{"id":"https://openalex.org/W65820918","doi":null,"title":"CD4 and CD8 T cell proliferation and differentiation in response to Listeria monocytogenes infection","display_name":"CD4 and CD8 T cell proliferation and differentiation in response to Listeria monocytogenes infection","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W65820918","mag":"65820918"},"language":"en","primary_location":{"id":"pmh:oai:repository.upenn.edu:dissertations-3471","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI3087402","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042447717","display_name":"Kathryn E. Foulds","orcid":"https://orcid.org/0000-0003-4418-6495","observed_orcids":["https://orcid.org/0000-0003-4418-6495"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kathryn E. Foulds","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4418-6495","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042447717"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9169999957084656},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/listeria-monocytogenes-infection","display_name":"Listeria monocytogenes infection","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tcr-transgenic-t-cells","display_name":"TCR transgenic T cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/adoptive-transfer","display_name":"adoptive transfer","score":0.8050000071525574},{"id":"https://openalex.org/keywords/clonal-competition","display_name":"clonal competition","score":0.8970000147819519},{"id":"https://openalex.org/keywords/precursor-frequency","display_name":"precursor frequency","score":0.9020000100135803},{"id":"https://openalex.org/keywords/effector-t-cells","display_name":"effector T cells","score":0.8199999928474426},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7440000176429749},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.6589999794960022},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C2781350384","wikidata":"https://www.wikidata.org/wiki/Q292015","display_name":"Listeria monocytogenes","level":3,"score":0.8998302817344666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5117947459220886},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5005195140838623},{"id":"https://openalex.org/C2777187800","wikidata":"https://www.wikidata.org/wiki/Q160653","display_name":"Listeria infection","level":5,"score":0.42919477820396423},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4263290762901306},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4148736298084259},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3899228572845459},{"id":"https://openalex.org/C2778682378","wikidata":"https://www.wikidata.org/wiki/Q746209","display_name":"Listeria","level":4,"score":0.38565412163734436},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3401073217391968},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2546914219856262},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20294299721717834}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.upenn.edu:dissertations-3471","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI3087402","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},{"id":"mag:65820918","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=3471&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1831732289","https://openalex.org/W1931750338","https://openalex.org/W2066706419","https://openalex.org/W2120304289","https://openalex.org/W127959263","https://openalex.org/W7140240634","https://openalex.org/W1969268279","https://openalex.org/W1908616178","https://openalex.org/W16825620","https://openalex.org/W165062004"],"abstract_inverted_index":{"Mounting":[0],"evidence":[1],"suggests":[2],"that":[3,6,52,80,158,182,281,297,326],"the":[4,31,82,96,145,160,164,175,195,215,218,225,262,298,309],"mechanisms":[5],"regulate":[7],"T":[8,27,41,54,67,87,104,109,121,137,155,180,187,206,235,240,270,275,283,305,315,328,341],"cell":[9,17,88,284,316],"proliferation,":[10],"acquisition":[11],"of":[12,33,84,98,127,150,167,177,197,201,220,224,264,268,301,311],"effector":[13,185],"function,":[14],"and":[15,19,25,39,50,60,106,173,237,247,266,286,296],"memory":[16],"formation":[18],"maintenance":[20],"are":[21],"different":[22],"for":[23],"CD4":[24,38,53,103,108,120,136,154,179,186,205,269,282,304,314,327],"CD8":[26,40,66,234,239,274,340],"cells.":[28,68,227,276,342],"We":[29],"compared":[30],"proliferation":[32],"adoptively":[34,230],"transferred":[35,101,117,135,151,231],"TCR":[36,118,152,203,232,302],"transgenic":[37,119,153,204,233,303],"cells":[42,55,105,110,122,138,156,172,181,188,207,236,241,271,306,329],"in":[43,63,95,111,129,214,291,337],"response":[44,112,130,292],"to":[45,65,113,131,293,339],"Listeria":[46],"monocytogenes":[47],"(LM)":[48],"infection":[49,133,147,213,295,336],"found":[51],"undergo":[56],"limited":[57,125,332],"division,":[58],"differentiation,":[59],"clonal":[61,253],"expansion":[62],"comparison":[64,338],"To":[69],"further":[70],"investigate":[71],"these":[72,171],"differences,":[73],"we":[74,91],"developed":[75],"an":[76],"adoptive":[77,299],"transfer":[78,196,219,300],"system":[79],"enables":[81],"visualization":[83],"primary":[85],"polyclonal":[86,107,238],"responses.":[89],"Surprisingly,":[90],"observed":[92],"a":[93,124,198,221,312],"difference":[94],"extent":[97,263,310],"division":[99,265,285],"between":[100],"monoclonal":[102],"LM":[114,132,212,294,335],"infection.":[115,251],"Adoptively":[116],"divided":[123,142,246],"number":[126,166,200,223],"times":[128],"while":[134],"from":[139,242],"C57BL/6":[140,243],"mice":[141,244],"extensively":[143,249],"under":[144],"same":[146,226],"conditions.":[148],"Titration":[149],"revealed":[157],"reducing":[159],"precursor":[161,259],"frequency":[162],"increased":[163,174],"mean":[165],"divisions":[168],"underwent":[169],"by":[170,191,256],"percent":[176],"responding":[178],"differentiated":[183,248],"into":[184],"as":[189],"determined":[190],"IFN-\u03b3":[192],"secretion.":[193],"Moreover,":[194],"low":[199],"naive":[202],"provided":[208],"better":[209],"protection":[210,333],"against":[211,334],"liver":[216],"than":[217,273],"large":[222],"In":[228],"contrast,":[229],"both":[245],"following":[250],"Thus,":[252],"competition":[254],"induced":[255],"abnormally":[257],"high":[258],"frequencies":[260],"limits":[261],"differentiation":[267,287],"more":[272],"These":[277],"results":[278],"also":[279],"show":[280],"is":[288],"quite":[289],"extensive":[290],"may":[307],"underestimate":[308],"natural":[313],"response.":[317],"However,":[318],"despite":[319],"this":[320],"robust":[321],"response,":[322],"our":[323],"data":[324],"indicates":[325],"provide":[330],"only":[331]},"counts_by_year":[],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2016-06-24T00:00:00"}
