{"id":"https://openalex.org/W66169179","doi":null,"title":"Activity-dependent ubiquitination of GluR1 mediates a distinct AMPAR endocytosis and sorting pathway in hippocampal neurons","display_name":"Activity-dependent ubiquitination of GluR1 mediates a distinct AMPAR endocytosis and sorting pathway in hippocampal neurons","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W66169179","mag":"66169179"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt2089q9td","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2089q9td","pdf_url":"https://escholarship.org/uc/item/2089q9td","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/2089q9td","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108076411","display_name":"Lindsay A. Schwarz","orcid":"https://orcid.org/0000-0002-0613-5518","observed_orcids":["https://orcid.org/0000-0002-0613-5518"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lindsay A. Schwarz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0613-5518","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108076411"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampa-receptors","display_name":"AMPA receptors","score":0.7279999852180481},{"id":"https://openalex.org/keywords/glur1","display_name":"GluR1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9750000238418579},{"id":"https://openalex.org/keywords/nedd4-1","display_name":"NEDD4-1","score":0.8230000138282776},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.875},{"id":"https://openalex.org/keywords/lysosome-trafficking","display_name":"lysosomal trafficking","score":0.8339999914169312},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.6779999732971191},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.9480000138282776},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.42100000381469727},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8320000171661377},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.781000018119812},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.6600000262260437},{"id":"https://openalex.org/keywords/lysine-ubiquitination-sites","display_name":"lysine ubiquitination sites","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.7930070161819458},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7656585574150085},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.7635102868080139},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6710469126701355},{"id":"https://openalex.org/C2777265272","wikidata":"https://www.wikidata.org/wiki/Q18030005","display_name":"NEDD4","level":5,"score":0.6529996395111084},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.637570858001709},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.6168113946914673},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.5750157237052917},{"id":"https://openalex.org/C156407911","wikidata":"https://www.wikidata.org/wiki/Q420160","display_name":"Dynamin","level":4,"score":0.5704825520515442},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4887387752532959},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.3649762272834778},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3448001444339752},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32438087463378906},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19515347480773926},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11646860837936401},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt2089q9td","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2089q9td","pdf_url":"https://escholarship.org/uc/item/2089q9td","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:66169179","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt2089q9td/qt2089q9td.pdf?t=ml5096","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt2089q9td","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2089q9td","pdf_url":"https://escholarship.org/uc/item/2089q9td","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W66169179.pdf","grobid_xml":"https://content.openalex.org/works/W66169179.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1507367785","https://openalex.org/W1507515137","https://openalex.org/W1557933310","https://openalex.org/W1625660792","https://openalex.org/W1984143997","https://openalex.org/W1989970319","https://openalex.org/W1991211989","https://openalex.org/W2027436298","https://openalex.org/W2054023762","https://openalex.org/W2062023115","https://openalex.org/W2067087475","https://openalex.org/W2091124764","https://openalex.org/W2097800224","https://openalex.org/W2106828113","https://openalex.org/W2109208582","https://openalex.org/W2119141725","https://openalex.org/W2124438437","https://openalex.org/W2128834282","https://openalex.org/W2161500245","https://openalex.org/W2161924138","https://openalex.org/W2164186781"],"related_works":["https://openalex.org/W1996669272","https://openalex.org/W1595234035","https://openalex.org/W2274202515","https://openalex.org/W2019147863","https://openalex.org/W2110241552","https://openalex.org/W2604570082","https://openalex.org/W2078650862","https://openalex.org/W2766178360","https://openalex.org/W4301457977","https://openalex.org/W2061570493"],"abstract_inverted_index":{"The":[0],"accurate":[1],"trafficking":[2,34,134,208,223],"of":[3,20,32,43,52,68,106,129,149,182,199],"AMPA":[4],"receptors":[5],"(AMPARs)":[6],"to":[7,62,83,100,111,135,140,153,209,231,240],"and":[8,23,65,132,207,224,236],"from":[9],"excitatory":[10],"glutamatergic":[11],"synapses":[12],"in":[13,35,71,88,98,138,151,190,229],"the":[14,36,136,141,210],"hippocampus":[15,37],"is":[16,56,109,172,186],"a":[17,57,104,167],"critical":[18],"component":[19],"mammalian":[21,78,94],"learning":[22],"memory.":[24],"In":[25],"conjunction,":[26],"recent":[27],"research":[28],"suggests":[29],"that":[30,50,77,93,108,121,166,180,197,238],"dysfunction":[31],"AMPAR":[33,142,222],"may":[38,80,243],"be":[39,112],"an":[40],"underlying":[41],"mechanism":[42],"Alzheimer's":[44],"disease.":[45],"Previous":[46],"work":[47],"has":[48],"shown":[49],"ubiquitination":[51,123,181,198],"integral":[53],"membrane":[54],"proteins":[55,70],"common":[58],"post-translational":[59],"modification":[60],"used":[61],"mediate":[63],"endocytosis":[64,206],"endocytic":[66],"sorting":[67],"surface":[69,130],"eukaryotic":[72],"cells.":[73],"Therefore,":[74],"we":[75,91,119,164,178],"hypothesized":[76],"AMPARs":[79,95,131,150,201],"become":[81,96],"ubiquitinated":[82,97,113],"regulate":[84,221],"their":[85,101,133,205],"synaptic":[86],"stability":[87],"neurons.":[89,192],"Here":[90],"report":[92],"response":[99,139,152,230],"activation.":[102],"Using":[103],"mutant":[105],"GluR1":[107,183],"unable":[110],"at":[114],"lysines":[115],"on":[116],"its":[117],"carboxy-terminus,":[118],"demonstrate":[120],"these":[122,194,213],"sites":[124],"are":[125],"required":[126],"for":[127,147,174],"internalization":[128,148],"lysosome":[137],"agonist":[143,157],"AMPA,":[144],"but":[145],"not":[146],"NMDA":[154],"receptor":[155],"(NMDAR)":[156],"NMDA.":[158],"Through":[159],"over-expression":[160],"or":[161],"RNAi-mediated":[162],"knockdown,":[163],"identify":[165],"specific":[168],"E3":[169],"ligase,":[170],"Nedd4-1,":[171],"necessary":[173],"this":[175,241],"process.":[176],"Finally,":[177],"show":[179,196],"by":[184,202],"Nedd4-1":[185,203],"much":[187],"more":[188],"prevalent":[189],"aged":[191],"Together,":[193],"data":[195],"GluR1-containing":[200],"mediates":[204],"lysosome.":[211],"Furthermore,":[212],"results":[214],"provide":[215],"insight":[216],"into":[217],"how":[218],"hippocampal":[219],"neurons":[220],"degradation":[225],"with":[226,245],"high":[227],"specificity":[228],"differing":[232],"neuronal":[233],"signaling":[234],"cues,":[235],"suggest":[237],"changes":[239],"pathway":[242],"occur":[244],"age":[246]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
