{"id":"https://openalex.org/W66011108","doi":null,"title":"Autocrine, endocrine and paracrine regulation of growth abnormalities in autosomal dominant polycystic kidney disease.","display_name":"Autocrine, endocrine and paracrine regulation of growth abnormalities in autosomal dominant polycystic kidney disease.","publication_year":1993,"publication_date":"1993-06-01","ids":{"openalex":"https://openalex.org/W66011108","mag":"66011108","pmid":"https://pubmed.ncbi.nlm.nih.gov/8223698"},"language":"en","primary_location":{"id":"pmid:8223698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8223698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cell biology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078994141","display_name":"Patricia D. Wilson","orcid":"https://orcid.org/0000-0003-0902-188X","observed_orcids":["https://orcid.org/0000-0003-0902-188X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P D Wilson","raw_affiliation_strings":["Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078669108","display_name":"Jing Du","orcid":"https://orcid.org/0000-0003-3128-9997","observed_orcids":["https://orcid.org/0000-0003-3128-9997","https://orcid.org/0000-0002-0085-3690"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Du","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060918390","display_name":"Jill T. Norman","orcid":"https://orcid.org/0000-0001-5293-4823","observed_orcids":["https://orcid.org/0000-0001-5293-4823"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J T Norman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.973,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.91320784,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"61","issue":"1","first_page":"131","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autosomal-dominant-polycystic-kidney-disease","display_name":"autosomal dominant polycystic kidney disease","score":1.0},{"id":"https://openalex.org/keywords/renal-cysts","display_name":"renal cysts","score":0.6629999876022339},{"id":"https://openalex.org/keywords/epithelial-cell-proliferation","display_name":"epithelial cell proliferation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/autocrine-growth-regulation","display_name":"autocrine growth regulation","score":0.6610000133514404},{"id":"https://openalex.org/keywords/paracrine-regulation","display_name":"paracrine regulation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/hormone-regulation","display_name":"hormonal regulation","score":0.843999981880188},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.9739999771118164},{"id":"https://openalex.org/keywords/egf-receptor","display_name":"EGF receptor","score":0.9729999899864197},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.7559999823570251},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8220000267028809},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":1.0},{"id":"https://openalex.org/keywords/renal-tubular-epithelium","display_name":"renal tubular epithelium","score":0.6990000009536743},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.6129999756813049},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.8289999961853027},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.7866617441177368},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.7704715728759766},{"id":"https://openalex.org/C2776266639","wikidata":"https://www.wikidata.org/wiki/Q2732398","display_name":"Autosomal dominant polycystic kidney disease","level":3,"score":0.7608162760734558},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7387574315071106},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7018254399299622},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.630660891532898},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5955672264099121},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5262895226478577},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.32207024097442627},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3168758749961853},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17088019847869873}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016891","descriptor_name":"Polycystic Kidney, Autosomal Dominant","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:8223698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8223698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1490041","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1490041/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Eur J Cell Biol , 61 (1) pp. 131-138. (1993)","raw_type":"Article"},{"id":"mag:66011108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8223698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6018222220","display_name":"CYST FORMATION IN POLYCYSTIC KIDNEY DISEASE","funder_award_id":"R01DK040698","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1998913984","https://openalex.org/W2204738624","https://openalex.org/W3138867025","https://openalex.org/W2117944927","https://openalex.org/W2071133433","https://openalex.org/W4231043483","https://openalex.org/W2167881829","https://openalex.org/W2389790694","https://openalex.org/W2382907696","https://openalex.org/W2298627547"],"abstract_inverted_index":{"Genetic":[0],"polycystic":[1],"kidney":[2],"disease":[3],"(ADPKD)":[4],"is":[5,17],"an":[6,76,167,183],"autosomal":[7],"dominant":[8],"trait":[9],"in":[10,29,121,133,138,143,148,175,198,210,224,227,238],"man,":[11],"the":[12,38,85,88,153,235],"phenotypic":[13],"expression":[14],"of":[15,23,33,40,48,79,87,101,140,155,170,185,234],"which":[16,206],"characterized":[18,45],"by":[19,46,84,173],"enormous":[20],"cystic":[21],"enlargement":[22],"renal":[24,64,187],"tubules.":[25],"Since":[26],"this":[27,41],"is,":[28],"part,":[30],"a":[31,231],"result":[32],"aberrant":[34],"epithelial":[35,54],"cell":[36,164],"proliferation,":[37],"nature":[39],"defect":[42],"has":[43],"been":[44],"comparison":[47],"growth":[49,114,171,179,202],"factor":[50,115,180,203],"action":[51],"on":[52],"defined":[53],"primary":[55],"monolayer":[56],"cultures":[57],"derived":[58],"from":[59],"individually":[60],"microdissected":[61],"normal":[62,186],"human":[63],"proximal":[65],"and":[66,69,93,95,117,147,152,158],"distal":[67],"tubules":[68],"ADPKD":[70,80,122,134,144,176,199,211,218,225],"cyst-lining":[71,145],"epithelia.":[72,177],"Mitogenic":[73],"assays":[74],"showed":[75],"increased":[77,99,127],"sensitivity":[78],"epithelia":[81,123,146,219],"to":[82,119,162,193,217],"stimulation":[83,172,197],"combination":[86],"endocrine":[89],"factors":[90],"hydrocortisone":[91],"(dexamethasone)":[92],"insulin,":[94],"Northern":[96],"analysis":[97],"suggested":[98,166,230],"levels":[100,129],"insulin":[102],"receptor":[103,132],"steady":[104],"state":[105],"mRNA.":[106],"The":[107,136],"most":[108],"potent,":[109],"single":[110],"mitogen":[111],"was":[112,124,182,191,207,214],"epidermal":[113],"(EGF),":[116],"hypersensitivity":[118],"EGF":[120,131,141,174,196],"correlated":[125],"with":[126],"mRNA":[128],"for":[130],"kidneys.":[135],"localization":[137],"vivo":[139],"immunoreactivity":[142,205],"(apical)":[149],"cyst":[150,212],"fluids":[151],"demonstration":[154],"EGF-receptor":[156],"immunostaining":[157],"specific":[159],"[125I]EGF":[160],"binding":[161],"apical":[163],"surfaces":[165],"autocrine":[168],"mechanism":[169],"Transforming":[178],"beta":[181],"inhibitor":[184],"tubule":[188],"proliferation":[189],"but":[190,220],"unable":[192],"completely":[194],"inhibit":[195],"cultures.":[200],"Platelet-derived":[201],"(PDGF)":[204],"also":[208],"seen":[209],"epithelia,":[213],"not":[215],"mitogenic":[216],"did":[221],"stimulate":[222],"division":[223],"fibroblasts":[226],"vitro.":[228],"This":[229],"paracrine":[232],"regulation":[233],"observed":[236],"fibrosis":[237],"ADPKD.":[239]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}