{"id":"https://openalex.org/W65734902","doi":"https://doi.org/10.1016/s0022-5347(17)38288-5","title":"Testosterone Dependent Regulation of the Enzymes involved in DNA Synthesis in the Rat Ventral Prostate","display_name":"Testosterone Dependent Regulation of the Enzymes involved in DNA Synthesis in the Rat Ventral Prostate","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W65734902","doi":"https://doi.org/10.1016/s0022-5347(17)38288-5","mag":"65734902","pmid":"https://pubmed.ncbi.nlm.nih.gov/1845773"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(17)38288-5","doi":"https://doi.org/10.1016/s0022-5347(17)38288-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)38288-5","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102802655","display_name":"Yoshihiro Okuda","orcid":"https://orcid.org/0000-0002-3602-005X","observed_orcids":["https://orcid.org/0000-0002-3602-005X"]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Okuda","raw_affiliation_strings":["From the Department of Urology, Kobe University School of Medicine, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Kobe University School of Medicine, Kobe, Japan","institution_ids":["https://openalex.org/I4210089895","https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110520132","display_name":"Masato Fujisawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Fujisawa","raw_affiliation_strings":["From the Department of Urology, Kobe University School of Medicine, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Kobe University School of Medicine, Kobe, Japan","institution_ids":["https://openalex.org/I4210089895","https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109844738","display_name":"Osamu Matsumoto","orcid":"https://orcid.org/0009-0000-3725-597X","observed_orcids":["https://orcid.org/0009-0000-3725-597X"]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Matsumoto","raw_affiliation_strings":["From the Department of Urology, Kobe University School of Medicine, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Kobe University School of Medicine, Kobe, Japan","institution_ids":["https://openalex.org/I4210089895","https://openalex.org/I65837984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109557379","display_name":"Sadao Kamidono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sadao Kamidono","raw_affiliation_strings":["From the Department of Urology, Kobe University School of Medicine, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Kobe University School of Medicine, Kobe, Japan","institution_ids":["https://openalex.org/I4210089895","https://openalex.org/I65837984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.4174,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.55525261,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"145","issue":"1","first_page":"188","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ventral-prostate","display_name":"ventral prostate","score":0.8330000042915344},{"id":"https://openalex.org/keywords/dna-polymerase-alpha","display_name":"DNA polymerase alpha","score":0.9129999876022339},{"id":"https://openalex.org/keywords/dna-polymerase-beta","display_name":"DNA polymerase beta","score":1.0},{"id":"https://openalex.org/keywords/dna-polymerase-gamma","display_name":"DNA polymerase gamma","score":1.0},{"id":"https://openalex.org/keywords/topoisomerase-i","display_name":"topoisomerase I","score":1.0},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/castration","display_name":"castration","score":0.9290000200271606},{"id":"https://openalex.org/keywords/androgen-regulation","display_name":"androgen regulation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/prostate-growth","display_name":"prostate growth","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.678658127784729},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5645099878311157},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.554575502872467},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.540884792804718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4959627091884613},{"id":"https://openalex.org/C2779256933","wikidata":"https://www.wikidata.org/wiki/Q58929","display_name":"Castration","level":3,"score":0.48093265295028687},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4693784713745117},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.46402719616889954},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.43162864446640015},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4189058542251587},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39529967308044434},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3579869270324707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2865639328956604},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19560730457305908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18625473976135254},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.18004357814788818}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009919","descriptor_name":"Orchiectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-5347(17)38288-5","doi":"https://doi.org/10.1016/s0022-5347(17)38288-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)38288-5","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:1845773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1845773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W95862372","https://openalex.org/W1548331687","https://openalex.org/W1770219813","https://openalex.org/W1775749144","https://openalex.org/W1977779461","https://openalex.org/W1980801968","https://openalex.org/W1982075384","https://openalex.org/W1986855888","https://openalex.org/W2008729782","https://openalex.org/W2024280138","https://openalex.org/W2033156694","https://openalex.org/W2046279523","https://openalex.org/W2057289892","https://openalex.org/W2081161013","https://openalex.org/W2097649022","https://openalex.org/W2415668750","https://openalex.org/W2419172758","https://openalex.org/W2472937150","https://openalex.org/W2893237000"],"related_works":["https://openalex.org/W1992598908","https://openalex.org/W2154549989","https://openalex.org/W2286924139","https://openalex.org/W2016415324","https://openalex.org/W2016794039","https://openalex.org/W2054708009","https://openalex.org/W2099002295","https://openalex.org/W1986855888","https://openalex.org/W2020397573","https://openalex.org/W1983009512"],"abstract_inverted_index":{"The":[0,32,84],"effects":[1],"of":[2,7,34,67,70,92,121,149],"testosterone":[3,72,102],"on":[4],"the":[5,28,52,68,81,93,112,119,147],"activities":[6,33,56,120],"DNA":[8,23,90,122],"polymerase":[9,123],"alpha,":[10,124],"beta,":[11,125],"and":[12,47,77,89,126,128,138],"gamma":[13,127],"as":[14,16],"well":[15],"topoisomerase":[17,129],"I":[18,130],"(all":[19],"enzymes":[20,37,141],"involved":[21],"in":[22,27,42,146],"synthesis)":[24],"were":[25,57],"examined":[26],"rat":[29,94],"ventral":[30,95],"prostate.":[31],"these":[35,105,140],"four":[36],"decreased":[38,97],"gradually":[39],"after":[40,98],"castration":[41],"comparison":[43],"with":[44],"normal":[45,61],"controls,":[46],"continued":[48],"to":[49,60,64,108],"decrease":[50],"until":[51,80],"14th":[53,82],"day.":[54,83],"Enzyme":[55],"almost":[58],"restored":[59],"within":[62],"48":[63],"72":[65],"hr.":[66],"commencement":[69],"daily":[71],"injections":[73],"(0.3":[74],"mg./0.2":[75],"ml.),":[76],"increased":[78,107],"successively":[79],"wet":[85],"weight,":[86],"protein":[87],"content,":[88],"content":[91],"prostate":[96],"castration,":[99],"while":[100],"following":[101],"therapy":[103],"all":[104],"parameters":[106],"equal":[109],"or":[110],"exceed":[111],"control":[113],"levels.":[114],"These":[115],"results":[116],"suggested":[117],"that":[118,139],"are":[131],"at":[132],"least":[133],"partially":[134],"regulated":[135],"by":[136],"testosterone,":[137],"play":[142],"an":[143],"important":[144],"role":[145],"regulation":[148],"prostatic":[150],"cellular":[151],"proliferation.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
