{"id":"https://openalex.org/W659369706","doi":null,"title":"Les phospholipases A2 s\u00e9cr\u00e9t\u00e9es et leurs r\u00e9cepteurs : propri\u00e9t\u00e9s mol\u00e9culaires et implication dans le cancer colorectal chez la souris","display_name":"Les phospholipases A2 s\u00e9cr\u00e9t\u00e9es et leurs r\u00e9cepteurs : propri\u00e9t\u00e9s mol\u00e9culaires et implication dans le cancer colorectal chez la souris","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W659369706","mag":"659369706"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/785725","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/785725","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/785725","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081242634","display_name":"Fanny Surrel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fanny Surrel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5081242634"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.6797000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.6797000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.13570000231266022,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.062300000339746475,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secretory-phospholipase-a2","display_name":"secretory phospholipase A2","score":0.9559999704360962},{"id":"https://openalex.org/keywords/native-structure","display_name":"native structure","score":0.5799999833106995},{"id":"https://openalex.org/keywords/lysophospholipids","display_name":"lysophospholipids","score":0.7450000047683716},{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.796999990940094},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8769999742507935},{"id":"https://openalex.org/keywords/gene-deletion","display_name":"gene deletion","score":0.6980000138282776},{"id":"https://openalex.org/keywords/colon-cancer-cell-proliferation","display_name":"colon cancer cell proliferation","score":0.5929999947547913},{"id":"https://openalex.org/keywords/tumor-gene-expression","display_name":"cancer gene expression","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.8120643496513367},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5341901183128357},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36271828413009644}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/785725","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/785725","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:659369706","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2006NICE4028","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:hdl:10068/785725","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/785725","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7024698419","https://openalex.org/W7048770226","https://openalex.org/W51174714","https://openalex.org/W7062147026","https://openalex.org/W418013106","https://openalex.org/W124222908","https://openalex.org/W37039514","https://openalex.org/W7047490564","https://openalex.org/W1270713503","https://openalex.org/W40091684"],"abstract_inverted_index":{"Les":[0],"phospholipases":[1],"A2":[2],"s\u00e9cr\u00e9t\u00e9es":[3],"(sPLA2)":[4],"de":[5,10,31,34,65,84,89,102,104,108,122,143,153,167,169,182,185,212,221,224,242,246,252],"mammif\u00e8res":[6],"constituent":[7],"une":[8],"famille":[9],"11":[11],"enzymes":[12],"qui":[13,92],"hydrolysent":[14],"les":[15,39,42,71,74,106],"phospholipides":[16],"pour":[17,125],"lib\u00e9rer":[18],"un":[19,23,146],"acide":[20],"gras":[21],"et":[22,41,138,233],"lysophospholipide.":[24],"Cette":[25,236],"r\u00e9action":[26],"est":[27,180,191],"\u00e0":[28,209],"la":[29,32,86,90,95,154,173,176,183,213],"base":[30],"production":[33,184],"nombreux":[35],"m\u00e9diateurs":[36,187],"lipidiques":[37],"comme":[38,58],"icosano\u00efdes":[40],"lysophospholipides":[43],"bioactifs.":[44],"Certaines":[45],"sPLA2":[46,97,107,118,142],"sont":[47,119],"aussi":[48],"capables":[49],"d'interagir":[50],"sp\u00e9cifiquement":[51],"avec":[52],"des":[53,77,100,120,140,164,229],"prot\u00e9ines":[54],"solubles":[55],"ou":[56],"membranaires":[57],"le":[59,111,157,199,219,234],"r\u00e9cepteur":[60,112],"M.":[61],"La":[62,189],"premi\u00e8re":[63],"partie":[64],"ce":[66,126],"travail":[67],"a":[68,207],"permis":[69],"d'\u00e9largir":[70],"connaissances":[72],"sur":[73,110,163],"propri\u00e9t\u00e9s":[75,101],"mol\u00e9culaires":[76],"sPLA2.":[78],"Tout":[79],"d'abord,":[80],"nous":[81,130,149],"avons":[82,131,150],"tent\u00e9":[83],"caract\u00e9riser":[85],"structure":[87],"native":[88],"sPLA2-IIF,":[91],"pourrait":[93,249],"\u00eatre":[94],"seule":[96],"dim\u00e9rique.":[98],"L'analyse":[99],"liaison":[103],"toutes":[105],"souris":[109,170,225],"M":[113],"murin":[114],"montre":[115],"que":[116,172],"5":[117],"ligands":[121],"haute":[123],"affinit\u00e9":[124],"r\u00e9cepteur.":[127],"De":[128],"plus,":[129],"analys\u00e9":[132],"l'expression":[133,251],"tissulaire":[134],"au":[135],"niveau":[136],"ARN":[137],"prot\u00e9ine":[139],"diff\u00e9rentes":[141],"souris.":[144],"Dans":[145],"deuxi\u00e8me":[147],"temps,":[148],"\u00e9valu\u00e9":[151],"l'implication":[152],"sPLA2-X":[155,174,190,217],"dans":[156,198,218,231],"cancer":[158,222],"colorectal.":[159],"L'approche":[160,204],"in":[161,205],"vitro":[162],"cellules":[165],"tumorales":[166],"c\u00f4lon":[168],"indique":[171],"active":[175],"prolif\u00e9ration":[177],"cellulaire,":[178],"laquelle":[179],"d\u00e9pendante":[181],"multiples":[186],"lipidiques.":[188],"\u00e9galement":[192],"capable":[193],"d'induire":[194],"diff\u00e9rents":[195],"g\u00e8nes":[196],"impliqu\u00e9s":[197],"d\u00e9veloppement":[200],"tumoral,":[201],"notamment":[202],"COX-2.":[203,253],"vivo":[206],"vis\u00e9":[208],"\u00e9tudier":[210],"l'effet":[211],"d\u00e9l\u00e9tion":[214,237],"du":[215,244],"g\u00e8ne":[216],"mod\u00e8le":[220],"colorectal":[223],"ApcD14":[226],"d\u00e9veloppant":[227],"spontan\u00e9ment":[228],"polypes":[230],"l'intestin":[232],"c\u00f4lon.":[235],"ne":[238],"semble":[239],"pas":[240],"entra\u00eener":[241],"variation":[243],"nombre":[245],"tumeurs,":[247],"mais":[248],"diminuer":[250]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}