{"id":"https://openalex.org/W66101164","doi":null,"title":"Eicosanoids, inflammation, and anti-inflammatory drugs.","display_name":"Eicosanoids, inflammation, and anti-inflammatory drugs.","publication_year":1989,"publication_date":"1989-09-01","ids":{"openalex":"https://openalex.org/W66101164","mag":"66101164","pmid":"https://pubmed.ncbi.nlm.nih.gov/2691152"},"language":"en","primary_location":{"id":"pmid:2691152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2691152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"D R Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D R Robinson","raw_affiliation_strings":["Department of Medicine, Massachusetts General Hospital, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Boston","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":0.3941,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.53685239,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"7 Suppl 3","issue":null,"first_page":"S155","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.996999979019165},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.8270000219345093},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.906000018119812},{"id":"https://openalex.org/keywords/leukotrienes","display_name":"leukotrienes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/platelet-activating-factor","display_name":"platelet-activating factor","score":0.9549999833106995},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.921999990940094},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.9539999961853027},{"id":"https://openalex.org/keywords/leukotriene-biosynthesis","display_name":"leukotriene biosynthesis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9190000295639038},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.8289999961853027},{"id":"https://openalex.org/keywords/dietary-polyunsaturated-fatty-acids","display_name":"dietary polyunsaturated fatty acids","score":0.8270000219345093},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.7059999704360962},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.7670000195503235},{"id":"https://openalex.org/keywords/t-cell-function","display_name":"T cell function","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.8207659721374512},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.6417447328567505},{"id":"https://openalex.org/C2776685179","wikidata":"https://www.wikidata.org/wiki/Q2704449","display_name":"Leukotriene B4","level":3,"score":0.6256644129753113},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.602834939956665},{"id":"https://openalex.org/C2779020240","wikidata":"https://www.wikidata.org/wiki/Q420577","display_name":"Platelet-activating factor","level":2,"score":0.5667029023170471},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.5538722276687622},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4975920021533966},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.48209741711616516},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.4639800190925598},{"id":"https://openalex.org/C2776352991","wikidata":"https://www.wikidata.org/wiki/Q407680","display_name":"Eicosanoid","level":4,"score":0.4497891068458557},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.44970980286598206},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4438198208808899},{"id":"https://openalex.org/C2777198256","wikidata":"https://www.wikidata.org/wiki/Q4860325","display_name":"Prostaglandin E","level":2,"score":0.428426057100296},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42056357860565186},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3625336289405823},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31859034299850464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3035043478012085},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.2610631585121155},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11892920732498169},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013931","descriptor_name":"Thromboxanes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015289","descriptor_name":"Leukotrienes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015777","descriptor_name":"Eicosanoids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2691152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2691152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"mag:66101164","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2691152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3891394503","display_name":"PROSTAGLANDINS IN RHEUMATIC DISEASES","funder_award_id":"R01AR019427","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W144666176","https://openalex.org/W1971322492","https://openalex.org/W2218044579","https://openalex.org/W2043086224","https://openalex.org/W940869377","https://openalex.org/W1994497688","https://openalex.org/W2053306032","https://openalex.org/W2007187686","https://openalex.org/W2337274797","https://openalex.org/W3021735178"],"abstract_inverted_index":{"Many":[0],"mediators":[1,37],"of":[2,35,104,119,126,150,153,165,171,180,202],"inflammation":[3],"are":[4,77,95,99,121,158],"derived":[5],"from":[6,31],"arachidonic":[7,29,166],"acid":[8,30,167],"including":[9],"prostaglandins,":[10],"leukotrienes,":[11],"and":[12,40,59,63,68,73,81,92,108,140,156,173,204],"other":[13,50],"oxygenated":[14],"derivatives.":[15],"In":[16],"addition,":[17],"platelet":[18,205],"activating":[19,206],"factor":[20,207],"is":[21,66],"an":[22],"acetylated":[23],"ether-linked":[24],"phospholipid":[25,32],"formed":[26],"by":[27,79,101,124,160,178],"cleaving":[28],"precursors.":[33],"Several":[34],"these":[36,144],"produce":[38],"vasodilation":[39],"increased":[41],"vascular":[42],"permeability":[43],"either":[44],"alone":[45],"or":[46],"acting":[47],"synergistically":[48],"with":[49],"mediators.":[51],"The":[52,111,133],"E":[53],"prostaglandins":[54,155],"also":[55],"stimulate":[56],"bone":[57],"resorption":[58],"activate":[60],"adenylate":[61],"cyclase,":[62],"leukotriene":[64,93,138,174],"B4":[65],"chemotactic":[67],"activates":[69],"leukocytes.":[70],"Both":[71],"B":[72],"T":[74,86],"cell":[75,87],"functions":[76],"inhibited":[78,159],"PGE2":[80],"some":[82,142],"lipoxygenase":[83],"products":[84],"alter":[85],"function":[88],"as":[89,114,116,187],"well.":[90],"Prostaglandin":[91],"synthesis":[94,201],"closely":[96],"regulated;":[97],"they":[98],"stimulated":[100],"a":[102],"number":[103],"activators,":[105],"hormones,":[106],"cytokines,":[107],"growth":[109],"factors.":[110],"major":[112],"therapeutic":[113,211],"well":[115],"toxic":[117],"effects":[118],"NSAIDs":[120,134],"accounted":[122],"for":[123],"inhibition":[125,164],"cyclooxygenase":[127],"activity":[128],"and,":[129],"therefore,":[130],"prostaglandin":[131,172],"synthesis.":[132],"do":[135],"not":[136],"inhibit":[137,199],"synthesis,":[139],"under":[141],"conditions":[143],"drugs":[145,197],"may":[146,176,208],"augment":[147],"the":[148,188,200],"production":[149,175],"leukotrienes.":[151],"Synthesis":[152],"both":[154],"leukotrienes":[157,203],"glucocorticoids":[161],"through":[162],"lipomodulin-mediated":[163],"release.":[168],"Nutritional":[169],"regulation":[170],"occur":[177],"substitution":[179],"alternative":[181],"dietary":[182],"polyunsaturated":[183],"fatty":[184,190],"acids":[185,191],"such":[186],"n-3":[189],"present":[192],"in":[193],"marine":[194],"lipids.":[195],"New":[196],"which":[198],"be":[209],"useful":[210],"agents.":[212]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
