{"id":"https://openalex.org/W658732113","doi":null,"title":"Preventive potential of N-acetylcysteine in oxidative stress-related complications of prematurity","display_name":"Preventive potential of N-acetylcysteine in oxidative stress-related complications of prematurity","publication_year":2004,"publication_date":"2004-05-01","ids":{"openalex":"https://openalex.org/W658732113","mag":"658732113"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/22804","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/22804","pdf_url":"http://hdl.handle.net/10138/22804","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/22804","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112508658","display_name":"Terhi Ahola","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Terhi Ahola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112508658"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bronchopulmonary-dysplasia","display_name":"bronchopulmonary dysplasia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.8220000267028809},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7860000133514404},{"id":"https://openalex.org/keywords/extremely-low-birth-weight-infants","display_name":"extremely low birth weight infants","score":0.796999990940094},{"id":"https://openalex.org/keywords/8-isoprostane","display_name":"8-isoprostane","score":0.8629999756813049},{"id":"https://openalex.org/keywords/ascorbyl-radical","display_name":"ascorbyl radical","score":0.8830000162124634},{"id":"https://openalex.org/keywords/thiol-metabolism","display_name":"thiol metabolism","score":0.8479999899864197},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cysteine","display_name":"cysteine","score":0.9419999718666077},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8980000019073486},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.4490000009536743},{"id":"https://openalex.org/keywords/periventricular-leukomalacia","display_name":"periventricular leukomalacia","score":0.7390000224113464},{"id":"https://openalex.org/keywords/oxygen-therapy","display_name":"oxygen therapy","score":0.5299999713897705},{"id":"https://openalex.org/keywords/risk-indicators","display_name":"risk indicators","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6560394167900085},{"id":"https://openalex.org/C2777847592","wikidata":"https://www.wikidata.org/wiki/Q375613","display_name":"Acetylcysteine","level":3,"score":0.618133008480072},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5659714341163635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16428375244140625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1363992691040039},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.09816643595695496},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0667693018913269}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/22804","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/22804","pdf_url":"http://hdl.handle.net/10138/22804","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral dissertation"},{"id":"mag:658732113","doi":null,"is_oa":false,"landing_page_url":"http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/ahola/preventi.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/22804","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/22804","pdf_url":"http://hdl.handle.net/10138/22804","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320310467","display_name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","ror":"https://ror.org/020cpqb94"},{"id":"https://openalex.org/F4320311816","display_name":"Finska L\u00e4kares\u00e4llskapet","ror":"https://ror.org/04vbzm272"},{"id":"https://openalex.org/F4320322456","display_name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/03bj5da63"},{"id":"https://openalex.org/F4320324148","display_name":"Orionin Tutkimuss\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0296s4x19"},{"id":"https://openalex.org/F4320325094","display_name":"Suomalainen L\u00e4\u00e4k\u00e4riseura Duodecim","ror":"https://ror.org/056xr2125"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W658732113.pdf","grobid_xml":"https://content.openalex.org/works/W658732113.grobid-xml"},"referenced_works_count":258,"referenced_works":["https://openalex.org/W36026161","https://openalex.org/W36409839","https://openalex.org/W42120779","https://openalex.org/W70039955","https://openalex.org/W108827801","https://openalex.org/W111825775","https://openalex.org/W146410082","https://openalex.org/W156532761","https://openalex.org/W282705305","https://openalex.org/W301492158","https://openalex.org/W357660346","https://openalex.org/W1489408430","https://openalex.org/W1500094754","https://openalex.org/W1503912260","https://openalex.org/W1507958108","https://openalex.org/W1508162082","https://openalex.org/W1544801022","https://openalex.org/W1550989404","https://openalex.org/W1566624716","https://openalex.org/W1580864703","https://openalex.org/W1581414347","https://openalex.org/W1601301295","https://openalex.org/W1655177618","https://openalex.org/W1734477456","https://openalex.org/W1738317710","https://openalex.org/W1786911182","https://openalex.org/W1826072933","https://openalex.org/W1827233390","https://openalex.org/W1853423207","https://openalex.org/W1887679324","https://openalex.org/W1891673831","https://openalex.org/W1915832533","https://openalex.org/W1940436875","https://openalex.org/W1940603260","https://openalex.org/W1956357383","https://openalex.org/W1964384663","https://openalex.org/W1964473500","https://openalex.org/W1965120955","https://openalex.org/W1965397817","https://openalex.org/W1965657572","https://openalex.org/W1966431585","https://openalex.org/W1966695504","https://openalex.org/W1967405067","https://openalex.org/W1968269372","https://openalex.org/W1968809092","https://openalex.org/W1969911349","https://openalex.org/W1971170290","https://openalex.org/W1971778935","https://openalex.org/W1972851188","https://openalex.org/W1973593141","https://openalex.org/W1975727369","https://openalex.org/W1977406521","https://openalex.org/W1977847681","https://openalex.org/W1979748445","https://openalex.org/W1981428946","https://openalex.org/W1983377205","https://openalex.org/W1983881370","https://openalex.org/W1983972871","https://openalex.org/W1984049469","https://openalex.org/W1984288246","https://openalex.org/W1984677592","https://openalex.org/W1985147981","https://openalex.org/W1985289402","https://openalex.org/W1985732522","https://openalex.org/W1986180694","https://openalex.org/W1986394834","https://openalex.org/W1987868867","https://openalex.org/W1988345578","https://openalex.org/W1988424962","https://openalex.org/W1990942290","https://openalex.org/W1990962982","https://openalex.org/W1991001058","https://openalex.org/W1992020870","https://openalex.org/W1992594096","https://openalex.org/W1992815766","https://openalex.org/W1994673004","https://openalex.org/W1995013280","https://openalex.org/W1995110990","https://openalex.org/W1995317658","https://openalex.org/W1996202382","https://openalex.org/W1996999580","https://openalex.org/W1997786521","https://openalex.org/W1998134551","https://openalex.org/W1998503377","https://openalex.org/W1999150852","https://openalex.org/W1999194263","https://openalex.org/W1999365716","https://openalex.org/W1999392732","https://openalex.org/W2000529161","https://openalex.org/W2002269747","https://openalex.org/W2002306720","https://openalex.org/W2002794726","https://openalex.org/W2002802172","https://openalex.org/W2002984469","https://openalex.org/W2003928089","https://openalex.org/W2004119748","https://openalex.org/W2005380677","https://openalex.org/W2005598261","https://openalex.org/W2006013749","https://openalex.org/W2006162058","https://openalex.org/W2006461547","https://openalex.org/W2008004149","https://openalex.org/W2008050730","https://openalex.org/W2008820196","https://openalex.org/W2009137800","https://openalex.org/W2009752174","https://openalex.org/W2010094123","https://openalex.org/W2011531678","https://openalex.org/W2011896559","https://openalex.org/W2014083430","https://openalex.org/W2014555650","https://openalex.org/W2015379175","https://openalex.org/W2016771524","https://openalex.org/W2016777097","https://openalex.org/W2019549525","https://openalex.org/W2020331459","https://openalex.org/W2020742643","https://openalex.org/W2021046651","https://openalex.org/W2022148560","https://openalex.org/W2022628608","https://openalex.org/W2026304182","https://openalex.org/W2026312693","https://openalex.org/W2026785305","https://openalex.org/W2027718872","https://openalex.org/W2029706246","https://openalex.org/W2029809671","https://openalex.org/W2030365747","https://openalex.org/W2030733295","https://openalex.org/W2031022721","https://openalex.org/W2033248531","https://openalex.org/W2034700245","https://openalex.org/W2034751609","https://openalex.org/W2036627796","https://openalex.org/W2037038152","https://openalex.org/W2037159487","https://openalex.org/W2037417765","https://openalex.org/W2037894687","https://openalex.org/W2039066512","https://openalex.org/W2039323982","https://openalex.org/W2040005638","https://openalex.org/W2040796847","https://openalex.org/W2041017075","https://openalex.org/W2041162136","https://openalex.org/W2042306961","https://openalex.org/W2042662902","https://openalex.org/W2042972763","https://openalex.org/W2043750262","https://openalex.org/W2044692086","https://openalex.org/W2044855063","https://openalex.org/W2044900376","https://openalex.org/W2046224781","https://openalex.org/W2046875107","https://openalex.org/W2047860382","https://openalex.org/W2049144694","https://openalex.org/W2052543033","https://openalex.org/W2054456296","https://openalex.org/W2055919206","https://openalex.org/W2056769172","https://openalex.org/W2057770637","https://openalex.org/W2057931934","https://openalex.org/W2058461613","https://openalex.org/W2058881562","https://openalex.org/W2059578393","https://openalex.org/W2060419524","https://openalex.org/W2061242359","https://openalex.org/W2061827507","https://openalex.org/W2061893277","https://openalex.org/W2062818405","https://openalex.org/W2063320607","https://openalex.org/W2063965713","https://openalex.org/W2065020384","https://openalex.org/W2065351980","https://openalex.org/W2066890355","https://openalex.org/W2066907234","https://openalex.org/W2068356987","https://openalex.org/W2068370664","https://openalex.org/W2069113218","https://openalex.org/W2069334549","https://openalex.org/W2074869372","https://openalex.org/W2077605695","https://openalex.org/W2078631643","https://openalex.org/W2078856699","https://openalex.org/W2080031230","https://openalex.org/W2080056920","https://openalex.org/W2082383849","https://openalex.org/W2083079891","https://openalex.org/W2083468617","https://openalex.org/W2085389145","https://openalex.org/W2086380721","https://openalex.org/W2086383563","https://openalex.org/W2087070965","https://openalex.org/W2088302531","https://openalex.org/W2089288497","https://openalex.org/W2089335039","https://openalex.org/W2091232570","https://openalex.org/W2091735640","https://openalex.org/W2092165372","https://openalex.org/W2092364565","https://openalex.org/W2092438643","https://openalex.org/W2092932922","https://openalex.org/W2093737679","https://openalex.org/W2094000643","https://openalex.org/W2094321502","https://openalex.org/W2095014707","https://openalex.org/W2095095015","https://openalex.org/W2098036791","https://openalex.org/W2098439388","https://openalex.org/W2099432167","https://openalex.org/W2099922198","https://openalex.org/W2107625098","https://openalex.org/W2109467704","https://openalex.org/W2112257614","https://openalex.org/W2113435013","https://openalex.org/W2120940234","https://openalex.org/W2121547107","https://openalex.org/W2122594892","https://openalex.org/W2122989989","https://openalex.org/W2123658190","https://openalex.org/W2124374786","https://openalex.org/W2128360784","https://openalex.org/W2132345115","https://openalex.org/W2132826785","https://openalex.org/W2133833958","https://openalex.org/W2134401145","https://openalex.org/W2140841363","https://openalex.org/W2140985089","https://openalex.org/W2141744832","https://openalex.org/W2141874177","https://openalex.org/W2142060219","https://openalex.org/W2147690198","https://openalex.org/W2150432453","https://openalex.org/W2152102146","https://openalex.org/W2154563160","https://openalex.org/W2156219228","https://openalex.org/W2157597415","https://openalex.org/W2158118268","https://openalex.org/W2158224502","https://openalex.org/W2160487932","https://openalex.org/W2161368024","https://openalex.org/W2162371077","https://openalex.org/W2165346935","https://openalex.org/W2169654509","https://openalex.org/W2169752101","https://openalex.org/W2175340332","https://openalex.org/W2188088995","https://openalex.org/W2211470888","https://openalex.org/W2224390832","https://openalex.org/W2258939519","https://openalex.org/W2268281862","https://openalex.org/W2313265919","https://openalex.org/W2313326603","https://openalex.org/W2315312762","https://openalex.org/W2338071630","https://openalex.org/W2397091600","https://openalex.org/W2406567705","https://openalex.org/W2409600169","https://openalex.org/W2412027018","https://openalex.org/W2885535710"],"related_works":["https://openalex.org/W3087732027","https://openalex.org/W2079527302","https://openalex.org/W2928124637","https://openalex.org/W2089940965","https://openalex.org/W7099541744","https://openalex.org/W2379701476","https://openalex.org/W4400764191","https://openalex.org/W2085850837","https://openalex.org/W3039294612","https://openalex.org/W4404550185"],"abstract_inverted_index":{"Background:":[0],"Oxygen":[1],"therapy":[2],"and":[3,15,51,97,121,142,161,172,184,191,217,220,229,270,344,397,405,433,451,507,517,521,530,547],"inflammation":[4],"are":[5],"key":[6],"factors":[7],"in":[8,35,90,102,117,125,193,199,222,238,244,310,335,348,386,403,436,444,460,464,527,534,538],"the":[9,18,40,69,106,113,123,126,147,164,174,200,205,209,301,328,336,363,409,423,480,551],"pathogenesis":[10],"of":[11,20,25,39,43,71,79,87,109,115,130,144,150,158,166,176,196,212,251,264,288,331,355,412,426,442,455,472,476,554],"bronchopulmonary":[12],"dysplasia":[13],"(BPD)":[14],"both":[16],"increase":[17,60,526],"generation":[19],"reactive":[21],"oxygen":[22],"species.The":[23],"synthesis":[24],"glutathione,":[26],"a":[27,47,52,83,131,154,194,248,275,284,428,473,541],"major":[28],"intracellular":[29,431],"antioxidant,":[30],"may":[31,358],"not":[32,305,489],"be":[33,316,359],"adequate":[34],"preterm":[36,72,103,118,245,445,461],"neonates":[37],"because":[38],"low":[41,92,224],"levels":[42],"cysteine":[44,219,399,432,536,546],"available.N-acetylcysteine":[45],"(NAC),":[46],"free":[48,495,504],"radical":[49,186,378,515],"scavenger":[50],"precursor":[53],"for":[54,261,361,366],"cysteine,":[55],"has":[56],"been":[57],"suggested":[58],"to":[59,81,98,162,318,449,540],"glutathione":[61,221,235,393,420,434,529,548],"synthesis.Aims:":[62],"To":[63],"determine":[64],"whether":[65],"NAC":[66,116,127,167,240,265,319],"treatment":[67,128,320,487],"improves":[68],"outcome":[70,138],"infants":[73,95,104,120,197,227,337,349,388,446],"by":[74],"preventing":[75],"oxidative":[76,88,159,356],"stress-related":[77],"complications":[78],"prematurity,":[80],"identify":[82,153],"suitable":[84,155],"risk":[85,156,175,364],"indicator":[86,157],"damage":[89,160],"extremely":[91],"birth":[93,225],"weight":[94,226,269,450],"(ELBWI)":[96],"evaluate":[99,163],"thiol":[100,206],"metabolism":[101,207],"during":[105,208,327,408,422,550],"first":[107,210,329,410,424,552],"week":[108,211,330,411,553],"life.Design:":[110],"We":[111],"investigated":[112],"pharmacokinetics":[114,441],"newborn":[119],"applied":[122],"results":[124],"protocol":[129],"randomized,":[132],"placebo-controlled,":[133],"double-blind":[134],"multicentre":[135,201],"trial.The":[136],"primary":[137],"measures":[139],"were":[140,321,333,483],"death":[141,309],"prevalence":[143],"BPD":[145,177,307,341,506],"at":[146,283,300,479],"gestational":[148,271,452,467],"age":[149],"36":[151,466],"weeks.To":[152],"effect":[165,372],"infusion":[168,286],"on":[169,173,188,373,380,485,493],"this":[170],"marker":[171,354],"or":[178,308,342,497],"death,":[179],"we":[180,214],"measured":[181],"plasma":[182,216,374,398,494,503,513,528,535],"8-isoprostane":[183,325,375,496],"ascorbyl":[185,377,498,514],"concentrations":[187,326,394,400,421,435,549],"days":[189,282],"3":[190,382],"7":[192],"subpopulation":[195],"participating":[198],"trial.To":[202],"further":[203],"clarify":[204],"life,":[213],"studied":[215,407],"erythrocyte":[218,234,545],"very":[223],"(VLBWI)":[228],"ELBWI,":[230,295],"as":[231,233,509,511],"well":[232,267,510],"cycle":[236],"enzymes":[237],"VLBWI.Results:":[239],"is":[241,255,447,457],"eliminated":[242],"slowly":[243],"infants,":[246,274],"with":[247,268],"mean":[249],"half-life":[250],"11":[252],"hours,":[253],"which":[254],"clearly":[256],"longer":[257],"than":[258,463],"that":[259,297,314],"described":[260],"adults.The":[262],"clearance":[263],"correlates":[266],"age.In":[272],"most":[273],"steady-state":[276],"concentration":[277,379],"was":[278,383,438,519],"reached":[279],"within":[280],"2-3":[281],"constant":[285],"rate":[287],"NAC.The":[289],"randomized":[290],"controlled":[291],"trial,":[292],"including":[293],"391":[294],"showed":[296],"intravenous":[298,477],"NAC,":[299,478],"dosage":[302,481],"used,":[303,482],"did":[304,488],"prevent":[306],"ELBWI.No":[311],"adverse":[312,367],"effects":[313,471],"could":[315],"ascribed":[317],"observed.Abstract":[322],"10":[323],"Plasma":[324],"life":[332],"higher":[334,385],"who":[338,350,389,414],"later":[339,351],"developed":[340,352,391,415],"died,":[343],"increased":[345,396],"significantly":[346,384],"more":[347],"PVL.This":[353],"stress":[357],"valuable":[360],"defining":[362],"group":[365],"outcome.NAC":[368],"had":[369,418],"no":[370,469],"significant":[371],"concentration.The":[376],"day":[381],"those":[387],"subsequently":[390],"PVL.Plasma":[392],"initially":[395,401],"decreased":[402],"VLBWI":[404],"ELBWI":[406,522],"life.Infants":[413],"RDS":[416],"already":[417],"lower":[419],"hours":[425],"life.Furthermore,":[427],"correlation":[429,543],"between":[430,501,512,544],"erythrocytes":[437],"present.":[439],"Conclusions:The":[440],"N-acetylcysteine":[443,456],"related":[448],"age.The":[453],"elimination":[454],"much":[458],"slower":[459],"newborns":[462],"adults.At":[465],"weeks":[468],"beneficial":[470],"6-day":[474],"course":[475],"demonstrated":[484],"BPD.NAC":[486],"have":[490,523],"any":[491],"impact":[492],"radical.An":[499],"association":[500],"elevated":[502],"8-isoprostane,":[505],"PVL,":[508,518],"signal":[516],"found.VLBWI":[520],"an":[524,531],"initial":[525,532],"decrease":[533],"concentration,":[537],"addition":[539],"positive":[542],"life.":[555]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
