https://openalex.org/W1501622688","https://openalex.org/W1529049599","https://openalex.org/W1541267199","https://openalex.org/W1556074533","https://openalex.org/W1556397944","https://openalex.org/W1594816032","https://openalex.org/W1684368268","https://openalex.org/W1967357002","https://openalex.org/W1972579416","https://openalex.org/W1975302052","https://openalex.org/W1978444428","https://openalex.org/W1979046783","https://openalex.org/W1984368478","https://openalex.org/W1986915554","https://openalex.org/W1988676936","https://openalex.org/W1988820029","https://openalex.org/W1989348564","https://openalex.org/W1994992553","https://openalex.org/W1996166611","https://openalex.org/W1997120050","https://openalex.org/W1998109533","https://openalex.org/W2004118951","https://openalex.org/W2004265420","https://openalex.org/W2005772009","https://openalex.org/W2011450194","https://openalex.org/W2011496335","https://openalex.org/W2013957985","https://openalex.org/W2014691697","https://openalex.org/W2016324431","https://openalex.org/W2016411894","https://openalex.org/W2022479132","https://openalex.org/W2022654189","https://openalex.org/W2026587663","https://openalex.org/W2026793879","https://openalex.org/W2031181070","https://openalex.org/W2033609439","https://openalex.org/W2034453108","https://openalex.org/W2035090622","https://openalex.org/W2035705275","https://openalex.org/W2040866200","https://openalex.org/W2048498211","https://openalex.org/W2048650676","https://openalex.org/W2050550932","https://openalex.org/W2051273046","https://openalex.org/W2052072164","https://openalex.org/W2053909439","https://openalex.org/W2054086319","https://openalex.org/W2054577579","https://openalex.org/W2055339217","https://openalex.org/W2069057542","https://openalex.org/W2069222462","https://openalex.org/W2069741364","https://openalex.org/W2071287384","https://openalex.org/W2071797996","https://openalex.org/W2072319418","https://openalex.org/W2073332142","https://openalex.org/W2074498182","https://openalex.org/W2076599994","https://openalex.org/W2077863458","https://openalex.org/W2078162851","https://openalex.org/W2078875535","https://openalex.org/W2080703817","https://openalex.org/W2081153295","https://openalex.org/W2081161499","https://openalex.org/W2081194315","https://openalex.org/W2082109123","https://openalex.org/W2082859469","https://openalex.org/W2088446168","https://openalex.org/W2089360863","https://openalex.org/W2092762167","https://openalex.org/W2093346797","https://openalex.org/W2093607035","https://openalex.org/W2093738396","https://openalex.org/W2098277878","https://openalex.org/W2098709113","https://openalex.org/W2098951793","https://openalex.org/W2102112708","https://openalex.org/W2105368549","https://openalex.org/W2108737830","https://openalex.org/W2109228085","https://openalex.org/W2110741989","https://openalex.org/W2118295225","https://openalex.org/W2119855769","https://openalex.org/W2122550040","https://openalex.org/W2124939414","https://openalex.org/W2126681873","https://openalex.org/W2127857578","https://openalex.org/W2129647383","https://openalex.org/W2132482152","https://openalex.org/W2134409536","https://openalex.org/W2135316980","https://openalex.org/W2139399313","https://openalex.org/W2144882747","https://openalex.org/W2153617971","https://openalex.org/W2153810829","https://openalex.org/W2154672996","https://openalex.org/W2155055267","https://openalex.org/W2157167463","https://openalex.org/W2158370300","https://openalex.org/W2159886305","https://openalex.org/W2159969071","https://openalex.org/W2161751456","https://openalex.org/W2163492066","https://openalex.org/W2167630284","https://openalex.org/W2169370014","https://openalex.org/W2171804213","https://openalex.org/W2171876105","https://openalex.org/W2346906038","https://openalex.org/W2428918274","https://openalex.org/W4249957287"],"related_works":["https://openalex.org/W7071215896","https://openalex.org/W3128718218","https://openalex.org/W1460420263","https://openalex.org/W7204038610","https://openalex.org/W6887675345","https://openalex.org/W2998001182","https://openalex.org/W4221088095","https://openalex.org/W2476109808","https://openalex.org/W4415929381","https://openalex.org/W2253478654"],"abstract_inverted_index":{"Autism":[0],"Spectrum":[1],"Disorder":[2],"(ASD)":[3],"is":[4,76,101,133],"a":[5,11,38,90,107,128,151,157],"psychiatric":[6],"disease":[7],"that":[8,130],"arises":[9],"from":[10],"complex":[12],"interplay":[13],"between":[14,109],"genetic":[15],"and":[16,45,117],"environmental":[17],"background.":[18],"Animal":[19,103],"models":[20,54,104],"have":[21],"been":[22],"used":[23],"to":[24,28,36,41,46,63],"gain":[25],"insight":[26],"in":[27,34,93,127,136],"the":[29,32,43,65,68,72,81,95,111,114,131,146,165,169],"aetiology":[30],"of":[31,67,71,113,168],"disorder,":[33],"order":[35],"find":[37],"gold":[39,152,158],"standard":[40,153,159],"drive":[42],"diagnosis,":[44],"search":[47],"for":[48,55,60],"treatments.":[49],"In":[50],"this":[51],"book,":[52],"rodent":[53],"ASD":[56],"are":[57,105],"critically":[58],"reviewed":[59],"their":[61],"use":[62],"mimic":[64],"complexity":[66,112],"developmental":[69],"biology":[70],"disorder.":[73],"Their":[74],"validity":[75],"evaluated,":[77],"as":[78,80,97],"well":[79],"applied":[82],"behavioural":[83,160],"phenotyping":[84,161],"assays.":[85],"Future":[86],"directions":[87],"point":[88],"towards":[89,148],"multi-model":[91],"approach,":[92],"which":[94],"body":[96],"one":[98],"functioning":[99],"system":[100],"emphasized.":[102],"always":[106],"compromise":[108],"mimicking":[110],"actual":[115],"disorder":[116],"designing":[118],"practical":[119],"experiments.":[120],"However,":[121],"these":[122],"experiments":[123],"should":[124],"be":[125],"designed":[126],"way":[129],"animal":[132,170],"minimally":[134],"restricted":[135],"performing":[137],"its":[138],"natural":[139],"behaviour.":[140],"Combining":[141],"knowledge,":[142],"we":[143],"narrow":[144],"down":[145],"funnel":[147],"not":[149],"only":[150],"model,":[154],"but":[155],"also":[156],"strategy,":[162],"thereby":[163],"increasing":[164],"translational":[166],"capacity":[167],"model.":[171]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
