{"id":"https://openalex.org/W65917259","doi":null,"title":"Characterisation of cytokine expression in early synovitis and established rheumatoid arthritis","display_name":"Characterisation of cytokine expression in early synovitis and established rheumatoid arthritis","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W65917259","mag":"65917259"},"language":"en","primary_location":{"id":"pmh:oai:etheses.bham.ac.uk:3340","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/3340/1/Yeo12PhD.pdf","pdf_url":"http://etheses.bham.ac.uk/3340/1/Yeo12PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://etheses.bham.ac.uk/3340/1/Yeo12PhD.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035168688","display_name":"Lorraine Yeo","orcid":"https://orcid.org/0000-0002-9638-4920","observed_orcids":["https://orcid.org/0000-0002-9638-4920"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lorraine Yeo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9638-4920","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035168688"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/synovial-fluid","display_name":"synovial fluid","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cytokine-mrna-expression","display_name":"cytokine mRNA expression","score":0.9570000171661377},{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.8669999837875366},{"id":"https://openalex.org/keywords/synovial-b-cells","display_name":"synovial B cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.8479999899864197},{"id":"https://openalex.org/keywords/bone-erosion","display_name":"bone erosion","score":0.9259999990463257},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.8960000276565552},{"id":"https://openalex.org/keywords/b-cell-depletion","display_name":"B-cell depletion","score":0.6110000014305115},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.6880000233650208},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.875},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9570000171661377},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9319999814033508},{"id":"https://openalex.org/keywords/disease-outcome","display_name":"disease outcome","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C2779244835","wikidata":"https://www.wikidata.org/wiki/Q538432","display_name":"Synovitis","level":3,"score":0.897124171257019},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.7148053646087646},{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.6886784434318542},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.6818111538887024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6730368137359619},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5790415406227112},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4932844042778015},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.4764980673789978},{"id":"https://openalex.org/C2777652487","wikidata":"https://www.wikidata.org/wiki/Q575064","display_name":"Synovial membrane","level":3,"score":0.4494627118110657},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4470922648906708},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3433111906051636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17134875059127808},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.11184778809547424},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0886368453502655},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.05028679966926575},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:etheses.bham.ac.uk:3340","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/3340/1/Yeo12PhD.pdf","pdf_url":"http://etheses.bham.ac.uk/3340/1/Yeo12PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:uilis.unsyiah.ac.id:49282","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/49282","pdf_url":"http://etheses.bham.ac.uk/3340/1/Yeo12PhD.pdf","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:hdl:10068/991235","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/991235","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:65917259","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/3340/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:49282","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/49282","pdf_url":"http://etheses.bham.ac.uk/3340/1/Yeo12PhD.pdf","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W65917259.pdf","grobid_xml":"https://content.openalex.org/works/W65917259.grobid-xml"},"referenced_works_count":373,"referenced_works":["https://openalex.org/W428857","https://openalex.org/W24568342","https://openalex.org/W63864630","https://openalex.org/W66578723","https://openalex.org/W67343583","https://openalex.org/W132651321","https://openalex.org/W342727306","https://openalex.org/W1467128762","https://openalex.org/W1479829890","https://openalex.org/W1488722235","https://openalex.org/W1493844743","https://openalex.org/W1500526256","https://openalex.org/W1513992440","https://openalex.org/W1514704168","https://openalex.org/W1521119381","https://openalex.org/W1522228912","https://openalex.org/W1524209515","https://openalex.org/W1525131362","https://openalex.org/W1533649117","https://openalex.org/W1534645474","https://openalex.org/W1548735689","https://openalex.org/W1549764586","https://openalex.org/W1553271826","https://openalex.org/W1576993812","https://openalex.org/W1577799117","https://openalex.org/W1579678099","https://openalex.org/W1582010536","https://openalex.org/W1582684824","https://openalex.org/W1593238885","https://openalex.org/W1596381381","https://openalex.org/W1638726768","https://openalex.org/W1664294856","https://openalex.org/W1673896094","https://openalex.org/W1677043489","https://openalex.org/W1718950278","https://openalex.org/W1849537180","https://openalex.org/W1850499851","https://openalex.org/W1872792607","https://openalex.org/W1873126901","https://openalex.org/W1884361988","https://openalex.org/W1887688645","https://openalex.org/W1893260165","https://openalex.org/W1917161620","https://openalex.org/W1918766733","https://openalex.org/W1920662684","https://openalex.org/W1932093217","https://openalex.org/W1961692091","https://openalex.org/W1962132325","https://openalex.org/W1964288816","https://openalex.org/W1965354549","https://openalex.org/W1966419386","https://openalex.org/W1966955868","https://openalex.org/W1967353266","https://openalex.org/W1967673722","https://openalex.org/W1969337384","https://openalex.org/W1970431545","https://openalex.org/W1970443937","https://openalex.org/W1971498104","https://openalex.org/W1971944674","https://openalex.org/W1972640874","https://openalex.org/W1974545869","https://openalex.org/W1974596630","https://openalex.org/W1975387489","https://openalex.org/W1975534320","https://openalex.org/W1976236239","https://openalex.org/W1976262436","https://openalex.org/W1977034424","https://openalex.org/W1977568667","https://openalex.org/W1979409864","https://openalex.org/W1980024538","https://openalex.org/W1980205607","https://openalex.org/W1981069044","https://openalex.org/W1982335273","https://openalex.org/W1982863587","https://openalex.org/W1982926364","https://openalex.org/W1984716802","https://openalex.org/W1984925443","https://openalex.org/W1985380203","https://openalex.org/W1985596848","https://openalex.org/W1985680749","https://openalex.org/W1986370046","https://openalex.org/W1988157050","https://openalex.org/W1988210099","https://openalex.org/W1988280501","https://openalex.org/W1988660834","https://openalex.org/W1990420620","https://openalex.org/W1991472750","https://openalex.org/W1994210565","https://openalex.org/W1994402720","https://openalex.org/W1995557967","https://openalex.org/W1996548067","https://openalex.org/W1997676632","https://openalex.org/W1998313940","https://openalex.org/W1998618256","https://openalex.org/W1998866269","https://openalex.org/W1999709426","https://openalex.org/W1999808834","https://openalex.org/W2000539788","https://openalex.org/W2000599573","https://openalex.org/W2001395916","https://openalex.org/W2001570214","https://openalex.org/W2001923326","https://openalex.org/W2002076761","https://openalex.org/W2003284223","https://openalex.org/W2004498697","https://openalex.org/W2005260135","https://openalex.org/W2005429018","https://openalex.org/W2006831045","https://openalex.org/W2007221590","https://openalex.org/W2008116475","https://openalex.org/W2008891564","https://openalex.org/W2009074857","https://openalex.org/W2009260285","https://openalex.org/W2010403624","https://openalex.org/W2010469851","https://openalex.org/W2011882192","https://openalex.org/W2012130146","https://openalex.org/W2012680181","https://openalex.org/W2013573826","https://openalex.org/W2015475019","https://openalex.org/W2015865604","https://openalex.org/W2016446407","https://openalex.org/W2016956768","https://openalex.org/W2017624184","https://openalex.org/W2018749808","https://openalex.org/W2018987167","https://openalex.org/W2020074258","https://openalex.org/W2020595414","https://openalex.org/W2021154537","https://openalex.org/W2021427813","https://openalex.org/W2022223746","https://openalex.org/W2022382622","https://openalex.org/W2023442831","https://openalex.org/W2023976647","https://openalex.org/W2024129110","https://openalex.org/W2024932182","https://openalex.org/W2026317814","https://openalex.org/W2026445156","https://openalex.org/W2026507759","https://openalex.org/W2027789508","https://openalex.org/W2028421750","https://openalex.org/W2029437196","https://openalex.org/W2030379432","https://openalex.org/W2030728818","https://openalex.org/W2031073334","https://openalex.org/W2031467908","https://openalex.org/W2032455754","https://openalex.org/W2032586021","https://openalex.org/W2033132851","https://openalex.org/W2033228977","https://openalex.org/W2033789194","https://openalex.org/W2035238168","https://openalex.org/W2035345908","https://openalex.org/W2035416199","https://openalex.org/W2037168774","https://openalex.org/W2037953230","https://openalex.org/W2038689279","https://openalex.org/W2038783844","https://openalex.org/W2040733258","https://openalex.org/W2040886398","https://openalex.org/W2042329182","https://openalex.org/W2042586707","https://openalex.org/W2043629172","https://openalex.org/W2043842269","https://openalex.org/W2043878173","https://openalex.org/W2044135591","https://openalex.org/W2046321585","https://openalex.org/W2046957298","https://openalex.org/W2047859232","https://openalex.org/W2048299560","https://openalex.org/W2050591560","https://openalex.org/W2052873213","https://openalex.org/W2054343352","https://openalex.org/W2054802348","https://openalex.org/W2056453924","https://openalex.org/W2058267243","https://openalex.org/W2060660496","https://openalex.org/W2061763227","https://openalex.org/W2063557216","https://openalex.org/W2063966481","https://openalex.org/W2064976851","https://openalex.org/W2065054671","https://openalex.org/W2065973297","https://openalex.org/W2066246367","https://openalex.org/W2066770609","https://openalex.org/W2068272711","https://openalex.org/W2068438004","https://openalex.org/W2068577743","https://openalex.org/W2069239740","https://openalex.org/W2069947868","https://openalex.org/W2071330332","https://openalex.org/W2072677308","https://openalex.org/W2072857434","https://openalex.org/W2073242835","https://openalex.org/W2074353882","https://openalex.org/W2075071553","https://openalex.org/W2076182160","https://openalex.org/W2076456688","https://openalex.org/W2076889715","https://openalex.org/W2077286174","https://openalex.org/W2078403452","https://openalex.org/W2078570379","https://openalex.org/W2079632471","https://openalex.org/W2080236371","https://openalex.org/W2080773404","https://openalex.org/W2080817427","https://openalex.org/W2081769727","https://openalex.org/W2082160392","https://openalex.org/W2082450021","https://openalex.org/W2084386397","https://openalex.org/W2084547554","https://openalex.org/W2085328964","https://openalex.org/W2086777769","https://openalex.org/W2087524031","https://openalex.org/W2087810525","https://openalex.org/W2088275003","https://openalex.org/W2090217704","https://openalex.org/W2090489482","https://openalex.org/W2090507061","https://openalex.org/W2090543816","https://openalex.org/W2091444591","https://openalex.org/W2092602103","https://openalex.org/W2092728238","https://openalex.org/W2093120748","https://openalex.org/W2093383759","https://openalex.org/W2094438002","https://openalex.org/W2094871379","https://openalex.org/W2097583687","https://openalex.org/W2098280147","https://openalex.org/W2098496304","https://openalex.org/W2099458192","https://openalex.org/W2100421363","https://openalex.org/W2100733561","https://openalex.org/W2101180663","https://openalex.org/W2101230909","https://openalex.org/W2101436588","https://openalex.org/W2102815214","https://openalex.org/W2103010344","https://openalex.org/W2103310388","https://openalex.org/W2103445654","https://openalex.org/W2104546854","https://openalex.org/W2104684814","https://openalex.org/W2104843745","https://openalex.org/W2105794709","https://openalex.org/W2106036990","https://openalex.org/W2106180367","https://openalex.org/W2107093945","https://openalex.org/W2107658161","https://openalex.org/W2107773968","https://openalex.org/W2107798540","https://openalex.org/W2108090439","https://openalex.org/W2108685327","https://openalex.org/W2109132899","https://openalex.org/W2109234631","https://openalex.org/W2109453427","https://openalex.org/W2110029125","https://openalex.org/W2110051910","https://openalex.org/W2110555227","https://openalex.org/W2110604741","https://openalex.org/W2110724503","https://openalex.org/W2111496861","https://openalex.org/W2112128505","https://openalex.org/W2112866067","https://openalex.org/W2113606609","https://openalex.org/W2114378805","https://openalex.org/W2114431960","https://openalex.org/W2115109015","https://openalex.org/W2115692677","https://openalex.org/W2116828514","https://openalex.org/W2117056389","https://openalex.org/W2117976432","https://openalex.org/W2121266814","https://openalex.org/W2122507029","https://openalex.org/W2122939321","https://openalex.org/W2123884480","https://openalex.org/W2124853228","https://openalex.org/W2125010485","https://openalex.org/W2125196174","https://openalex.org/W2126197815","https://openalex.org/W2127568644","https://openalex.org/W2128952811","https://openalex.org/W2129806278","https://openalex.org/W2129840266","https://openalex.org/W2129961994","https://openalex.org/W2130859054","https://openalex.org/W2132402446","https://openalex.org/W2134717682","https://openalex.org/W2134753241","https://openalex.org/W2135117001","https://openalex.org/W2135403031","https://openalex.org/W2136357996","https://openalex.org/W2136692335","https://openalex.org/W2138784254","https://openalex.org/W2138796127","https://openalex.org/W2139008734","https://openalex.org/W2139056292","https://openalex.org/W2139162201","https://openalex.org/W2140211595","https://openalex.org/W2141063536","https://openalex.org/W2142257636","https://openalex.org/W2142396487","https://openalex.org/W2142802169","https://openalex.org/W2143065147","https://openalex.org/W2144679801","https://openalex.org/W2145619229","https://openalex.org/W2146444493","https://openalex.org/W2146677641","https://openalex.org/W2146934000","https://openalex.org/W2147780684","https://openalex.org/W2148078801","https://openalex.org/W2148172224","https://openalex.org/W2148198599","https://openalex.org/W2148740102","https://openalex.org/W2149380153","https://openalex.org/W2149661493","https://openalex.org/W2149768460","https://openalex.org/W2149849190","https://openalex.org/W2151015601","https://openalex.org/W2151539516","https://openalex.org/W2151566241","https://openalex.org/W2152264968","https://openalex.org/W2152348310","https://openalex.org/W2152402241","https://openalex.org/W2152569901","https://openalex.org/W2152578289","https://openalex.org/W2152746369","https://openalex.org/W2152808869","https://openalex.org/W2153191296","https://openalex.org/W2153434457","https://openalex.org/W2154545609","https://openalex.org/W2156049613","https://openalex.org/W2157130851","https://openalex.org/W2157710399","https://openalex.org/W2157713142","https://openalex.org/W2158854771","https://openalex.org/W2159543436","https://openalex.org/W2161151160","https://openalex.org/W2161160497","https://openalex.org/W2161384788","https://openalex.org/W2161417660","https://openalex.org/W2161854417","https://openalex.org/W2162280373","https://openalex.org/W2162633493","https://openalex.org/W2162640475","https://openalex.org/W2166044756","https://openalex.org/W2166203843","https://openalex.org/W2166732256","https://openalex.org/W2168125040","https://openalex.org/W2168516002","https://openalex.org/W2168748351","https://openalex.org/W2169015738","https://openalex.org/W2169031577","https://openalex.org/W2170384111","https://openalex.org/W2172079193","https://openalex.org/W2172291057","https://openalex.org/W2281049980","https://openalex.org/W2304614250","https://openalex.org/W2329486472","https://openalex.org/W2344899703","https://openalex.org/W2346802470","https://openalex.org/W2398757557","https://openalex.org/W2399367456","https://openalex.org/W2401338057","https://openalex.org/W2403051111","https://openalex.org/W2410773255","https://openalex.org/W2417180220","https://openalex.org/W2417861829","https://openalex.org/W2472195779","https://openalex.org/W2784110492","https://openalex.org/W4254761345","https://openalex.org/W4313333839","https://openalex.org/W4313343453","https://openalex.org/W4313347845"],"related_works":["https://openalex.org/W2103445654","https://openalex.org/W4256641552","https://openalex.org/W2335351623","https://openalex.org/W2124853228","https://openalex.org/W2044408790","https://openalex.org/W2106948642","https://openalex.org/W2138900092","https://openalex.org/W2318323485","https://openalex.org/W2086581767","https://openalex.org/W2096304334"],"abstract_inverted_index":{"In":[0,190],"rheumatoid":[1],"arthritis":[2,201],"(RA),":[3],"chronic":[4],"inflammation":[5],"and":[6,34,37,78,128,158,182,193,199,227,231],"destruction":[7],"of":[8,16,98,234,242,256],"the":[9,146,162,229],"joint":[10],"is":[11,213,240],"driven":[12],"by":[13,122,130],"local":[14],"production":[15],"cytokines.":[17],"My":[18],"aims":[19],"were":[20,141,195],"to":[21,38,43,53,61,204],"characterise":[22],"cytokine":[23,63,163,210,238],"mRNA":[24,64,164,211],"expression":[25,65,165,212,239],"in":[26,32,41,47,51,66,113,116,125,134,154,159,170,183,197,216,228],"multiple":[27],"synovial":[28,45,67,91,126,135,138,156,244],"fluid":[29,68,92],"cell":[30,148],"populations":[31],"early":[33,48,171,186,198,217,230,251],"established":[35,57,188,200,232],"RA":[36,90,177,222],"study":[39],"these,":[40],"addition":[42],"whole":[44,155],"tissue,":[46,127],"synovitis":[49,172,218,252],"patients":[50,173,184,202,219],"relation":[52],"disease":[54],"outcome.":[55],"I":[56,83],"a":[58,107],"novel":[59,86],"method":[60],"determine":[62],"CD4":[69],"T":[70,73],"cells,":[71,74,76,161],"CD8":[72],"B":[75,93,111,123,132,147],"macrophages":[77],"neutrophils":[79],"directly":[80],"ex":[81],"vivo.":[82],"made":[84],"several":[85],"observations,":[87],"for":[88,110,250],"example":[89],"cells":[94,112,124,133],"expressed":[95,121],"high":[96],"levels":[97,140],"RANKL.":[99],"As":[100],"RANKL":[101,118,139],"drives":[102],"bone":[103,114],"resorption,":[104],"this":[105],"suggests":[106,236],"potential":[108],"role":[109],"erosion":[115],"RA.":[117,189,257],"protein":[119],"was":[120,167],"mainly":[129],"memory":[131],"fluid.":[136],"Furthermore,":[137],"reduced":[142],"after":[143],"treatment":[144],"with":[145,185],"depleting":[149],"therapy,":[150],"rituximab.":[151],"Overall,":[152],"both":[153],"tissue":[157],"sorted":[160],"profile":[166],"very":[168],"similar":[169,215],"who":[174,220],"subsequently":[175],"developed":[176],"or":[178,187,223,254],"had":[179],"resolving":[180,225],"synovitis,":[181],"comparison,":[191],"cytokines":[192],"chemokines":[194],"upregulated":[196],"compared":[203],"uninflamed":[205],"controls.":[206],"The":[207],"finding":[208],"that":[209,237],"largely":[214],"develop":[221],"have":[224],"disease,":[226],"phases":[233],"RA,":[235],"reflective":[241],"general":[243],"inflammation,":[245],"rather":[246],"than":[247],"being":[248],"specific":[249],"outcome":[253],"stage":[255]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
