{"id":"https://openalex.org/W65828984","doi":"https://doi.org/10.1371/journal.pmed.1001685","title":"Efficacy and Safety of the RTS,S/AS01 Malaria Vaccine during 18 Months after Vaccination: A Phase 3 Randomized, Controlled Trial in Children and Young Infants at 11 African Sites","display_name":"Efficacy and Safety of the RTS,S/AS01 Malaria Vaccine during 18 Months after Vaccination: A Phase 3 Randomized, Controlled Trial in Children and Young Infants at 11 African Sites","publication_year":2014,"publication_date":"2014-07-29","ids":{"openalex":"https://openalex.org/W65828984","doi":"https://doi.org/10.1371/journal.pmed.1001685","mag":"65828984","pmid":"https://pubmed.ncbi.nlm.nih.gov/25072396","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4114488"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pmed.1001685","doi":"https://doi.org/10.1371/journal.pmed.1001685","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1001685","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001685&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001685&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"The RTSS Clinical Trials Partnership (2014)","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]}],"countries":["DK","GB"],"is_corresponding":true,"raw_author_name":"The RTSS Clinical Trials Partnership (2014)","raw_affiliation_strings":["St. George's, University of London, United Kingdom","K\u00f8benhavns Universitet, Faculty of Health and Medical Sciences, Department of Immunology and Microbiology, Centre for Medical Parasitology, DK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. George's, University of London, United Kingdom","institution_ids":["https://openalex.org/I165862685"]},{"raw_affiliation_string":"K\u00f8benhavns Universitet, Faculty of Health and Medical Sciences, Department of Immunology and Microbiology, Centre for Medical Parasitology, DK","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I165862685"],"apc_list":{"value":6460,"currency":"USD","value_usd":6460},"apc_paid":{"value":6460,"currency":"USD","value_usd":6460},"fwci":57.5387,"has_fulltext":true,"cited_by_count":518,"citation_normalized_percentile":{"value":0.99937524,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"11","issue":"7","first_page":"e1001685","last_page":"e1001685"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12402","display_name":"Travel-related health issues","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rts-s-as01","display_name":"RTS,S/AS01","score":0.9509999752044678},{"id":"https://openalex.org/keywords/malaria-vaccine","display_name":"malaria vaccine","score":0.9649999737739563},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.8960000276565552},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.9900000095367432},{"id":"https://openalex.org/keywords/clinical-malaria","display_name":"clinical malaria","score":0.531000018119812},{"id":"https://openalex.org/keywords/severe-malaria","display_name":"severe malaria","score":0.9959999918937683},{"id":"https://openalex.org/keywords/malaria-hospitalization","display_name":"malaria hospitalization","score":0.968999981880188},{"id":"https://openalex.org/keywords/all-cause-hospitalization","display_name":"all-cause hospitalization","score":0.8339999914169312},{"id":"https://openalex.org/keywords/waning-immunity","display_name":"waning immunity","score":0.6669999957084656},{"id":"https://openalex.org/keywords/vaccine-adverse-events","display_name":"vaccine adverse events","score":0.5690000057220459},{"id":"https://openalex.org/keywords/meningitis","display_name":"meningitis","score":0.7080000042915344},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.3580000102519989},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.8169999718666077},{"id":"https://openalex.org/keywords/malaria-transmission-intensity","display_name":"malaria transmission intensity","score":0.6600000262260437},{"id":"https://openalex.org/keywords/african-children","display_name":"African children","score":0.4620000123977661},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.7749999761581421},{"id":"https://openalex.org/keywords/rts-s","display_name":"RTS,S","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8475186824798584},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.8399592041969299},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.7977325916290283},{"id":"https://openalex.org/C2781034427","wikidata":"https://www.wikidata.org/wiki/Q6741353","display_name":"Malaria vaccine","level":4,"score":0.7471793293952942},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.523926317691803},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5092982053756714},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.46993502974510193},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.469706267118454},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.42919689416885376},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.41185176372528076},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32737278938293457},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3151591718196869},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.2951670289039612}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017954","descriptor_name":"Africa South of the Sahara","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1371/journal.pmed.1001685","doi":"https://doi.org/10.1371/journal.pmed.1001685","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1001685","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001685&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3090245","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4114488","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4114488","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4114488","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Med","raw_type":"Text"},{"id":"pmid:25072396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25072396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS medicine","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/afe8135c-d79f-440c-b7b8-46ec1b6b1450","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/afe8135c-d79f-440c-b7b8-46ec1b6b1450","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theander, T G, Lusingu, J P A & RTS,S Clinical Trials Partnership 2014, 'Efficacy and Safety of the RTS,S/AS01 Malaria Vaccine during 18 Months after Vaccination : A Phase 3 Randomized, Controlled Trial in Children and Young Infants at 11 African Sites', P L o S Medicine (Online), vol. 11, no. 7, e1001685, pp. 1-24. https://doi.org/10.1371/journal.pmed.1001685","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:edoc.unibas.ch:34606","doi":null,"is_oa":false,"landing_page_url":"http://edoc.unibas.ch/34606/1/20140812154601_53ea1a9932086.pdf","pdf_url":"http://edoc.unibas.ch/34606/1/20140812154601_53ea1a9932086.pdf","source":{"id":"https://openalex.org/S4306401836","display_name":"edoc (University of Basel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1850255","host_organization_name":"University of Basel","host_organization_lineage":["https://openalex.org/I1850255"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:researchonline.lshtm.ac.uk:2299178","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1001685>","pdf_url":null,"source":{"id":"https://openalex.org/S4306402527","display_name":"LSHTM Research Online (London School of Hygiene and Tropical Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210089966","host_organization_name":"London School of Hygiene & Tropical Medicine","host_organization_lineage":["https://openalex.org/I4210089966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:09d7679c0bf84b1893a6c44f6322e42f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/09d7679c0bf84b1893a6c44f6322e42f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Medicine, Vol 11, Iss 7, p e1001685 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1121374","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Efficacy_and_Safety_of_the_RTS_S_AS01_Malaria_Vaccine_during_18_Months_after_Vaccination_A_Phase_3_Randomized_Controlled_Trial_in_Children_and_Young_Infants_at_11_African_Sites_/1121374","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:ba02191f-3d43-4d8b-be9b-e10e9bbe747b","doi":null,"is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:ba02191f-3d43-4d8b-be9b-e10e9bbe747b","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"},{"id":"doi:10.5451/unibas-ep34606","doi":"https://doi.org/10.5451/unibas-ep34606","is_oa":true,"landing_page_url":"https://doi.org/10.5451/unibas-ep34606","pdf_url":null,"source":{"id":"https://openalex.org/S4306401836","display_name":"edoc (University of Basel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1850255","host_organization_name":"University of Basel","host_organization_lineage":["https://openalex.org/I1850255"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:2141411856","doi":null,"is_oa":false,"landing_page_url":"https://edoc.unibas.ch/34606/1/20140812154601_53ea1a9932086.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1371/journal.pmed.1001685","doi":"https://doi.org/10.1371/journal.pmed.1001685","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1001685","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001685&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G4973618217","display_name":"Oxford part of Kenya MOP renewal 2010 - 2015","funder_award_id":"092654","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320306115","display_name":"United States Agency for International Development","ror":"https://ror.org/01n6e6j62"},{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320306882","display_name":"American Society of Tropical Medicine and Hygiene","ror":"https://ror.org/018eag955"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320311430","display_name":"London School of Hygiene and Tropical Medicine","ror":"https://ror.org/00a0jsq62"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320326620","display_name":"National Health Laboratory Service","ror":"https://ror.org/00znvbk37"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W65828984.pdf","grobid_xml":"https://content.openalex.org/works/W65828984.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1971209330","https://openalex.org/W1980875835","https://openalex.org/W2004574254","https://openalex.org/W2033491184","https://openalex.org/W2034645256","https://openalex.org/W2044889291","https://openalex.org/W2046182783","https://openalex.org/W2073186204","https://openalex.org/W2074122062","https://openalex.org/W2088688332","https://openalex.org/W2092595719","https://openalex.org/W2094077008","https://openalex.org/W2094431581","https://openalex.org/W2095554063","https://openalex.org/W2100923855","https://openalex.org/W2107181087","https://openalex.org/W2108476551","https://openalex.org/W2112775837","https://openalex.org/W2117914570","https://openalex.org/W2124892357","https://openalex.org/W2128856307","https://openalex.org/W2137315308","https://openalex.org/W2138692289","https://openalex.org/W2142936476","https://openalex.org/W2144207524","https://openalex.org/W2151087339","https://openalex.org/W2161311583","https://openalex.org/W2163541387","https://openalex.org/W2163861382","https://openalex.org/W2169170846","https://openalex.org/W2244674613","https://openalex.org/W2340524139","https://openalex.org/W2341767081","https://openalex.org/W4241516881"],"related_works":["https://openalex.org/W2108476551","https://openalex.org/W2244674613","https://openalex.org/W2095300212","https://openalex.org/W7043155673","https://openalex.org/W4254848468","https://openalex.org/W2280201363","https://openalex.org/W2127104623","https://openalex.org/W2942029710","https://openalex.org/W2113838865","https://openalex.org/W2472994826"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"malaria":[2,36,66,119,149,175,223,292,310,330,343],"vaccine":[3,18,24,74,101,298],"could":[4,336],"be":[5,337],"an":[6,338],"important":[7,339],"addition":[8,340],"to":[9,54,84,88,105,113,129,135,142,157,165,189,199,235,240,249,253,341],"current":[10,342],"control":[11,280,344],"strategies.":[12],"We":[13],"report":[14],"the":[15,22,70,97,277,294,302,308,327,355,358],"safety":[16],"and":[17,46,121,137,196,221,237,251,267,270,273,279,290],"efficacy":[19],"(VE)":[20],"of":[21,58,219,288,325,329],"RTS,S/AS01":[23,59,278,284,335],"during":[25,69,96],"18":[26,71,295],"mo":[27,51,72,99,296],"following":[28],"vaccination":[29],"at":[30,322],"11":[31],"African":[32],"sites":[33,193,232],"with":[34,168,301,307],"varying":[35],"transmission.":[37],"METHODS":[38],"AND":[39],"FINDINGS:":[40],"6,537":[41],"infants":[42,151,203,246,275],"aged":[43,49],"6-12":[44],"wk":[45],"8,923":[47],"children":[48,68,195,228,269,316],"5-17":[50],"were":[52,247],"randomized":[53],"receive":[55],"three":[56],"doses":[57],"or":[60,177],"comparator":[61],"vaccine.":[62],"VE":[63,95,115,146,206,312],"against":[64,116,147,172],"clinical":[65,148,220,289],"in":[67,150,194,202,210,265,271,276,305,315,318,345,354],"after":[73,100,297],"dose":[75,102,299],"3":[76],"(per":[77,204],"protocol)":[78],"was":[79,108,124,152,258,313,333],"46%":[80],"(95%":[81,110,126,132,139,154],"CI":[82,111,127,133,140,155,163],"42%":[83],"50%)":[85],"(range":[86],"40%":[87],"77%;":[89],"VE,":[90,326],"p<0.01":[91],"across":[92,192,231],"all":[93],"sites).":[94],"20":[98],"1":[103],"(intention":[104],"treat":[106],"[ITT])":[107],"45%":[109],"41%":[112,131],"49%).":[114],"severe":[117,173,222,291],"malaria,":[118,174],"hospitalization,":[120,176],"all-cause":[122,178],"hospitalization":[123],"34%":[125],"15%":[128],"48%),":[130],"30%":[134],"50%),":[136],"19%":[138],"11%":[141],"27%),":[143],"respectively":[144,255],"(ITT).":[145,256],"27%":[153,161],"20%":[156],"32%,":[158],"per":[159,226],"protocol;":[160],"[95%":[162],"21%":[164],"33%],":[166],"ITT),":[167],"no":[169],"significant":[170],"protection":[171],"hospitalization.":[179],"Post-vaccination":[180],"anti-circumsporozoite":[181],"antibody":[182],"geometric":[183],"mean":[184],"titer":[185],"varied":[186],"from":[187,197,233,238],"348":[188],"787":[190],"EU/ml":[191,201],"117":[198],"335":[200],"protocol).":[205],"waned":[207],"over":[208,293],"time":[209],"both":[211],"age":[212],"categories":[213],"(Schoenfeld":[214],"residuals":[215],"p<0.001).":[216],"The":[217],"number":[218,328],"cases":[224,287,331],"averted":[225,332],"1,000":[227],"vaccinated":[229],"ranged":[230],"37":[234],"2,365":[236],"-1":[239],"49,":[241],"respectively;":[242],"corresponding":[243],"ranges":[244],"among":[245],"-10":[248],"1,402":[250],"-13":[252],"37,":[254],"Meningitis":[257],"reported":[259],"as":[260],"a":[261],"serious":[262],"adverse":[263],"event":[264],"16/5,949":[266],"1/2,974":[268],"9/4,358":[272],"3/2,179":[274],"groups,":[281],"respectively.":[282],"CONCLUSIONS:":[283],"prevented":[285],"many":[286],"3,":[300],"highest":[303],"impact":[304],"areas":[306],"greatest":[309],"incidence.":[311],"higher":[314],"than":[317],"infants,":[319],"but":[320],"even":[321],"modest":[323],"levels":[324],"substantial.":[334],"Africa.":[346],"TRIAL":[347],"REGISTRATION:":[348],"www.ClinicalTrials.gov":[349],"NCT00866619":[350],"Please":[351],"see":[352],"later":[353],"article":[356],"for":[357],"Editors'":[359],"Summary.":[360]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":54},{"year":2024,"cited_by_count":36},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":35},{"year":2021,"cited_by_count":51},{"year":2020,"cited_by_count":43},{"year":2019,"cited_by_count":32},{"year":2018,"cited_by_count":42},{"year":2017,"cited_by_count":48},{"year":2016,"cited_by_count":53},{"year":2015,"cited_by_count":64},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}