{"id":"https://openalex.org/W65807130","doi":null,"title":"Synthesis of Retigabine Analogues for the Treatment of Tinnitus and Progress Towards a Concise Route to XJB-5-131","display_name":"Synthesis of Retigabine Analogues for the Treatment of Tinnitus and Progress Towards a Concise Route to XJB-5-131","publication_year":2015,"publication_date":"2015-01-09","ids":{"openalex":"https://openalex.org/W65807130","mag":"65807130"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:23723","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/23723/1/NLReedMastersThesis.pdf","pdf_url":"http://d-scholarship.pitt.edu/23723/1/NLReedMastersThesis.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/23723/1/NLReedMastersThesis.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055460310","display_name":"Nicholas L. Reed","orcid":"https://orcid.org/0000-0003-4234-5464","observed_orcids":["https://orcid.org/0000-0003-4234-5464"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nicholas L. Reed","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4234-5464","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5055460310"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00014423,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.16130000352859497,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.16130000352859497,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.14139999449253082,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.12129999697208405,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tinnitus","display_name":"tinnitus","score":0.8930000066757202},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.5849999785423279},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6160532832145691},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5366828441619873},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5363966226577759},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.5137161016464233},{"id":"https://openalex.org/C2776992516","wikidata":"https://www.wikidata.org/wiki/Q192309","display_name":"Tinnitus","level":2,"score":0.4947452247142792},{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.4273705780506134},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.4265739917755127},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.41078606247901917},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3818206191062927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22932091355323792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20670393109321594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11086329817771912},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09502044320106506},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.07815882563591003},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:23723","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/23723/1/NLReedMastersThesis.pdf","pdf_url":"http://d-scholarship.pitt.edu/23723/1/NLReedMastersThesis.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:65807130","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/23723/1/NLReedMastersThesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:23723","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/23723/1/NLReedMastersThesis.pdf","pdf_url":"http://d-scholarship.pitt.edu/23723/1/NLReedMastersThesis.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W65807130.pdf","grobid_xml":"https://content.openalex.org/works/W65807130.grobid-xml"},"referenced_works_count":131,"referenced_works":["https://openalex.org/W95012175","https://openalex.org/W142358202","https://openalex.org/W1494311973","https://openalex.org/W1500064345","https://openalex.org/W1511940890","https://openalex.org/W1521918318","https://openalex.org/W1524194494","https://openalex.org/W1561275687","https://openalex.org/W1577063795","https://openalex.org/W1596694562","https://openalex.org/W1700971463","https://openalex.org/W1890033220","https://openalex.org/W1957081846","https://openalex.org/W1964587864","https://openalex.org/W1966429015","https://openalex.org/W1967108876","https://openalex.org/W1968923950","https://openalex.org/W1969680395","https://openalex.org/W1970264142","https://openalex.org/W1972852194","https://openalex.org/W1973012484","https://openalex.org/W1976130530","https://openalex.org/W1978052787","https://openalex.org/W1978750616","https://openalex.org/W1979078517","https://openalex.org/W1981123674","https://openalex.org/W1982816693","https://openalex.org/W1983137097","https://openalex.org/W1983345629","https://openalex.org/W1985901897","https://openalex.org/W1985940938","https://openalex.org/W1987576100","https://openalex.org/W1987908892","https://openalex.org/W1991608816","https://openalex.org/W1994385134","https://openalex.org/W1994977533","https://openalex.org/W1997537641","https://openalex.org/W1999767542","https://openalex.org/W2000054304","https://openalex.org/W2002588125","https://openalex.org/W2002919711","https://openalex.org/W2006215136","https://openalex.org/W2007814829","https://openalex.org/W2007880358","https://openalex.org/W2009672754","https://openalex.org/W2009724820","https://openalex.org/W2014044940","https://openalex.org/W2018443255","https://openalex.org/W2019973925","https://openalex.org/W2020794407","https://openalex.org/W2024208769","https://openalex.org/W2024358879","https://openalex.org/W2024627319","https://openalex.org/W2029233326","https://openalex.org/W2030698387","https://openalex.org/W2031220839","https://openalex.org/W2031889189","https://openalex.org/W2032734987","https://openalex.org/W2038273655","https://openalex.org/W2041367643","https://openalex.org/W2046038952","https://openalex.org/W2048291574","https://openalex.org/W2048669504","https://openalex.org/W2051771057","https://openalex.org/W2052341221","https://openalex.org/W2055418677","https://openalex.org/W2055456981","https://openalex.org/W2055775240","https://openalex.org/W2056331364","https://openalex.org/W2057053309","https://openalex.org/W2059690890","https://openalex.org/W2060962807","https://openalex.org/W2060981140","https://openalex.org/W2063559756","https://openalex.org/W2064771200","https://openalex.org/W2067417420","https://openalex.org/W2067960639","https://openalex.org/W2069483578","https://openalex.org/W2071029740","https://openalex.org/W2073245622","https://openalex.org/W2074369546","https://openalex.org/W2074969587","https://openalex.org/W2076827995","https://openalex.org/W2083720874","https://openalex.org/W2086759170","https://openalex.org/W2086930673","https://openalex.org/W2088734315","https://openalex.org/W2089950817","https://openalex.org/W2090091933","https://openalex.org/W2091222088","https://openalex.org/W2091786294","https://openalex.org/W2094253183","https://openalex.org/W2094349878","https://openalex.org/W2100604679","https://openalex.org/W2101204196","https://openalex.org/W2102235589","https://openalex.org/W2103729102","https://openalex.org/W2107708548","https://openalex.org/W2113178062","https://openalex.org/W2116087305","https://openalex.org/W2116437973","https://openalex.org/W2116751466","https://openalex.org/W2117696416","https://openalex.org/W2121029205","https://openalex.org/W2121966499","https://openalex.org/W2125604156","https://openalex.org/W2129431237","https://openalex.org/W2130845643","https://openalex.org/W2137263523","https://openalex.org/W2138758167","https://openalex.org/W2144153642","https://openalex.org/W2144958723","https://openalex.org/W2147323138","https://openalex.org/W2148312119","https://openalex.org/W2165331014","https://openalex.org/W2169980084","https://openalex.org/W2220416376","https://openalex.org/W2276265918","https://openalex.org/W2315512556","https://openalex.org/W2316282723","https://openalex.org/W2327115808","https://openalex.org/W2328521607","https://openalex.org/W2332062914","https://openalex.org/W2333730762","https://openalex.org/W2404364250","https://openalex.org/W2949715121","https://openalex.org/W2950574384","https://openalex.org/W2950621140","https://openalex.org/W2951504858","https://openalex.org/W2951730105","https://openalex.org/W2953278212"],"related_works":["https://openalex.org/W7072192112","https://openalex.org/W6941394258","https://openalex.org/W4409668907","https://openalex.org/W2613378983","https://openalex.org/W4281789870","https://openalex.org/W2922427931","https://openalex.org/W2331752076","https://openalex.org/W2119213449","https://openalex.org/W2736070324","https://openalex.org/W2591372701"],"abstract_inverted_index":{"The":[0,96],"first":[1],"part":[2,98],"of":[3,9,15,37,47,50,65,69,74,99],"this":[4,100],"thesis":[5,101],"describes":[6,102],"the":[7,13,35,51,58,63,72,80],"synthesis":[8,64],"retigabine":[10],"analogues":[11],"for":[12,79],"treatment":[14],"tinnitus.":[16],"Retigabine":[17],"is":[18,91],"a":[19,66,111,134],"clinically":[20],"proven":[21],"anticonvulsant":[22],"that":[23],"modulates":[24],"potassium":[25,82],"ion":[26,83],"channel":[27],"activity":[28],"and":[29,53,77,87,106,138],"has":[30],"been":[31],"shown":[32],"to":[33,44,93,104,109,117,129],"stop":[34],"onset":[36],"tinnitus":[38],"when":[39],"administered":[40],"shortly":[41],"after":[42],"exposure":[43],"extreme":[45],"levels":[46],"sound.":[48],"Alteration":[49],"fluorophenyl":[52],"carbamate":[54],"functionalities":[55],"present":[56],"in":[57,62,88,124],"parent":[59],"compound":[60],"resulted":[61],"small":[67],"library":[68],"compounds":[70],"with":[71],"goal":[73],"improving":[75],"potency":[76],"selectivity":[78],"Kv7.2/3":[81],"channels.":[84],"In":[85],"vivo":[86],"vitro":[89],"testing":[90],"underway":[92],"determine":[94],"efficacy.":[95],"second":[97],"efforts":[103],"develop":[105],"improved":[107],"route":[108,128],"XJB-5-131,":[110],"truncated":[112],"Gramicidin":[113],"S-derived":[114],"peptide":[115],"designed":[116],"control":[118],"reactive":[119],"oxygen":[120],"species":[121],"(ROS)":[122],"production":[123],"mitochondria.":[125],"A":[126],"new":[127],"XJB-5-131":[130],"was":[131],"explored":[132],"utilizing":[133],"stereoselective":[135],"\u03b1-alkenylation":[136],"protocol":[137],"starting":[139],"from":[140],"vinyl":[141],"boronic":[142],"acids.":[143]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}